EIF2AK3 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description eukaryotic translation initiation factor 2-alpha kinase 3|The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010] (NCBI Entrez Gene Database, 9451)
External Link https://ncbi.nlm.nih.gov/gene/9451
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Genes

500 genes differentially expressed following the EIF2AK3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0235201
KDM5D lysine (K)-specific demethylase 5D 0.016656
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0157214
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.015561
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0143468
DEFB1 defensin, beta 1 0.0131588
SST somatostatin 0.0131295
CRYAB crystallin, alpha B 0.0129037
CLEC3B C-type lectin domain family 3, member B 0.0119223
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0119105
KLK5 kallikrein-related peptidase 5 0.0116522
LCN2 lipocalin 2 0.011401
CXCL8 chemokine (C-X-C motif) ligand 8 0.0113543
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.011081
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.0109332
SC5D sterol-C5-desaturase 0.0108999
MXRA7 matrix-remodelling associated 7 0.0107983
CFB complement factor B 0.0107817
GPM6B glycoprotein M6B 0.0107132
S100A9 S100 calcium binding protein A9 0.0106248
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.010493
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.0102382
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.0102071
CLEC2B C-type lectin domain family 2, member B 0.0101911
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0101871
TUBB2A tubulin, beta 2A class IIa 0.0101141
KRT14 keratin 14, type I 0.0101078
AQP1 aquaporin 1 (Colton blood group) 0.00999121
HSPA2 heat shock 70kDa protein 2 0.00978775
BTG3 BTG family, member 3 0.00958646
ASS1 argininosuccinate synthase 1 0.00958097
KLK10 kallikrein-related peptidase 10 0.00943056
CRABP2 cellular retinoic acid binding protein 2 0.00941716
LY96 lymphocyte antigen 96 0.00924304
KLK11 kallikrein-related peptidase 11 0.00921122
IFITM3 interferon induced transmembrane protein 3 0.00897571
SPON1 spondin 1, extracellular matrix protein 0.00876986
S100A8 S100 calcium binding protein A8 0.00869389
NUPR1 nuclear protein, transcriptional regulator, 1 0.00865872
KLK8 kallikrein-related peptidase 8 0.00856029
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.00854619
ZIC1 Zic family member 1 0.00854215
SLPI secretory leukocyte peptidase inhibitor 0.00848137
PIP prolactin-induced protein 0.00843871
EIF5A eukaryotic translation initiation factor 5A 0.00841876
VSIG4 V-set and immunoglobulin domain containing 4 0.00837795
CCDC86 coiled-coil domain containing 86 0.00834236
BEX4 brain expressed, X-linked 4 0.00831003
CCL4 chemokine (C-C motif) ligand 4 0.00829797
MSMO1 methylsterol monooxygenase 1 0.0082755
TMEM100 transmembrane protein 100 0.00826693
C1QB complement component 1, q subcomponent, B chain 0.00817093
KLK7 kallikrein-related peptidase 7 0.00808903
C1QA complement component 1, q subcomponent, A chain 0.00801797
OXA1L oxidase (cytochrome c) assembly 1-like 0.00796994
MT1E metallothionein 1E 0.00793037
DCN decorin 0.00780441
GPX3 glutathione peroxidase 3 0.00777199
A2M alpha-2-macroglobulin 0.00775506
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.00768016
F3 coagulation factor III (thromboplastin, tissue factor) 0.00758709
TNNT1 troponin T type 1 (skeletal, slow) 0.00757356
KRT6A keratin 6A, type II 0.0075434
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.00752027
DAAM2 dishevelled associated activator of morphogenesis 2 0.00746951
LTF lactotransferrin 0.00746048
FABP4 fatty acid binding protein 4, adipocyte 0.00744376
KRT5 keratin 5, type II 0.00743757
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.00736532
CYB5A cytochrome b5 type A (microsomal) 0.00734139
RAB38 RAB38, member RAS oncogene family 0.00732873
S100A2 S100 calcium binding protein A2 0.00731333
SLC43A3 solute carrier family 43, member 3 0.00727121
CLCA2 chloride channel accessory 2 0.00725286
EGR3 early growth response 3 0.00723914
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.00722538
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.00722338
HSPA1A heat shock 70kDa protein 1A 0.00720822
CST6 cystatin E/M 0.00716859
SPRR1B small proline-rich protein 1B 0.0071629
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 0.0071484
KRT23 keratin 23, type I 0.00714301
ACTA1 actin, alpha 1, skeletal muscle 0.00713784
EGR1 early growth response 1 0.00712531
NXN nucleoredoxin 0.00706408
NPY neuropeptide Y 0.0069893
STK10 serine/threonine kinase 10 0.00696846
KAZN kazrin, periplakin interacting protein 0.0069594
ATF3 activating transcription factor 3 0.00694237
MMP10 matrix metallopeptidase 10 0.00691969
KRT6B keratin 6B, type II 0.00686932
CCND2 cyclin D2 0.00684455
NOP10 NOP10 ribonucleoprotein 0.00684352
GSTA4 glutathione S-transferase alpha 4 0.00683067
GPR137B G protein-coupled receptor 137B 0.00680327
DHCR24 24-dehydrocholesterol reductase 0.00677833
PLK2 polo-like kinase 2 0.0067763
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.00673142
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.00672251
GJA1 gap junction protein, alpha 1, 43kDa 0.00671883
CADM1 cell adhesion molecule 1 0.00671517
AK1 adenylate kinase 1 0.00667066
CPM carboxypeptidase M 0.00665396
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.00662474
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.00657926
KRT16 keratin 16, type I 0.00655959
PLVAP plasmalemma vesicle associated protein 0.00655713
TRIM29 tripartite motif containing 29 0.00654147
H1-2 H1.2 linker histone, cluster member 0.00651609
RNF167 ring finger protein 167 0.00649498
FN1 fibronectin 1 0.00649437
PDZK1IP1 PDZK1 interacting protein 1 0.00649158
RUNX3 runt-related transcription factor 3 0.00647314
FCGBP Fc fragment of IgG binding protein 0.00644725
SOWAHC sosondowah ankyrin repeat domain family member C 0.00643281
FGF13 fibroblast growth factor 13 0.00640267
CD36 CD36 molecule (thrombospondin receptor) 0.00639678
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.00639502
REEP1 receptor accessory protein 1 0.00639096
GPC4 glypican 4 0.00638992
NEFH neurofilament, heavy polypeptide 0.00637321
ARMCX2 armadillo repeat containing, X-linked 2 0.00637231
IFITM1 interferon induced transmembrane protein 1 0.00636573
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.00636229
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00633528
GARS1 glycyl-tRNA synthetase 1 0.0063253
TXNDC9 thioredoxin domain containing 9 0.00632212
STXBP6 syntaxin binding protein 6 (amisyn) 0.00632125
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.00631798
AHNAK2 AHNAK nucleoprotein 2 0.00630815
DPT dermatopontin 0.0062987
IFI6 interferon, alpha-inducible protein 6 0.00629555
LPAR6 lysophosphatidic acid receptor 6 0.00628425
IFITM2 interferon induced transmembrane protein 2 0.00627781
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.00625613
CYB5R1 cytochrome b5 reductase 1 0.00625347
PMP22 peripheral myelin protein 22 0.00622611
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.00621377
HMOX1 heme oxygenase 1 0.00620296
IL1RN interleukin 1 receptor antagonist 0.00619589
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00619297
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.00618135
COG2 component of oligomeric golgi complex 2 0.0061809
SYNM synemin, intermediate filament protein 0.00611947
SH3BGR SH3 domain binding glutamate-rich protein 0.00606645
MB myoglobin 0.00602789
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 0.00601367
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00601214
WISP2 WNT1 inducible signaling pathway protein 2 0.00599685
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.00598452
ANG angiogenin, ribonuclease, RNase A family, 5 0.00597361
PKP1 plakophilin 1 0.00591819
PLP1 proteolipid protein 1 0.00591546
PRMT5 protein arginine methyltransferase 5 0.00591134
TYRP1 tyrosinase-related protein 1 0.00590913
KLHL41 kelch-like family member 41 0.00589879
COX7B cytochrome c oxidase subunit VIIb 0.00587481
NPEPL1 aminopeptidase-like 1 0.00587186
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.00585897
DDIT3 DNA-damage-inducible transcript 3 0.00584971
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.00583856
AKR1C2 aldo-keto reductase family 1, member C2 0.0058309
SPARCL1 SPARC-like 1 (hevin) 0.00582021
CRCT1 cysteine-rich C-terminal 1 0.0058098
PPL periplakin 0.00579895
IQGAP2 IQ motif containing GTPase activating protein 2 0.00579749
MYO5A myosin VA (heavy chain 12, myoxin) 0.00578507
JPT1 Jupiter microtubule associated homolog 1 0.00577042
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.0057609
ZBED2 zinc finger, BED-type containing 2 0.00574781
ACP5 acid phosphatase 5, tartrate resistant 0.00574762
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.00573838
RGCC regulator of cell cycle 0.00573686
RYR1 ryanodine receptor 1 (skeletal) 0.00572584
KLHL21 kelch-like family member 21 0.00570523
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00570315
KLF6 Kruppel-like factor 6 0.00570094
CHRDL1 chordin-like 1 0.00568799
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00566574
TMSB15A thymosin beta 15a 0.00566054
CD99 CD99 molecule 0.00565172
COLEC12 collectin sub-family member 12 0.00564741
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.00563165
TNNC2 troponin C type 2 (fast) 0.00563145
WBP5 WW domain binding protein 5 0.00562719
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.00562125
PON2 paraoxonase 2 0.00559581
ALOX15B arachidonate 15-lipoxygenase, type B 0.0055845
LEPROT leptin receptor overlapping transcript 0.00558136
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 0.00557856
MT1X metallothionein 1X 0.00556568
NGDN neuroguidin, EIF4E binding protein 0.00555746
TWIST1 twist family bHLH transcription factor 1 0.00553679
TMEM45A transmembrane protein 45A 0.00553556
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.00552164
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.00551565
HIGD1A HIG1 hypoxia inducible domain family, member 1A 0.00549885
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00549006
HOXD1 homeobox D1 0.00548992
MX1 MX dynamin-like GTPase 1 0.00547545
SNAI2 snail family zinc finger 2 0.00547036
AOX1 aldehyde oxidase 1 0.00545664
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.00545332
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.00543566
EFNA1 ephrin-A1 0.0054285
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.00540263
TSPAN15 tetraspanin 15 0.00539707
MRPL40 mitochondrial ribosomal protein L40 0.00538371
SPRR1A small proline-rich protein 1A 0.00537394
MBL2 mannose-binding lectin (protein C) 2, soluble 0.00536807
S100A7 S100 calcium binding protein A7 0.00536453
RSL1D1 ribosomal L1 domain containing 1 0.00536316
IFI27 interferon, alpha-inducible protein 27 0.00535263
RTN2 reticulon 2 0.00534755
FOLR2 folate receptor 2 (fetal) 0.00534279
CCL20 chemokine (C-C motif) ligand 20 0.00533281
SLIRP SRA stem-loop interacting RNA binding protein 0.00531906
LGALS1 lectin, galactoside-binding, soluble, 1 0.0053189
CPE carboxypeptidase E 0.00531814
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.00531562
DDR2 discoidin domain receptor tyrosine kinase 2 0.00531387
NPC2 Niemann-Pick disease, type C2 0.00530012
FOSL2 FOS-like antigen 2 0.00529211
EVI2A ecotropic viral integration site 2A 0.00528575
NEU1 sialidase 1 (lysosomal sialidase) 0.00528428
REEP5 receptor accessory protein 5 0.00527688
MXRA5 matrix-remodelling associated 5 0.00527386
RNF144A ring finger protein 144A 0.00526978
FABP3 fatty acid binding protein 3, muscle and heart 0.00526745
CDH5 cadherin 5, type 2 (vascular endothelium) 0.00526106
PARP2 poly (ADP-ribose) polymerase 2 0.00526062
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.00524144
TIMP2 TIMP metallopeptidase inhibitor 2 0.00523938
SEPP1 selenoprotein P, plasma, 1 0.0052348
CALML5 calmodulin-like 5 0.00523215
UPP1 uridine phosphorylase 1 0.00522749
PON3 paraoxonase 3 0.00522517
IL24 interleukin 24 0.00521843
S100A14 S100 calcium binding protein A14 0.00521157
CD163 CD163 molecule 0.0052064
CLTB clathrin, light chain B 0.00519107
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.00518968
DSG1 desmoglein 1 0.00516842
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00516048
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00514883
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 0.00514537
DERL2 derlin 2 0.00511135
COL11A1 collagen, type XI, alpha 1 0.0051111
STAB1 stabilin 1 0.00510779
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.00509754

decreased expression

Symbol Name Standardized Value
XIC X chromosome inactivation center -0.0182347
PTK2 protein tyrosine kinase 2 -0.0128953
AMIGO2 adhesion molecule with Ig-like domain 2 -0.0126625
SMC1A structural maintenance of chromosomes 1A -0.0108541
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0102723
TESC tescalcin -0.00995168
UGDH UDP-glucose 6-dehydrogenase -0.00991905
PLS1 plastin 1 -0.00983765
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.00903065
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.00898428
MARCKSL1 MARCKS-like 1 -0.00891815
CTSZ cathepsin Z -0.00888208
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0087619
TRIB3 tribbles pseudokinase 3 -0.00860773
CIAO3 cytosolic iron-sulfur assembly component 3 -0.0085262
PLCB4 phospholipase C, beta 4 -0.00840904
ARMT1 acidic residue methyltransferase 1 -0.00824257
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.00820891
PBX1 pre-B-cell leukemia homeobox 1 -0.00818247
MANSC1 MANSC domain containing 1 -0.00805928
LY75 lymphocyte antigen 75 -0.00803541
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -0.00797445
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.00794732
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00774305
PWP1 PWP1 homolog (S. cerevisiae) -0.00773969
POSTN periostin, osteoblast specific factor -0.00772686
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -0.00768115
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -0.00755758
AKAP7 A kinase (PRKA) anchor protein 7 -0.00749913
TFF1 trefoil factor 1 -0.00748139
CEP55 centrosomal protein 55kDa -0.00741001
ECT2 epithelial cell transforming 2 -0.00733896
TBL1X transducin (beta)-like 1X-linked -0.00722028
AGR2 anterior gradient 2 -0.0072201
ESR1 estrogen receptor 1 -0.00720219
CD200 CD200 molecule -0.0072014
GCH1 GTP cyclohydrolase 1 -0.00719072
EPCAM epithelial cell adhesion molecule -0.00717891
LTBP1 latent transforming growth factor beta binding protein 1 -0.00713337
ARID4B AT rich interactive domain 4B (RBP1-like) -0.00711765
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0071044
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -0.00708205
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.00705569
FBP1 fructose-1,6-bisphosphatase 1 -0.00700043
MMP12 matrix metallopeptidase 12 -0.00698089
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.00695814
CDKN2A cyclin-dependent kinase inhibitor 2A -0.00693788
BASP1 brain abundant, membrane attached signal protein 1 -0.00691663
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -0.00689721
MSLN mesothelin -0.00687224
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00684255
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -0.00683514
KRT8 keratin 8, type II -0.00677798
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.00676753
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.00673414
LTB lymphotoxin beta (TNF superfamily, member 3) -0.00672512
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.00672275
GUCY2C guanylate cyclase 2C -0.0066941
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -0.00667235
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0065892
LGALS2 lectin, galactoside-binding, soluble, 2 -0.00658665
TRAF5 TNF receptor-associated factor 5 -0.00658119
UXT ubiquitously-expressed, prefoldin-like chaperone -0.00656916
KIF11 kinesin family member 11 -0.00653657
ATP13A3 ATPase type 13A3 -0.00652063
MAP7 microtubule-associated protein 7 -0.00651986
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0064882
TFEC transcription factor EC -0.00638528
PXMP2 peroxisomal membrane protein 2, 22kDa -0.00637594
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.00637149
HLA-DOB major histocompatibility complex, class II, DO beta -0.00636411
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.00636277
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.00636086
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.00630564
CXCL13 chemokine (C-X-C motif) ligand 13 -0.00627099
SH3YL1 SH3 and SYLF domain containing 1 -0.00624485
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0062356
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.00622948
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.00620532
HEPH hephaestin -0.00618737
DHFR dihydrofolate reductase -0.00618153
BDNF brain-derived neurotrophic factor -0.00613099
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -0.00605681
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.00605555
ALCAM activated leukocyte cell adhesion molecule -0.00605125
LSR lipolysis stimulated lipoprotein receptor -0.00605078
VEGFA vascular endothelial growth factor A -0.0060402
UGCG UDP-glucose ceramide glucosyltransferase -0.00603845
CDK14 cyclin-dependent kinase 14 -0.00602833
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.005984
NR2F6 nuclear receptor subfamily 2, group F, member 6 -0.00595306
TMEM176A transmembrane protein 176A -0.00595061
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -0.00594529
MTCL1 microtubule crosslinking factor 1 -0.00593393
CCL19 chemokine (C-C motif) ligand 19 -0.00591399
S100P S100 calcium binding protein P -0.00591344
TLK2 tousled-like kinase 2 -0.00588799
ZBTB18 zinc finger and BTB domain containing 18 -0.00587387
DMD dystrophin -0.00587072
PTCH1 patched 1 -0.00586746
NEK2 NIMA-related kinase 2 -0.00586153
NUP153 nucleoporin 153kDa -0.00586125
DCK deoxycytidine kinase -0.0058404
C2CD5 C2 calcium-dependent domain containing 5 -0.00577338
TSC22D1 TSC22 domain family, member 1 -0.00577159
ZNF107 zinc finger protein 107 -0.00573986
SLC35A5 solute carrier family 35, member A5 -0.00573278
WEE1 WEE1 G2 checkpoint kinase -0.0057275
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -0.00570471
BCLAF1 BCL2-associated transcription factor 1 -0.00567893
SH3BGRL SH3 domain binding glutamate-rich protein like -0.00565475
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 -0.00562693
GEM GTP binding protein overexpressed in skeletal muscle -0.00561293
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.00560732
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.00560554
IGSF6 immunoglobulin superfamily, member 6 -0.00558871
CXCL9 chemokine (C-X-C motif) ligand 9 -0.00553678
CANT1 calcium activated nucleotidase 1 -0.0055072
FUBP1 far upstream element (FUSE) binding protein 1 -0.00550112
PF4 platelet factor 4 -0.00549336
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0054794
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.00546598
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0054616
IL2RG interleukin 2 receptor, gamma -0.00546012
AOC1 amine oxidase, copper containing 1 -0.00544424
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -0.00544364
NR1H3 nuclear receptor subfamily 1, group H, member 3 -0.00543815
ADORA2B adenosine A2b receptor -0.00543688
TRAPPC2 trafficking protein particle complex 2 -0.00543221
DYNLT3 dynein, light chain, Tctex-type 3 -0.00542461
TFF3 trefoil factor 3 (intestinal) -0.00538787
CRLF1 cytokine receptor-like factor 1 -0.00537882
PKP2 plakophilin 2 -0.00537325
RUFY3 RUN and FYVE domain containing 3 -0.00537272
NDC80 NDC80 kinetochore complex component -0.00535286
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -0.00534294
RGS13 regulator of G-protein signaling 13 -0.00533565
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -0.00533308
LMNB1 lamin B1 -0.00531525
ADAM12 ADAM metallopeptidase domain 12 -0.00531147
VCAN versican -0.00529285
CCNB1 cyclin B1 -0.00528463
CTSB cathepsin B -0.00528079
RAD23B RAD23 homolog B (S. cerevisiae) -0.00527691
DRAM1 DNA-damage regulated autophagy modulator 1 -0.00525926
HIP1 huntingtin interacting protein 1 -0.00525607
YEATS4 YEATS domain containing 4 -0.00524746
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.00524305
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -0.0052375
LY6E lymphocyte antigen 6 complex, locus E -0.00523083
HDAC6 histone deacetylase 6 -0.00522325
INSIG1 insulin induced gene 1 -0.00521814
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00521802
ZDHHC17 zinc finger, DHHC-type containing 17 -0.00521727
COL6A3 collagen, type VI, alpha 3 -0.00521473
KRT18 keratin 18, type I -0.00520315
PTGDS prostaglandin D2 synthase 21kDa (brain) -0.00520125
TYMS thymidylate synthetase -0.00517838
TRH thyrotropin-releasing hormone -0.00517416
COL5A2 collagen, type V, alpha 2 -0.00516639
TPI1 triosephosphate isomerase 1 -0.00515701
ATG3 autophagy related 3 -0.00514552
SYNJ2 synaptojanin 2 -0.00514514
GATA6 GATA binding protein 6 -0.00514022
EDRF1 erythroid differentiation regulatory factor 1 -0.0051344
PAWR PRKC, apoptosis, WT1, regulator -0.00513297
ADRA2A adrenoceptor alpha 2A -0.00512167
VWA8 von Willebrand factor A domain containing 8 -0.00511361
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -0.00511243
ADD3 adducin 3 (gamma) -0.00508771
NPR3 natriuretic peptide receptor 3 -0.00508735
SCAMP1 secretory carrier membrane protein 1 -0.00507598
CCR7 chemokine (C-C motif) receptor 7 -0.00507316
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00505872
KIAA0226L KIAA0226-like -0.0050585
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00504766
MYB v-myb avian myeloblastosis viral oncogene homolog -0.00504568
LYZ lysozyme -0.00503031
ANXA6 annexin A6 -0.0050264
LOXL1 lysyl oxidase-like 1 -0.00501277
PRKCA protein kinase C, alpha -0.00500868
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.00500648
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.00499735
CA12 carbonic anhydrase XII -0.00499489
TSPAN13 tetraspanin 13 -0.00499094
AGRN agrin -0.00498451
SPC25 SPC25, NDC80 kinetochore complex component -0.00498169
NELL2 NEL-like 2 (chicken) -0.00496772
IGFBP1 insulin-like growth factor binding protein 1 -0.00496354
PSD3 pleckstrin and Sec7 domain containing 3 -0.00496333
PLCH1 phospholipase C, eta 1 -0.00495348
MED14 mediator complex subunit 14 -0.00494762
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.00494666
FABP1 fatty acid binding protein 1, liver -0.00494122
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.00493722
RAB11A RAB11A, member RAS oncogene family -0.00493364
SCD5 stearoyl-CoA desaturase 5 -0.00492835
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.00492006
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -0.0049115
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -0.00491037
PUM2 pumilio RNA-binding family member 2 -0.00490957
NFE2 nuclear factor, erythroid 2 -0.00490348
HAL histidine ammonia-lyase -0.00490288
TMEM14A transmembrane protein 14A -0.00490196
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -0.00489279
RMI1 RecQ mediated genome instability 1 -0.00488348
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.00487615
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.00487016
RPAP3 RNA polymerase II associated protein 3 -0.00486459
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00486304
SIRPG signal-regulatory protein gamma -0.00485738
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0048559
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -0.00485394
TM2D3 TM2 domain containing 3 -0.00484709
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.00481586
SMC2 structural maintenance of chromosomes 2 -0.00481474
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.00480658
LARS1 leucyl-tRNA synthetase 1 -0.00480657
DDAH2 dimethylarginine dimethylaminohydrolase 2 -0.00479329
LPIN2 lipin 2 -0.00477594
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -0.00476774
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -0.0047633
TOB1 transducer of ERBB2, 1 -0.00475327
FKTN fukutin -0.00475143
KCTD3 potassium channel tetramerization domain containing 3 -0.00474579
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.00474491
HMGB2 high mobility group box 2 -0.00474226
HAS2 hyaluronan synthase 2 -0.00473922
PAX5 paired box 5 -0.0047363
PARPBP PARP1 binding protein -0.00473213
ZNF185 zinc finger protein 185 (LIM domain) -0.00472081
CRNKL1 crooked neck pre-mRNA splicing factor 1 -0.00470163
CAPN6 calpain 6 -0.00469174
CKAP2 cytoskeleton associated protein 2 -0.00468889
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.00468826
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -0.00468435
DSCC1 DNA replication and sister chromatid cohesion 1 -0.00467993
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.00467649
NREP neuronal regeneration related protein -0.00467124
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.00466694
ANO1 anoctamin 1, calcium activated chloride channel -0.00466568
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0046432
TIMELESS timeless circadian clock -0.00463567
LRP4 low density lipoprotein receptor-related protein 4 -0.00463503
ZMYM3 zinc finger, MYM-type 3 -0.00463453
RPA1 replication protein A1, 70kDa -0.00463417
TOP2A topoisomerase (DNA) II alpha 170kDa -0.00462857
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -0.00462635
COL1A1 collagen, type I, alpha 1 -0.0046086
FAM102A family with sequence similarity 102, member A -0.00460733