EN1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description engrailed homeobox 1|Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2019)
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Genes

349 genes differentially expressed following the EN1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 3.43891
PON1 paraoxonase 1 3.43891
MBLAC1 metallo-beta-lactamase domain containing 1 3.43891
CCL5 chemokine (C-C motif) ligand 5 3.43891
GJB5 gap junction protein, beta 5, 31.1kDa 3.43891
GJB1 gap junction protein, beta 1, 32kDa 3.43891
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.43891
FETUB fetuin B 3.43891
REN renin 3.43891
AVPR2 arginine vasopressin receptor 2 3.43891
PRELP proline/arginine-rich end leucine-rich repeat protein 3.43891
HEATR9 HEAT repeat containing 9 3.43891
DPF3 D4, zinc and double PHD fingers, family 3 3.43891
TBX22 T-box 22 3.43891
KLHL35 kelch-like family member 35 3.43891
NDRG1 N-myc downstream regulated 1 3.43891
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.43891
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.43891
NOTO notochord homeobox 3.43891
FGF23 fibroblast growth factor 23 3.43891
IGFL3 IGF-like family member 3 3.43891
OC90 otoconin 90 3.43891
PNOC prepronociceptin 3.43891
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.43891
IL23R interleukin 23 receptor 3.43891
NR2F1 nuclear receptor subfamily 2, group F, member 1 3.43891
RBP4 retinol binding protein 4, plasma 3.43891
CHRDL2 chordin-like 2 3.43891
OR52I2 olfactory receptor, family 52, subfamily I, member 2 3.43891
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.43891
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.43891
HEPACAM hepatic and glial cell adhesion molecule 3.43891
GUCA2A guanylate cyclase activator 2A (guanylin) 3.43891
PCDHGA11 protocadherin gamma subfamily A, 11 3.43891
FGF9 fibroblast growth factor 9 3.43891
HEPHL1 hephaestin-like 1 3.43891
TAS2R19 taste receptor, type 2, member 19 3.43891
MYO16 myosin XVI 3.43891
GALR2 galanin receptor 2 3.43891
AIRE autoimmune regulator 3.43891
CPLX4 complexin 4 3.43891
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.43891
OR51A7 olfactory receptor, family 51, subfamily A, member 7 3.43891
HIC1 hypermethylated in cancer 1 3.43891
ZPLD1 zona pellucida-like domain containing 1 3.43891
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.43891
LOC124900192 uncharacterized LOC124900192 3.43891
PCDHGA9 protocadherin gamma subfamily A, 9 3.43891
CAPN9 calpain 9 3.43891
SCEL sciellin 3.43891
ELOVL3 ELOVL fatty acid elongase 3 3.43891
LOC122455340 uncharacterized LOC122455340 3.43891
SMLR1 small leucine-rich protein 1 3.43891
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.43891
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.43891
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.43891
GIPC3 GIPC PDZ domain containing family, member 3 3.43891
SPATS1 spermatogenesis associated, serine-rich 1 3.43891
TEX53 testis expressed 53 3.43891
FAM240C family with sequence similarity 240 member C 3.43891
IRF2-DT IRF2 divergent transcript 3.43891
DUSP13B dual specificity phosphatase 13B 3.43891
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.43891
H1-8 H1.8 linker histone 3.43891
ITPRID1 ITPR interacting domain containing 1 3.43891
H2BC3 H2B clustered histone 3 3.43891
NECTIN4 nectin cell adhesion molecule 4 3.43891
GRAP GRB2-related adaptor protein 3.43891
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.43891
C15ORF62 chromosome 15 open reading frame 62 3.43891
TBX3 T-box 3 3.43891
HAPLN2 hyaluronan and proteoglycan link protein 2 3.43891
ANXA13 annexin A13 3.43891
C3ORF80 chromosome 3 open reading frame 80 3.43891
FAM78A family with sequence similarity 78, member A 3.43891
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.43891
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.43891
PCDHA8 protocadherin alpha 8 3.43891
FOXD1 forkhead box D1 3.43891
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.43891
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.43891
GATA4 GATA binding protein 4 3.43891
SYT15 synaptotagmin XV 3.43891
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.43891
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.43891
WNT9B wingless-type MMTV integration site family, member 9B 3.43891
OR2D3 olfactory receptor, family 2, subfamily D, member 3 3.43891
IL1R2 interleukin 1 receptor, type II 3.43891
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.43891
OVOL1 ovo-like zinc finger 1 3.43891
OR5H2 olfactory receptor, family 5, subfamily H, member 2 3.43891
PADI6 peptidyl arginine deiminase, type VI 3.43891
APOC4 apolipoprotein C-IV 3.43891
COL6A5 collagen, type VI, alpha 5 3.43891
SAMD9 sterile alpha motif domain containing 9 3.43891
ERICH6 glutamate-rich 6 3.43891
POU2AF1 POU class 2 associating factor 1 3.43891
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.43891
FGR FGR proto-oncogene, Src family tyrosine kinase 3.43891
RSAD2 radical S-adenosyl methionine domain containing 2 3.43891
TMEM132E transmembrane protein 132E 3.43891
CCL27 chemokine (C-C motif) ligand 27 3.43891
LRRC43 leucine rich repeat containing 43 3.43891
CCDC154 coiled-coil domain containing 154 3.43891
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.43891
IL17REL interleukin 17 receptor E-like 3.43891
KRT15 keratin 15, type I 3.43891
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.43891
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.43891
HRCT1 histidine rich carboxyl terminus 1 3.43891
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.43891
CD244 CD244 molecule, natural killer cell receptor 2B4 3.43891
NPFFR1 neuropeptide FF receptor 1 3.43891
HPD 4-hydroxyphenylpyruvate dioxygenase 3.43891
C2ORF66 chromosome 2 open reading frame 66 3.43891
CRHR1 corticotropin releasing hormone receptor 1 3.43891
GLOD5 glyoxalase domain containing 5 3.43891
ARR3 arrestin 3, retinal (X-arrestin) 3.43891
FOXE3 forkhead box E3 3.43891
EVPLL envoplakin-like 3.43891
COX7B2 cytochrome c oxidase subunit VIIb2 3.43891
ADGRA1 adhesion G protein-coupled receptor A1 3.43891
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.43891
INO80 INO80 complex subunit 3.43891
UBQLNL ubiquilin-like 3.43891
TEKT2 tektin 2 (testicular) 3.43891
RGCC regulator of cell cycle 3.43891
RBM24 RNA binding motif protein 24 3.43891
TGM3 transglutaminase 3 3.43891
GH2 growth hormone 2 3.43891
PIH1D2 PIH1 domain containing 2 3.43891
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.43891
UBXN10 UBX domain protein 10 3.43891
GPR150 G protein-coupled receptor 150 3.43891
LAMP5 lysosomal-associated membrane protein family, member 5 3.43891
GOLGA8R golgin A8 family, member R 3.43891
CXCR4 chemokine (C-X-C motif) receptor 4 3.43891
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.43891
FOXP3 forkhead box P3 3.43891
SIDT1 SID1 transmembrane family, member 1 3.43891
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.43891
RFPL1 ret finger protein-like 1 3.43891
ST18 suppression of tumorigenicity 18, zinc finger 3.43891
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.43891
ADGRF5 adhesion G protein-coupled receptor F5 3.43891
FADS6 fatty acid desaturase 6 3.43891
ALOX15B arachidonate 15-lipoxygenase, type B 3.43891
PRRX1 paired related homeobox 1 3.43891
ANKRD33 ankyrin repeat domain 33 3.43891
CARD9 caspase recruitment domain family, member 9 3.43891
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.43891
NUTM2D NUT family member 2D 3.43891
AOC3 amine oxidase, copper containing 3 3.43891
CA5A carbonic anhydrase VA, mitochondrial 3.43891
NT5DC4 5'-nucleotidase domain containing 4 3.43891
TPPP2 tubulin polymerization-promoting protein family member 2 3.43891
GSTA2 glutathione S-transferase alpha 2 3.43891
BICD1 bicaudal D homolog 1 (Drosophila) 3.39611
NWD1 NACHT and WD repeat domain containing 1 3.34166
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 3.1554
NPC2 Niemann-Pick disease, type C2 3.0725
LIN28B lin-28 homolog B (C. elegans) 3.04138
FAM133A family with sequence similarity 133, member A 3.04138
TJP2 tight junction protein 2 2.99012
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2.99012
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.99012
H4C9 H4 clustered histone 9 2.97162
ZNF670 zinc finger protein 670 2.94562
PTPN2 protein tyrosine phosphatase, non-receptor type 2 2.78076
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 2.6002
LINC02610 long intergenic non-protein coding RNA 2610 2.59697
F2R coagulation factor II (thrombin) receptor 2.56876
MAST1 microtubule associated serine/threonine kinase 1 2.5607
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.53359
DPY30 dpy-30 homolog (C. elegans) 2.41863
EGFL6 EGF-like-domain, multiple 6 2.39726
UFSP1 UFM1-specific peptidase 1 (non-functional) 2.39726
GSG1L GSG1-like 2.367
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 2.34729
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2.33971
POM121 POM121 transmembrane nucleoporin 2.33706
FAM120A family with sequence similarity 120A 2.33572
ANGPT2 angiopoietin 2 2.33483
EMD emerin 2.32924
PLK5 polo-like kinase 5 2.32924
LRRC63 leucine rich repeat containing 63 2.32924
SPATC1 spermatogenesis and centriole associated 1 2.32924
TAMALIN trafficking regulator and scaffold protein tamalin 2.32924
CHCT1 CHD1 helical C-terminal domain containing 1 2.32924
SCIN scinderin 2.32924
DLEC1 deleted in lung and esophageal cancer 1 2.32924
GRK7 G protein-coupled receptor kinase 7 2.32924
DNAH8 dynein, axonemal, heavy chain 8 2.32924
PNLIPRP2 pancreatic lipase-related protein 2 2.32924
TRHR thyrotropin-releasing hormone receptor 2.32924
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2.31839
GTSE1 G-2 and S-phase expressed 1 2.30923
RERGL RERG/RAS-like 2.308
MAN2A2 mannosidase, alpha, class 2A, member 2 2.30786
CLBA1 clathrin binding box of aftiphilin containing 1 2.28969
ZNF491 zinc finger protein 491 2.28407
PCSK6 proprotein convertase subtilisin/kexin type 6 2.28316
ZNF664-RFLNA ZNF664-RFLNA readthrough 2.26341
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) 2.23067
POU6F2 POU class 6 homeobox 2 2.2165
LINGO2 leucine rich repeat and Ig domain containing 2 2.20089
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.20089
ELP4 elongator acetyltransferase complex subunit 4 2.19333
ZNF454 zinc finger protein 454 2.18744
NDRG2 NDRG family member 2 2.17124
DMC1 DNA meiotic recombinase 1 2.16717
SDCBP2 syndecan binding protein (syntenin) 2 2.16489
FGF13 fibroblast growth factor 13 2.16132
PANK4 pantothenate kinase 4 2.1445
HNRNPA1L3 heterogeneous nuclear ribonucleoprotein A1 like 3 2.12751
ETFRF1 electron transfer flavoprotein regulatory factor 1 2.12022
FNDC3A fibronectin type III domain containing 3A 2.11008
A2M alpha-2-macroglobulin 2.08642
SMIM11 small integral membrane protein 11 2.07055
H1-0 H1.0 linker histone 2.062
NRG1 neuregulin 1 2.03462
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.03462
LTC4S leukotriene C4 synthase 2.01305
TRAPPC11 trafficking protein particle complex 11 2.00112

decreased expression

Symbol Name Standardized Value
LCN15 lipocalin 15 -3.43891
CD101 CD101 molecule -3.43891
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -3.43891
IL32 interleukin 32 -3.43891
ANXA1 annexin A1 -3.43891
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -3.43891
NELL1 NEL-like 1 (chicken) -3.43891
MYO7B myosin VIIB -3.43891
GJA9 gap junction protein, alpha 9, 59kDa -3.43891
OR2A5 olfactory receptor, family 2, subfamily A, member 5 -3.43891
GFI1B growth factor independent 1B transcription repressor -3.43891
KRTAP5-11 keratin associated protein 5-11 -3.43891
DNAH10 dynein, axonemal, heavy chain 10 -3.43891
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -3.43891
HGD homogentisate 1,2-dioxygenase -3.43891
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -3.43891
TMEM121 transmembrane protein 121 -3.43891
IDUA iduronidase, alpha-L- -3.43891
RAPSN receptor-associated protein of the synapse -3.43891
KRT77 keratin 77, type II -3.43891
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -3.43891
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -3.43891
AVP arginine vasopressin -3.43891
PODNL1 podocan-like 1 -3.43891
NWD2 NACHT and WD repeat domain containing 2 -3.43891
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -3.43891
BTBD19 BTB (POZ) domain containing 19 -3.43891
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -3.43891
SV2B synaptic vesicle glycoprotein 2B -3.43891
CORO6 coronin 6 -3.43891
AMN amnion associated transmembrane protein -3.43891
ITGA11 integrin, alpha 11 -3.43891
ASTL astacin-like metallo-endopeptidase (M12 family) -3.43891
KLK6 kallikrein-related peptidase 6 -3.43891
GC group-specific component (vitamin D binding protein) -3.43891
RBM44 RNA binding motif protein 44 -3.43891
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -3.43891
KIFBP kinesin family binding protein -3.43891
ARHGAP40 Rho GTPase activating protein 40 -3.43891
MYOT myotilin -3.43891
SAMD4A sterile alpha motif domain containing 4A -3.43891
PHETA1 PH domain containing endocytic trafficking adaptor 1 -3.43891
TEX29 testis expressed 29 -3.43891
MYOCOS myocilin opposite strand -3.43891
ANKRD55 ankyrin repeat domain 55 -3.43891
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -3.43891
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -3.35135
F3 coagulation factor III (thromboplastin, tissue factor) -3.34103
TTPA tocopherol (alpha) transfer protein -3.34103
XPO4 exportin 4 -3.24467
WDR31 WD repeat domain 31 -3.20223
DPH1 diphthamide biosynthesis 1 -3.07433
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -2.876
PGRMC2 progesterone receptor membrane component 2 -2.81
GLDN gliomedin -2.8056
DERL2 derlin 2 -2.76794
ERCC2 excision repair cross-complementation group 2 -2.71444
MVD mevalonate (diphospho) decarboxylase -2.63974
SLC18B1 solute carrier family 18, subfamily B, member 1 -2.62891
RBBP4 retinoblastoma binding protein 4 -2.62578
ZNF845 zinc finger protein 845 -2.59683
INTS4 integrator complex subunit 4 -2.57816
LMF1 lipase maturation factor 1 -2.54009
STX4 syntaxin 4 -2.5191
COL1A2 collagen, type I, alpha 2 -2.51671
ATG9A autophagy related 9A -2.50553
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.5024
BMP1 bone morphogenetic protein 1 -2.5024
EFNB1 ephrin-B1 -2.5024
STC1 stanniocalcin 1 -2.48678
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.46867
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -2.45664
CAPN13 calpain 13 -2.45561
RFC3 replication factor C (activator 1) 3, 38kDa -2.42882
RAI14 retinoic acid induced 14 -2.35248
TSSK3 testis-specific serine kinase 3 -2.34296
ANKRD65 ankyrin repeat domain 65 -2.34296
TOLLIP toll interacting protein -2.33971
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.33971
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.33483
LDB1 LIM domain binding 1 -2.32924
SORCS2 sortilin-related VPS10 domain containing receptor 2 -2.32924
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.28969
DUSP23 dual specificity phosphatase 23 -2.28969
RENBP renin binding protein -2.28969
HYPK huntingtin interacting protein K -2.27619
KLHL22 kelch-like family member 22 -2.27566
ARID4A AT rich interactive domain 4A (RBP1-like) -2.27466
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B -2.27466
MEGF10 multiple EGF-like-domains 10 -2.26341
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) -2.25598
SPTAN1 spectrin, alpha, non-erythrocytic 1 -2.24022
GPN3 GPN-loop GTPase 3 -2.22858
MTX1 metaxin 1 -2.22369
DISP2 dispatched homolog 2 (Drosophila) -2.21911
CSRNP1 cysteine-serine-rich nuclear protein 1 -2.21911
NPIPB11 nuclear pore complex interacting protein family, member B11 -2.21889
JPT2 Jupiter microtubule associated homolog 2 -2.21742
SYT9 synaptotagmin IX -2.21526
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.21486
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.20089
NR5A2 nuclear receptor subfamily 5, group A, member 2 -2.17328
DNM3 dynamin 3 -2.16489
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -2.15601
REDIC1 regulator of DNA class I crossover intermediates 1 -2.15451
ZNF718 zinc finger protein 718 -2.15112
ACTN1 actinin, alpha 1 -2.14721
XPR1 xenotropic and polytropic retrovirus receptor 1 -2.1279
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.12751
MPLKIP M-phase specific PLK1 interacting protein -2.10399
TBPL1 TBP-like 1 -2.06678
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.05669
DCTN5 dynactin 5 (p25) -2.04885
GNAS GNAS complex locus -2.04831
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.04482
EDC4 enhancer of mRNA decapping 4 -2.04003
SH2D4A SH2 domain containing 4A -2.02323
CCND2 cyclin D2 -2.01585
MAPK4 mitogen-activated protein kinase 4 -2.01425
NUBP2 nucleotide binding protein 2 -2.01425
PNO1 partner of NOB1 homolog (S. cerevisiae) -2.01405
ROR2 receptor tyrosine kinase-like orphan receptor 2 -2.01305
SOX6 SRY (sex determining region Y)-box 6 -2.01198
DGKQ diacylglycerol kinase, theta 110kDa -2.01128
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -2.00068