EIF4EBP1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description eukaryotic translation initiation factor 4E binding protein 1|This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1978)
External Link http://www.ncbi.nlm.nih.gov/gene/1978
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95 interacting proteins for EIF4EBP1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATM ATM serine/threonine kinase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCSER2 coiled-coil serine-rich protein 2
CDK1 cyclin-dependent kinase 1
CENPJ centromere protein J
CEP170B centrosomal protein 170B
CEP192 centrosomal protein 192kDa
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
CNTROB centrobin, centrosomal BRCA2 interacting protein
CSNK1E casein kinase 1, epsilon
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EEF1A1P5 eukaryotic translation elongation factor 1 alpha 1 pseudogene 5
EID1 EP300 interacting inhibitor of differentiation 1
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF4E eukaryotic translation initiation factor 4E
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
FGFR1OP2 FGFR1 oncogene partner 2
FRYL FRY-like
FUS FUS RNA binding protein
GEMIN5 gem (nuclear organelle) associated protein 5
GFOD1 glucose-fructose oxidoreductase domain containing 1
GSK3B glycogen synthase kinase 3 beta
HDAC6 histone deacetylase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPA8 heat shock 70kDa protein 8
IRAK4 interleukin-1 receptor-associated kinase 4
KIAA1522 KIAA1522
KLHL25 kelch-like family member 25
LATS1 large tumor suppressor kinase 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRK2 leucine-rich repeat kinase 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MOB4 MOB family member 4, phocein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVD mevalonate (diphospho) decarboxylase
NCBP2 nuclear cap binding protein subunit 2, 20kDa
OFD1 oral-facial-digital syndrome 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PARN poly(A)-specific ribonuclease
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic)
RHEB Ras homolog enriched in brain
RHEBL1 Ras homolog enriched in brain like 1
RICTOR RPTOR independent companion of MTOR, complex 2
RNMT RNA (guanine-7-) methyltransferase
RORC RAR-related orphan receptor C
RPS11 ribosomal protein S11
RPS2 ribosomal protein S2
RPS6 ribosomal protein S6
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
SACK1B scaffolding CK1 anchoring protein B
SIKE1 suppressor of IKBKE 1
SLMAP sarcolemma associated protein
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
STRIP1 striatin interacting protein 1
STRN striatin, calmodulin binding protein
STRN3 striatin, calmodulin binding protein 3
STRN4 striatin, calmodulin binding protein 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
UBAC1 UBA domain containing 1
UBC ubiquitin C