| Dataset | PhosphoSitePlus Substrates of Kinases |
| Category | physical interactions |
| Type | kinase |
| Description | eukaryotic translation initiation factor 2-alpha kinase 3|The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010] (NCBI Entrez Gene Database, 9451) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/9451 |
| Similar Terms | |
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2 substrates of the kinase EIF2AK3 from the curated PhosphoSitePlus Substrates of Kinases dataset.
