EPHA2 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description EPH receptor A2|This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 1969)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase EPHA2 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
THEMIS2 thymocyte selection associated family member 2 100.0
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 99.93
IPO8 importin 8 99.91
RABL6 RAB, member RAS oncogene family-like 6 99.85
YEATS2 YEATS domain containing 2 99.82
MCEMP1 mast cell-expressed membrane protein 1 99.71
DPF2 D4, zinc and double PHD fingers family 2 99.65
ZNF598 zinc finger protein 598 99.61
TWF1 twinfilin actin binding protein 1 99.59
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 99.58
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 99.56
RNF2 ring finger protein 2 99.54
SH2D1B SH2 domain containing 1B 99.5
ALOX5 arachidonate 5-lipoxygenase 99.47
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.43
CFAP97 cilia and flagella associated protein 97 99.41
HBS1L HBS1-like translational GTPase 99.32
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 99.3
ZSCAN25 zinc finger and SCAN domain containing 25 99.26
PRRC2B proline-rich coiled-coil 2B 99.19
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 99.15
LAX1 lymphocyte transmembrane adaptor 1 99.1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 99.1
SHE Src homology 2 domain containing E 99.08
CAPN2 calpain 2, (m/II) large subunit 99.04
FHOD1 formin homology 2 domain containing 1 99.04
PTPRB protein tyrosine phosphatase, receptor type, B 98.99
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 98.9
MAGED2 melanoma antigen family D2 98.88
CENPE centromere protein E, 312kDa 98.86
IKZF3 IKAROS family zinc finger 3 (Aiolos) 98.82
RABGAP1L RAB GTPase activating protein 1-like 98.8
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 98.775
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 98.71
SLC39A3 solute carrier family 39 (zinc transporter), member 3 98.62
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 98.58
ARRDC3 arrestin domain containing 3 98.45
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 98.43
FGD6 FYVE, RhoGEF and PH domain containing 6 98.42
KCTD12 potassium channel tetramerization domain containing 12 98.4
EIF1 eukaryotic translation initiation factor 1 98.38
EIF1B eukaryotic translation initiation factor 1B 98.38
FHIT fragile histidine triad 98.27
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 98.27
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 98.25
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 98.21
GAPT GRB2-binding adaptor protein, transmembrane 98.12
N4BP3 NEDD4 binding protein 3 98.03
SF3A3 splicing factor 3a, subunit 3, 60kDa 97.99
C9ORF78 chromosome 9 open reading frame 78 97.96
ARID4B AT rich interactive domain 4B (RBP1-like) 97.94
SHTN1 shootin 1 97.92
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 97.9
NAP1L1 nucleosome assembly protein 1-like 1 97.72
HDAC6 histone deacetylase 6 97.68
DLG3 discs, large homolog 3 (Drosophila) 97.65
ARHGAP35 Rho GTPase activating protein 35 97.645
TRIP11 thyroid hormone receptor interactor 11 97.64
TWF2 twinfilin actin binding protein 2 97.62
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 97.61
ARHGAP5 Rho GTPase activating protein 5 97.57
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 97.53
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 97.53
VSIG4 V-set and immunoglobulin domain containing 4 97.51
LY6G6F lymphocyte antigen 6 complex, locus G6F 97.48
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 97.44
CNOT9 CCR4-NOT transcription complex subunit 9 97.42
RAD9A RAD9 homolog A (S. pombe) 97.42
ARHGAP30 Rho GTPase activating protein 30 97.33
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 97.31
STING1 stimulator of interferon response cGAMP interactor 1 97.31
LST1 leukocyte specific transcript 1 97.26
CEP43 centrosomal protein 43 97.18
CD244 CD244 molecule, natural killer cell receptor 2B4 97.145
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 97.13
SPRY4 sprouty homolog 4 (Drosophila) 97.09
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 97.0
PDCD5 programmed cell death 5 96.93
FYB2 FYN binding protein 2 96.89
C1ORF210 chromosome 1 open reading frame 210 96.83
ACOX1 acyl-CoA oxidase 1, palmitoyl 96.81
F5 coagulation factor V (proaccelerin, labile factor) 96.8
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 96.78
GREB1 growth regulation by estrogen in breast cancer 1 96.65
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 96.59
BLNK B-cell linker 96.58
TRIOBP TRIO and F-actin binding protein 96.545
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 96.52
IFITM2 interferon induced transmembrane protein 2 96.5
DLG2 discs, large homolog 2 (Drosophila) 96.45
PTPRH protein tyrosine phosphatase, receptor type, H 96.41
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 96.34
EPB41L5 erythrocyte membrane protein band 4.1 like 5 96.24
MCC mutated in colorectal cancers 96.23
EPHB6 EPH receptor B6 96.11
KLC3 kinesin light chain 3 96.08
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 96.04
UMPS uridine monophosphate synthetase 95.99
PTPRA protein tyrosine phosphatase, receptor type, A 95.93
GCSAML germinal center-associated, signaling and motility-like 95.885