EMD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description emerin|Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2010)
Similar Terms
Downloads & Tools

Genes

337 genes differentially expressed following the EMD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TEX29 testis expressed 29 2.80585
CFAP74 cilia and flagella associated protein 74 2.80585
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.80585
PAGE4 P antigen family, member 4 (prostate associated) 2.80585
SYTL4 synaptotagmin-like 4 2.80585
NELL1 NEL-like 1 (chicken) 2.80585
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.80585
TEKT1 tektin 1 2.80585
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.80585
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.80585
OXER1 oxoeicosanoid (OXE) receptor 1 2.80585
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.80585
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.80585
FYB2 FYN binding protein 2 2.80585
C1ORF146 chromosome 1 open reading frame 146 2.80585
CFAP99 cilia and flagella associated protein 99 2.80585
PXT1 peroxisomal, testis specific 1 2.80585
PLAAT2 phospholipase A and acyltransferase 2 2.80585
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.80585
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.80585
DAW1 dynein assembly factor with WDR repeat domains 1 2.80585
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.80585
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.79507
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.79507
SPINK6 serine peptidase inhibitor, Kazal type 6 2.79507
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.79507
SBK3 SH3 domain binding kinase family, member 3 2.79507
TALDO1 transaldolase 1 2.79507
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.79507
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.79507
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.79507
LAPTM5 lysosomal protein transmembrane 5 2.79507
TMEM212 transmembrane protein 212 2.79507
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.79507
CST11 cystatin 11 2.79507
PDYN prodynorphin 2.79507
ZNF467 zinc finger protein 467 2.79507
SLC9C2 solute carrier family 9, member C2 (putative) 2.79507
GFI1 growth factor independent 1 transcription repressor 2.79507
ANKRD34C ankyrin repeat domain 34C 2.79507
STRA8 stimulated by retinoic acid 8 2.79507
BIRC7 baculoviral IAP repeat containing 7 2.79507
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.79507
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.79507
RGPD3 RANBP2-like and GRIP domain containing 3 2.79507
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 2.79507
TLX3 T-cell leukemia homeobox 3 2.79507
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.79507
TM4SF1 transmembrane 4 L six family member 1 2.79507
DSG3 desmoglein 3 2.79507
SOX14 SRY (sex determining region Y)-box 14 2.79507
SOX18 SRY (sex determining region Y)-box 18 2.79507
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.79507
GLYAT glycine-N-acyltransferase 2.79507
FOXR1 forkhead box R1 2.79507
RSPO1 R-spondin 1 2.79507
DLX4 distal-less homeobox 4 2.79507
SYCP1 synaptonemal complex protein 1 2.79507
CIMIP2A ciliary microtubule inner protein 2A 2.79507
ALDOB aldolase B, fructose-bisphosphate 2.79507
PLG plasminogen 2.79507
LTB4R2 leukotriene B4 receptor 2 2.79507
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.79507
ELOVL3 ELOVL fatty acid elongase 3 2.79507
STX11 syntaxin 11 2.79507
FOXN4 forkhead box N4 2.79507
ADRB1 adrenoceptor beta 1 2.79507
CES4A carboxylesterase 4A 2.79507
DEFB108B defensin, beta 108B 2.79507
STYXL2 serine/threonine/tyrosine interacting like 2 2.79507
LOC124903372 uncharacterized LOC124903372 2.79507
TMEM238L transmembrane protein 238 like 2.79507
H3C14 H3 clustered histone 14 2.79507
GARIN1A golgi associated RAB2 interactor 1A 2.79507
ELOA2 elongin A2 2.79507
PLPP4 phospholipid phosphatase 4 2.79507
PIERCE1 piercer of microtubule wall 1 2.79507
SMIM41 small integral membrane protein 41 2.79507
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.79507
FOXC2 forkhead box C2 2.79507
KHDC1L KH homology domain containing 1-like 2.79507
ACP5 acid phosphatase 5, tartrate resistant 2.79507
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.79507
MAL mal, T-cell differentiation protein 2.79507
TACR2 tachykinin receptor 2 2.79507
C1ORF87 chromosome 1 open reading frame 87 2.79507
RAB44 RAB44, member RAS oncogene family 2.79507
IL12RB1 interleukin 12 receptor, beta 1 2.79507
ZNF436 zinc finger protein 436 2.79507
SCRT1 scratch family zinc finger 1 2.79507
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.79507
MIP major intrinsic protein of lens fiber 2.79507
SOAT2 sterol O-acyltransferase 2 2.79507
ACE2 angiotensin I converting enzyme 2 2.79507
GDF6 growth differentiation factor 6 2.79507
GPR84 G protein-coupled receptor 84 2.79507
BLNK B-cell linker 2.79507
GJD2 gap junction protein, delta 2, 36kDa 2.79507
C6ORF118 chromosome 6 open reading frame 118 2.79507
TBX3 T-box 3 2.79507
NKX3-1 NK3 homeobox 1 2.79507
TMEM86A transmembrane protein 86A 2.79507
SEMG1 semenogelin I 2.79507
ARHGAP20 Rho GTPase activating protein 20 2.79507
IGFBP5 insulin-like growth factor binding protein 5 2.79507
HBE1 hemoglobin, epsilon 1 2.79507
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.79507
C11ORF97 chromosome 11 open reading frame 97 2.79507
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.79507
TIGD3 tigger transposable element derived 3 2.79507
IL21R interleukin 21 receptor 2.79507
VAX2 ventral anterior homeobox 2 2.79507
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.79507
CLEC7A C-type lectin domain family 7, member A 2.79507
AQP1 aquaporin 1 (Colton blood group) 2.79507
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.79507
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.79507
NUTM2F NUT family member 2F 2.79507
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.79507
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.79507
AGR2 anterior gradient 2 2.79507
PRND prion protein 2 (dublet) 2.79507
RORC RAR-related orphan receptor C 2.79507
JSRP1 junctional sarcoplasmic reticulum protein 1 2.79507
PBK PDZ binding kinase 2.79507
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 2.79507
SYNGR4 synaptogyrin 4 2.79507
BCL2L15 BCL2-like 15 2.79507
MYLK2 myosin light chain kinase 2 2.79507
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.79507
C1ORF105 chromosome 1 open reading frame 105 2.79507
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.79507
ESPNL espin-like 2.79507
OTP orthopedia homeobox 2.79507
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.79507
CHIT1 chitinase 1 (chitotriosidase) 2.79507
CFAP47 cilia and flagella associated protein 47 2.79507
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.79507
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.79507
WFDC9 WAP four-disulfide core domain 9 2.79507
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.79507
MAB21L1 mab-21-like 1 (C. elegans) 2.79507
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.79507
RAB40AL RAB40A, member RAS oncogene family-like 2.79507
MRPL11 mitochondrial ribosomal protein L11 2.79507
TEX12 testis expressed 12 2.79507
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.79507
SNTN sentan, cilia apical structure protein 2.79507
ASCL5 achaete-scute family bHLH transcription factor 5 2.79507
PITX1 paired-like homeodomain 1 2.79507
AMIGO3 adhesion molecule with Ig-like domain 3 2.79507
VTA1 vesicle (multivesicular body) trafficking 1 2.79507
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 2.79507
PSG8 pregnancy specific beta-1-glycoprotein 8 2.79507
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.79507
TPRX1 tetra-peptide repeat homeobox 1 2.79507
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.79507
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.79507
NWD1 NACHT and WD repeat domain containing 1 2.79507
NMUR2 neuromedin U receptor 2 2.79507
LBX2 ladybird homeobox 2 2.79507
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.79507
C17ORF78 chromosome 17 open reading frame 78 2.79507
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.79507
POPDC2 popeye domain containing 2 2.79507
TICAM1 toll-like receptor adaptor molecule 1 2.79507
TGM2 transglutaminase 2 2.79507
BIN2 bridging integrator 2 2.79507
GRAPL GRB2-related adaptor protein-like 2.79507
UNC93A unc-93 homolog A (C. elegans) 2.71497
VIRMA vir like m6A methyltransferase associated 2.65889
INTS3 integrator complex subunit 3 2.51559
H3C12 H3 clustered histone 12 2.5146
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.51446
ADAM29 ADAM metallopeptidase domain 29 2.51446
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.50109
FBLN7 fibulin 7 2.50109
SRF serum response factor (c-fos serum response element-binding transcription factor) 2.46441
RAB12 RAB12, member RAS oncogene family 2.46181
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 2.43426
CAND1 cullin-associated and neddylation-dissociated 1 2.42379
PLD5 phospholipase D family, member 5 2.41189
TERF2IP telomeric repeat binding factor 2, interacting protein 2.38768
OSER1 oxidative stress responsive serine-rich 1 2.33592
RNLS renalase, FAD-dependent amine oxidase 2.33467
HDGF hepatoma-derived growth factor 2.32467
PDIA6 protein disulfide isomerase family A, member 6 2.32065
RWDD1 RWD domain containing 1 2.32065
COL24A1 collagen, type XXIV, alpha 1 2.31611
SLC25A30 solute carrier family 25, member 30 2.30421
MYBPC2 myosin binding protein C, fast type 2.29321
TKFC triokinase/FMN cyclase 2.26892
HEXB hexosaminidase B (beta polypeptide) 2.26398
BTBD10 BTB (POZ) domain containing 10 2.26376
TMEM184A transmembrane protein 184A 2.25113
TEAD3 TEA domain family member 3 2.25113
EIF4H eukaryotic translation initiation factor 4H 2.25113
FKBP2 FK506 binding protein 2, 13kDa 2.25113
TMEM35B transmembrane protein 35B 2.25113
DENND6A DENN/MADD domain containing 6A 2.25113
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 2.21514
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.212
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.17662
EPHB4 EPH receptor B4 2.17403
KHK ketohexokinase (fructokinase) 2.16145
NOTCH2NLC notch 2 N-terminal like C 2.1488
ANGPT2 angiopoietin 2 2.13718
MEGF10 multiple EGF-like-domains 10 2.13718
PTMA prothymosin, alpha 2.1304
NGFR nerve growth factor receptor 2.11319
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.10132
DRC2 dynein regulatory complex subunit 2 2.0978
CPN1 carboxypeptidase N, polypeptide 1 2.09453
EXT2 exostosin glycosyltransferase 2 2.0906
OXTR oxytocin receptor 2.06876
JMJD1C jumonji domain containing 1C 2.06717
TARBP2 TAR (HIV-1) RNA binding protein 2 2.06185
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.06185
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 2.06185
HPS6 Hermansky-Pudlak syndrome 6 2.06185
MYL11 myosin light chain 11 2.04122
NOXA1 NADPH oxidase activator 1 2.04034
FBXW10B F-box and WD repeat domain containing 10B 2.02833
STX17 syntaxin 17 2.01403

decreased expression

Symbol Name Standardized Value
PON3 paraoxonase 3 -2.80585
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.80585
PRSS50 protease, serine, 50 -2.80585
SPAG4 sperm associated antigen 4 -2.80585
CRIP2 cysteine-rich protein 2 -2.80585
GYPE glycophorin E (MNS blood group) -2.79507
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.79507
ITK IL2-inducible T-cell kinase -2.79507
AMDHD1 amidohydrolase domain containing 1 -2.79507
COL6A6 collagen, type VI, alpha 6 -2.79507
WDR48 WD repeat domain 48 -2.79507
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.79507
PCDHB11 protocadherin beta 11 -2.79507
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.79507
FBLN5 fibulin 5 -2.79507
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.79507
MUC1 mucin 1, cell surface associated -2.79507
PGAM2 phosphoglycerate mutase 2 (muscle) -2.79507
COL4A1 collagen, type IV, alpha 1 -2.79507
RNF39 ring finger protein 39 -2.79507
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.79507
CLCF1 cardiotrophin-like cytokine factor 1 -2.79507
PIGM phosphatidylinositol glycan anchor biosynthesis, class M -2.79507
CLSTN1 calsyntenin 1 -2.79507
SPTBN5 spectrin, beta, non-erythrocytic 5 -2.79507
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -2.79507
FCRLB Fc receptor-like B -2.79507
DMRT2 doublesex and mab-3 related transcription factor 2 -2.79507
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.79507
CDH22 cadherin 22, type 2 -2.79507
H2BC13 H2B clustered histone 13 -2.79507
PEAK3 PEAK family member 3 -2.79507
FAM151A family with sequence similarity 151, member A -2.79507
C10ORF143 chromosome 10 open reading frame 143 -2.79507
MLIP muscular LMNA-interacting protein -2.79507
TTC36 tetratricopeptide repeat domain 36 -2.79507
MTMR11 myotubularin related protein 11 -2.79507
BAHCC1 BAH domain and coiled-coil containing 1 -2.79507
MPPED1 metallophosphoesterase domain containing 1 -2.79507
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -2.79507
PEAR1 platelet endothelial aggregation receptor 1 -2.79507
LRRK2 leucine-rich repeat kinase 2 -2.79507
C1ORF115 chromosome 1 open reading frame 115 -2.79387
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.78965
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.71968
AOAH acyloxyacyl hydrolase (neutrophil) -2.68957
DXO decapping exoribonuclease -2.67068
MTNR1A melatonin receptor 1A -2.67068
ZNF140 zinc finger protein 140 -2.64173
GNG10 guanine nucleotide binding protein (G protein), gamma 10 -2.63044
TMEM80 transmembrane protein 80 -2.55304
FCRL5 Fc receptor-like 5 -2.50858
LNPK lunapark, ER junction formation factor -2.50534
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.48238
ZNF697 zinc finger protein 697 -2.47942
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.44185
GRHL2 grainyhead-like 2 (Drosophila) -2.4363
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.42183
UNC5A unc-5 homolog A (C. elegans) -2.42183
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -2.41424
ANO9 anoctamin 9 -2.38768
UBE2Z ubiquitin-conjugating enzyme E2Z -2.38563
RYR1 ryanodine receptor 1 (skeletal) -2.37052
RPN2 ribophorin II -2.36747
METTL6 methyltransferase like 6 -2.34256
STXBP6 syntaxin binding protein 6 (amisyn) -2.34256
FAHD1 fumarylacetoacetate hydrolase domain containing 1 -2.32794
GLA galactosidase, alpha -2.32065
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.26892
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -2.26846
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.25113
KMT5A lysine methyltransferase 5A -2.25113
HMGA2 high mobility group AT-hook 2 -2.25113
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.24404
ARK2C arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C -2.24404
ZNF506 zinc finger protein 506 -2.24404
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 -2.23938
GPRIN3 GPRIN family member 3 -2.23471
ENTR1 endosome associated trafficking regulator 1 -2.23465
LRRIQ1 leucine-rich repeats and IQ motif containing 1 -2.22636
AMER1 APC membrane recruitment protein 1 -2.22636
LOC124904542 uncharacterized LOC124904542 -2.22636
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.22636
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.21514
NEK9 NIMA-related kinase 9 -2.1619
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -2.16145
MEF2B myocyte enhancer factor 2B -2.16145
CBX3 chromobox homolog 3 -2.1571
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.15701
PANK1 pantothenate kinase 1 -2.1505
NINJ1 ninjurin 1 -2.13599
RIBC2 RIB43A domain with coiled-coils 2 -2.1304
TMEM61 transmembrane protein 61 -2.1304
CCDC7 coiled-coil domain containing 7 -2.1259
PPT1 palmitoyl-protein thioesterase 1 -2.12549
PUM3 pumilio RNA binding family member 3 -2.11319
L3MBTL1 l(3)mbt-like 1 (Drosophila) -2.0993
EPPK1 epiplakin 1 -2.07925
PNMA8B PNMA family member 8B -2.06769
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -2.06717
IRAK4 interleukin-1 receptor-associated kinase 4 -2.06185
TARS3 threonyl-tRNA synthetase 3 -2.06185
SMIM29 small integral membrane protein 29 -2.06185
IFT122 intraflagellar transport 122 -2.05942
COL23A1 collagen, type XXIII, alpha 1 -2.05375
FRMD4B FERM domain containing 4B -2.05283
RAB28 RAB28, member RAS oncogene family -2.04946
CGAS cyclic GMP-AMP synthase -2.04122
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit -2.04122
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.03774
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -2.02754
RUMY3 RUMY family member 3 -2.01
TMEM131L transmembrane 131 like -2.00716