Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
Category | transcriptomics |
Type | gene perturbation |
Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
External Link | http://www.broadinstitute.org/gsea/msigdb/cards/EGFR_UP.V1_UP |
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388 genes differentially expressed following the EGFR_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Symbol | Name |
---|---|
A2M | alpha-2-macroglobulin |
ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
ACTG2 | actin, gamma 2, smooth muscle, enteric |
ADM | adrenomedullin |
AGO2 | argonaute RISC catalytic component 2 |
AKAP12 | A kinase (PRKA) anchor protein 12 |
ALAS1 | 5'-aminolevulinate synthase 1 |
ANGPTL4 | angiopoietin-like 4 |
AOX1 | aldehyde oxidase 1 |
APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 |
ARID5B | AT rich interactive domain 5B (MRF1-like) |
ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 |
ASPH | aspartate beta-hydroxylase |
ATF3 | activating transcription factor 3 |
ATXN1 | ataxin 1 |
BACE2 | beta-site APP-cleaving enzyme 2 |
BCL3 | B-cell CLL/lymphoma 3 |
BMP7 | bone morphogenetic protein 7 |
C8ORF4 | chromosome 8 open reading frame 4 |
CADPS2 | Ca++-dependent secretion activator 2 |
CAPN2 | calpain 2, (m/II) large subunit |
CASP7 | caspase 7, apoptosis-related cysteine peptidase |
CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
CCDC68 | coiled-coil domain containing 68 |
CCL2 | chemokine (C-C motif) ligand 2 |
CCL22 | chemokine (C-C motif) ligand 22 |
CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
CEBPD | CCAAT/enhancer binding protein (C/EBP), delta |
CEMIP | cell migration inducing protein, hyaluronan binding |
CLDN1 | claudin 1 |
CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene |
COL5A2 | collagen, type V, alpha 2 |
COTL1 | coactosin-like F-actin binding protein 1 |
CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 |
CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
CTGF | connective tissue growth factor |
CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 |
CXADR | coxsackie virus and adenovirus receptor |
CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 |
CYR61 | cysteine-rich, angiogenic inducer, 61 |
DBNDD2 | dysbindin (dystrobrevin binding protein 1) domain containing 2 |
DRAM1 | DNA-damage regulated autophagy modulator 1 |
DUSP4 | dual specificity phosphatase 4 |
DUSP5 | dual specificity phosphatase 5 |
DUSP6 | dual specificity phosphatase 6 |
EDN1 | endothelin 1 |
EGFR | epidermal growth factor receptor |
EGLN3 | egl-9 family hypoxia-inducible factor 3 |
ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) |
ELL2 | elongation factor, RNA polymerase II, 2 |
ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
EPAS1 | endothelial PAS domain protein 1 |
ERO1L | ERO1-like (S. cerevisiae) |
ETHE1 | ethylmalonic encephalopathy 1 |
ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
ETV5 | ets variant 5 |
EXT1 | exostosin glycosyltransferase 1 |
F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
FADS3 | fatty acid desaturase 3 |
FERMT2 | fermitin family member 2 |
FGB | fibrinogen beta chain |
FGFR3 | fibroblast growth factor receptor 3 |
FGG | fibrinogen gamma chain |
FHOD1 | formin homology 2 domain containing 1 |
FNDC3B | fibronectin type III domain containing 3B |
GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
GAL | galanin/GMAP prepropeptide |
GBP1 | guanylate binding protein 1, interferon-inducible |
GBP2 | guanylate binding protein 2, interferon-inducible |
GCLM | glutamate-cysteine ligase, modifier subunit |
GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 |
GJA1 | gap junction protein, alpha 1, 43kDa |
GK | glycerol kinase |
GK3P | glycerol kinase 3 pseudogene |
GLRX | glutaredoxin (thioltransferase) |
GRAMD3 | GRAM domain containing 3 |
HBEGF | heparin-binding EGF-like growth factor |
HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 |
HK2 | hexokinase 2 |
HOMER1 | homer scaffolding protein 1 |
HSPA2 | heat shock 70kDa protein 2 |
ICAM1 | intercellular adhesion molecule 1 |
IDO1 | indoleamine 2,3-dioxygenase 1 |
IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 |
IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 |
IL15RA | interleukin 15 receptor, alpha |
IL1R1 | interleukin 1 receptor, type I |
IL4R | interleukin 4 receptor |
IMPA1 | inositol(myo)-1(or 4)-monophosphatase 1 |
INHBA | inhibin, beta A |
IQCG | IQ motif containing G |
IRF1 | interferon regulatory factor 1 |
ISG20 | interferon stimulated exonuclease gene 20kDa |
ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
ITGB6 | integrin, beta 6 |
JUNB | jun B proto-oncogene |
KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 |
KLF4 | Kruppel-like factor 4 (gut) |
KRT7 | keratin 7, type II |
KRT81 | keratin 81, type II |
KTN1 | kinectin 1 (kinesin receptor) |
LHFPL2 | lipoma HMGIC fusion partner-like 2 |
LIF | leukemia inhibitory factor |
LOXL2 | lysyl oxidase-like 2 |
LPAR6 | lysophosphatidic acid receptor 6 |
LPIN1 | lipin 1 |
LPP | LIM domain containing preferred translocation partner in lipoma |
LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
LRRC16A | leucine rich repeat containing 16A |
MALL | mal, T-cell differentiation protein-like |
MAOA | monoamine oxidase A |
MAP2K4 | mitogen-activated protein kinase kinase 4 |
MAP3K5 | mitogen-activated protein kinase kinase kinase 5 |
MBNL2 | muscleblind-like splicing regulator 2 |
MEIS3P1 | Meis homeobox 3 pseudogene 1 |
MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A |
MGLL | monoglyceride lipase |
MIR22HG | MIR22 host gene |
MMP1 | matrix metallopeptidase 1 |
MMP10 | matrix metallopeptidase 10 |
MPZL2 | myelin protein zero-like 2 |
NFIL3 | nuclear factor, interleukin 3 regulated |
NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
NT5C2 | 5'-nucleotidase, cytosolic II |
P2RY6 | pyrimidinergic receptor P2Y, G-protein coupled, 6 |
PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
PCDH9 | protocadherin 9 |
PDE4B | phosphodiesterase 4B, cAMP-specific |
PDLIM7 | PDZ and LIM domain 7 (enigma) |
PGM3 | phosphoglucomutase 3 |
PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
PIGA | phosphatidylinositol glycan anchor biosynthesis, class A |
PLAC1 | placenta-specific 1 |
PLAGL1 | pleiomorphic adenoma gene-like 1 |
PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 |
PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 |
PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 |
PTPRE | protein tyrosine phosphatase, receptor type, E |
RAB27A | RAB27A, member RAS oncogene family |
RCAN1 | regulator of calcineurin 1 |
RGS16 | regulator of G-protein signaling 16 |
RHOQ | ras homolog family member Q |
RND1 | Rho family GTPase 1 |
RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase |
RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
S100A8 | S100 calcium binding protein A8 |
S100A9 | S100 calcium binding protein A9 |
S100P | S100 calcium binding protein P |
SAMD4A | sterile alpha motif domain containing 4A |
SAT1 | spermidine/spermine N1-acetyltransferase 1 |
SCCPDH | saccharopine dehydrogenase (putative) |
SDCBP | syndecan binding protein (syntenin) |
SEC23A | Sec23 homolog A (S. cerevisiae) |
SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
SEPT10 | septin 10 |
SGMS1 | sphingomyelin synthase 1 |
SGPP1 | sphingosine-1-phosphate phosphatase 1 |
SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 |
SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
SLC9A6 | solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 |
SLCO2A1 | solute carrier organic anion transporter family, member 2A1 |
SMCO4 | single-pass membrane protein with coiled-coil domains 4 |
SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa |
SNX16 | sorting nexin 16 |
SOCS2 | suppressor of cytokine signaling 2 |
SOD2 | superoxide dismutase 2, mitochondrial |
SOWAHC | sosondowah ankyrin repeat domain family member C |
SPAG1 | sperm associated antigen 1 |
SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 |
SQRDL | sulfide quinone reductase-like (yeast) |
SUSD6 | sushi domain containing 6 |
TAF1A | TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa |
TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) |
TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
TGFB2 | transforming growth factor, beta 2 |
TMEM121 | transmembrane protein 121 |
TMEM45A | transmembrane protein 45A |
TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 |
TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b |
TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 |
TNNT1 | troponin T type 1 (skeletal, slow) |
TNS3 | tensin 3 |
TUBB2A | tubulin, beta 2A class IIa |
VAV3 | vav 3 guanine nucleotide exchange factor |
WIPI1 | WD repeat domain, phosphoinositide interacting 1 |
WNT5A | wingless-type MMTV integration site family, member 5A |
ZNF281 | zinc finger protein 281 |
Symbol | Name |
---|---|
ABLIM1 | actin binding LIM protein 1 |
ACKR3 | atypical chemokine receptor 3 |
ADD3 | adducin 3 (gamma) |
AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase |
ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit |
ANGEL2 | angel homolog 2 (Drosophila) |
ANK3 | ankyrin 3, node of Ranvier (ankyrin G) |
ANXA9 | annexin A9 |
APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 |
ARL3 | ADP-ribosylation factor-like 3 |
ARL4A | ADP-ribosylation factor-like 4A |
ARMC9 | armadillo repeat containing 9 |
ARMCX1 | armadillo repeat containing, X-linked 1 |
ASCL1 | achaete-scute family bHLH transcription factor 1 |
ATF7IP | activating transcription factor 7 interacting protein |
BAZ2B | bromodomain adjacent to zinc finger domain, 2B |
BCL2 | B-cell CLL/lymphoma 2 |
BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 |
BDKRB2 | bradykinin receptor B2 |
BRCC3 | BRCA1/BRCA2-containing complex, subunit 3 |
BRIP1 | BRCA1 interacting protein C-terminal helicase 1 |
BST2 | bone marrow stromal cell antigen 2 |
BTG3 | BTG family, member 3 |
C16ORF45 | chromosome 16 open reading frame 45 |
C18ORF8 | chromosome 18 open reading frame 8 |
C9ORF3 | chromosome 9 open reading frame 3 |
CADM1 | cell adhesion molecule 1 |
CALB2 | calbindin 2 |
CALCR | calcitonin receptor |
CASP6 | caspase 6, apoptosis-related cysteine peptidase |
CAV1 | caveolin 1, caveolae protein, 22kDa |
CBFA2T3 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 |
CBR4 | carbonyl reductase 4 |
CDKN2AIP | CDKN2A interacting protein |
CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 |
CENPU | centromere protein U |
CHN1 | chimerin 1 |
CLK4 | CDC-like kinase 4 |
COL9A3 | collagen, type IX, alpha 3 |
CPE | carboxypeptidase E |
CSTA | cystatin A (stefin A) |
CTSH | cathepsin H |
CYBA | cytochrome b-245, alpha polypeptide |
CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 |
DCAF6 | DDB1 and CUL4 associated factor 6 |
DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
DEPDC1 | DEP domain containing 1 |
DERA | deoxyribose-phosphate aldolase (putative) |
DLC1 | DLC1 Rho GTPase activating protein |
DMXL2 | Dmx-like 2 |
DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 |
DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
E2F8 | E2F transcription factor 8 |
EFHD1 | EF-hand domain family, member D1 |
EFNB2 | ephrin-B2 |
EGR3 | early growth response 3 |
EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
ELF5 | E74-like factor 5 (ets domain transcription factor) |
ELOVL2 | ELOVL fatty acid elongase 2 |
ELOVL5 | ELOVL fatty acid elongase 5 |
ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) |
EPB41L2 | erythrocyte membrane protein band 4.1-like 2 |
EPS8 | epidermal growth factor receptor pathway substrate 8 |
EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
FAM50A | family with sequence similarity 50, member A |
FANCL | Fanconi anemia, complementation group L |
FTO | fat mass and obesity associated |
GALC | galactosylceramidase |
GFRA1 | GDNF family receptor alpha 1 |
GOLGA8A | golgin A8 family, member A |
GPATCH1 | G patch domain containing 1 |
GPER1 | G protein-coupled estrogen receptor 1 |
GRB10 | growth factor receptor-bound protein 10 |
GREB1 | growth regulation by estrogen in breast cancer 1 |
GTF2I | general transcription factor IIi |
GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
H2BFS | H2B histone family, member S (pseudogene) |
HEBP1 | heme binding protein 1 |
HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
HIRA | histone cell cycle regulator |
HIST1H1C | histone cluster 1, H1c |
HIST1H2AC | histone cluster 1, H2ac |
HIST1H2AE | histone cluster 1, H2ae |
HIST1H2AG | histone cluster 1, H2ag |
HIST1H2BD | histone cluster 1, H2bd |
HIST1H2BE | histone cluster 1, H2be |
HIST1H2BF | histone cluster 1, H2bf |
HIST1H2BG | histone cluster 1, H2bg |
HIST1H2BH | histone cluster 1, H2bh |
HIST1H2BI | histone cluster 1, H2bi |
HIST1H3H | histone cluster 1, H3h |
HIST1H4H | histone cluster 1, H4h |
HSPA4L | heat shock 70kDa protein 4-like |
IAPP | islet amyloid polypeptide |
ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
IFI27 | interferon, alpha-inducible protein 27 |
IFI44 | interferon-induced protein 44 |
IFI44L | interferon-induced protein 44-like |
IFI6 | interferon, alpha-inducible protein 6 |
IGF1R | insulin-like growth factor 1 receptor |
INPP5F | inositol polyphosphate-5-phosphatase F |
IRS1 | insulin receptor substrate 1 |
KIAA0430 | KIAA0430 |
KIAA1324 | KIAA1324 |
KIAA1467 | KIAA1467 |
KIF11 | kinesin family member 11 |
KIF5C | kinesin family member 5C |
KRIT1 | KRIT1, ankyrin repeat containing |
LLGL2 | lethal giant larvae homolog 2 (Drosophila) |
LTBP1 | latent transforming growth factor beta binding protein 1 |
LTN1 | listerin E3 ubiquitin protein ligase 1 |
MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
MATN2 | matrilin 2 |
MDK | midkine (neurite growth-promoting factor 2) |
METTL3 | methyltransferase like 3 |
MEX3D | mex-3 RNA binding family member D |
MFF | mitochondrial fission factor |
MICB | MHC class I polypeptide-related sequence B |
MOCOS | molybdenum cofactor sulfurase |
MPDZ | multiple PDZ domain protein |
MSMB | microseminoprotein, beta- |
MYB | v-myb avian myeloblastosis viral oncogene homolog |
NCAPG2 | non-SMC condensin II complex, subunit G2 |
NDC1 | NDC1 transmembrane nucleoporin |
NDUFA5 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 |
NET1 | neuroepithelial cell transforming 1 |
NME3 | NME/NM23 nucleoside diphosphate kinase 3 |
NMU | neuromedin U |
NPY1R | neuropeptide Y receptor Y1 |
NREP | neuronal regeneration related protein |
NRIP1 | nuclear receptor interacting protein 1 |
NUP205 | nucleoporin 205kDa |
OSR2 | odd-skipped related transciption factor 2 |
OVOL2 | ovo-like zinc finger 2 |
PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 |
PCYOX1 | prenylcysteine oxidase 1 |
PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
PDLIM3 | PDZ and LIM domain 3 |
PDZK1 | PDZ domain containing 1 |
PEG10 | paternally expressed 10 |
PGR | progesterone receptor |
PHF20 | PHD finger protein 20 |
POLI | polymerase (DNA directed) iota |
POT1 | protection of telomeres 1 |
PRKACB | protein kinase, cAMP-dependent, catalytic, beta |
PRKD3 | protein kinase D3 |
PRPF6 | pre-mRNA processing factor 6 |
PRR15L | proline rich 15-like |
PRR7 | proline rich 7 (synaptic) |
PSPH | phosphoserine phosphatase |
PTBP2 | polypyrimidine tract binding protein 2 |
RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
RCN1 | reticulocalbin 1, EF-hand calcium binding domain |
RFWD3 | ring finger and WD repeat domain 3 |
RHOBTB3 | Rho-related BTB domain containing 3 |
RNF43 | ring finger protein 43 |
RPP25 | ribonuclease P/MRP 25kDa subunit |
RUFY1 | RUN and FYVE domain containing 1 |
SATB2 | SATB homeobox 2 |
SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) |
SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) |
SGK3 | serum/glucocorticoid regulated kinase family, member 3 |
SH3GLB2 | SH3-domain GRB2-like endophilin B2 |
SIGMAR1 | sigma non-opioid intracellular receptor 1 |
SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 |
SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 |
SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 |
SMAD7 | SMAD family member 7 |
SNX7 | sorting nexin 7 |
SOX3 | SRY (sex determining region Y)-box 3 |
SPTBN1 | spectrin, beta, non-erythrocytic 1 |
SSFA2 | sperm specific antigen 2 |
STIL | SCL/TAL1 interrupting locus |
SYCP2 | synaptonemal complex protein 2 |
TAF12 | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa |
TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 |
TCAF1 | TRPM8 channel-associated factor 1 |
TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
TMEM106B | transmembrane protein 106B |
TMEM187 | transmembrane protein 187 |
TMPRSS3 | transmembrane protease, serine 3 |
TRIM24 | tripartite motif containing 24 |
TSC22D3 | TSC22 domain family, member 3 |
TSPAN5 | tetraspanin 5 |
TTC39A | tetratricopeptide repeat domain 39A |
WIPF1 | WAS/WASL interacting protein family, member 1 |
WISP2 | WNT1 inducible signaling pathway protein 2 |
XK | X-linked Kx blood group |
ZNF107 | zinc finger protein 107 |
ZNF273 | zinc finger protein 273 |
ZNF43 | zinc finger protein 43 |
ZSCAN18 | zinc finger and SCAN domain containing 18 |