EPOR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description erythropoietin receptor|This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 2057)
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Genes

303 genes differentially expressed following the EPOR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM71 transmembrane protein 71 2.98663
DOK2 docking protein 2, 56kDa 2.98663
TNS4 tensin 4 2.98663
GREM1 gremlin 1, DAN family BMP antagonist 2.98663
GCSAM germinal center-associated, signaling and motility 2.98663
TMEM275 transmembrane protein 275 2.98663
VXN vexin 2.98663
MRC1 mannose receptor, C type 1 2.98663
RLN3 relaxin 3 2.98663
CELA1 chymotrypsin-like elastase family, member 1 2.98663
AKAIN1 A-kinase anchor inhibitor 1 2.98663
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.98663
SMIM5 small integral membrane protein 5 2.96372
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.96372
DIO3 deiodinase, iodothyronine, type III 2.96372
PNMA5 paraneoplastic Ma antigen family member 5 2.96372
LY6G6F lymphocyte antigen 6 complex, locus G6F 2.96372
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.96372
AVPR2 arginine vasopressin receptor 2 2.96372
SP7 Sp7 transcription factor 2.96372
TUBB1 tubulin, beta 1 class VI 2.96372
SIGLEC9 sialic acid binding Ig-like lectin 9 2.96372
HBA1 hemoglobin, alpha 1 2.96372
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.96372
S100A5 S100 calcium binding protein A5 2.96372
PNOC prepronociceptin 2.96372
R3HDML R3H domain containing-like 2.96372
WFDC11 WAP four-disulfide core domain 11 2.96372
KRTAP5-9 keratin associated protein 5-9 2.96372
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.96372
PRDM8 PR domain containing 8 2.96372
RTP3 receptor (chemosensory) transporter protein 3 2.96372
OIT3 oncoprotein induced transcript 3 2.96372
SPACA5 sperm acrosome associated 5 2.96372
HMX1 H6 family homeobox 1 2.96372
HMX3 H6 family homeobox 3 2.96372
MYOZ2 myozenin 2 2.96372
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.96372
PRDM13 PR domain containing 13 2.96372
KIAA1755 KIAA1755 2.96372
BHMT2 betaine--homocysteine S-methyltransferase 2 2.96372
MMRN1 multimerin 1 2.96372
PCDHB1 protocadherin beta 1 2.96372
TEX13B testis expressed 13B 2.96372
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.96372
KL klotho 2.96372
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.96372
TMCO2 transmembrane and coiled-coil domains 2 2.96372
TTR transthyretin 2.96372
FOXC1 forkhead box C1 2.96372
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.96372
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.96372
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.96372
DEFB108B defensin, beta 108B 2.96372
CCDC9B coiled-coil domain containing 9B 2.96372
CGB3 chorionic gonadotropin subunit beta 3 2.96372
NFILZ NFIL3 like basic leucine zipper 2.96372
MYMK myomaker, myoblast fusion factor 2.96372
SPATA31G1 SPATA31 subfamily G member 1 2.96372
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.96372
ADIG adipogenin 2.96372
PGLYRP2 peptidoglycan recognition protein 2 2.96372
SPATA31A6 SPATA31 subfamily A, member 6 2.96372
CARD16 caspase recruitment domain family, member 16 2.96372
ASB15 ankyrin repeat and SOCS box containing 15 2.96372
NKAPL NFKB activating protein-like 2.96372
SLFN11 schlafen family member 11 2.96372
GPR4 G protein-coupled receptor 4 2.96372
PDILT protein disulfide isomerase-like, testis expressed 2.96372
OR5H2 olfactory receptor, family 5, subfamily H, member 2 2.96372
GGT5 gamma-glutamyltransferase 5 2.96372
MAGEB3 melanoma antigen family B3 2.96372
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.96372
AMHR2 anti-Mullerian hormone receptor, type II 2.96372
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.96372
RNF113B ring finger protein 113B 2.96372
ZNF257 zinc finger protein 257 2.96372
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.96372
LOC124905976 uncharacterized LOC124905976 2.96372
ICAM2 intercellular adhesion molecule 2 2.96372
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.96372
ENDOU endonuclease, polyU-specific 2.96372
SIRPD signal-regulatory protein delta 2.96372
CABP7 calcium binding protein 7 2.96372
CABP5 calcium binding protein 5 2.96372
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.96372
HGFAC HGF activator 2.96372
RETN resistin 2.96372
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.96372
WDFY4 WDFY family member 4 2.96372
C9ORF57 chromosome 9 open reading frame 57 2.96372
TAGAP T-cell activation RhoGTPase activating protein 2.96372
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.96372
AQP8 aquaporin 8 2.96372
OR2V2 olfactory receptor, family 2, subfamily V, member 2 2.96372
SPATA4 spermatogenesis associated 4 2.96372
TMEM207 transmembrane protein 207 2.96372
COX7B2 cytochrome c oxidase subunit VIIb2 2.96372
DNTT DNA nucleotidylexotransferase 2.96372
TAS2R50 taste receptor, type 2, member 50 2.96372
CHI3L2 chitinase 3-like 2 2.96372
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 2.96372
DHH desert hedgehog 2.96372
FBXO47 F-box protein 47 2.96372
SMIM23 small integral membrane protein 23 2.96372
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.96372
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.96372
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 2.96372
PSG3 pregnancy specific beta-1-glycoprotein 3 2.96372
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.96372
TEX38 testis expressed 38 2.96372
TGM4 transglutaminase 4 2.96372
TAS2R46 taste receptor, type 2, member 46 2.96372
KCNK18 potassium channel, two pore domain subfamily K, member 18 2.96372
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.96372
HOXA11 homeobox A11 2.96372
NLRP6 NLR family, pyrin domain containing 6 2.96372
C5ORF46 chromosome 5 open reading frame 46 2.96372
TRIML1 tripartite motif family-like 1 2.96372
FKBP1C FK506 binding protein 1C 2.96372
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.96372
POTEC POTE ankyrin domain family, member C 2.96372
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like 2.96372
TICAM1 toll-like receptor adaptor molecule 1 2.96372
PURB purine-rich element binding protein B 2.95962
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 2.95844
ZFAND3 zinc finger, AN1-type domain 3 2.93857
HAP1 huntingtin-associated protein 1 2.93218
CNTN6 contactin 6 2.92969
PIKFYVE phosphoinositide kinase, FYVE finger containing 2.90803
LIAT1 ligand of ATE1 2.90004
SLC25A44 solute carrier family 25, member 44 2.82629
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.70667
CCNK cyclin K 2.68394
VBP1 von Hippel-Lindau binding protein 1 2.60402
VIPR2 vasoactive intestinal peptide receptor 2 2.592
NPNT nephronectin 2.57123
SOX5 SRY (sex determining region Y)-box 5 2.54958
FANCF Fanconi anemia, complementation group F 2.52361
UPP1 uridine phosphorylase 1 2.51952
GALC galactosylceramidase 2.51478
CMTR1 cap methyltransferase 1 2.49547
PBK PDZ binding kinase 2.48958
EFCAB10 EF-hand calcium binding domain 10 2.4244
CIAO1 cytosolic iron-sulfur assembly component 1 2.4176
FASTKD5 FAST kinase domains 5 2.39532
TLR5 toll-like receptor 5 2.39532
GPSM1 G-protein signaling modulator 1 2.39506
ADAT3 adenosine deaminase, tRNA-specific 3 2.31731
SPIN3 spindlin family, member 3 2.31731
GOLGA6D golgin A6 family, member D 2.31731
CAMLG calcium modulating ligand 2.29554
DEFB134 defensin, beta 134 2.26382
TJAP1 tight junction associated protein 1 (peripheral) 2.24104
LRRC71 leucine rich repeat containing 71 2.24027
ERICH6B glutamate-rich 6B 2.23871
COLEC10 collectin sub-family member 10 (C-type lectin) 2.23871
MARCKS myristoylated alanine-rich protein kinase C substrate 2.23357
KIF3C kinesin family member 3C 2.2293
TMSB4X thymosin beta 4, X-linked 2.21249
MED1 mediator complex subunit 1 2.20988
AKAP8L A kinase (PRKA) anchor protein 8-like 2.19474
GDF11 growth differentiation factor 11 2.19231
OXSR1 oxidative stress responsive 1 2.19231
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 2.1898
MICB MHC class I polypeptide-related sequence B 2.1834
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.16268
GRK7 G protein-coupled receptor kinase 7 2.15684
LRRC26 leucine rich repeat containing 26 2.15684
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 2.13361
XAB2 XPA binding protein 2 2.13016
MRTFB myocardin related transcription factor B 2.10495
EPX eosinophil peroxidase 2.10495
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.10495
C22ORF42 chromosome 22 open reading frame 42 2.10495
DNAAF6 dynein axonemal assembly factor 6 2.10495
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.10218
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.07503
MRS2 MRS2 magnesium transporter 2.07079
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.06223
MORC3 MORC family CW-type zinc finger 3 2.06007
RLIM ring finger protein, LIM domain interacting 2.06007
CYRIA CYFIP related Rac1 interactor A 2.0483
PDE7A phosphodiesterase 7A 2.04623
MDC1 mediator of DNA-damage checkpoint 1 2.04623
SERTAD4 SERTA domain containing 4 2.0359
TTC27 tetratricopeptide repeat domain 27 2.03577
OVOL1 ovo-like zinc finger 1 2.03489
FN1 fibronectin 1 2.03407
FNIP1 folliculin interacting protein 1 2.03339
NGLY1 N-glycanase 1 2.02958
JPH4 junctophilin 4 2.01586
MEGF6 multiple EGF-like-domains 6 2.01524
EXOC1 exocyst complex component 1 2.00721

decreased expression

Symbol Name Standardized Value
TMC2 transmembrane channel-like 2 -2.98663
INSYN1 inhibitory synaptic factor 1 -2.98663
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -2.98663
TRAF3IP3 TRAF3 interacting protein 3 -2.98663
CLNK cytokine-dependent hematopoietic cell linker -2.98663
SPTBN5 spectrin, beta, non-erythrocytic 5 -2.98663
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.98663
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.98663
RHEX regulator of hemoglobinization and erythroid cell expansion -2.98663
CBLN3 cerebellin 3 precursor -2.96372
MSX1 msh homeobox 1 -2.96372
ZG16B zymogen granule protein 16B -2.96372
SCRT2 scratch family zinc finger 2 -2.96372
TEX101 testis expressed 101 -2.96372
SMYD1 SET and MYND domain containing 1 -2.96372
VTN vitronectin -2.96372
CALML6 calmodulin-like 6 -2.96372
STMND1 stathmin domain containing 1 -2.96372
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -2.96372
ADAM21 ADAM metallopeptidase domain 21 -2.96372
PGM5 phosphoglucomutase 5 -2.96372
NEUROD2 neuronal differentiation 2 -2.96372
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) -2.96372
VCX3A variable charge, X-linked 3A -2.96372
TRADD TNFRSF1A-associated via death domain -2.96372
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -2.96372
FAM151A family with sequence similarity 151, member A -2.96372
MEPE matrix extracellular phosphoglycoprotein -2.96372
DLX3 distal-less homeobox 3 -2.96372
DRP2 dystrophin related protein 2 -2.96372
HAO2 hydroxyacid oxidase 2 (long chain) -2.96372
ASB9 ankyrin repeat and SOCS box containing 9 -2.96372
GBX1 gastrulation brain homeobox 1 -2.96372
FAM240A family with sequence similarity 240 member A -2.96372
APOC2 apolipoprotein C-II -2.96372
GOLGA8T golgin A8 family, member T -2.96372
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2.96372
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 -2.96372
NLN neurolysin (metallopeptidase M3 family) -2.90261
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.87957
C21ORF91 chromosome 21 open reading frame 91 -2.87957
CLPSL2 colipase-like 2 -2.84871
ZNRD2 zinc ribbon domain containing 2 -2.83321
NPHP1 nephronophthisis 1 (juvenile) -2.73508
SLC35H1 solute carrier family 35 member H1 -2.72404
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.70895
IKZF2 IKAROS family zinc finger 2 (Helios) -2.6467
DOCK10 dedicator of cytokinesis 10 -2.63879
ZNF846 zinc finger protein 846 -2.61374
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.60621
SSPN sarcospan -2.60402
RASA4B RAS p21 protein activator 4B -2.56129
DPH5 diphthamide biosynthesis 5 -2.48634
GOLGA4 golgin A4 -2.47253
KHDC1 KH homology domain containing 1 -2.4622
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.42248
PAPPA2 pappalysin 2 -2.37844
MYO1C myosin IC -2.35723
GORASP2 golgi reassembly stacking protein 2, 55kDa -2.33667
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -2.31917
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.31731
TCL1B T-cell leukemia/lymphoma 1B -2.27138
ZIC3 Zic family member 3 -2.26219
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 -2.24357
ADAP1 ArfGAP with dual PH domains 1 -2.24072
ZAR1L zygote arrest 1-like -2.24072
CCDC92 coiled-coil domain containing 92 -2.23871
DENND4A DENN/MADD domain containing 4A -2.23871
TREH trehalase (brush-border membrane glycoprotein) -2.23871
JUNB jun B proto-oncogene -2.23052
CRACDL CRACD like -2.23008
MCF2 MCF.2 cell line derived transforming sequence -2.20626
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.18682
CALCRL calcitonin receptor-like -2.1834
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.1834
RAD9B RAD9 homolog B (S. pombe) -2.1834
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -2.1834
ATXN2L ataxin 2-like -2.16601
CNOT8 CCR4-NOT transcription complex, subunit 8 -2.16268
RB1CC1 RB1-inducible coiled-coil 1 -2.16268
CDHR2 cadherin-related family member 2 -2.1409
RNF167 ring finger protein 167 -2.1409
ELOF1 elongation factor 1 homolog (S. cerevisiae) -2.13003
REPS1 RALBP1 associated Eps domain containing 1 -2.10737
GDI2 GDP dissociation inhibitor 2 -2.10218
HSPG2 heparan sulfate proteoglycan 2 -2.09153
SRRM4 serine/arginine repetitive matrix 4 -2.09153
CGREF1 cell growth regulator with EF-hand domain 1 -2.07449
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.07086
TRAF5 TNF receptor-associated factor 5 -2.06223
EDNRA endothelin receptor type A -2.0553
CA8 carbonic anhydrase VIII -2.04623
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.04623
IMP3 IMP3, U3 small nucleolar ribonucleoprotein -2.04435
EEF1G eukaryotic translation elongation factor 1 gamma -2.03532
CLSTN3 calsyntenin 3 -2.03532
INMT indolethylamine N-methyltransferase -2.03489
CNPY4 canopy FGF signaling regulator 4 -2.02958
ZNF154 zinc finger protein 154 -2.01524
VMO1 vitelline membrane outer layer 1 homolog (chicken) -2.01524
UBL4A ubiquitin-like 4A -2.01524
LMNTD1 lamin tail domain containing 1 -2.01524
METTL16 methyltransferase like 16 -2.01524
PLB1 phospholipase B1 -2.01524
TBX6 T-box 6 -2.01524
SRF serum response factor (c-fos serum response element-binding transcription factor) -2.01127
CASD1 CAS1 domain containing 1 -2.00562
NKX1-2 NK1 homeobox 2 -2.00562
ZBTB37 zinc finger and BTB domain containing 37 -2.00318