EPOR Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description erythropoietin receptor|This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 2057)
External Link http://www.ncbi.nlm.nih.gov/gene/2057
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Genes

57 interacting proteins for EPOR from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATXN2L ataxin 2-like
BTK Bruton agammaglobulinemia tyrosine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CISH cytokine inducible SH2-containing protein
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
EPO erythropoietin
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRAP GRB2-related adaptor protein
GRB2 growth factor receptor-bound protein 2
IL3RA interleukin 3 receptor, alpha (low affinity)
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLK3 kallikrein-related peptidase 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MST1R macrophage stimulating 1 receptor
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOSIP nitric oxide synthase interacting protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRO protein tyrosine phosphatase, receptor type, O
RAP1A RAP1A, member of RAS oncogene family
SH2B2 SH2B adaptor protein 2
SH2B3 SH2B adaptor protein 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
SYP synaptophysin
TEC tec protein tyrosine kinase
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor