EGFR_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/EGFR_UP.V1_UP
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Genes

388 genes differentially expressed following the EGFR_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
AKAP12 A kinase (PRKA) anchor protein 12
ALAS1 5'-aminolevulinate synthase 1
ANGPTL4 angiopoietin-like 4
AOX1 aldehyde oxidase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARID5B AT rich interactive domain 5B (MRF1-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATXN1 ataxin 1
BACE2 beta-site APP-cleaving enzyme 2
BCL3 B-cell CLL/lymphoma 3
BMP7 bone morphogenetic protein 7
C8ORF4 chromosome 8 open reading frame 4
CADPS2 Ca++-dependent secretion activator 2
CAPN2 calpain 2, (m/II) large subunit
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC68 coiled-coil domain containing 68
CCL2 chemokine (C-C motif) ligand 2
CCL22 chemokine (C-C motif) ligand 22
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CLDN1 claudin 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL5A2 collagen, type V, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELL2 elongation factor, RNA polymerase II, 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
ERO1L ERO1-like (S. cerevisiae)
ETHE1 ethylmalonic encephalopathy 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
EXT1 exostosin glycosyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS3 fatty acid desaturase 3
FERMT2 fermitin family member 2
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FHOD1 formin homology 2 domain containing 1
FNDC3B fibronectin type III domain containing 3B
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GJA1 gap junction protein, alpha 1, 43kDa
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GLRX glutaredoxin (thioltransferase)
GRAMD3 GRAM domain containing 3
HBEGF heparin-binding EGF-like growth factor
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HK2 hexokinase 2
HOMER1 homer scaffolding protein 1
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL15RA interleukin 15 receptor, alpha
IL1R1 interleukin 1 receptor, type I
IL4R interleukin 4 receptor
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INHBA inhibin, beta A
IQCG IQ motif containing G
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB6 integrin, beta 6
JUNB jun B proto-oncogene
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KTN1 kinectin 1 (kinesin receptor)
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LOXL2 lysyl oxidase-like 2
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
LPP LIM domain containing preferred translocation partner in lipoma
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC16A leucine rich repeat containing 16A
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MEIS3P1 Meis homeobox 3 pseudogene 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MPZL2 myelin protein zero-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NT5C2 5'-nucleotidase, cytosolic II
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH9 protocadherin 9
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM7 PDZ and LIM domain 7 (enigma)
PGM3 phosphoglucomutase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PLAC1 placenta-specific 1
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRE protein tyrosine phosphatase, receptor type, E
RAB27A RAB27A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RGS16 regulator of G-protein signaling 16
RHOQ ras homolog family member Q
RND1 Rho family GTPase 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCCPDH saccharopine dehydrogenase (putative)
SDCBP syndecan binding protein (syntenin)
SEC23A Sec23 homolog A (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT10 septin 10
SGMS1 sphingomyelin synthase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX16 sorting nexin 16
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SOWAHC sosondowah ankyrin repeat domain family member C
SPAG1 sperm associated antigen 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQRDL sulfide quinone reductase-like (yeast)
SUSD6 sushi domain containing 6
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB2 transforming growth factor, beta 2
TMEM121 transmembrane protein 121
TMEM45A transmembrane protein 45A
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TUBB2A tubulin, beta 2A class IIa
VAV3 vav 3 guanine nucleotide exchange factor
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNT5A wingless-type MMTV integration site family, member 5A
ZNF281 zinc finger protein 281

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANGEL2 angel homolog 2 (Drosophila)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA9 annexin A9
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARL3 ADP-ribosylation factor-like 3
ARL4A ADP-ribosylation factor-like 4A
ARMC9 armadillo repeat containing 9
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATF7IP activating transcription factor 7 interacting protein
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BDKRB2 bradykinin receptor B2
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BST2 bone marrow stromal cell antigen 2
BTG3 BTG family, member 3
C16ORF45 chromosome 16 open reading frame 45
C18ORF8 chromosome 18 open reading frame 8
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CALB2 calbindin 2
CALCR calcitonin receptor
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBR4 carbonyl reductase 4
CDKN2AIP CDKN2A interacting protein
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CENPU centromere protein U
CHN1 chimerin 1
CLK4 CDC-like kinase 4
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CTSH cathepsin H
CYBA cytochrome b-245, alpha polypeptide
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCAF6 DDB1 and CUL4 associated factor 6
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEPDC1 DEP domain containing 1
DERA deoxyribose-phosphate aldolase (putative)
DLC1 DLC1 Rho GTPase activating protein
DMXL2 Dmx-like 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELF5 E74-like factor 5 (ets domain transcription factor)
ELOVL2 ELOVL fatty acid elongase 2
ELOVL5 ELOVL fatty acid elongase 5
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM50A family with sequence similarity 50, member A
FANCL Fanconi anemia, complementation group L
FTO fat mass and obesity associated
GALC galactosylceramidase
GFRA1 GDNF family receptor alpha 1
GOLGA8A golgin A8 family, member A
GPATCH1 G patch domain containing 1
GPER1 G protein-coupled estrogen receptor 1
GRB10 growth factor receptor-bound protein 10
GREB1 growth regulation by estrogen in breast cancer 1
GTF2I general transcription factor IIi
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HSPA4L heat shock 70kDa protein 4-like
IAPP islet amyloid polypeptide
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
INPP5F inositol polyphosphate-5-phosphatase F
IRS1 insulin receptor substrate 1
KIAA0430 KIAA0430
KIAA1324 KIAA1324
KIAA1467 KIAA1467
KIF11 kinesin family member 11
KIF5C kinesin family member 5C
KRIT1 KRIT1, ankyrin repeat containing
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LTBP1 latent transforming growth factor beta binding protein 1
LTN1 listerin E3 ubiquitin protein ligase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
METTL3 methyltransferase like 3
MEX3D mex-3 RNA binding family member D
MFF mitochondrial fission factor
MICB MHC class I polypeptide-related sequence B
MOCOS molybdenum cofactor sulfurase
MPDZ multiple PDZ domain protein
MSMB microseminoprotein, beta-
MYB v-myb avian myeloblastosis viral oncogene homolog
NCAPG2 non-SMC condensin II complex, subunit G2
NDC1 NDC1 transmembrane nucleoporin
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NET1 neuroepithelial cell transforming 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NUP205 nucleoporin 205kDa
OSR2 odd-skipped related transciption factor 2
OVOL2 ovo-like zinc finger 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCYOX1 prenylcysteine oxidase 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM3 PDZ and LIM domain 3
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PGR progesterone receptor
PHF20 PHD finger protein 20
POLI polymerase (DNA directed) iota
POT1 protection of telomeres 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKD3 protein kinase D3
PRPF6 pre-mRNA processing factor 6
PRR15L proline rich 15-like
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
PTBP2 polypyrimidine tract binding protein 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFWD3 ring finger and WD repeat domain 3
RHOBTB3 Rho-related BTB domain containing 3
RNF43 ring finger protein 43
RPP25 ribonuclease P/MRP 25kDa subunit
RUFY1 RUN and FYVE domain containing 1
SATB2 SATB homeobox 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGK3 serum/glucocorticoid regulated kinase family, member 3
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SNX7 sorting nexin 7
SOX3 SRY (sex determining region Y)-box 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SSFA2 sperm specific antigen 2
STIL SCL/TAL1 interrupting locus
SYCP2 synaptonemal complex protein 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCAF1 TRPM8 channel-associated factor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM106B transmembrane protein 106B
TMEM187 transmembrane protein 187
TMPRSS3 transmembrane protease, serine 3
TRIM24 tripartite motif containing 24
TSC22D3 TSC22 domain family, member 3
TSPAN5 tetraspanin 5
TTC39A tetratricopeptide repeat domain 39A
WIPF1 WAS/WASL interacting protein family, member 1
WISP2 WNT1 inducible signaling pathway protein 2
XK X-linked Kx blood group
ZNF107 zinc finger protein 107
ZNF273 zinc finger protein 273
ZNF43 zinc finger protein 43
ZSCAN18 zinc finger and SCAN domain containing 18
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