EIF2AK3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description eukaryotic translation initiation factor 2-alpha kinase 3|The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010] (NCBI Entrez Gene Database, 9451)
External Link http://www.ncbi.nlm.nih.gov/gene/9451
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Genes

71 interacting proteins for EIF2AK3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ARHGAP35 Rho GTPase activating protein 35
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF7 activating transcription factor 7
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
COPS5 COP9 signalosome subunit 5
CSMD1 CUB and Sushi multiple domains 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DNAH9 dynein, axonemal, heavy chain 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DROSHA drosha, ribonuclease type III
E2F3 E2F transcription factor 3
EBF1 early B-cell factor 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHB6 EPH receptor B6
ERCC5 excision repair cross-complementation group 5
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HNF1A HNF1 homeobox A
HSF4 heat shock transcription factor 4
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDI2 isopentenyl-diphosphate delta isomerase 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
KDM2A lysine (K)-specific demethylase 2A
KIF13B kinesin family member 13B
KMT2B lysine (K)-specific methyltransferase 2B
LPAR2 lysophosphatidic acid receptor 2
LPAR4 lysophosphatidic acid receptor 4
LSM1 LSM1, U6 small nuclear RNA associated
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED23 mediator complex subunit 23
MTMR6 myotubularin related protein 6
NCOR2 nuclear receptor corepressor 2
NFE2L2 nuclear factor, erythroid 2-like 2
NKRF NFKB repressing factor
OLA1 Obg-like ATPase 1
OSBPL1A oxysterol binding protein-like 1A
PANX3 pannexin 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDH9 protocadherin 9
POU2F3 POU class 2 homeobox 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RHBDL3 rhomboid, veinlet-like 3 (Drosophila)
SAE1 SUMO1 activating enzyme subunit 1
SENP7 SUMO1/sentrin specific peptidase 7
SIN3A SIN3 transcription regulator family member A
SMO smoothened, frizzled class receptor
SPEN spen family transcriptional repressor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAF3IP3 TRAF3 interacting protein 3
TRIB3 tribbles pseudokinase 3
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
WDR35 WD repeat domain 35
WNK4 WNK lysine deficient protein kinase 4
WNT16 wingless-type MMTV integration site family, member 16
YY1 YY1 transcription factor
ZMYND8 zinc finger, MYND-type containing 8
ZNF443 zinc finger protein 443