ELK4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ELK4, ETS-domain protein (SRF accessory protein 1)|This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2005)
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Genes

326 genes differentially expressed following the ELK4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KLF5 Kruppel-like factor 5 (intestinal) 3.42808
CAPN11 calpain 11 3.42808
ZC3H12D zinc finger CCCH-type containing 12D 3.42808
AVPR1B arginine vasopressin receptor 1B 3.42808
SOST sclerostin 3.42808
KRTAP13-4 keratin associated protein 13-4 3.42808
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.42808
FAM163A family with sequence similarity 163, member A 3.42808
SPMIP9 sperm microtubule inner protein 9 3.42808
LCNL1 lipocalin-like 1 3.42808
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 3.42808
TMPRSS15 transmembrane protease, serine 15 3.42808
SLC9C2 solute carrier family 9, member C2 (putative) 3.42808
CFHR3 complement factor H-related 3 3.42808
RNF133 ring finger protein 133 3.42808
TBPL2 TATA box binding protein like 2 3.42808
FZD1 frizzled class receptor 1 3.42808
DNAAF8 dynein axonemal assembly factor 8 3.42808
SMIM22 small integral membrane protein 22 3.42808
TBC1D28 TBC1 domain family, member 28 3.42808
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.42808
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.42702
NANOS2 nanos homolog 2 (Drosophila) 3.42702
PRICKLE4 prickle homolog 4 (Drosophila) 3.42702
HEATR9 HEAT repeat containing 9 3.42702
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.42702
GNLY granulysin 3.42702
SLC46A3 solute carrier family 46, member 3 3.42702
COL20A1 collagen, type XX, alpha 1 3.42702
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.42702
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 3.42702
SCGN secretagogin, EF-hand calcium binding protein 3.42702
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.42702
IYD iodotyrosine deiodinase 3.42702
CEMP1 cementum protein 1 3.42702
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 3.42702
ADAD2 adenosine deaminase domain containing 2 3.42702
ANKRD34C ankyrin repeat domain 34C 3.42702
CXCL2 chemokine (C-X-C motif) ligand 2 3.42702
POSTN periostin, osteoblast specific factor 3.42702
CD68 CD68 molecule 3.42702
LACTBL1 lactamase, beta-like 1 3.42702
SOWAHB sosondowah ankyrin repeat domain family member B 3.42702
GMNC geminin coiled-coil domain containing 3.42702
S100A5 S100 calcium binding protein A5 3.42702
MEI1 meiosis inhibitor 1 3.42702
APOA2 apolipoprotein A-II 3.42702
PAX4 paired box 4 3.42702
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.42702
ZNF662 zinc finger protein 662 3.42702
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.42702
HES3 hes family bHLH transcription factor 3 3.42702
NCF1 neutrophil cytosolic factor 1 3.42702
PNMA5 paraneoplastic Ma antigen family member 5 3.42702
KRT20 keratin 20, type I 3.42702
CASP1 caspase 1, apoptosis-related cysteine peptidase 3.42702
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 3.42702
GNRH2 gonadotropin-releasing hormone 2 3.42702
FAM240A family with sequence similarity 240 member A 3.42702
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.42702
RAG2 recombination activating gene 2 3.42702
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.42702
VN1R1 vomeronasal 1 receptor 1 3.42702
STMN4 stathmin-like 4 3.42702
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.42702
CD79A CD79a molecule, immunoglobulin-associated alpha 3.42702
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 3.42702
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.42702
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.42702
SQOR sulfide quinone oxidoreductase 3.42702
CFAP97D2 CFAP97 domain containing 2 3.42702
CTXND1 cortexin domain containing 1 3.42702
H4C14 H4 clustered histone 14 3.42702
H3-7 H3.7 histone (putative) 3.42702
IHO1 interactor of HORMAD1 1 3.42702
TEX55 testis expressed 55 3.42702
CFAP97D1 CFAP97 domain containing 1 3.42702
ANKRD40CL ANKRD40 C-terminal like 3.42702
TMPRSS3 transmembrane protease, serine 3 3.42702
ACSL5 acyl-CoA synthetase long-chain family member 5 3.42702
RAB36 RAB36, member RAS oncogene family 3.42702
NHLRC4 NHL repeat containing 4 3.42702
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.42702
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.42702
PCDHA7 protocadherin alpha 7 3.42702
ACTL10 actin-like 10 3.42702
NPFF neuropeptide FF-amide peptide precursor 3.42702
ATP13A4 ATPase type 13A4 3.42702
LOC390937 Ets2 repressor factor-like 3.42702
MYH13 myosin, heavy chain 13, skeletal muscle 3.42702
TBX3 T-box 3 3.42702
PRR4 proline rich 4 (lacrimal) 3.42702
IMPG1 interphotoreceptor matrix proteoglycan 1 3.42702
DYNLRB2 dynein, light chain, roadblock-type 2 3.42702
GATA3 GATA binding protein 3 3.42702
IL16 interleukin 16 3.42702
WNT9B wingless-type MMTV integration site family, member 9B 3.42702
MYOCD myocardin 3.42702
VCX3A variable charge, X-linked 3A 3.42702
GJD3 gap junction protein, delta 3, 31.9kDa 3.42702
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 3.42702
PKDREJ polycystin (PKD) family receptor for egg jelly 3.42702
TMPPE transmembrane protein with metallophosphoesterase domain 3.42702
PRSS54 protease, serine, 54 3.42702
TECRL trans-2,3-enoyl-CoA reductase-like 3.42702
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.42702
CSF1R colony stimulating factor 1 receptor 3.42702
GH2 growth hormone 2 3.42702
RNF224 ring finger protein 224 3.42702
LRRC74B leucine rich repeat containing 74B 3.42702
CLCA1 chloride channel accessory 1 3.42702
APOL6 apolipoprotein L, 6 3.42702
LAMP5 lysosomal-associated membrane protein family, member 5 3.42702
LAMP3 lysosomal-associated membrane protein 3 3.42702
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.42702
CD28 CD28 molecule 3.42702
ERMN ermin, ERM-like protein 3.42702
CALR3 calreticulin 3 3.42702
CCDC185 coiled-coil domain containing 185 3.42702
VNN1 vanin 1 3.42702
HHLA2 HERV-H LTR-associating 2 3.42702
ZNF541 zinc finger protein 541 3.42702
BCO1 beta-carotene oxygenase 1 3.42702
NOG noggin 3.42702
RRH retinal pigment epithelium-derived rhodopsin homolog 3.42702
RBMXL3 RNA binding motif protein, X-linked-like 3 3.42702
RSAD2 radical S-adenosyl methionine domain containing 2 3.42702
DSC1 desmocollin 1 3.42702
FNDC9 fibronectin type III domain containing 9 3.42702
LRRK2 leucine-rich repeat kinase 2 3.42702
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.42702
IL27 interleukin 27 3.42702
MYOZ2 myozenin 2 3.42702
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.42702
NMUR2 neuromedin U receptor 2 3.42702
STEAP4 STEAP family member 4 3.42702
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.42702
NEUROD1 neuronal differentiation 1 3.42702
ZC2HC1B zinc finger, C2HC-type containing 1B 3.42702
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.42702
FGF9 fibroblast growth factor 9 3.42702
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.42702
ICAM2 intercellular adhesion molecule 2 3.42702
PHOX2A paired-like homeobox 2a 3.42702
KRT15 keratin 15, type I 3.42702
TAS2R10 taste receptor, type 2, member 10 3.42702
IL25 interleukin 25 3.42702
IKZF3 IKAROS family zinc finger 3 (Aiolos) 3.42702
FKBP1C FK506 binding protein 1C 3.42702
FGF23 fibroblast growth factor 23 3.37612
SOX30 SRY (sex determining region Y)-box 30 3.37612
MYOZ1 myozenin 1 3.37612
GLRB glycine receptor, beta 3.26406
H1-3 H1.3 linker histone, cluster member 3.241
SHROOM1 shroom family member 1 3.19402
GLIS1 GLIS family zinc finger 1 3.12071
EDAR ectodysplasin A receptor 3.12071
EPN1 epsin 1 3.11673
SUMO2 small ubiquitin-like modifier 2 3.09295
VCL vinculin 3.06212
XYLT2 xylosyltransferase II 2.98067
H1-4 H1.4 linker histone, cluster member 2.97995
KLK7 kallikrein-related peptidase 7 2.96447
RPA1 replication protein A1, 70kDa 2.95878
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 2.93836
RAB28 RAB28, member RAS oncogene family 2.70759
CALM1 calmodulin 1 (phosphorylase kinase, delta) 2.65501
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.64275
NUP107 nucleoporin 107kDa 2.61061
TRAPPC14 trafficking protein particle complex subunit 14 2.59034
CFAP298 cilia and flagella associated protein 298 2.58008
KATNAL1 katanin p60 subunit A-like 1 2.5799
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 2.57676
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.53992
MARCHF10 membrane associated ring-CH-type finger 10 2.52242
CCDC170 coiled-coil domain containing 170 2.52242
DCST2 DC-STAMP domain containing 2 2.52242
RBM44 RNA binding motif protein 44 2.52242
MUCL3 mucin like 3 2.48941
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.42145
CDH10 cadherin 10, type 2 (T2-cadherin) 2.41038
CNGB3 cyclic nucleotide gated channel beta 3 2.41038
EBF4 early B-cell factor 4 2.41038
MRPL21 mitochondrial ribosomal protein L21 2.41038
FGF2 fibroblast growth factor 2 (basic) 2.38024
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 2.37787
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.37597
SLC35E3 solute carrier family 35, member E3 2.37132
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.3707
NPIPB15 nuclear pore complex interacting protein family, member B15 2.36866
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2.28647
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.28506
RNF43 ring finger protein 43 2.27127
INPP5F inositol polyphosphate-5-phosphatase F 2.20782
REST RE1-silencing transcription factor 2.20782
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 2.20782
KIDINS220 kinase D-interacting substrate, 220kDa 2.19511
BUB3 BUB3 mitotic checkpoint protein 2.17949
CCND1 cyclin D1 2.17949
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 2.17949
SRP54 signal recognition particle 54kDa 2.16936
PCDHA13 protocadherin alpha 13 2.1538
ZNF576 zinc finger protein 576 2.15181
PSEN2 presenilin 2 2.14553
BRMS1L breast cancer metastasis-suppressor 1-like 2.1405
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.13994
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.12952
CCT2 chaperonin containing TCP1, subunit 2 (beta) 2.12157
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.11885
POM121L2 POM121 transmembrane nucleoporin-like 2 2.11861
CUL7 cullin 7 2.11861
INAFM2 InaF-motif containing 2 2.11861
RGS20 regulator of G-protein signaling 20 2.11861
FANCD2 Fanconi anemia, complementation group D2 2.11861
TPK1 thiamin pyrophosphokinase 1 2.11861
FBXO16 F-box protein 16 2.11861
SIRAL2 SIR2 antiphage like 2 2.10137
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.07595
NUP37 nucleoporin 37kDa 2.07368
EED embryonic ectoderm development 2.06476
ZNF701 zinc finger protein 701 2.05042
ZNF844 zinc finger protein 844 2.0468

decreased expression

Symbol Name Standardized Value
CHL1 cell adhesion molecule L1-like -3.42702
TEP1 telomerase-associated protein 1 -3.42702
NPNT nephronectin -3.42702
MMP23B matrix metallopeptidase 23B -3.31417
RTN4RL1 reticulon 4 receptor-like 1 -3.241
COL8A1 collagen, type VIII, alpha 1 -3.241
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -3.241
SP100 SP100 nuclear antigen -3.241
LPAR5 lysophosphatidic acid receptor 5 -3.241
TBX15 T-box 15 -3.241
ZEB2 zinc finger E-box binding homeobox 2 -3.241
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -3.241
GDNF glial cell derived neurotrophic factor -3.241
BHLHE40 basic helix-loop-helix family, member e40 -3.241
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -3.241
LYNX1 Ly6/neurotoxin 1 -3.241
THRSP thyroid hormone responsive -3.241
GPR20 G protein-coupled receptor 20 -3.241
FAM221B family with sequence similarity 221, member B -3.241
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -3.241
NFE2 nuclear factor, erythroid 2 -3.241
IL12A interleukin 12A -3.241
BTC betacellulin -3.241
GC group-specific component (vitamin D binding protein) -3.241
FGR FGR proto-oncogene, Src family tyrosine kinase -3.241
RANBP3L RAN binding protein 3-like -3.241
CYS1 cystin 1 -3.241
CFAP61 cilia and flagella associated protein 61 -3.241
KLHDC8A kelch domain containing 8A -3.241
BGN biglycan -3.241
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.241
PNMA8C PNMA family member 8C -3.241
UPK1B uroplakin 1B -3.241
HCRT hypocretin (orexin) neuropeptide precursor -3.241
HRH4 histamine receptor H4 -3.241
AGTR1 angiotensin II receptor, type 1 -3.241
ZFP92 ZFP92 zinc finger protein -3.241
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -3.12071
OR3A2 olfactory receptor, family 3, subfamily A, member 2 -3.10731
PLA2G10 phospholipase A2, group X -3.10731
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -3.10731
C19ORF25 chromosome 19 open reading frame 25 -3.09502
RBP2 retinol binding protein 2, cellular -3.02054
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 -3.01296
IFNGR1 interferon gamma receptor 1 -2.90195
ARHGAP5 Rho GTPase activating protein 5 -2.90121
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like -2.83716
CEP97 centrosomal protein 97kDa -2.76478
HMX2 H6 family homeobox 2 -2.65501
ERI2 ERI1 exoribonuclease family member 2 -2.65247
C21ORF58 chromosome 21 open reading frame 58 -2.63665
ZNF622 zinc finger protein 622 -2.62875
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.59692
HAPLN1 hyaluronan and proteoglycan link protein 1 -2.59318
STRIP1 striatin interacting protein 1 -2.54525
ULK1 unc-51 like autophagy activating kinase 1 -2.45331
DNAH14 dynein, axonemal, heavy chain 14 -2.42723
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.41038
C20ORF203 chromosome 20 open reading frame 203 -2.41038
SPICP3 Spi-C transcription factor pseudogene 3 -2.41038
MAP6D1 MAP6 domain containing 1 -2.41038
ALOX12 arachidonate 12-lipoxygenase -2.37773
CRACR2B calcium release activated channel regulator 2B -2.36004
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.31988
GPRIN2 G protein regulated inducer of neurite outgrowth 2 -2.26457
SART1 squamous cell carcinoma antigen recognized by T cells -2.26107
CNTRL centriolin -2.23586
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.21127
PDGFRB platelet-derived growth factor receptor, beta polypeptide -2.20782
TTI1 TELO2 interacting protein 1 -2.20685
EIF3B eukaryotic translation initiation factor 3, subunit B -2.1947
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.18706
PVALB parvalbumin -2.18475
FSCN1 fascin actin-bundling protein 1 -2.17593
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -2.16381
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.1405
NEURL2 neuralized E3 ubiquitin protein ligase 2 -2.1405
FRMD4B FERM domain containing 4B -2.12952
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -2.12952
EFCAB8 EF-hand calcium binding domain 8 -2.12952
CCDC196 coiled-coil domain containing 196 -2.12952
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) -2.12935
PORCN porcupine homolog (Drosophila) -2.1292
FBLN5 fibulin 5 -2.12581
CPNE8 copine VIII -2.12581
ZNF687 zinc finger protein 687 -2.12416
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -2.11861
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -2.07779
STK33 serine/threonine kinase 33 -2.07764
PLAC1 placenta-specific 1 -2.07595
CRLF2 cytokine receptor-like factor 2 -2.07595
CD79B CD79b molecule, immunoglobulin-associated beta -2.07595
FAM199X family with sequence similarity 199, X-linked -2.06813
ATP13A2 ATPase type 13A2 -2.06813
COQ3 coenzyme Q3 methyltransferase -2.06756
FAM222B family with sequence similarity 222, member B -2.06476
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -2.06476
SYN3 synapsin III -2.05605
HES1 hes family bHLH transcription factor 1 -2.04469
C19ORF85 chromosome 19 open reading frame 85 -2.04225
RAB14 RAB14, member RAS oncogene family -2.02936
CYCS cytochrome c, somatic -2.01852
GPATCH8 G patch domain containing 8 -2.0157
CREB1 cAMP responsive element binding protein 1 -2.00425