EI24 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description etoposide induced 2.4|This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 9538)
Similar Terms
Downloads & Tools

Genes

311 genes differentially expressed following the EI24 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
USP26 ubiquitin specific peptidase 26 2.66064
BATF basic leucine zipper transcription factor, ATF-like 2.66064
ASB17 ankyrin repeat and SOCS box containing 17 2.66064
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.66064
SSTR3 somatostatin receptor 3 2.66064
FAM86B2 family with sequence similarity 86, member B2 2.66064
MFAP5 microfibrillar associated protein 5 2.66064
C19ORF67 chromosome 19 open reading frame 67 2.66064
GPR20 G protein-coupled receptor 20 2.66064
OLIG3 oligodendrocyte transcription factor 3 2.66064
FFAR4 free fatty acid receptor 4 2.66064
TKTL1 transketolase-like 1 2.66064
IL22RA1 interleukin 22 receptor, alpha 1 2.66064
DNASE1L2 deoxyribonuclease I-like 2 2.66064
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.66064
GRXCR2 glutaredoxin, cysteine rich 2 2.66064
SIRPB1 signal-regulatory protein beta 1 2.66064
ADTRP androgen-dependent TFPI-regulating protein 2.66064
CXORF65 chromosome X open reading frame 65 2.66064
SKOR2 SKI family transcriptional corepressor 2 2.66064
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.66064
MYOM3 myomesin 3 2.66064
BIRC3 baculoviral IAP repeat containing 3 2.66064
TMC2 transmembrane channel-like 2 2.66064
KLLN killin, p53-regulated DNA replication inhibitor 2.66064
LUZP4 leucine zipper protein 4 2.66064
LDHC lactate dehydrogenase C 2.66064
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.66064
OIT3 oncoprotein induced transcript 3 2.66064
PRR29 proline rich 29 2.66064
RTP3 receptor (chemosensory) transporter protein 3 2.66064
CPLX3 complexin 3 2.66064
KRT72 keratin 72, type II 2.66064
HBZ hemoglobin, zeta 2.66064
PCDH8 protocadherin 8 2.66064
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.66064
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.66064
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.66064
DLL4 delta-like 4 (Drosophila) 2.66064
SPRR2A small proline-rich protein 2A 2.66064
S100A3 S100 calcium binding protein A3 2.66064
PNOC prepronociceptin 2.66064
FAM9B family with sequence similarity 9, member B 2.66064
ZNF503 zinc finger protein 503 2.66064
CATSPERQ catsper channel auxiliary subunit theta 2.66064
CCDC9B coiled-coil domain containing 9B 2.66064
H1-6 H1.6 linker histone, cluster member 2.66064
SQOR sulfide quinone oxidoreductase 2.66064
AVPR1A arginine vasopressin receptor 1A 2.66064
GPX5 glutathione peroxidase 5 2.66064
ADGRG7 adhesion G protein-coupled receptor G7 2.66064
RCVRN recoverin 2.66064
STX11 syntaxin 11 2.66064
MYOCOS myocilin opposite strand 2.66064
GASK1B golgi associated kinase 1B 2.66064
H2BW2 H2B.W histone 2 2.66064
SPMAP1 sperm microtubule associated protein 1 2.66064
OR1R1 olfactory receptor family 1 subfamily R member 1 2.66064
FAM90A12 family with sequence similarity 90 member A12 2.66064
SPMIP1 sperm microtubule inner protein 1 2.66064
LITAFD LITAF domain containing 2.66064
H4C14 H4 clustered histone 14 2.66064
SERTM2 serine rich and transmembrane domain containing 2 2.66064
AKAIN1 A-kinase anchor inhibitor 1 2.66064
KRT86 keratin 86, type II 2.66064
SPRR2D small proline-rich protein 2D 2.66064
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.66064
CD48 CD48 molecule 2.66064
MAG myelin associated glycoprotein 2.66064
MAGEB3 melanoma antigen family B3 2.66064
PTPRC protein tyrosine phosphatase, receptor type, C 2.66064
IZUMO4 IZUMO family member 4 2.66064
RS1 retinoschisin 1 2.66064
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.66064
KLHL35 kelch-like family member 35 2.66064
OR51B2 olfactory receptor, family 51, subfamily B, member 2 (gene/pseudogene) 2.66064
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.66064
CCDC91 coiled-coil domain containing 91 2.66064
DOK2 docking protein 2, 56kDa 2.66064
TSPAN8 tetraspanin 8 2.66064
CFC1 cripto, FRL-1, cryptic family 1 2.66064
GDF9 growth differentiation factor 9 2.66064
IL1RN interleukin 1 receptor antagonist 2.66064
ZAN zonadhesin (gene/pseudogene) 2.66064
RNF113B ring finger protein 113B 2.66064
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.66064
CFAP74 cilia and flagella associated protein 74 2.66064
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.66064
C2CD4B C2 calcium-dependent domain containing 4B 2.66064
TRIM55 tripartite motif containing 55 2.66064
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.66064
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.66064
SPATA4 spermatogenesis associated 4 2.66064
WFDC6 WAP four-disulfide core domain 6 2.66064
KLHL41 kelch-like family member 41 2.66064
PSG8 pregnancy specific beta-1-glycoprotein 8 2.66064
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.66064
KLHL1 kelch-like family member 1 2.66064
C18ORF63 chromosome 18 open reading frame 63 2.66064
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.66064
CLIC5 chloride intracellular channel 5 2.66064
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 2.66064
LRRC46 leucine rich repeat containing 46 2.66064
ENDOU endonuclease, polyU-specific 2.66064
CLEC7A C-type lectin domain family 7, member A 2.66064
PCDHGA2 protocadherin gamma subfamily A, 2 2.66064
LMOD2 leiomodin 2 (cardiac) 2.66064
ISL1 ISL LIM homeobox 1 2.66064
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.66064
ZBTB7A zinc finger and BTB domain containing 7A 2.66064
LMX1B LIM homeobox transcription factor 1, beta 2.66064
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.66064
CSF1R colony stimulating factor 1 receptor 2.66064
GCGR glucagon receptor 2.66064
PSG3 pregnancy specific beta-1-glycoprotein 3 2.66064
ZC3H12D zinc finger CCCH-type containing 12D 2.66064
CPA1 carboxypeptidase A1 (pancreatic) 2.66064
SAMD5 sterile alpha motif domain containing 5 2.66064
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.66064
PHOX2A paired-like homeobox 2a 2.66064
COL6A5 collagen, type VI, alpha 5 2.66064
PLA1A phospholipase A1 member A 2.66064
SLC22A24 solute carrier family 22, member 24 2.66064
HRCT1 histidine rich carboxyl terminus 1 2.66064
IL19 interleukin 19 2.66064
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.66064
CHRM1 cholinergic receptor, muscarinic 1 2.66064
CLEC2A C-type lectin domain family 2, member A 2.66064
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.66064
HEPN1 hepatocellular carcinoma, down-regulated 1 2.66064
POTEA POTE ankyrin domain family, member A 2.66064
CCDC87 coiled-coil domain containing 87 2.66064
GLRA1 glycine receptor, alpha 1 2.66064
ASCL5 achaete-scute family bHLH transcription factor 5 2.66064
PADI1 peptidyl arginine deiminase, type I 2.66064
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.66064
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 2.66064
APOL3 apolipoprotein L, 3 2.66064
HHIPL2 HHIP-like 2 2.66064
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.66064
CLCF1 cardiotrophin-like cytokine factor 1 2.66064
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.66064
TOP2A topoisomerase (DNA) II alpha 170kDa 2.66064
ONECUT3 one cut homeobox 3 2.66064
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.66064
TMEM156 transmembrane protein 156 2.66064
PATE2 prostate and testis expressed 2 2.66064
NF2 neurofibromin 2 (merlin) 2.64666
NSF N-ethylmaleimide-sensitive factor 2.6335
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 2.6335
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2.54629
NOMO2 NODAL modulator 2 2.54245
PIMREG PICALM interacting mitotic regulator 2.49795
CRCP CGRP receptor component 2.48952
RIOK3 RIO kinase 3 2.44066
MINAR1 membrane integral NOTCH2 associated receptor 1 2.43908
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.40655
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.3805
BIN2 bridging integrator 2 2.37125
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 2.34945
CD79A CD79a molecule, immunoglobulin-associated alpha 2.34945
SYNGR4 synaptogyrin 4 2.34945
UGDH UDP-glucose 6-dehydrogenase 2.33533
ARHGAP33 Rho GTPase activating protein 33 2.3297
ETV3L ets variant 3-like 2.32901
ZNF320 zinc finger protein 320 2.3171
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa 2.3171
TNR tenascin R 2.31492
MARVELD2 MARVEL domain containing 2 2.30226
GMEB1 glucocorticoid modulatory element binding protein 1 2.30226
TCF15 transcription factor 15 (basic helix-loop-helix) 2.30226
ROR1 receptor tyrosine kinase-like orphan receptor 1 2.27583
PRKCB protein kinase C, beta 2.27024
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.25665
DGKK diacylglycerol kinase, kappa 2.22995
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.22479
TMTC1 transmembrane and tetratricopeptide repeat containing 1 2.21598
WDR5B WD repeat domain 5B 2.21586
CCNB2 cyclin B2 2.20738
MSI2 musashi RNA-binding protein 2 2.17319
ARMC3 armadillo repeat containing 3 2.15869
AURKA aurora kinase A 2.15656
WDR91 WD repeat domain 91 2.15545
CUZD1 CUB and zona pellucida-like domains 1 2.15322
SRSF5 serine/arginine-rich splicing factor 5 2.14861
CCNK cyclin K 2.12957
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 2.12957
PCED1B PC-esterase domain containing 1B 2.10274
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.10021
CA1 carbonic anhydrase I 2.09894
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.09744
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 2.08864
C1ORF21 chromosome 1 open reading frame 21 2.0843
ZNF576 zinc finger protein 576 2.0843
GNPAT glyceronephosphate O-acyltransferase 2.08351
LTC4S leukotriene C4 synthase 2.07384
ERBB4 erb-b2 receptor tyrosine kinase 4 2.04547
JAKMIP3 Janus kinase and microtubule interacting protein 3 2.02285
DNAAF10 dynein axonemal assembly factor 10 2.02285
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.01386
RNF208 ring finger protein 208 2.01386
CARMIL2 capping protein regulator and myosin 1 linker 2 2.01386
LRRC55 leucine rich repeat containing 55 2.01386
STXBP4 syntaxin binding protein 4 2.01277

decreased expression

Symbol Name Standardized Value
EI24 etoposide induced 2.4 -3.28565
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E -2.66064
CD8A CD8a molecule -2.66064
TMEM86A transmembrane protein 86A -2.66064
PARK7 parkinson protein 7 -2.66064
DMTN dematin actin binding protein -2.66064
DNAAF1 dynein, axonemal, assembly factor 1 -2.66064
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.66064
RBM45 RNA binding motif protein 45 -2.66064
SLC23A3 solute carrier family 23, member 3 -2.66064
CRELD1 cysteine-rich with EGF-like domains 1 -2.66064
HRH4 histamine receptor H4 -2.66064
F2 coagulation factor II (thrombin) -2.66064
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.66064
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.66064
SLC25A41 solute carrier family 25, member 41 -2.66064
MRPL27 mitochondrial ribosomal protein L27 -2.66064
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.66064
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.66064
FAM81B family with sequence similarity 81, member B -2.66064
FNDC8 fibronectin type III domain containing 8 -2.66064
TCEA3 transcription elongation factor A (SII), 3 -2.66064
FBXL19 F-box and leucine-rich repeat protein 19 -2.66064
FGR FGR proto-oncogene, Src family tyrosine kinase -2.66064
PHF20L1 PHD finger protein 20-like 1 -2.66064
TMEM150B transmembrane protein 150B -2.66064
HUS1B HUS1 checkpoint homolog b (S. pombe) -2.66064
RTL9 retrotransposon Gag like 9 -2.66064
CLDN14 claudin 14 -2.66064
MUC20 mucin 20, cell surface associated -2.66064
ARHGAP15 Rho GTPase activating protein 15 -2.66064
OTP orthopedia homeobox -2.66064
MOCOS molybdenum cofactor sulfurase -2.66064
GK3 glycerol kinase 3 -2.66064
ZPBP zona pellucida binding protein -2.66064
CSAG3 CSAG family, member 3 -2.66064
NPFFR1 neuropeptide FF receptor 1 -2.66064
BHLHE40 basic helix-loop-helix family, member e40 -2.5941
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.58102
FAM151A family with sequence similarity 151, member A -2.57095
C19ORF47 chromosome 19 open reading frame 47 -2.52089
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -2.49422
LY75 lymphocyte antigen 75 -2.47741
FRMPD1 FERM and PDZ domain containing 1 -2.40124
ABHD6 abhydrolase domain containing 6 -2.39048
EPS8 epidermal growth factor receptor pathway substrate 8 -2.38798
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.37599
E2F1 E2F transcription factor 1 -2.36244
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.34994
TRIM8 tripartite motif containing 8 -2.34945
KLHDC4 kelch domain containing 4 -2.34411
LOC124904542 uncharacterized LOC124904542 -2.33383
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.33383
CAPN14 calpain 14 -2.30226
N4BP2L1 NEDD4 binding protein 2-like 1 -2.30226
MBLAC1 metallo-beta-lactamase domain containing 1 -2.30226
MRPL43 mitochondrial ribosomal protein L43 -2.29376
COL18A1 collagen, type XVIII, alpha 1 -2.27583
FAM32A family with sequence similarity 32, member A -2.27442
MAPKBP1 mitogen-activated protein kinase binding protein 1 -2.2728
GREM2 gremlin 2, DAN family BMP antagonist -2.27024
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.27024
DDT D-dopachrome tautomerase -2.24918
FCRL5 Fc receptor-like 5 -2.24882
WAS Wiskott-Aldrich syndrome -2.23381
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.23063
MRPS7 mitochondrial ribosomal protein S7 -2.21586
SNPH syntaphilin -2.21531
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.21531
TRIM6 tripartite motif containing 6 -2.20603
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -2.19716
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 -2.16005
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.15993
KIAA0319L KIAA0319-like -2.15545
PCDHB15 protocadherin beta 15 -2.15545
SORCS3 sortilin-related VPS10 domain containing receptor 3 -2.15545
MMRN2 multimerin 2 -2.15545
ZIC3 Zic family member 3 -2.14861
GMPPB GDP-mannose pyrophosphorylase B -2.13338
HPDL 4-hydroxyphenylpyruvate dioxygenase-like -2.12957
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 -2.12957
PNMA2 paraneoplastic Ma antigen 2 -2.12957
MBLAC2 metallo-beta-lactamase domain containing 2 -2.12781
POMP proteasome maturation protein -2.12051
ZNF444 zinc finger protein 444 -2.12051
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -2.09744
TMPRSS11D transmembrane protease, serine 11D -2.08351
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -2.08351
ZIC5 Zic family member 5 -2.08351
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.08258
RIT2 Ras-like without CAAX 2 -2.07918
ZNF776 zinc finger protein 776 -2.07384
ZFAND4 zinc finger, AN1-type domain 4 -2.06868
DOCK10 dedicator of cytokinesis 10 -2.06607
DTX4 deltex 4, E3 ubiquitin ligase -2.06607
PUS1 pseudouridylate synthase 1 -2.05341
FAM234A family with sequence similarity 234 member A -2.04386
IMMT inner membrane protein, mitochondrial -2.03457
TMEM243 transmembrane protein 243, mitochondrial -2.02667
MEPCE methylphosphate capping enzyme -2.02285
AHI1 Abelson helper integration site 1 -2.00813
SLC35E2B solute carrier family 35, member E2B -2.00813
ATL3 atlastin GTPase 3 -2.00813
USP8 ubiquitin specific peptidase 8 -2.00736
IFT70B intraflagellar transport 70B -2.00736
KIF5C kinesin family member 5C -2.00225
ZNF460 zinc finger protein 460 -2.00225