EML4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description echinoderm microtubule associated protein like 4|This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015] (NCBI Entrez Gene Database, 27436)
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Genes

349 genes differentially expressed following the EML4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ECI2 enoyl-CoA delta isomerase 2 2.3767
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.3767
PRB1 proline-rich protein BstNI subfamily 1 2.3767
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.3767
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.3767
TMPRSS11F transmembrane protease, serine 11F 2.3767
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.3767
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.3767
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.3767
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.3767
ZNF503 zinc finger protein 503 2.3767
IL12RB1 interleukin 12 receptor, beta 1 2.3767
PCDHA2 protocadherin alpha 2 2.3767
PCDHA3 protocadherin alpha 3 2.3767
TLR6 toll-like receptor 6 2.3767
IL6 interleukin 6 2.3767
ZIC1 Zic family member 1 2.3767
MEOX2 mesenchyme homeobox 2 2.3767
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 2.3767
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.3767
PPP1R42 protein phosphatase 1, regulatory subunit 42 2.3767
LTBP2 latent transforming growth factor beta binding protein 2 2.3767
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.3767
PCDHA5 protocadherin alpha 5 2.3767
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.3767
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.3767
IGFL2 IGF-like family member 2 2.3767
GPR22 G protein-coupled receptor 22 2.3767
VAMP5 vesicle-associated membrane protein 5 2.3767
TRIM74 tripartite motif containing 74 2.3767
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.3767
BIRC3 baculoviral IAP repeat containing 3 2.3767
TDRD1 tudor domain containing 1 2.3767
LCN12 lipocalin 12 2.3767
CRH corticotropin releasing hormone 2.3767
TRDN triadin 2.3767
PLK5 polo-like kinase 5 2.3767
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.3767
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.3767
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.3767
PTX3 pentraxin 3, long 2.3767
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.3767
CABP4 calcium binding protein 4 2.3767
NANOS3 nanos homolog 3 (Drosophila) 2.3767
CD160 CD160 molecule 2.3767
PCDHB9 protocadherin beta 9 2.3767
TNNI1 troponin I type 1 (skeletal, slow) 2.3767
GRXCR2 glutaredoxin, cysteine rich 2 2.3767
CLEC19A C-type lectin domain family 19, member A 2.3767
TMEM100 transmembrane protein 100 2.3767
SHE Src homology 2 domain containing E 2.3767
CATSPERH catsper channel auxiliary subunit eta 2.3767
HJV hemojuvelin BMP co-receptor 2.3767
PLAAT4 phospholipase A and acyltransferase 4 2.3767
SMIM38 small integral membrane protein 38 2.3767
MYOCOS myocilin opposite strand 2.3767
CCN3 cellular communication network factor 3 2.3767
ALPG alkaline phosphatase, germ cell 2.3767
ODAD1 outer dynein arm docking complex subunit 1 2.3767
PNMA8B PNMA family member 8B 2.3767
NECTIN4 nectin cell adhesion molecule 4 2.3767
YIPF7 Yip1 domain family, member 7 2.3767
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.3767
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.3767
GARIN6 golgi associated RAB2 interactor family member 6 2.3767
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.3767
SPATA31G1 SPATA31 subfamily G member 1 2.3767
CIMIP4 ciliary microtubule inner protein 4 2.3767
EXOC1L exocyst complex component 1 like 2.3767
LINC02268 long intergenic non-protein coding RNA 2268 2.3767
KIF1C-AS1 KIF1C antisense RNA 1 2.3767
LOC124903372 uncharacterized LOC124903372 2.3767
RHEX regulator of hemoglobinization and erythroid cell expansion 2.3767
SMIM31 small integral membrane protein 31 2.3767
LY6L lymphocyte antigen 6 family member L 2.3767
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.3767
C2ORF72 chromosome 2 open reading frame 72 2.3767
CLDN16 claudin 16 2.3767
FAM228A family with sequence similarity 228, member A 2.3767
C15ORF62 chromosome 15 open reading frame 62 2.3767
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 2.3767
LTB lymphotoxin beta (TNF superfamily, member 3) 2.3767
PRG4 proteoglycan 4 2.3767
ACE2 angiotensin I converting enzyme 2 2.3767
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.3767
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.3767
GTSF1 gametocyte specific factor 1 2.3767
C1QL2 complement component 1, q subcomponent-like 2 2.3767
ZNF441 zinc finger protein 441 2.3767
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.3767
WDR64 WD repeat domain 64 2.3767
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.3767
ACER1 alkaline ceramidase 1 2.3767
RHCG Rh family, C glycoprotein 2.3767
RD3 retinal degeneration 3 2.3767
DNAAF1 dynein, axonemal, assembly factor 1 2.3767
FIMP1 fertilization-influencing membrane protein 1 2.3767
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.3767
GIPR gastric inhibitory polypeptide receptor 2.3767
TMPRSS7 transmembrane protease, serine 7 2.3767
TMPRSS3 transmembrane protease, serine 3 2.3767
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.3767
ANKRD11 ankyrin repeat domain 11 2.3767
KCTD19 potassium channel tetramerization domain containing 19 2.3767
ZC3H12D zinc finger CCCH-type containing 12D 2.3767
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) 2.3767
CCDC154 coiled-coil domain containing 154 2.3767
SEMG1 semenogelin I 2.3767
CHIT1 chitinase 1 (chitotriosidase) 2.3767
BRD9 bromodomain containing 9 2.3767
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.3767
NSUN6 NOP2/Sun domain family, member 6 2.3767
C17ORF107 chromosome 17 open reading frame 107 2.3767
RPIA ribose 5-phosphate isomerase A 2.3767
C9ORF57 chromosome 9 open reading frame 57 2.3767
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.3767
TMEM86B transmembrane protein 86B 2.3767
DAW1 dynein assembly factor with WDR repeat domains 1 2.3767
PLA2G12B phospholipase A2, group XIIB 2.3767
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.3767
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.3767
EPHA5 EPH receptor A5 2.3767
STMND1 stathmin domain containing 1 2.3767
SMAD2 SMAD family member 2 2.3767
RGS11 regulator of G-protein signaling 11 2.3767
TMEM204 transmembrane protein 204 2.3767
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 2.3767
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.3767
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.3767
NIT2 nitrilase family, member 2 2.3767
SEC14L5 SEC14-like 5 (S. cerevisiae) 2.3767
KISS1 KiSS-1 metastasis-suppressor 2.3767
TTC14 tetratricopeptide repeat domain 14 2.3767
TPSG1 tryptase gamma 1 2.3767
SVOP SV2 related protein homolog (rat) 2.3767
CDHR2 cadherin-related family member 2 2.3767
HK3 hexokinase 3 (white cell) 2.3767
EFCAB9 EF-hand calcium binding domain 9 2.3767
GPR12 G protein-coupled receptor 12 2.3767
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.3767
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.3767
CTAGE9 CTAGE family, member 9 2.3767
HSPA1L heat shock 70kDa protein 1-like 2.3767
FAM111A family with sequence similarity 111, member A 2.3767
KLK11 kallikrein-related peptidase 11 2.3767
LDLRAD1 low density lipoprotein receptor class A domain containing 1 2.3767
RECQL RecQ helicase-like 2.3767
TM4SF19 transmembrane 4 L six family member 19 2.3767
MYO1A myosin IA 2.3767
CXORF49C chromosome X open reading frame 49C 2.3767
PANO1 proapoptotic nucleolar protein 1 2.3767
TTC24 tetratricopeptide repeat domain 24 2.3767
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.3767
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.3767
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.3767
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.3767
SPACA1 sperm acrosome associated 1 2.3767
ZNF831 zinc finger protein 831 2.3767
GOLGA8H golgin A8 family, member H 2.3767
LARP7 La ribonucleoprotein domain family, member 7 2.3767
CCL25 chemokine (C-C motif) ligand 25 2.3767
CPLX1 complexin 1 2.3767
SPEN spen family transcriptional repressor 2.3767
TBATA thymus, brain and testes associated 2.3767
RHOG ras homolog family member G 2.3767
CYGB cytoglobin 2.3767
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.3767
NLRP7 NLR family, pyrin domain containing 7 2.3767
IL17B interleukin 17B 2.3767
INSL3 insulin-like 3 (Leydig cell) 2.3767
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.3767
MEIOB meiosis specific with OB domains 2.3767
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.3767
PADI6 peptidyl arginine deiminase, type VI 2.3767
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.3767
EFCAB12 EF-hand calcium binding domain 12 2.3767
NLRP3 NLR family, pyrin domain containing 3 2.3767
FAIM2 Fas apoptotic inhibitory molecule 2 2.3767
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.3767
CD226 CD226 molecule 2.3767
APOA1 apolipoprotein A-I 2.3767
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.33726
ZNF280B zinc finger protein 280B 2.30948
IDO1 indoleamine 2,3-dioxygenase 1 2.28944
IGSF1 immunoglobulin superfamily, member 1 2.27484
TSHR thyroid stimulating hormone receptor 2.25589
ZNF442 zinc finger protein 442 2.25589
PACS2 phosphofurin acidic cluster sorting protein 2 2.25589
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.25589
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.24248
STX7 syntaxin 7 2.23062
FBXO16 F-box protein 16 2.2131
SAMD4B sterile alpha motif domain containing 4B 2.2131
GOLGA1 golgin A1 2.2131
C18ORF54 chromosome 18 open reading frame 54 2.2131
ACOT7 acyl-CoA thioesterase 7 2.2131
GALT galactose-1-phosphate uridylyltransferase 2.2131
DEDD2 death effector domain containing 2 2.2131
FEM1B fem-1 homolog b (C. elegans) 2.2131
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 2.20722
GANC glucosidase, alpha; neutral C 2.20722
PLCL1 phospholipase C-like 1 2.19642
IGF2R insulin-like growth factor 2 receptor 2.18658
ATAD3A ATPase family, AAA domain containing 3A 2.18658
COBL cordon-bleu WH2 repeat protein 2.18658
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 2.16771
KATNAL1 katanin p60 subunit A-like 1 2.14964
MSRB1 methionine sulfoxide reductase B1 2.14423
MTCL1 microtubule crosslinking factor 1 2.13787
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 2.13223
LHFPL6 LHFPL tetraspan subfamily member 6 2.1124
RPL38 ribosomal protein L38 2.10558
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 2.09569
TTBK2 tau tubulin kinase 2 2.08575
SYT16 synaptotagmin XVI 2.08408
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 2.07756
ARMC9 armadillo repeat containing 9 2.07281
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.07204
HEXA hexosaminidase A (alpha polypeptide) 2.04816
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 2.03493
GPR27 G protein-coupled receptor 27 2.03493
PHF23 PHD finger protein 23 2.03493
ETV6 ets variant 6 2.03062
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.03062
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 2.03062
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 2.02064
VAC14 Vac14 homolog (S. cerevisiae) 2.02064

decreased expression

Symbol Name Standardized Value
EML4 echinoderm microtubule associated protein like 4 -2.83128
NALCN sodium leak channel, non selective -2.3767
CD320 CD320 molecule -2.3767
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.3767
TWF2 twinfilin actin binding protein 2 -2.3767
TRIM27 tripartite motif containing 27 -2.3767
RGS12 regulator of G-protein signaling 12 -2.3767
DYDC2 DPY30 domain containing 2 -2.3767
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.3767
ZFPM2 zinc finger protein, FOG family member 2 -2.3767
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 -2.3767
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -2.3767
APLF aprataxin and PNKP like factor -2.3767
DERL3 derlin 3 -2.3767
CNTN3 contactin 3 (plasmacytoma associated) -2.3767
ARID5B AT rich interactive domain 5B (MRF1-like) -2.3767
TOP2B topoisomerase (DNA) II beta 180kDa -2.3767
CRACR2A calcium release activated channel regulator 2A -2.3767
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -2.3767
FAM171B family with sequence similarity 171, member B -2.3767
RNF43 ring finger protein 43 -2.3767
WFDC10B WAP four-disulfide core domain 10B -2.3767
RAB9A RAB9A, member RAS oncogene family -2.3767
MEIS3 Meis homeobox 3 -2.3767
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator -2.3767
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.3767
SBK2 SH3 domain binding kinase family, member 2 -2.3767
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -2.3767
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.3767
ACSF3 acyl-CoA synthetase family member 3 -2.3767
ADAM17 ADAM metallopeptidase domain 17 -2.3767
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.3767
FOSL1 FOS-like antigen 1 -2.3767
MRPL41 mitochondrial ribosomal protein L41 -2.3767
INMT indolethylamine N-methyltransferase -2.3767
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.3767
EID1 EP300 interacting inhibitor of differentiation 1 -2.3767
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -2.3767
GPN3 GPN-loop GTPase 3 -2.3767
FLT4 fms-related tyrosine kinase 4 -2.36363
CWC15 CWC15 spliceosome-associated protein -2.35868
PXMP4 peroxisomal membrane protein 4, 24kDa -2.3385
AKAP5 A kinase (PRKA) anchor protein 5 -2.33838
SMIM1 small integral membrane protein 1 (Vel blood group) -2.33478
PLAG1 pleiomorphic adenoma gene 1 -2.31353
SLC10A3 solute carrier family 10, member 3 -2.30956
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.30956
INSIG1 insulin induced gene 1 -2.28944
INAFM1 InaF-motif containing 1 -2.25285
ELMO2 engulfment and cell motility 2 -2.25076
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -2.2131
CD1D CD1d molecule -2.2131
TXLNB taxilin beta -2.2131
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.2131
ZSWIM1 zinc finger, SWIM-type containing 1 -2.2131
MNS1 meiosis-specific nuclear structural 1 -2.2131
FAM43B family with sequence similarity 43, member B -2.2131
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -2.2131
RPS21-DT RPS21 divergent transcript -2.2131
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -2.2131
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.2131
ZNF233 zinc finger protein 233 -2.2131
KLHL34 kelch-like family member 34 -2.2131
COL8A1 collagen, type VIII, alpha 1 -2.2131
ZSCAN22 zinc finger and SCAN domain containing 22 -2.2131
WDR90 WD repeat domain 90 -2.2131
PTGDR prostaglandin D2 receptor (DP) -2.2131
PCP4L1 Purkinje cell protein 4 like 1 -2.2131
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.2131
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -2.2131
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.2131
GLB1L2 galactosidase, beta 1-like 2 -2.2131
AMH anti-Mullerian hormone -2.2131
CCDC121 coiled-coil domain containing 121 -2.2131
SHLD3 shieldin complex subunit 3 -2.2131
MSMP microseminoprotein, prostate associated -2.2131
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.2131
RSRC2 arginine/serine-rich coiled-coil 2 -2.2131
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.2131
SCN3B sodium channel, voltage gated, type III beta subunit -2.2131
LEKR1 leucine, glutamate and lysine rich 1 -2.2131
SMC5 structural maintenance of chromosomes 5 -2.2131
MIXL1 Mix paired-like homeobox -2.2131
EBI3 Epstein-Barr virus induced 3 -2.2131
GRM7 glutamate receptor, metabotropic 7 -2.2131
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.2131
NRSN1 neurensin 1 -2.2131
CNTN5 contactin 5 -2.2131
ANGPTL7 angiopoietin-like 7 -2.2131
PYDC1 PYD (pyrin domain) containing 1 -2.20722
FGD3 FYVE, RhoGEF and PH domain containing 3 -2.20722
IFT172 intraflagellar transport 172 -2.20722
HSPA4 heat shock 70kDa protein 4 -2.20661
PLAC8L1 PLAC8-like 1 -2.20589
ZNF433 zinc finger protein 433 -2.20491
CCDC82 coiled-coil domain containing 82 -2.20178
ZNF367 zinc finger protein 367 -2.1975
TRAPPC2L trafficking protein particle complex 2-like -2.19654
GRHL2 grainyhead-like 2 (Drosophila) -2.18906
SCAND1 SCAN domain containing 1 -2.18658
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.18142
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -2.15436
ANKRD45 ankyrin repeat domain 45 -2.15247
PHB1 prohibitin 1 -2.14423
SAT2 spermidine/spermine N1-acetyltransferase family member 2 -2.14361
AKTIP AKT interacting protein -2.13512
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.13509
C19ORF12 chromosome 19 open reading frame 12 -2.12581
PPIB peptidylprolyl isomerase B (cyclophilin B) -2.11393
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.09569
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.09087
OOEP oocyte expressed protein -2.08575
GXYLT2 glucoside xylosyltransferase 2 -2.06025
TRIP10 thyroid hormone receptor interactor 10 -2.05105
QTRT1 queuine tRNA-ribosyltransferase 1 -2.05097
YBX1 Y box binding protein 1 -2.0482
NID2 nidogen 2 (osteonidogen) -2.0435
EP400 E1A binding protein p400 -2.03813
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -2.03062
ZNF747 zinc finger protein 747 -2.02649
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.02649
LHX4 LIM homeobox 4 -2.00846