EIF4EBP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description eukaryotic translation initiation factor 4E binding protein 1|This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1978)
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Genes

325 genes differentially expressed following the EIF4EBP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLDN9 claudin 9 2.84473
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.84473
NANOS3 nanos homolog 3 (Drosophila) 2.84473
FABP1 fatty acid binding protein 1, liver 2.84473
FGL2 fibrinogen-like 2 2.84473
SSTR1 somatostatin receptor 1 2.84473
NCF1 neutrophil cytosolic factor 1 2.84473
TBX15 T-box 15 2.84473
CLEC19A C-type lectin domain family 19, member A 2.84473
PDZD9 PDZ domain containing 9 2.84473
CTRC chymotrypsin C (caldecrin) 2.84473
CARD16 caspase recruitment domain family, member 16 2.84473
FGF21 fibroblast growth factor 21 2.84473
CCDC13 coiled-coil domain containing 13 2.84473
TUBA3E tubulin, alpha 3e 2.84473
SYCP1 synaptonemal complex protein 1 2.84473
GJA5 gap junction protein, alpha 5, 40kDa 2.84473
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.84473
TMPRSS11D transmembrane protease, serine 11D 2.84473
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.84473
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.84473
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.84473
FAM131A family with sequence similarity 131, member A 2.84473
CCL5 chemokine (C-C motif) ligand 5 2.84473
ZNF560 zinc finger protein 560 2.84473
ANKK1 ankyrin repeat and kinase domain containing 1 2.84473
NPIPA5 nuclear pore complex interacting protein family, member A5 2.84473
BFSP2 beaded filament structural protein 2, phakinin 2.84473
TAS2R19 taste receptor, type 2, member 19 2.84473
TRPC5OS TRPC5 opposite strand 2.84473
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.84473
FBN2 fibrillin 2 2.84473
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.84473
HIC1 hypermethylated in cancer 1 2.84473
CD160 CD160 molecule 2.84473
OCSTAMP osteoclast stimulatory transmembrane protein 2.84473
ACTL7A actin-like 7A 2.84473
GJB3 gap junction protein, beta 3, 31kDa 2.84473
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.84473
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.84473
PAX2 paired box 2 2.84473
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.84473
ASB12 ankyrin repeat and SOCS box containing 12 2.84473
ASB10 ankyrin repeat and SOCS box containing 10 2.84473
TUBB1 tubulin, beta 1 class VI 2.84473
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.84473
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.84473
DRC5 dynein regulatory complex subunit 5 2.84473
JAML junction adhesion molecule like 2.84473
PLPPR4 phospholipid phosphatase related 4 2.84473
SLURP2 secreted LY6/PLAUR domain containing 2 2.84473
MYOCOS myocilin opposite strand 2.84473
CCDC9B coiled-coil domain containing 9B 2.84473
CAVIN2 caveolae associated protein 2 2.84473
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.84473
GBP6 guanylate binding protein family, member 6 2.84473
SCEL sciellin 2.84473
VXN vexin 2.84473
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.84473
TMEM273 transmembrane protein 273 2.84473
SPEGNB SPEG neighbor 2.84473
FAM240A family with sequence similarity 240 member A 2.84473
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.84473
CPNE8-AS1 CPNE8 antisense RNA 1 2.84473
INSYN1 inhibitory synaptic factor 1 2.84473
SERTM2 serine rich and transmembrane domain containing 2 2.84473
GLYATL1B glycine-N-acyltransferase like 1B 2.84473
GARIN6 golgi associated RAB2 interactor family member 6 2.84473
GSTT4 glutathione S-transferase theta 4 2.84473
GPR35 G protein-coupled receptor 35 2.84473
PNLIPRP3 pancreatic lipase-related protein 3 2.84473
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.84473
FAM186B family with sequence similarity 186, member B 2.84473
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.84473
PRRT4 proline-rich transmembrane protein 4 2.84473
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.84473
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.84473
SPMIP10 sperm microtubule inner protein 10 2.84473
IL31RA interleukin 31 receptor A 2.84473
MAL mal, T-cell differentiation protein 2.84473
CLEC3A C-type lectin domain family 3, member A 2.84473
TCF23 transcription factor 23 2.84473
RGS21 regulator of G-protein signaling 21 2.84473
PGA5 pepsinogen 5, group I (pepsinogen A) 2.84473
KRT80 keratin 80, type II 2.84473
TMPRSS7 transmembrane protease, serine 7 2.84473
WDR64 WD repeat domain 64 2.84473
TSPAN8 tetraspanin 8 2.84473
TSPAN1 tetraspanin 1 2.84473
GPR84 G protein-coupled receptor 84 2.84473
LRRC71 leucine rich repeat containing 71 2.84473
OOSP1 oocyte secreted protein 1, pseudogene 2.84473
OPN5 opsin 5 2.84473
TEX101 testis expressed 101 2.84473
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.84473
ZBED6 zinc finger, BED-type containing 6 2.84473
PDCD1 programmed cell death 1 2.84473
TSPAN32 tetraspanin 32 2.84473
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.84473
KRT15 keratin 15, type I 2.84473
KRT17 keratin 17, type I 2.84473
GFI1B growth factor independent 1B transcription repressor 2.84473
ZSCAN4 zinc finger and SCAN domain containing 4 2.84473
BTNL3 butyrophilin-like 3 2.84473
CXCR4 chemokine (C-X-C motif) receptor 4 2.84473
DEFB107B defensin, beta 107B 2.84473
DMTN dematin actin binding protein 2.84473
CD80 CD80 molecule 2.84473
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.84473
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.84473
WFDC10A WAP four-disulfide core domain 10A 2.84473
RNF222 ring finger protein 222 2.84473
AQP10 aquaporin 10 2.84473
GH1 growth hormone 1 2.84473
VTCN1 V-set domain containing T cell activation inhibitor 1 2.84473
SP100 SP100 nuclear antigen 2.84473
TPSB2 tryptase beta 2 (gene/pseudogene) 2.84473
C11ORF16 chromosome 11 open reading frame 16 2.84473
SPINK9 serine peptidase inhibitor, Kazal type 9 2.84473
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.84473
CD28 CD28 molecule 2.84473
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.84473
ERVV-1 endogenous retrovirus group V, member 1 2.84473
RIN1 Ras and Rab interactor 1 2.84473
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.84473
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.84473
EVI2A ecotropic viral integration site 2A 2.84473
GOLGA8K golgin A8 family, member K 2.84473
RBM20 RNA binding motif protein 20 2.84473
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.84473
NPBWR1 neuropeptides B/W receptor 1 2.84473
CLEC4D C-type lectin domain family 4, member D 2.84473
OCM oncomodulin 2.84473
LMOD3 leiomodin 3 (fetal) 2.84473
VWA7 von Willebrand factor A domain containing 7 2.84473
COL17A1 collagen, type XVII, alpha 1 2.84473
KLK11 kallikrein-related peptidase 11 2.84473
SIRPG signal-regulatory protein gamma 2.84473
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.84473
PHACTR3 phosphatase and actin regulator 3 2.84473
TUBAL3 tubulin, alpha-like 3 2.84473
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.84473
KCNK18 potassium channel, two pore domain subfamily K, member 18 2.84473
GGN gametogenetin 2.84473
AOC1 amine oxidase, copper containing 1 2.84473
C5ORF46 chromosome 5 open reading frame 46 2.84473
ICAM2 intercellular adhesion molecule 2 2.84473
GHRH growth hormone releasing hormone 2.84473
VPREB3 pre-B lymphocyte 3 2.84473
MNX1 motor neuron and pancreas homeobox 1 2.84473
PITX2 paired-like homeodomain 2 2.84473
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.84473
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.84473
SCIN scinderin 2.84473
CD180 CD180 molecule 2.84473
PCDHGA12 protocadherin gamma subfamily A, 12 2.84473
FGF7 fibroblast growth factor 7 2.84473
FGF6 fibroblast growth factor 6 2.84473
IFITM10 interferon induced transmembrane protein 10 2.84473
PGM5 phosphoglucomutase 5 2.84473
CCNO cyclin O 2.84473
LHB luteinizing hormone beta polypeptide 2.84473
ZPLD1 zona pellucida-like domain containing 1 2.84473
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.84473
TGM6 transglutaminase 6 2.84473
SSX3 synovial sarcoma, X breakpoint 3 2.84473
SLC51B solute carrier family 51, beta subunit 2.84473
SNTN sentan, cilia apical structure protein 2.84473
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.83481
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.83394
BLNK B-cell linker 2.79411
CHMP3 charged multivesicular body protein 3 2.76628
DYNC2I2 dynein 2 intermediate chain 2 2.76536
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.7482
MRPS33 mitochondrial ribosomal protein S33 2.74622
ZMAT4 zinc finger, matrin-type 4 2.67777
C2ORF15 chromosome 2 open reading frame 15 2.57663
FLAD1 flavin adenine dinucleotide synthetase 1 2.55906
RAB2B RAB2B, member RAS oncogene family 2.55747
FADS2 fatty acid desaturase 2 2.55747
FBXO42 F-box protein 42 2.55495
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.5273
ACLY ATP citrate lyase 2.5173
AVP arginine vasopressin 2.5173
FAM43B family with sequence similarity 43, member B 2.5173
FRK fyn-related Src family tyrosine kinase 2.5173
MRPL17 mitochondrial ribosomal protein L17 2.46141
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.46103
CCDC134 coiled-coil domain containing 134 2.45442
CCDC85B coiled-coil domain containing 85B 2.45442
ZNF573 zinc finger protein 573 2.38101
ASPN asporin 2.3684
CD7 CD7 molecule 2.3303
DOT1L DOT1-like histone H3K79 methyltransferase 2.30784
OAZ1 ornithine decarboxylase antizyme 1 2.28715
STX1B syntaxin 1B 2.2522
MCPH1 microcephalin 1 2.24463
TMEM54 transmembrane protein 54 2.24079
WDR83OS WD repeat domain 83 opposite strand 2.24079
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.21716
BDH2 3-hydroxybutyrate dehydrogenase, type 2 2.2155
INTS4 integrator complex subunit 4 2.21536
MAGED1 melanoma antigen family D1 2.21536
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.21356
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.20128
COPG2 coatomer protein complex, subunit gamma 2 2.19816
GARS1 glycyl-tRNA synthetase 1 2.18983
PARP6 poly (ADP-ribose) polymerase family, member 6 2.18761
GUK1 guanylate kinase 1 2.15917
VCL vinculin 2.13687
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 2.13687
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 2.13687
SHISA6 shisa family member 6 2.12936
GK5 glycerol kinase 5 (putative) 2.10391
RALGDS ral guanine nucleotide dissociation stimulator 2.10391
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.10166
UGP2 UDP-glucose pyrophosphorylase 2 2.07931
BEAN1 brain expressed, associated with NEDD4, 1 2.05192
INSC inscuteable homolog (Drosophila) 2.02879
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 2.02879
RPS26 ribosomal protein S26 2.02829
CSNK1G2 casein kinase 1, gamma 2 2.02678
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.01845

decreased expression

Symbol Name Standardized Value
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.84473
ALPL alkaline phosphatase, liver/bone/kidney -2.84473
KIRREL2 kin of IRRE like 2 (Drosophila) -2.84473
NBPF10 neuroblastoma breakpoint family, member 10 -2.84473
ZNF691 zinc finger protein 691 -2.84473
C19ORF38 chromosome 19 open reading frame 38 -2.84473
CNBD2 cyclic nucleotide binding domain containing 2 -2.84473
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.84473
RUNDC3A RUN domain containing 3A -2.84473
TAS1R1 taste receptor, type 1, member 1 -2.83481
C17ORF107 chromosome 17 open reading frame 107 -2.83481
IL17REL interleukin 17 receptor E-like -2.83481
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.83481
CLDN23 claudin 23 -2.83481
TMIGD3 transmembrane and immunoglobulin domain containing 3 -2.83481
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -2.83481
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.83481
IZUMO1 izumo sperm-egg fusion 1 -2.83481
NELL1 NEL-like 1 (chicken) -2.83481
GPR78 G protein-coupled receptor 78 -2.83481
LOC105378220 macrophage receptor MARCO-like -2.83481
IRF4 interferon regulatory factor 4 -2.83481
KIF12 kinesin family member 12 -2.83481
TSNAXIP1 translin-associated factor X interacting protein 1 -2.83481
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.83481
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.83481
FNDC1 fibronectin type III domain containing 1 -2.83481
COL20A1 collagen, type XX, alpha 1 -2.83481
MAP7D3 MAP7 domain containing 3 -2.83481
DNAI2 dynein, axonemal, intermediate chain 2 -2.83481
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.83481
NDRG1 N-myc downstream regulated 1 -2.83481
CIMAP1D CIMAP1 family member D -2.83481
TAS2R31 taste receptor, type 2, member 31 -2.83481
SRL sarcalumenin -2.83481
GOLGA6C golgin A6 family, member C -2.83481
CDC20B cell division cycle 20B -2.83481
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -2.83481
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.83097
ACP6 acid phosphatase 6, lysophosphatidic -2.7573
CCDC142 coiled-coil domain containing 142 -2.74622
CRIP3 cysteine-rich protein 3 -2.72517
RBP5 retinol binding protein 5, cellular -2.70582
MAGEE1 melanoma antigen family E1 -2.66767
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.65446
COA3 cytochrome c oxidase assembly factor 3 -2.65349
TMEM229B transmembrane protein 229B -2.62572
C1ORF35 chromosome 1 open reading frame 35 -2.52507
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.5173
RRH retinal pigment epithelium-derived rhodopsin homolog -2.5173
PTAFR platelet-activating factor receptor -2.5173
CHD5 chromodomain helicase DNA binding protein 5 -2.5173
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -2.50561
MYRFL myelin regulatory factor-like -2.45442
TMEM132A transmembrane protein 132A -2.43107
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.35609
PLPP6 phospholipid phosphatase 6 -2.34221
C8ORF88 chromosome 8 open reading frame 88 -2.32582
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.31499
SMC5 structural maintenance of chromosomes 5 -2.3141
MRPS18A mitochondrial ribosomal protein S18A -2.3055
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.305
STRAP serine/threonine kinase receptor associated protein -2.29836
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.26388
CAPN15 calpain 15 -2.26388
SLCO6A1 solute carrier organic anion transporter family, member 6A1 -2.24882
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.22399
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.21879
INAFM1 InaF-motif containing 1 -2.21879
KIF2A kinesin heavy chain member 2A -2.21536
RIPK4 receptor-interacting serine-threonine kinase 4 -2.21536
CFAP73 cilia and flagella associated protein 73 -2.21466
PCDH19 protocadherin 19 -2.21466
FKRP fukutin related protein -2.21356
CDK5 cyclin-dependent kinase 5 -2.18067
KCTD2 potassium channel tetramerization domain containing 2 -2.17468
C1D C1D nuclear receptor corepressor -2.17468
WWTR1 WW domain containing transcription regulator 1 -2.16701
PLAC8L1 PLAC8-like 1 -2.14769
CLCNKA chloride channel, voltage-sensitive Ka -2.14078
CCNP cyclin P -2.14078
SSR4 signal sequence receptor, delta -2.14078
PGD phosphogluconate dehydrogenase -2.13687
TACC1 transforming, acidic coiled-coil containing protein 1 -2.13687
PPAT phosphoribosyl pyrophosphate amidotransferase -2.11908
TAFA5 TAFA chemokine like family member 5 -2.0985
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -2.0892
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -2.08652
C17ORF75 chromosome 17 open reading frame 75 -2.07931
ZMYND19 zinc finger, MYND-type containing 19 -2.05843
MANBAL mannosidase, beta A, lysosomal-like -2.05843
SOX10 SRY (sex determining region Y)-box 10 -2.05355
STOML1 stomatin (EPB72)-like 1 -2.05355
NXT2 nuclear transport factor 2-like export factor 2 -2.04692
PAWR PRKC, apoptosis, WT1, regulator -2.04261
C2ORF76 chromosome 2 open reading frame 76 -2.04261
KRI1 KRI1 homolog (S. cerevisiae) -2.0393
LIMCH1 LIM and calponin homology domains 1 -2.02678
B3GAT2 beta-1,3-glucuronyltransferase 2 -2.01955
SH3PXD2A SH3 and PX domains 2A -2.01733
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.00167
ZNF730 zinc finger protein 730 -2.0004