EOMES Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description eomesodermin|This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 8320)
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Genes

312 genes differentially expressed following the EOMES gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CSF1R colony stimulating factor 1 receptor 3.64335
GIMAP4 GTPase, IMAP family member 4 3.64335
PROX2 prospero homeobox 2 3.64335
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.64335
SPAG8 sperm associated antigen 8 3.64335
SPINK9 serine peptidase inhibitor, Kazal type 9 3.64335
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.64335
MRLN myoregulin 3.64335
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.64335
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.64335
PTCRA pre T-cell antigen receptor alpha 3.64335
MMP10 matrix metallopeptidase 10 3.64335
PSKH2 protein serine kinase H2 3.64335
SPMIP10 sperm microtubule inner protein 10 3.64335
CDCP2 CUB domain containing protein 2 3.64335
OXER1 oxoeicosanoid (OXE) receptor 1 3.64335
CBY2 chibby family member 2 3.64335
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.64335
MSMP microseminoprotein, prostate associated 3.64335
CERS3 ceramide synthase 3 3.64335
TRIM77 tripartite motif containing 77 3.51252
TDRD6 tudor domain containing 6 3.51252
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.51252
SIRPB1 signal-regulatory protein beta 1 3.51252
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.51252
PCDH8 protocadherin 8 3.51252
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 3.51252
SFTPC surfactant protein C 3.51252
UMOD uromodulin 3.51252
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.51252
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.51252
BATF basic leucine zipper transcription factor, ATF-like 3.51252
OR51L1 olfactory receptor, family 51, subfamily L, member 1 3.51252
ASCL1 achaete-scute family bHLH transcription factor 1 3.51252
ICAM2 intercellular adhesion molecule 2 3.51252
NEUROD2 neuronal differentiation 2 3.51252
APOA5 apolipoprotein A-V 3.51252
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.51252
NRSN1 neurensin 1 3.51252
LOC124906892 uncharacterized LOC124906892 3.51252
SNAI2 snail family zinc finger 2 3.51252
BTBD16 BTB (POZ) domain containing 16 3.51252
KIAA1755 KIAA1755 3.51252
RNF133 ring finger protein 133 3.51252
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.51252
COPZ2 coatomer protein complex, subunit zeta 2 3.51252
TMEM89 transmembrane protein 89 3.51252
C8ORF74 chromosome 8 open reading frame 74 3.51252
SMIM9 small integral membrane protein 9 3.51252
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.51252
OSGIN1 oxidative stress induced growth inhibitor 1 3.51252
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.51252
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.51252
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.51252
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.51252
GPR85 G protein-coupled receptor 85 3.51252
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.51252
RASAL3 RAS protein activator like 3 3.51252
CFAP45 cilia and flagella associated protein 45 3.51252
ELOVL3 ELOVL fatty acid elongase 3 3.51252
HTRA4 HtrA serine peptidase 4 3.51252
CIMAP1D CIMAP1 family member D 3.51252
SERTM2 serine rich and transmembrane domain containing 2 3.51252
CFAP100 cilia and flagella associated protein 100 3.51252
CCN5 cellular communication network factor 5 3.51252
LBHD2 LBH domain containing 2 3.51252
CCDC9B coiled-coil domain containing 9B 3.51252
ROPN1B rhophilin associated tail protein 1B 3.51252
BEND2 BEN domain containing 2 3.51252
TBX5 T-box 5 3.51252
BHLHA9 basic helix-loop-helix family, member a9 3.51252
VTN vitronectin 3.51252
GPR52 G protein-coupled receptor 52 3.51252
IZUMO3 IZUMO family member 3 3.51252
CABP4 calcium binding protein 4 3.51252
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.51252
PGAM4 phosphoglycerate mutase family member 4 3.51252
GLUD2 glutamate dehydrogenase 2 3.51252
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.51252
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.51252
INHBC inhibin, beta C 3.51252
TLR8 toll-like receptor 8 3.51252
OVOL3 ovo-like zinc finger 3 3.51252
UROC1 urocanate hydratase 1 3.51252
NXPE4 neurexophilin and PC-esterase domain family, member 4 3.51252
CCDC13 coiled-coil domain containing 13 3.51252
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.51252
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.51252
FAM187B family with sequence similarity 187, member B 3.51252
SPMIP7 sperm microtubule inner protein 7 3.51252
GOLGA8R golgin A8 family, member R 3.51252
TRIM55 tripartite motif containing 55 3.51252
CLEC4D C-type lectin domain family 4, member D 3.51252
CDH10 cadherin 10, type 2 (T2-cadherin) 3.51252
CPA2 carboxypeptidase A2 (pancreatic) 3.51252
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.51252
WFDC9 WAP four-disulfide core domain 9 3.51252
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.51252
OR10R2 olfactory receptor, family 10, subfamily R, member 2 3.51252
CTAGE4 CTAGE family, member 4 3.51252
C9ORF64 chromosome 9 open reading frame 64 3.51252
RETNLB resistin like beta 3.51252
UBQLNL ubiquilin-like 3.51252
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.51252
EXTL1 exostosin-like glycosyltransferase 1 3.51252
CNTF ciliary neurotrophic factor 3.51252
EGR2 early growth response 2 3.51252
ASTL astacin-like metallo-endopeptidase (M12 family) 3.51252
LRRC15 leucine rich repeat containing 15 3.51252
ZNF831 zinc finger protein 831 3.51252
NPY2R neuropeptide Y receptor Y2 3.51252
LAMB3 laminin, beta 3 3.51252
IL25 interleukin 25 3.51252
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.51252
LMAN1L lectin, mannose-binding, 1 like 3.51252
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.51252
CTRB1 chymotrypsinogen B1 3.51252
NTN5 netrin 5 3.51252
CFI complement factor I 3.51252
GSTA1 glutathione S-transferase alpha 1 3.51252
FCRL1 Fc receptor-like 1 3.51252
PDCD1LG2 programmed cell death 1 ligand 2 3.51252
GFRAL GDNF family receptor alpha like 3.51252
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 3.51252
SOWAHA sosondowah ankyrin repeat domain family member A 3.51252
ADGRF5 adhesion G protein-coupled receptor F5 3.51252
TEX38 testis expressed 38 3.51252
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.51252
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.51252
DMRTC1 DMRT-like family C1 3.51252
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.51252
PRAP1 proline-rich acidic protein 1 3.51252
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.51252
CYBB cytochrome b-245, beta polypeptide 3.51252
SLITRK2 SLIT and NTRK-like family, member 2 3.51252
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.51252
C9ORF57 chromosome 9 open reading frame 57 3.51252
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.51252
CABP7 calcium binding protein 7 3.51252
WFDC10A WAP four-disulfide core domain 10A 3.51252
TAS2R41 taste receptor, type 2, member 41 3.51252
PLSCR2 phospholipid scramblase 2 3.43854
TMEM130 transmembrane protein 130 3.22467
TTC17 tetratricopeptide repeat domain 17 3.16957
PLA2G4B phospholipase A2, group IVB (cytosolic) 3.00868
ZMYND8 zinc finger, MYND-type containing 8 2.9941
CA3 carbonic anhydrase III 2.9476
SCN11A sodium channel, voltage gated, type XI alpha subunit 2.85158
TMEM91 transmembrane protein 91 2.8246
SERINC1 serine incorporator 1 2.80355
CCDC171 coiled-coil domain containing 171 2.80355
DHDDS dehydrodolichyl diphosphate synthase 2.73462
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2.69972
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 2.65692
THRB thyroid hormone receptor, beta 2.59647
ZUP1 zinc finger containing ubiquitin peptidase 1 2.56558
PSEN2 presenilin 2 2.52415
KCNK6 potassium channel, two pore domain subfamily K, member 6 2.46588
RIPK4 receptor-interacting serine-threonine kinase 4 2.39272
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.39272
LMNTD2 lamin tail domain containing 2 2.39272
ENKUR enkurin, TRPC channel interacting protein 2.39272
NIBAN3 niban apoptosis regulator 3 2.39272
C2ORF72 chromosome 2 open reading frame 72 2.39272
KLHL31 kelch-like family member 31 2.39272
PRODH proline dehydrogenase (oxidase) 1 2.39272
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 2.39272
RGPD1 RANBP2-like and GRIP domain containing 1 2.39272
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.39272
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.39272
TP53BP2 tumor protein p53 binding protein 2 2.38731
RASEF RAS and EF-hand domain containing 2.3674
KMT2B lysine (K)-specific methyltransferase 2B 2.35829
SPTBN4 spectrin, beta, non-erythrocytic 4 2.34358
LHFPL1 lipoma HMGIC fusion partner-like 1 2.32764
KIAA0408 KIAA0408 2.32764
LMNB2 lamin B2 2.3205
SCML2 sex comb on midleg-like 2 (Drosophila) 2.30617
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 2.301
DND1 DND microRNA-mediated repression inhibitor 1 2.28968
MFF mitochondrial fission factor 2.28968
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.28968
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.28962
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.25015
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.24856
KRABD2 KRAB domain containing 2 2.21872
LGALS8 lectin, galactoside-binding, soluble, 8 2.20718
IL27RA interleukin 27 receptor, alpha 2.20051
PLCD4 phospholipase C, delta 4 2.19507
PRKCSH protein kinase C substrate 80K-H 2.18743
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) 2.18743
ANKRD13A ankyrin repeat domain 13A 2.18743
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.18243
HP1BP3 heterochromatin protein 1, binding protein 3 2.17686
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.1663
SPINDOC spindlin interactor and repressor of chromatin binding 2.16
GGPS1 geranylgeranyl diphosphate synthase 1 2.13971
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 2.09668
DDR1 discoidin domain receptor tyrosine kinase 1 2.09461
SET SET nuclear proto-oncogene 2.06005
ERAP1 endoplasmic reticulum aminopeptidase 1 2.0434
PEX16 peroxisomal biogenesis factor 16 2.01514
USPL1 ubiquitin specific peptidase like 1 2.01514
RNF149 ring finger protein 149 2.01514
AKIP1 A kinase (PRKA) interacting protein 1 2.01514
NTM neurotrimin 2.00901
KLHL13 kelch-like family member 13 2.00901
PRKN parkin RBR E3 ubiquitin protein ligase 2.00896
TADA1 transcriptional adaptor 1 2.00421

decreased expression

Symbol Name Standardized Value
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -3.64335
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -3.64335
IL11 interleukin 11 -3.64335
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -3.64335
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -3.64335
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -3.64335
HSF5 heat shock transcription factor family member 5 -3.64335
NGEF neuronal guanine nucleotide exchange factor -3.64335
PCDHGA6 protocadherin gamma subfamily A, 6 -3.64335
KHDC3L KH domain containing 3-like, subcortical maternal complex member -3.51252
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -3.51252
LDHC lactate dehydrogenase C -3.51252
SOX30 SRY (sex determining region Y)-box 30 -3.51252
SMYD1 SET and MYND domain containing 1 -3.51252
JAML junction adhesion molecule like -3.51252
HCRTR2 hypocretin (orexin) receptor 2 -3.51252
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 -3.51252
TSPAN1 tetraspanin 1 -3.51252
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 -3.51252
ASIC1 acid sensing (proton gated) ion channel 1 -3.51252
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.51252
TLE6 transducin-like enhancer of split 6 -3.51252
OVGP1 oviductal glycoprotein 1, 120kDa -3.51252
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -3.51252
FOXA2 forkhead box A2 -3.51252
UNC13D unc-13 homolog D (C. elegans) -3.51252
ACBD4 acyl-CoA binding domain containing 4 -3.51252
FRZB frizzled-related protein -3.51252
CD247 CD247 molecule -3.51252
ARHGAP40 Rho GTPase activating protein 40 -3.51252
CD70 CD70 molecule -3.51252
KLK15 kallikrein-related peptidase 15 -3.51252
ITGA8 integrin, alpha 8 -3.51252
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -3.51252
GPRASP2 G protein-coupled receptor associated sorting protein 2 -3.44218
COTL1 coactosin-like F-actin binding protein 1 -3.24586
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) -3.16957
PTGES3L prostaglandin E synthase 3 (cytosolic)-like -3.16038
SNAI1 snail family zinc finger 1 -3.07016
GRHL1 grainyhead-like 1 (Drosophila) -3.03753
ARRDC3 arrestin domain containing 3 -3.00868
ZNF484 zinc finger protein 484 -2.94068
TECTA tectorin alpha -2.90938
CLDN7 claudin 7 -2.87814
IGSF5 immunoglobulin superfamily, member 5 -2.84351
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.78489
PI15 peptidase inhibitor 15 -2.73462
ANKMY1 ankyrin repeat and MYND domain containing 1 -2.69649
ABI2 abl-interactor 2 -2.68194
PILRB paired immunoglobin-like type 2 receptor beta -2.62577
TRIM52 tripartite motif containing 52 -2.61518
NOS3 nitric oxide synthase 3 (endothelial cell) -2.5551
VWF von Willebrand factor -2.5551
CLIC2 chloride intracellular channel 2 -2.5551
ZNF846 zinc finger protein 846 -2.55506
UNG uracil-DNA glycosylase -2.5381
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.51906
ARL4C ADP-ribosylation factor-like 4C -2.46588
FDX2 ferredoxin 2 -2.46502
PRPH2 peripherin 2 (retinal degeneration, slow) -2.44454
ZNF766 zinc finger protein 766 -2.406
SIAH2 siah E3 ubiquitin protein ligase 2 -2.39272
KLF8 Kruppel-like factor 8 -2.39272
ZNF613 zinc finger protein 613 -2.38637
TIGD5 tigger transposable element derived 5 -2.38637
ZNF646 zinc finger protein 646 -2.38555
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.38093
CCNT2 cyclin T2 -2.37709
MSC musculin -2.3757
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -2.36763
SCAND3 SCAN domain containing 3 -2.34901
HSBP1 heat shock factor binding protein 1 -2.32764
GPR34 G protein-coupled receptor 34 -2.32551
ARID5B AT rich interactive domain 5B (MRF1-like) -2.28968
JHY junctional cadherin complex regulator -2.28252
ALPK2 alpha-kinase 2 -2.28252
RC3H1 ring finger and CCCH-type domains 1 -2.24856
TXN thioredoxin -2.22723
TLE5 TLE family member 5, transcriptional modulator -2.2234
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.21648
TSBP1 testis expressed basic protein 1 -2.20337
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -2.19405
ZNF620 zinc finger protein 620 -2.18743
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.16935
SCGB3A2 secretoglobin, family 3A, member 2 -2.1663
CHPF chondroitin polymerizing factor -2.16011
RPS24 ribosomal protein S24 -2.15
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -2.14334
USP39 ubiquitin specific peptidase 39 -2.09829
BOP1 block of proliferation 1 -2.09829
TPP1 tripeptidyl peptidase I -2.09669
REEP3 receptor accessory protein 3 -2.07691
RALBP1 ralA binding protein 1 -2.07691
TMED9 transmembrane emp24 protein transport domain containing 9 -2.07691
TRIP4 thyroid hormone receptor interactor 4 -2.06182
MROH1 maestro heat-like repeat family member 1 -2.06005
TK2 thymidine kinase 2, mitochondrial -2.02028
MRPS25 mitochondrial ribosomal protein S25 -2.01413
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.00901
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) -2.00453
B3GLCT beta 3-glucosyltransferase -2.00348
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 -2.00116
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -2.00116