EGR1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description early growth response 1|The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014] (NCBI Entrez Gene Database, 1958)
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Genes

363 genes differentially expressed following the EGR1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NGFR nerve growth factor receptor 3.23146
TMEM190 transmembrane protein 190 3.23146
WNT16 wingless-type MMTV integration site family, member 16 3.23146
ALPK2 alpha-kinase 2 3.23146
PCDHGC3 protocadherin gamma subfamily C, 3 3.23146
TMEM100 transmembrane protein 100 3.23146
ADPRH ADP-ribosylarginine hydrolase 3.23146
C1QTNF7 C1q and tumor necrosis factor related protein 7 3.23146
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.23146
RUNX3 runt-related transcription factor 3 3.23146
PXT1 peroxisomal, testis specific 1 3.23146
NHLH1 nescient helix loop helix 1 3.23146
TM4SF20 transmembrane 4 L six family member 20 3.23146
TMEM233 transmembrane protein 233 3.23146
EFCAB3 EF-hand calcium binding domain 3 3.23146
COLEC10 collectin sub-family member 10 (C-type lectin) 3.23146
TUBA8 tubulin, alpha 8 3.23146
ACOT1 acyl-CoA thioesterase 1 3.23146
TCERG1L transcription elongation regulator 1-like 3.23146
RHCE Rh blood group, CcEe antigens 3.23146
AMPD1 adenosine monophosphate deaminase 1 3.23146
PRR22 proline rich 22 3.23146
C20ORF204 chromosome 20 open reading frame 204 3.23146
RGS8 regulator of G-protein signaling 8 3.23146
MGAT4D MGAT4 family, member D 3.23146
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.23146
LTB lymphotoxin beta (TNF superfamily, member 3) 3.23146
IL5RA interleukin 5 receptor, alpha 3.18371
TAS2R13 taste receptor, type 2, member 13 3.18371
FER1L6 fer-1-like family member 6 3.18371
LGALS4 lectin, galactoside-binding, soluble, 4 3.18371
DDN dendrin 3.18371
CPLX3 complexin 3 3.18371
ZFP57 ZFP57 zinc finger protein 3.18371
C21ORF140 chromosome 21 open reading frame 140 3.18371
ALOX15 arachidonate 15-lipoxygenase 3.18371
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.18371
WDR87 WD repeat domain 87 3.18371
SIX1 SIX homeobox 1 3.18371
ZNF503 zinc finger protein 503 3.18371
ELF4 E74-like factor 4 (ets domain transcription factor) 3.18371
GYS2 glycogen synthase 2 (liver) 3.18371
CLEC12A C-type lectin domain family 12, member A 3.18371
PTK6 protein tyrosine kinase 6 3.18371
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.18371
GPR20 G protein-coupled receptor 20 3.18371
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 3.18371
HYKK hydroxylysine kinase 3.18371
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.18371
HIPK4 homeodomain interacting protein kinase 4 3.18371
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.18371
DEFB124 defensin, beta 124 3.18371
HEPHL1 hephaestin-like 1 3.18371
MSC musculin 3.18371
LBX2 ladybird homeobox 2 3.18371
SKOR1 SKI family transcriptional corepressor 1 3.18371
BATF basic leucine zipper transcription factor, ATF-like 3.18371
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 3.18371
PAX7 paired box 7 3.18371
FETUB fetuin B 3.18371
RFX6 regulatory factor X, 6 3.18371
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 3.18371
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.18371
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.18371
H2BK1 H2B.K variant histone 1 3.18371
RCVRN recoverin 3.18371
PAPOLB poly(A) polymerase beta (testis specific) 3.18371
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.18371
MIOX myo-inositol oxygenase 3.18371
DOK2 docking protein 2, 56kDa 3.18371
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.18371
DLK1 delta-like 1 homolog (Drosophila) 3.18371
PXDC1 PX domain containing 1 3.18371
LRRC71 leucine rich repeat containing 71 3.18371
LTB4R2 leukotriene B4 receptor 2 3.18371
PSPN persephin 3.18371
SPEM2 SPEM family member 2 3.18371
H2BW1 H2B.W histone 1 3.18371
DEFB131B defensin beta 131B 3.18371
FLACC1 flagellum associated containing coiled-coil domains 1 3.18371
RTL9 retrotransposon Gag like 9 3.18371
CRACDL CRACD like 3.18371
NSG2 neuronal vesicle trafficking associated 2 3.18371
STING1 stimulator of interferon response cGAMP interactor 1 3.18371
NECTIN4 nectin cell adhesion molecule 4 3.18371
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.18371
FGFBP1 fibroblast growth factor binding protein 1 3.18371
OOSP1 oocyte secreted protein 1, pseudogene 3.18371
NR1I2 nuclear receptor subfamily 1, group I, member 2 3.18371
CATSPERD catsper channel auxiliary subunit delta 3.18371
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.18371
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 3.18371
IRF5 interferon regulatory factor 5 3.18371
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.18371
FPR3 formyl peptide receptor 3 3.18371
PRB1 proline-rich protein BstNI subfamily 1 3.18371
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.18371
ULBP1 UL16 binding protein 1 3.18371
SCRT2 scratch family zinc finger 2 3.18371
C7ORF57 chromosome 7 open reading frame 57 3.18371
S100B S100 calcium binding protein B 3.18371
NPFF neuropeptide FF-amide peptide precursor 3.18371
CCDC121 coiled-coil domain containing 121 3.18371
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.18371
C1QL2 complement component 1, q subcomponent-like 2 3.18371
MIA melanoma inhibitory activity 3.18371
REC114 REC114 meiotic recombination protein 3.18371
OR2A14 olfactory receptor, family 2, subfamily A, member 14 3.18371
PLVAP plasmalemma vesicle associated protein 3.18371
PRSS54 protease, serine, 54 3.18371
KLHL6 kelch-like family member 6 3.18371
THTPA thiamine triphosphatase 3.18371
AQP8 aquaporin 8 3.18371
EME2 essential meiotic structure-specific endonuclease subunit 2 3.18371
PHF21A PHD finger protein 21A 3.18371
JSRP1 junctional sarcoplasmic reticulum protein 1 3.18371
SPATA4 spermatogenesis associated 4 3.18371
CDH10 cadherin 10, type 2 (T2-cadherin) 3.18371
TRIM50 tripartite motif containing 50 3.18371
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.18371
CCL15 chemokine (C-C motif) ligand 15 3.18371
TNR tenascin R 3.18371
CST5 cystatin D 3.18371
TBPL2 TATA box binding protein like 2 3.18371
LRRC32 leucine rich repeat containing 32 3.18371
PCDHGB2 protocadherin gamma subfamily B, 2 3.18371
SPZ1 spermatogenic leucine zipper 1 3.18371
CCDC154 coiled-coil domain containing 154 3.18371
BRDT bromodomain, testis-specific 3.18371
RAD21L1 RAD21-like 1 (S. pombe) 3.18371
CT55 cancer/testis antigen 55 3.18371
EDN3 endothelin 3 3.18371
DNAH12 dynein, axonemal, heavy chain 12 3.18371
LCT lactase 3.18371
VWA3B von Willebrand factor A domain containing 3B 3.18371
CHI3L2 chitinase 3-like 2 3.18371
CTSS cathepsin S 3.18371
IDI2 isopentenyl-diphosphate delta isomerase 2 3.18371
CAPSL calcyphosine-like 3.18371
CSNK1A1L casein kinase 1, alpha 1-like 3.18371
C10ORF105 chromosome 10 open reading frame 105 3.18371
TTC24 tetratricopeptide repeat domain 24 3.18371
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.18371
STRC stereocilin 3.18371
GJC2 gap junction protein, gamma 2, 47kDa 3.18371
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.18371
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.18371
PRSS33 protease, serine, 33 3.18371
GSTA1 glutathione S-transferase alpha 1 3.18371
CABP5 calcium binding protein 5 3.18371
THBD thrombomodulin 3.18371
PDZRN4 PDZ domain containing ring finger 4 3.18371
LRRK2 leucine-rich repeat kinase 2 3.18371
KLK15 kallikrein-related peptidase 15 3.18371
CATIP ciliogenesis associated TTC17 interacting protein 3.18371
KLK5 kallikrein-related peptidase 5 3.18371
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.18371
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.18371
CRYBA1 crystallin, beta A1 3.18371
PLA2G12B phospholipase A2, group XIIB 3.18371
TRHR thyrotropin-releasing hormone receptor 3.18371
CD226 CD226 molecule 3.18371
LHX6 LIM homeobox 6 3.18371
GH2 growth hormone 2 3.18371
CLCA1 chloride channel accessory 1 3.18371
ZBED6 zinc finger, BED-type containing 6 3.18371
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.18371
TAS2R43 taste receptor, type 2, member 43 3.18371
ST18 suppression of tumorigenicity 18, zinc finger 3.18371
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.18371
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.18371
TSHR thyroid stimulating hormone receptor 3.18371
CD34 CD34 molecule 3.18371
NPPB natriuretic peptide B 3.18371
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.18371
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.18371
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.18371
CRYAA crystallin, alpha A 3.18371
CARD9 caspase recruitment domain family, member 9 3.18371
C5AR2 complement component 5a receptor 2 3.18371
POU3F2 POU class 3 homeobox 2 3.18371
CALML5 calmodulin-like 5 3.18371
SP100 SP100 nuclear antigen 3.18371
SLITRK6 SLIT and NTRK-like family, member 6 3.18371
POTEF POTE ankyrin domain family, member F 3.18371
CARD6 caspase recruitment domain family, member 6 3.18371
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 3.13347
SCAF8 SR-related CTD-associated factor 8 3.11917
STX11 syntaxin 11 3.07652
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 3.04662
PRSS3 protease, serine, 3 2.98348
MCOLN1 mucolipin 1 2.854
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.78488
RHOXF1 Rhox homeobox family, member 1 2.73951
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 2.67507
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 2.63936
TMEM232 transmembrane protein 232 2.63381
DSTN destrin (actin depolymerizing factor) 2.60599
FREM2 FRAS1 related extracellular matrix protein 2 2.60015
EFCAB13 EF-hand calcium binding domain 13 2.56882
UBQLN4 ubiquilin 4 2.55134
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.54198
MASTL microtubule associated serine/threonine kinase-like 2.53841
SLC35E4 solute carrier family 35, member E4 2.5191
CNKSR1 connector enhancer of kinase suppressor of Ras 1 2.51867
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 2.50515
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.47546
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.44873
PLN phospholamban 2.41892
LRRC38 leucine rich repeat containing 38 2.41892
LIX1L Lix1 homolog (chicken) like 2.40669
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.40666
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.40412
TTPA tocopherol (alpha) transfer protein 2.40412
AAK1 AP2 associated kinase 1 2.39019
DNAH8 dynein, axonemal, heavy chain 8 2.37791
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.37791
OSTN osteocrin 2.37791
ADM2 adrenomedullin 2 2.35884
SELENBP1 selenium binding protein 1 2.34385
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 2.31138
PLXND1 plexin D1 2.30192
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.28197
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.19271
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 2.17323
INKA1 inka box actin regulator 1 2.16023
RABEP1 rabaptin, RAB GTPase binding effector protein 1 2.16023
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.16023
VAMP4 vesicle-associated membrane protein 4 2.16023
LAMA4 laminin, alpha 4 2.16023
GGACT gamma-glutamylamine cyclotransferase 2.16023
ITGA11 integrin, alpha 11 2.16023
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.16023
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.16023
ZNF611 zinc finger protein 611 2.16023
ZNF764 zinc finger protein 764 2.13739
MSH6 mutS homolog 6 2.11598
TSPAN9 tetraspanin 9 2.11075
GRAMD1A GRAM domain containing 1A 2.10663
S100A4 S100 calcium binding protein A4 2.10362
ESS2 ess-2 splicing factor homolog 2.0928
DUSP3 dual specificity phosphatase 3 2.08775
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.08373
AMDHD2 amidohydrolase domain containing 2 2.06947
SEC31A SEC31 homolog A (S. cerevisiae) 2.06582
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 2.04438
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.04156
TANK TRAF family member-associated NFKB activator 2.04121

decreased expression

Symbol Name Standardized Value
DCTN1 dynactin 1 -3.18371
TEX261 testis expressed 261 -3.18371
ADAM28 ADAM metallopeptidase domain 28 -3.18371
CELA2B chymotrypsin-like elastase family, member 2B -3.18371
ZNF175 zinc finger protein 175 -3.18371
ODAD4 outer dynein arm docking complex subunit 4 -3.18371
TNS4 tensin 4 -3.13821
SHISA7 shisa family member 7 -3.13821
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -3.13821
AQP4 aquaporin 4 -3.13821
TMEM179 transmembrane protein 179 -3.13821
BAIAP3 BAI1-associated protein 3 -3.13821
VCX3B variable charge, X-linked 3B -3.13821
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -3.13821
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -3.13821
ANXA1 annexin A1 -3.13821
IL32 interleukin 32 -3.13821
TNMD tenomodulin -3.13821
NPIPA7 nuclear pore complex interacting protein family, member A7 -3.13821
LDHC lactate dehydrogenase C -3.13821
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -3.13821
PCDHB12 protocadherin beta 12 -3.13821
TP53INP2 tumor protein p53 inducible nuclear protein 2 -3.13821
LOC124905976 uncharacterized LOC124905976 -3.13821
FXYD2 FXYD domain containing ion transport regulator 2 -3.13821
OXER1 oxoeicosanoid (OXE) receptor 1 -3.13821
ICAM5 intercellular adhesion molecule 5, telencephalin -3.13821
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.13821
CALR3 calreticulin 3 -3.13821
LOC122539214 Zinc finger protein LOC122539214 -3.13821
INSM1 insulinoma-associated 1 -3.13821
CTSF cathepsin F -3.13821
PKD1L1 polycystic kidney disease 1 like 1 -3.13821
CRHR1 corticotropin releasing hormone receptor 1 -3.13821
FAT2 FAT atypical cadherin 2 -3.13821
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.13821
DLEC1 deleted in lung and esophageal cancer 1 -3.13821
ATP10B ATPase, class V, type 10B -3.13821
MCUR1 mitochondrial calcium uniporter regulator 1 -3.13323
PEX19 peroxisomal biogenesis factor 19 -3.05091
STK38 serine/threonine kinase 38 -3.02885
NUBP1 nucleotide binding protein 1 -3.02849
CRB2 crumbs family member 2 -3.01194
KMT2D lysine (K)-specific methyltransferase 2D -3.00837
ZCCHC3 zinc finger, CCHC domain containing 3 -2.95877
LEFTY2 left-right determination factor 2 -2.883
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 -2.81568
CHIC2 cysteine-rich hydrophobic domain 2 -2.80834
NUDT22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 -2.78668
TMEM114 transmembrane protein 114 -2.70671
FBXW4 F-box and WD repeat domain containing 4 -2.69577
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 -2.67052
ZBTB25 zinc finger and BTB domain containing 25 -2.6505
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.59363
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 -2.57676
HES1 hes family bHLH transcription factor 1 -2.55294
ARMH1 armadillo like helical domain containing 1 -2.53285
DMXL1 Dmx-like 1 -2.53284
THAP10 THAP domain containing 10 -2.49356
KCTD7 potassium channel tetramerization domain containing 7 -2.4694
TRAPPC5 trafficking protein particle complex 5 -2.42395
PCDHGA5 protocadherin gamma subfamily A, 5 -2.40669
MYL11 myosin light chain 11 -2.40669
RNF207 ring finger protein 207 -2.37791
TMEM116 transmembrane protein 116 -2.3479
PHF11 PHD finger protein 11 -2.34385
GRN granulin -2.26768
CKAP2 cytoskeleton associated protein 2 -2.26646
GOLM1 golgi membrane protein 1 -2.26177
INAVA innate immunity activator -2.24325
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.22414
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.22395
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.22395
FRMD6 FERM domain containing 6 -2.22378
DENND1C DENN/MADD domain containing 1C -2.22076
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -2.18657
PHACTR2 phosphatase and actin regulator 2 -2.17316
BACE1 beta-site APP-cleaving enzyme 1 -2.17017
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -2.16785
MSRB3 methionine sulfoxide reductase B3 -2.16023
DEPTOR DEP domain containing MTOR-interacting protein -2.16023
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.16023
IGSF6 immunoglobulin superfamily, member 6 -2.16023
DHDH dihydrodiol dehydrogenase (dimeric) -2.16023
DDIT3 DNA-damage-inducible transcript 3 -2.14351
GLT8D2 glycosyltransferase 8 domain containing 2 -2.13739
RAP1B RAP1B, member of RAS oncogene family -2.11324
IGHMBP2 immunoglobulin mu binding protein 2 -2.08775
SFMBT1 Scm-like with four mbt domains 1 -2.08665
ICAM3 intercellular adhesion molecule 3 -2.08665
ZNF805 zinc finger protein 805 -2.08665
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.07503
CALHM6 calcium homeostasis modulator family member 6 -2.06947
ZNF260 zinc finger protein 260 -2.06947
CRLF1 cytokine receptor-like factor 1 -2.06582
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.06582
ZNF45 zinc finger protein 45 -2.06582
FBXO3 F-box protein 3 -2.06293
EGFL7 EGF-like-domain, multiple 7 -2.05303
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -2.04533
NTAQ1 N-terminal glutamine amidase 1 -2.04156
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) -2.04156
TTLL4 tubulin tyrosine ligase-like family member 4 -2.0412
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -2.0412
ENAH enabled homolog (Drosophila) -2.0412
CRTC3 CREB regulated transcription coactivator 3 -2.03763
GPR162 G protein-coupled receptor 162 -2.03446
SGCZ sarcoglycan, zeta -2.03446
TFF3 trefoil factor 3 (intestinal) -2.03446
ACSL3 acyl-CoA synthetase long-chain family member 3 -2.03446
ZNF511 zinc finger protein 511 -2.03395
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.0308
DDA1 DET1 and DDB1 associated 1 -2.02865
MORN2 MORN repeat containing 2 -2.01448
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.00945