EPO Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description erythropoietin|This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2056)
External Link http://www.ncbi.nlm.nih.gov/gene/2056
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Genes

26 interacting proteins for EPO from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BTK Bruton agammaglobulinemia tyrosine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DOK2 docking protein 2, 56kDa
EP300 E1A binding protein p300
EPOR erythropoietin receptor
GAB1 GRB2-associated binding protein 1
GRB2 growth factor receptor-bound protein 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PLCG1 phospholipase C, gamma 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAP1A RAP1A, member of RAS oncogene family
RB1 retinoblastoma 1
SH2B3 SH2B adaptor protein 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOS1 son of sevenless homolog 1 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TEC tec protein tyrosine kinase
VAV2 vav 2 guanine nucleotide exchange factor