EIF2AK1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description eukaryotic translation initiation factor 2-alpha kinase 1|The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 27102)
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Genes

353 genes differentially expressed following the EIF2AK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
VWA5B2 von Willebrand factor A domain containing 5B2 4.17494
NEU4 sialidase 4 4.17494
SSTR5 somatostatin receptor 5 4.17494
TAS2R1 taste receptor, type 2, member 1 4.17494
C19ORF67 chromosome 19 open reading frame 67 4.17494
ANKRD34A ankyrin repeat domain 34A 4.17494
STRA8 stimulated by retinoic acid 8 4.17494
BIRC3 baculoviral IAP repeat containing 3 4.17494
PTGFR prostaglandin F receptor (FP) 4.17494
GADL1 glutamate decarboxylase-like 1 4.17494
TDRD1 tudor domain containing 1 4.17494
C2ORF80 chromosome 2 open reading frame 80 4.17494
RSPO3 R-spondin 3 4.17494
GDNF glial cell derived neurotrophic factor 4.17494
SCGN secretagogin, EF-hand calcium binding protein 4.17494
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 4.17494
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 4.17494
PI16 peptidase inhibitor 16 4.17494
PTX3 pentraxin 3, long 4.17494
OR2B6 olfactory receptor, family 2, subfamily B, member 6 4.17494
OSGIN1 oxidative stress induced growth inhibitor 1 4.17494
GRXCR2 glutaredoxin, cysteine rich 2 4.17494
LRRC14B leucine rich repeat containing 14B 4.17494
SLC25A41 solute carrier family 25, member 41 4.17494
CEP295NL CEP295 N-terminal like 4.17494
C9ORF152 chromosome 9 open reading frame 152 4.17494
RGPD4 RANBP2-like and GRIP domain containing 4 4.17494
MYO1G myosin IG 4.17494
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 4.17494
OIT3 oncoprotein induced transcript 3 4.17494
THEMIS thymocyte selection associated 4.17494
SLC10A5 solute carrier family 10, member 5 4.17494
KRTAP5-5 keratin associated protein 5-5 4.17494
TPH1 tryptophan hydroxylase 1 4.17494
DSPP dentin sialophosphoprotein 4.17494
RBP4 retinol binding protein 4, plasma 4.17494
GALP galanin-like peptide 4.17494
CD33 CD33 molecule 4.17494
MYO16 myosin XVI 4.17494
TRPC5OS TRPC5 opposite strand 4.17494
RGPD3 RANBP2-like and GRIP domain containing 3 4.17494
CPB1 carboxypeptidase B1 (tissue) 4.17494
OC90 otoconin 90 4.17494
GMNC geminin coiled-coil domain containing 4.17494
RIMBP3C RIMS binding protein 3C 4.17494
ADAT3 adenosine deaminase, tRNA-specific 3 4.17494
S100A3 S100 calcium binding protein A3 4.17494
WNT8B wingless-type MMTV integration site family, member 8B 4.17494
GNRH2 gonadotropin-releasing hormone 2 4.17494
OR5V1 olfactory receptor, family 5, subfamily V, member 1 4.17494
ANO3 anoctamin 3 4.17494
AMPD1 adenosine monophosphate deaminase 1 4.17494
NPAP1 nuclear pore associated protein 1 4.17494
FAM90A12 family with sequence similarity 90 member A12 4.17494
CD300LF CD300 molecule-like family member f 4.17494
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 4.17494
RCVRN recoverin 4.17494
SPI1 Spi-1 proto-oncogene 4.17494
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 4.17494
PKD2L1 polycystic kidney disease 2-like 1 4.17494
TBC1D3L TBC1 domain family, member 3L 4.17494
OR6F1 olfactory receptor, family 6, subfamily F, member 1 4.17494
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 4.17494
TMPRSS3 transmembrane protease, serine 3 4.17494
OR52E5 olfactory receptor, family 52, subfamily E, member 5 4.17494
ROPN1B rhophilin associated tail protein 1B 4.17494
SPATS1 spermatogenesis associated, serine-rich 1 4.17494
SPMIP1 sperm microtubule inner protein 1 4.17494
EZHIP EZH inhibitory protein 4.17494
IQCN IQ motif containing N 4.17494
H2BW2 H2B.W histone 2 4.17494
H4C13 H4 clustered histone 13 4.17494
GARIN1A golgi associated RAB2 interactor 1A 4.17494
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 4.17494
VXN vexin 4.17494
CIROP ciliated left-right organizer metallopeptidase 4.17494
LORICRIN loricrin cornified envelope precursor protein 4.17494
H3-5 H3.5 histone 4.17494
TBX10 T-box 10 4.17494
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 4.17494
SIM2 single-minded family bHLH transcription factor 2 4.17494
SCN10A sodium channel, voltage gated, type X alpha subunit 4.17494
CCR6 chemokine (C-C motif) receptor 6 4.17494
CCDC13 coiled-coil domain containing 13 4.17494
LOC124901449 uncharacterized LOC124901449 4.17494
IL12RB1 interleukin 12 receptor, beta 1 4.17494
FPR2 formyl peptide receptor 2 4.17494
ZNF98 zinc finger protein 98 4.17494
CFHR3 complement factor H-related 3 4.17494
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 4.17494
LRRD1 leucine-rich repeats and death domain containing 1 4.17494
IL5 interleukin 5 4.17494
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 4.17494
HNF1B HNF1 homeobox B 4.17494
DLK1 delta-like 1 homolog (Drosophila) 4.17494
SOAT2 sterol O-acyltransferase 2 4.17494
IL16 interleukin 16 4.17494
LRRC70 leucine rich repeat containing 70 4.17494
FGFBP2 fibroblast growth factor binding protein 2 4.17494
SASH3 SAM and SH3 domain containing 3 4.17494
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 4.17494
S100P S100 calcium binding protein P 4.17494
PRR18 proline rich 18 4.17494
SH3TC1 SH3 domain and tetratricopeptide repeats 1 4.17494
PARP3 poly (ADP-ribose) polymerase family, member 3 4.17494
ZC3H12D zinc finger CCCH-type containing 12D 4.17494
DUOX2 dual oxidase 2 4.17494
AQP2 aquaporin 2 (collecting duct) 4.17494
BTNL3 butyrophilin-like 3 4.17494
KLHL6 kelch-like family member 6 4.17494
NYX nyctalopin 4.17494
EFCAB12 EF-hand calcium binding domain 12 4.17494
PHGR1 proline/histidine/glycine-rich 1 4.17494
TNR tenascin R 4.17494
CSTA cystatin A (stefin A) 4.17494
POU4F1 POU class 4 homeobox 1 4.17494
ERICH4 glutamate-rich 4 4.17494
RFPL1 ret finger protein-like 1 4.17494
TMEM132D transmembrane protein 132D 4.17494
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 4.17494
APOB apolipoprotein B 4.17494
OPTC opticin 4.17494
ERMN ermin, ERM-like protein 4.17494
IL21R interleukin 21 receptor 4.17494
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 4.17494
GSC2 goosecoid homeobox 2 4.17494
TG thyroglobulin 4.17494
ITGB7 integrin, beta 7 4.17494
KLK3 kallikrein-related peptidase 3 4.17494
FBXO47 F-box protein 47 4.17494
CHI3L2 chitinase 3-like 2 4.17494
DMRT1 doublesex and mab-3 related transcription factor 1 4.17494
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 4.17494
SYNGR4 synaptogyrin 4 4.17494
OTOP2 otopetrin 2 4.17494
OR4D2 olfactory receptor, family 4, subfamily D, member 2 4.17494
POU2AF1 POU class 2 associating factor 1 4.17494
TRIM50 tripartite motif containing 50 4.17494
PSKH2 protein serine kinase H2 4.17494
PGR progesterone receptor 4.17494
CCNI2 cyclin I family, member 2 4.17494
PAGE4 P antigen family, member 4 (prostate associated) 4.17494
GLT1D1 glycosyltransferase 1 domain containing 1 4.17494
KRT17 keratin 17, type I 4.17494
IRX4 iroquois homeobox 4 4.17494
MMEL1 membrane metallo-endopeptidase-like 1 4.17494
GRAPL GRB2-related adaptor protein-like 4.17494
TEX29 testis expressed 29 4.17494
NUTM2F NUT family member 2F 4.17494
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 4.17494
XCR1 chemokine (C motif) receptor 1 4.17494
KCNK15 potassium channel, two pore domain subfamily K, member 15 4.17494
GPR17 G protein-coupled receptor 17 4.17494
AOC1 amine oxidase, copper containing 1 4.17494
LPA lipoprotein, Lp(a) 4.17494
NLRP11 NLR family, pyrin domain containing 11 4.17494
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 4.17494
ITGAD integrin, alpha D 4.17494
IRX5 iroquois homeobox 5 4.17494
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 4.17494
OR56B1 olfactory receptor, family 56, subfamily B, member 1 4.17494
PXT1 peroxisomal, testis specific 1 4.17494
CNR2 cannabinoid receptor 2 (macrophage) 4.17494
TBC1D28 TBC1 domain family, member 28 4.17494
PCDHAC1 protocadherin alpha subfamily C, 1 4.17494
PLA2G4E phospholipase A2, group IVE 4.17494
LRRC74B leucine rich repeat containing 74B 4.17494
GPR146 G protein-coupled receptor 146 4.10596
IDO2 indoleamine 2,3-dioxygenase 2 4.10596
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 4.10596
XAB2 XPA binding protein 2 3.73842
DNAAF8 dynein axonemal assembly factor 8 3.43681
HYPK huntingtin interacting protein K 3.02156
PVALEF parvalbumin like EF-hand containing 3.02156
GRM2 glutamate receptor, metabotropic 2 3.02156
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.02156
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 3.02156
FRS3 fibroblast growth factor receptor substrate 3 3.02156
MOGAT3 monoacylglycerol O-acyltransferase 3 3.02156
RHCG Rh family, C glycoprotein 2.98075
DRC1 dynein regulatory complex subunit 1 2.98075
EPB41L1 erythrocyte membrane protein band 4.1-like 1 2.98075
CFAP58 cilia and flagella associated protein 58 2.9294
H1-0 H1.0 linker histone 2.77911
DISP2 dispatched homolog 2 (Drosophila) 2.74438
TMEM11 transmembrane protein 11 2.63961
MRPL19 mitochondrial ribosomal protein L19 2.61047
PCDHGA5 protocadherin gamma subfamily A, 5 2.55251
ICMT isoprenylcysteine carboxyl methyltransferase 2.50416
TESK1 testis-specific kinase 1 2.49853
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2.48239
NDRG2 NDRG family member 2 2.47147
COL23A1 collagen, type XXIII, alpha 1 2.46216
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.46169
PCDH17 protocadherin 17 2.4336
GLRX5 glutaredoxin 5 2.40747
AADAT aminoadipate aminotransferase 2.37914
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.34895
PLB1 phospholipase B1 2.34655
FGF9 fibroblast growth factor 9 2.34655
TTLL12 tubulin tyrosine ligase-like family member 12 2.34479
CTBS chitobiase, di-N-acetyl- 2.25817
USP39 ubiquitin specific peptidase 39 2.2545
SH3YL1 SH3 and SYLF domain containing 1 2.2545
PLA2G2C phospholipase A2, group IIC 2.2545
ETNPPL ethanolamine-phosphate phospho-lyase 2.2545
SPACDR sperm acrosome developmental regulator 2.22144
PDZRN4 PDZ domain containing ring finger 4 2.22144
PTPRE protein tyrosine phosphatase, receptor type, E 2.22144
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.22144
TP53I3 tumor protein p53 inducible protein 3 2.18994
RNF141 ring finger protein 141 2.17992
TMEM59L transmembrane protein 59-like 2.17966
SGF29 SAGA complex associated factor 29 2.17514
ATG9A autophagy related 9A 2.16359
LRRC59 leucine rich repeat containing 59 2.1534
IGBP1 immunoglobulin (CD79A) binding protein 1 2.13333
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.13073
ARHGAP39 Rho GTPase activating protein 39 2.11463
RBM22 RNA binding motif protein 22 2.10878
SMIM1 small integral membrane protein 1 (Vel blood group) 2.10399
MOCS3 molybdenum cofactor synthesis 3 2.09228
CFAP221 cilia and flagella associated protein 221 2.09186
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2.08434
SNED1 sushi, nidogen and EGF-like domains 1 2.07352
SH3BP5L SH3-binding domain protein 5-like 2.06365
DVL2 dishevelled segment polarity protein 2 2.06112
SYAP1 synapse associated protein 1 2.05947
SSUH2 ssu-2 homolog (C. elegans) 2.04535
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.04329
IL17RB interleukin 17 receptor B 2.04105
SIDT2 SID1 transmembrane family, member 2 2.04105
SYNRG synergin, gamma 2.03533
ERCC4 excision repair cross-complementation group 4 2.02813
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 2.02813
SLC35F6 solute carrier family 35, member F6 2.01675
ZNF606 zinc finger protein 606 2.01675
RASL10A RAS-like, family 10, member A 2.01505
PACS2 phosphofurin acidic cluster sorting protein 2 2.00778
VBP1 von Hippel-Lindau binding protein 1 2.00671
STOML1 stomatin (EPB72)-like 1 2.0028
ADAM33 ADAM metallopeptidase domain 33 2.0028
GFRA2 GDNF family receptor alpha 2 2.0028
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 2.0028

decreased expression

Symbol Name Standardized Value
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -4.17494
OOSP1 oocyte secreted protein 1, pseudogene -4.17494
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -4.17494
ECM1 extracellular matrix protein 1 -4.17494
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -4.17494
USP50 ubiquitin specific peptidase 50 -4.17494
ZMYND12 zinc finger, MYND-type containing 12 -4.17494
CD6 CD6 molecule -4.17494
NOTO notochord homeobox -4.17494
GRID1 glutamate receptor, ionotropic, delta 1 -4.17494
CDC20B cell division cycle 20B -4.17494
FRMPD1 FERM and PDZ domain containing 1 -4.17494
ANGPTL3 angiopoietin-like 3 -4.17494
COL19A1 collagen, type XIX, alpha 1 -4.17494
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 -4.17494
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -4.17494
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) -4.17494
TPPP tubulin polymerization promoting protein -4.17494
LOC124902436 talanin -4.17494
PCDHGA11 protocadherin gamma subfamily A, 11 -4.17494
CPB2 carboxypeptidase B2 (plasma) -4.17494
MNX1 motor neuron and pancreas homeobox 1 -4.17494
ARRDC2 arrestin domain containing 2 -4.17494
AMIGO1 adhesion molecule with Ig-like domain 1 -4.17494
KRT86 keratin 86, type II -4.17494
GOLGA8N golgin A8 family, member N -4.17494
RBM20 RNA binding motif protein 20 -4.17494
RBM24 RNA binding motif protein 24 -4.17494
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled -4.17494
NR5A1 nuclear receptor subfamily 5, group A, member 1 -4.17494
LYPD5 LY6/PLAUR domain containing 5 -4.17494
RIMBP2 RIMS binding protein 2 -4.17494
UBE2L5 ubiquitin conjugating enzyme E2 L5 -4.17494
CCNA1 cyclin A1 -4.17494
H3-7 H3.7 histone (putative) -4.17494
PNMA8B PNMA family member 8B -4.17494
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -4.17494
PLN phospholamban -4.17494
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -4.17494
THBD thrombomodulin -4.17494
KISS1 KiSS-1 metastasis-suppressor -4.17494
PCDHGA9 protocadherin gamma subfamily A, 9 -4.17494
LYNX1 Ly6/neurotoxin 1 -4.17494
ANAPC2 anaphase promoting complex subunit 2 -4.16343
SMIM38 small integral membrane protein 38 -4.16343
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 -3.14739
REM2 RAS (RAD and GEM)-like GTP binding 2 -3.11239
ZNF624 zinc finger protein 624 -3.11239
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -3.11239
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.11239
NOX4 NADPH oxidase 4 -3.10042
RTN3 reticulon 3 -3.08279
MOCS2 molybdenum cofactor synthesis 2 -3.07817
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -3.01483
ANKRD31 ankyrin repeat domain 31 -2.98075
HSPA4L heat shock 70kDa protein 4-like -2.95541
H2BC12 H2B clustered histone 12 -2.86402
SENP6 SUMO1/sentrin specific peptidase 6 -2.85029
KIFAP3 kinesin-associated protein 3 -2.82074
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) -2.65241
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.65241
MROH8 maestro heat-like repeat family member 8 -2.65241
CFAP251 cilia and flagella associated protein 251 -2.63243
ZNF444 zinc finger protein 444 -2.46956
UNC5A unc-5 homolog A (C. elegans) -2.42476
MYO6 myosin VI -2.41396
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.41238
CGNL1 cingulin-like 1 -2.40893
IPP intracisternal A particle-promoted polypeptide -2.40593
TAS2R31 taste receptor, type 2, member 31 -2.39459
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.34895
ZNF75A zinc finger protein 75a -2.34895
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.33353
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.33286
IFRD2 interferon-related developmental regulator 2 -2.30595
ZCCHC18 zinc finger, CCHC domain containing 18 -2.25587
RRH retinal pigment epithelium-derived rhodopsin homolog -2.25587
LDB2 LIM domain binding 2 -2.25528
SRI sorcin -2.2535
ZNF552 zinc finger protein 552 -2.24225
TSSK6 testis-specific serine kinase 6 -2.21709
SMIM41 small integral membrane protein 41 -2.21709
SEC23A Sec23 homolog A (S. cerevisiae) -2.17992
ALG10 ALG10, alpha-1,2-glucosyltransferase -2.17992
ZNF483 zinc finger protein 483 -2.17992
LUC7L LUC7-like (S. cerevisiae) -2.17514
SH3GL2 SH3-domain GRB2-like 2 -2.15804
FBXO31 F-box protein 31 -2.14572
CRTC3 CREB regulated transcription coactivator 3 -2.12887
C8ORF82 chromosome 8 open reading frame 82 -2.11184
OPTN optineurin -2.09905
SERINC2 serine incorporator 2 -2.08792
ATP10A ATPase, class V, type 10A -2.06112
ZMYND11 zinc finger, MYND-type containing 11 -2.05947
YARS1 tyrosyl-tRNA synthetase 1 -2.05804
CPD carboxypeptidase D -2.05487
LNX2 ligand of numb-protein X 2 -2.04671
BCCIP BRCA2 and CDKN1A interacting protein -2.04535
TMEM168 transmembrane protein 168 -2.03533
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -2.03533
TMEM248 transmembrane protein 248 -2.03533
GJB7 gap junction protein, beta 7, 25kDa -2.03169
PHPT1 phosphohistidine phosphatase 1 -2.02813
HAUS5 HAUS augmin-like complex, subunit 5 -2.01675
SLC37A3 solute carrier family 37, member 3 -2.00778
INSL3 insulin-like 3 (Leydig cell) -2.00778
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.00778
RPL10A ribosomal protein L10a -2.00778
TMEM186 transmembrane protein 186 -2.00671