| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | eukaryotic translation initiation factor 2 alpha kinase 4|This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 440275) |
| External Link | https://ncbi.nlm.nih.gov/gene/440275 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the EIF2AK4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | 0.026593 |
| ADIRF | adipogenesis regulatory factor | 0.0164391 |
| AREG | amphiregulin | 0.01214 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.0119886 |
| STXBP2 | syntaxin binding protein 2 | 0.0113451 |
| CLU | clusterin | 0.0113026 |
| HOPX | HOP homeobox | 0.0112103 |
| NNMT | nicotinamide N-methyltransferase | 0.011019 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.0106585 |
| XIC | X chromosome inactivation center | 0.0103252 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.010205 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.0101521 |
| CST7 | cystatin F (leukocystatin) | 0.0101395 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00956365 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.00941673 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00940302 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00930371 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00930115 |
| ECM1 | extracellular matrix protein 1 | 0.00924262 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0091816 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00918053 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00910224 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.0090149 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00876241 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.00863295 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00848837 |
| CLEC3B | C-type lectin domain family 3, member B | 0.00846521 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00846118 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00843457 |
| ZNF395 | zinc finger protein 395 | 0.00829438 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00828447 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.00828384 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.00827665 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00824985 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00821015 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00819573 |
| APOD | apolipoprotein D | 0.00817852 |
| EFHD1 | EF-hand domain family, member D1 | 0.00817569 |
| SRGN | serglycin | 0.00815481 |
| NOTCH2NL | notch 2 N-terminal like | 0.00815004 |
| PERP | PERP, TP53 apoptosis effector | 0.00814411 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00811729 |
| BCL2L1 | BCL2-like 1 | 0.00792036 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00786977 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.00771884 |
| TPD52 | tumor protein D52 | 0.00768039 |
| SLC38A1 | solute carrier family 38, member 1 | 0.00762153 |
| TNS3 | tensin 3 | 0.00761762 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.0075935 |
| TPST2 | tyrosylprotein sulfotransferase 2 | 0.00757925 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.00757269 |
| ZNF721 | zinc finger protein 721 | 0.00752867 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.00748392 |
| MXRA7 | matrix-remodelling associated 7 | 0.0074305 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00742779 |
| SNAI2 | snail family zinc finger 2 | 0.00731232 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00731046 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00729815 |
| RPS27L | ribosomal protein S27-like | 0.00727912 |
| RGS13 | regulator of G-protein signaling 13 | 0.0071547 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00714516 |
| IL18 | interleukin 18 | 0.00705194 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | 0.00705158 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00701868 |
| IER5 | immediate early response 5 | 0.0070174 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00701664 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | 0.00699116 |
| ZNF652 | zinc finger protein 652 | 0.00695023 |
| ZNF160 | zinc finger protein 160 | 0.00693869 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | 0.00692035 |
| PAX5 | paired box 5 | 0.00689323 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0067794 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00676378 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.00674136 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.00673062 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00671281 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | 0.00670678 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00669114 |
| RND3 | Rho family GTPase 3 | 0.00667882 |
| REXO2 | RNA exonuclease 2 | 0.00666876 |
| FKBP14 | FK506 binding protein 14, 22 kDa | 0.00664887 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.00662629 |
| ELOB | elongin B | 0.00659494 |
| PPP1R16B | protein phosphatase 1, regulatory subunit 16B | 0.00657977 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00657374 |
| RIN2 | Ras and Rab interactor 2 | 0.00653574 |
| DAAM2 | dishevelled associated activator of morphogenesis 2 | 0.00650706 |
| GNLY | granulysin | 0.00647598 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.00644927 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 0.00642745 |
| PLA1A | phospholipase A1 member A | 0.00638496 |
| PIP | prolactin-induced protein | 0.00636385 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.00634429 |
| TSPAN13 | tetraspanin 13 | 0.00634259 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.00632575 |
| HSPB11 | heat shock protein family B (small), member 11 | 0.00630238 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00629883 |
| CTSW | cathepsin W | 0.00629407 |
| VWF | von Willebrand factor | 0.00628106 |
| PXDC1 | PX domain containing 1 | 0.0061966 |
| PDGFD | platelet derived growth factor D | 0.00618567 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00617039 |
| MALL | mal, T-cell differentiation protein-like | 0.00615835 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.00615808 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.00611549 |
| HBD | hemoglobin, delta | 0.0061134 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00608564 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) | 0.00607036 |
| TARP | TCR gamma alternate reading frame protein | 0.00604498 |
| CA12 | carbonic anhydrase XII | 0.00601149 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00599993 |
| COG7 | component of oligomeric golgi complex 7 | 0.00599962 |
| CLIC2 | chloride intracellular channel 2 | 0.00598825 |
| STC2 | stanniocalcin 2 | 0.00598484 |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.00596404 |
| DUSP7 | dual specificity phosphatase 7 | 0.00595925 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00592467 |
| HBB | hemoglobin, beta | 0.00590371 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00590178 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 0.005878 |
| PALLD | palladin, cytoskeletal associated protein | 0.00587611 |
| TXLNA | taxilin alpha | 0.0058631 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00585446 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00584947 |
| FAM162A | family with sequence similarity 162, member A | 0.00584414 |
| ANKMY2 | ankyrin repeat and MYND domain containing 2 | 0.00583133 |
| TUFT1 | tuftelin 1 | 0.00579843 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00579257 |
| JAG1 | jagged 1 | 0.00577037 |
| LOXL2 | lysyl oxidase-like 2 | 0.00575642 |
| IPO13 | importin 13 | 0.00572029 |
| GGT1 | gamma-glutamyltransferase 1 | 0.00568888 |
| ITGB4 | integrin, beta 4 | 0.00568624 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.0056791 |
| DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila) | 0.00566156 |
| MYO1B | myosin IB | 0.00563898 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00563136 |
| NPY | neuropeptide Y | 0.00559215 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.00559198 |
| GTF2H3 | general transcription factor IIH, polypeptide 3, 34kDa | 0.00557988 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00557695 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00557567 |
| GLA | galactosidase, alpha | 0.00557382 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00557363 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.00557217 |
| EZR | ezrin | 0.00555771 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.00555504 |
| CTBP2 | C-terminal binding protein 2 | 0.00555107 |
| METTL5 | methyltransferase like 5 | 0.00554183 |
| FRZB | frizzled-related protein | 0.0055294 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.00551026 |
| WASL | Wiskott-Aldrich syndrome-like | 0.00550469 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00549833 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00549662 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | 0.00548915 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | 0.00548184 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.00548115 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.00546153 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00545687 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00542644 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00540903 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | 0.00539116 |
| FAM107A | family with sequence similarity 107, member A | 0.00537709 |
| POLR1B | polymerase (RNA) I polypeptide B, 128kDa | 0.00537603 |
| HGD | homogentisate 1,2-dioxygenase | 0.00535781 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | 0.00535516 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | 0.00533491 |
| NKG7 | natural killer cell granule protein 7 | 0.00532799 |
| FAM46C | family with sequence similarity 46, member C | 0.00532782 |
| CPNE1 | copine I | 0.00532147 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00530517 |
| MINK1 | misshapen-like kinase 1 | 0.00529907 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 0.00529735 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.00529595 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | 0.00529053 |
| CD79B | CD79b molecule, immunoglobulin-associated beta | 0.0052826 |
| PTPRCAP | protein tyrosine phosphatase, receptor type, C-associated protein | 0.00527694 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | 0.00526816 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 0.00526358 |
| KRT20 | keratin 20, type I | 0.00525707 |
| MITF | microphthalmia-associated transcription factor | 0.00523852 |
| LY75 | lymphocyte antigen 75 | 0.00522683 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.00522573 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00521951 |
| SFN | stratifin | 0.00521857 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00521236 |
| POP7 | processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) | 0.00520677 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00520311 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.0052022 |
| XAB2 | XPA binding protein 2 | 0.00520052 |
| TAOK1 | TAO kinase 1 | 0.00519769 |
| MGST3 | microsomal glutathione S-transferase 3 | 0.00519464 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0051911 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.00518647 |
| RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | 0.00518389 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00517659 |
| DLX5 | distal-less homeobox 5 | 0.00517081 |
| FSTL1 | follistatin-like 1 | 0.00516027 |
| PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | 0.00515901 |
| RYBP | RING1 and YY1 binding protein | 0.00515495 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | 0.00510122 |
| AMACR | alpha-methylacyl-CoA racemase | 0.00508888 |
| EAF2 | ELL associated factor 2 | 0.00508794 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00508681 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | 0.00508137 |
| FCN3 | ficolin (collagen/fibrinogen domain containing) 3 | 0.00508109 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00507408 |
| DUSP3 | dual specificity phosphatase 3 | 0.005066 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | 0.00506453 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.00506101 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0050598 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.00505349 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.00505291 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.00504767 |
| TRIM8 | tripartite motif containing 8 | 0.00504609 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00501207 |
| TOB1 | transducer of ERBB2, 1 | 0.00499902 |
| LPAR1 | lysophosphatidic acid receptor 1 | 0.00499389 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.0049878 |
| PPAP2A | phosphatidic acid phosphatase type 2A | 0.0049817 |
| PTK6 | protein tyrosine kinase 6 | 0.00496654 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.00494391 |
| MIR22HG | MIR22 host gene | 0.0049395 |
| CLIC3 | chloride intracellular channel 3 | 0.00492194 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | 0.00491918 |
| CLC | Charcot-Leyden crystal galectin | 0.00491678 |
| GLUD1 | glutamate dehydrogenase 1 | 0.00491413 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.00491146 |
| RGCC | regulator of cell cycle | 0.00490751 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.00490412 |
| MAGEB2 | melanoma antigen family B2 | 0.00489634 |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.00489633 |
| VEGFC | vascular endothelial growth factor C | 0.0048881 |
| CCNG2 | cyclin G2 | 0.00485287 |
| PHF20 | PHD finger protein 20 | 0.00482259 |
| SIK1 | salt-inducible kinase 1 | 0.00481214 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.00481172 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.00480518 |
| ESR1 | estrogen receptor 1 | 0.00479284 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.00478916 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | 0.00475815 |
| EVA1B | eva-1 homolog B (C. elegans) | 0.00475276 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.00474463 |
| PFDN4 | prefoldin subunit 4 | 0.0047385 |
| LPPR1 | lipid phosphate phosphatase-related protein type 1 | 0.00473842 |
| STX8 | syntaxin 8 | 0.00473152 |
| FSCN1 | fascin actin-bundling protein 1 | 0.0047304 |
| SCAND1 | SCAN domain containing 1 | 0.00472874 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.00472687 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.017011 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0109184 |
| NRN1 | neuritin 1 | -0.0106022 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.0104753 |
| MX1 | MX dynamin-like GTPase 1 | -0.0102501 |
| CALCA | calcitonin-related polypeptide alpha | -0.0102122 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0101596 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00994364 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00976551 |
| MEIS2 | Meis homeobox 2 | -0.00957931 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00946613 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.0091635 |
| NELL2 | NEL-like 2 (chicken) | -0.00913742 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00902503 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00884895 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.00882538 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.00871444 |
| NID1 | nidogen 1 | -0.00869777 |
| NLGN4X | neuroligin 4, X-linked | -0.008668 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00847337 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00833477 |
| MDFIC | MyoD family inhibitor domain containing | -0.00828249 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0082743 |
| DMD | dystrophin | -0.00823856 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00817884 |
| NREP | neuronal regeneration related protein | -0.00812564 |
| LAMA4 | laminin, alpha 4 | -0.00808071 |
| PEG3 | paternally expressed 3 | -0.00805914 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | -0.00797506 |
| IFI44L | interferon-induced protein 44-like | -0.00783386 |
| PLBD1 | phospholipase B domain containing 1 | -0.00783329 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00779712 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.0077603 |
| IFI44 | interferon-induced protein 44 | -0.00774437 |
| GPC3 | glypican 3 | -0.00774068 |
| NSG1 | neuron specific gene family member 1 | -0.0077064 |
| IFRD2 | interferon-related developmental regulator 2 | -0.00761291 |
| GAS1 | growth arrest-specific 1 | -0.00755061 |
| ELOVL2 | ELOVL fatty acid elongase 2 | -0.0072968 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.00726751 |
| SYBU | syntabulin (syntaxin-interacting) | -0.00718451 |
| CFI | complement factor I | -0.00717471 |
| C7 | complement component 7 | -0.00714102 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00705648 |
| SAMHD1 | SAM domain and HD domain 1 | -0.00701146 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.00699773 |
| SVIL | supervillin | -0.00696443 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.00695913 |
| PDZD2 | PDZ domain containing 2 | -0.00689028 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00688395 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | -0.0068535 |
| PRMT1 | protein arginine methyltransferase 1 | -0.00682914 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00678296 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00676793 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.00674551 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00671797 |
| BAX | BCL2-associated X protein | -0.0066912 |
| TSPAN8 | tetraspanin 8 | -0.00663083 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.00663082 |
| C1R | complement component 1, r subcomponent | -0.00662356 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.0065971 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00658731 |
| PRKD1 | protein kinase D1 | -0.0065801 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | -0.00657899 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.00657874 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.00654847 |
| GAS2 | growth arrest-specific 2 | -0.00654618 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00654008 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00654005 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | -0.00653307 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | -0.00641738 |
| FZD6 | frizzled class receptor 6 | -0.00641215 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00639274 |
| TRMT5 | tRNA methyltransferase 5 | -0.00637193 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00636673 |
| TSPYL5 | TSPY-like 5 | -0.00632379 |
| C5AR1 | complement component 5a receptor 1 | -0.00631611 |
| PER3 | period circadian clock 3 | -0.00630544 |
| TADA2A | transcriptional adaptor 2A | -0.0062803 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.00625281 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.00619206 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.00617005 |
| TMOD1 | tropomodulin 1 | -0.00612107 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00611215 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.00610681 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.00609731 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00607916 |
| BNC2 | basonuclin 2 | -0.0060779 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00607681 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | -0.0060697 |
| FGL2 | fibrinogen-like 2 | -0.00604193 |
| PLN | phospholamban | -0.00603529 |
| FABP7 | fatty acid binding protein 7, brain | -0.00601798 |
| SELL | selectin L | -0.00601162 |
| PNMA8A | PNMA family member 8A | -0.00598336 |
| COPS7A | COP9 signalosome subunit 7A | -0.0059699 |
| PLP1 | proteolipid protein 1 | -0.00596086 |
| USP18 | ubiquitin specific peptidase 18 | -0.00594896 |
| ARRB2 | arrestin, beta 2 | -0.00593331 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00593064 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.00590612 |
| STON1 | stonin 1 | -0.00588692 |
| GPR183 | G protein-coupled receptor 183 | -0.00586543 |
| MAL | mal, T-cell differentiation protein | -0.00582442 |
| ATF3 | activating transcription factor 3 | -0.00582204 |
| MGP | matrix Gla protein | -0.00581904 |
| VCAN | versican | -0.00580802 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.00580553 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.00580039 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00579915 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.00579122 |
| KLF6 | Kruppel-like factor 6 | -0.00573516 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0057262 |
| HLA-F | major histocompatibility complex, class I, F | -0.00570328 |
| EGR2 | early growth response 2 | -0.00568403 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00560206 |
| CHEK2 | checkpoint kinase 2 | -0.00556997 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.00555203 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00554465 |
| LMNB1 | lamin B1 | -0.00554456 |
| PRKCA | protein kinase C, alpha | -0.00554386 |
| RLN1 | relaxin 1 | -0.00554313 |
| LY6D | lymphocyte antigen 6 complex, locus D | -0.00553945 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00553436 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00552635 |
| SALL2 | spalt-like transcription factor 2 | -0.00552632 |
| EMP2 | epithelial membrane protein 2 | -0.00549589 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00549004 |
| TPI1 | triosephosphate isomerase 1 | -0.00548058 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00547776 |
| TRAPPC3 | trafficking protein particle complex 3 | -0.00546795 |
| AURKB | aurora kinase B | -0.00546709 |
| PUF60 | poly-U binding splicing factor 60KDa | -0.00545633 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00542182 |
| CALCB | calcitonin-related polypeptide beta | -0.00541642 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00540587 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.00540157 |
| C1S | complement component 1, s subcomponent | -0.00539638 |
| GANAB | glucosidase, alpha; neutral AB | -0.00538902 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00537679 |
| PTN | pleiotrophin | -0.00537664 |
| AK4 | adenylate kinase 4 | -0.00536727 |
| H1-0 | H1.0 linker histone | -0.0053545 |
| CSPG5 | chondroitin sulfate proteoglycan 5 (neuroglycan C) | -0.00534505 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.00533912 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | -0.00533688 |
| MMP10 | matrix metallopeptidase 10 | -0.00533117 |
| PXDN | peroxidasin | -0.00532197 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.00531864 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00531425 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.00528948 |
| EDNRB | endothelin receptor type B | -0.00526055 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.0052506 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00524096 |
| PRPF19 | pre-mRNA processing factor 19 | -0.0052393 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.00522415 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.00520351 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | -0.00518219 |
| FHL1 | four and a half LIM domains 1 | -0.00517752 |
| NES | nestin | -0.0051767 |
| MX2 | MX dynamin-like GTPase 2 | -0.00517344 |
| GAS7 | growth arrest-specific 7 | -0.0051731 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -0.00515721 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.00515217 |
| SELENOW | selenoprotein W | -0.00512843 |
| GSTT1 | glutathione S-transferase theta 1 | -0.00512741 |
| TYRP1 | tyrosinase-related protein 1 | -0.00511113 |
| MSL1 | male-specific lethal 1 homolog (Drosophila) | -0.00510834 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00510466 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00509998 |
| TUBA1A | tubulin, alpha 1a | -0.00508159 |
| AOX1 | aldehyde oxidase 1 | -0.00506207 |
| OGN | osteoglycin | -0.00506184 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00504802 |
| FHOD3 | formin homology 2 domain containing 3 | -0.00504628 |
| RET | ret proto-oncogene | -0.00504609 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -0.00504555 |
| EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 | -0.00504528 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | -0.00503369 |
| HSPA12A | heat shock 70kDa protein 12A | -0.00502155 |
| DENND2B | DENN domain containing 2B | -0.00501341 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.00501034 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.00500609 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | -0.00499219 |
| KLHDC3 | kelch domain containing 3 | -0.0049821 |
| PCP4 | Purkinje cell protein 4 | -0.00497532 |
| SYK | spleen tyrosine kinase | -0.00497208 |
| STAT5A | signal transducer and activator of transcription 5A | -0.00496503 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00496242 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | -0.00496033 |
| DOK5 | docking protein 5 | -0.00495367 |
| IPO5 | importin 5 | -0.00495303 |
| MEN1 | multiple endocrine neoplasia I | -0.00495101 |
| COL1A2 | collagen, type I, alpha 2 | -0.00494404 |
| TRIM36 | tripartite motif containing 36 | -0.00493722 |
| FUS | FUS RNA binding protein | -0.00493185 |
| DZIP1 | DAZ interacting zinc finger protein 1 | -0.00492679 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00492196 |
| KLK8 | kallikrein-related peptidase 8 | -0.00492054 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00491808 |
| CBS | cystathionine-beta-synthase | -0.00491166 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00491037 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | -0.00490814 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.00490181 |
| BST2 | bone marrow stromal cell antigen 2 | -0.00489466 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | -0.0048888 |
| PITX3 | paired-like homeodomain 3 | -0.00488381 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0048823 |
| CLEC5A | C-type lectin domain family 5, member A | -0.00487969 |
| APOL2 | apolipoprotein L, 2 | -0.0048724 |
| MAPK14 | mitogen-activated protein kinase 14 | -0.00486748 |
| HLA-B | major histocompatibility complex, class I, B | -0.00485929 |
| FLOT2 | flotillin 2 | -0.00483497 |
| RTN1 | reticulon 1 | -0.00483076 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | -0.00482444 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0048239 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | -0.00482387 |
| FLOT1 | flotillin 1 | -0.00481681 |
| AZIN1 | antizyme inhibitor 1 | -0.00481404 |
| AMPH | amphiphysin | -0.00479717 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00479075 |
| TEAD4 | TEA domain family member 4 | -0.00478173 |
| ACAD8 | acyl-CoA dehydrogenase family, member 8 | -0.00477962 |
| ERLIN2 | ER lipid raft associated 2 | -0.00477588 |
| GPC4 | glypican 4 | -0.00477448 |
| CHRDL1 | chordin-like 1 | -0.00476376 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | -0.00476324 |
| TRAF4 | TNF receptor-associated factor 4 | -0.00476256 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00476119 |
| QKI | QKI, KH domain containing, RNA binding | -0.00475821 |
| NFIC | nuclear factor I/C (CCAAT-binding transcription factor) | -0.0047548 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.00475081 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0047505 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.0047502 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00474697 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00473732 |
| B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | -0.00473453 |
| THAP9-AS1 | THAP9 antisense RNA 1 | -0.00473242 |
| GPM6B | glycoprotein M6B | -0.00472804 |
| OBI1 | ORC ubiquitin ligase 1 | -0.00472129 |
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | -0.00471791 |
| LRRC8D | leucine rich repeat containing 8 family, member D | -0.00471586 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.00471113 |
| ALB | albumin | -0.00469868 |
| RELN | reelin | -0.00469771 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | -0.00467616 |
| EPAS1 | endothelial PAS domain protein 1 | -0.00467569 |
| ATP10B | ATPase, class V, type 10B | -0.00466728 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | -0.00466028 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | -0.00464577 |
