ERAP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description endoplasmic reticulum aminopeptidase 1|The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 51752)
Similar Terms
Downloads & Tools

Genes

365 genes differentially expressed following the ERAP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.18819
ACRBP acrosin binding protein 2.18819
SPINK9 serine peptidase inhibitor, Kazal type 9 2.18819
NRG1 neuregulin 1 2.18819
KIF19 kinesin family member 19 2.18819
MROH5 maestro heat-like repeat family member 5 2.18819
PRODH proline dehydrogenase (oxidase) 1 2.18819
NOXA1 NADPH oxidase activator 1 2.18819
VCX3B variable charge, X-linked 3B 2.18819
ITK IL2-inducible T-cell kinase 2.18819
CCDC121 coiled-coil domain containing 121 2.18819
TSKS testis-specific serine kinase substrate 2.18819
KLHL1 kelch-like family member 1 2.18819
SF1 splicing factor 1 2.18819
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.18819
ZNF804A zinc finger protein 804A 2.18819
SERF1A small EDRK-rich factor 1A (telomeric) 2.18819
C20ORF204 chromosome 20 open reading frame 204 2.18819
CA4 carbonic anhydrase IV 2.18819
LOXHD1 lipoxygenase homology domains 1 2.18819
CFH complement factor H 2.18819
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.14922
LOC102723564 uncharacterized LOC102723564 2.14922
ADAMTSL2 ADAMTS-like 2 2.14922
GPR52 G protein-coupled receptor 52 2.14922
SCG2 secretogranin II 2.14922
PROKR1 prokineticin receptor 1 2.14922
CDH4 cadherin 4, type 1, R-cadherin (retinal) 2.14922
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.14922
UCN urocortin 2.14922
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.14922
TAS2R31 taste receptor, type 2, member 31 2.14922
ZNF98 zinc finger protein 98 2.14922
TMPRSS11E transmembrane protease, serine 11E 2.14922
CD274 CD274 molecule 2.14922
CD96 CD96 molecule 2.14922
CCDC63 coiled-coil domain containing 63 2.14922
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.14922
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.14922
C3ORF22 chromosome 3 open reading frame 22 2.14922
PRPF31 pre-mRNA processing factor 31 2.14922
ANKRD34A ankyrin repeat domain 34A 2.14922
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 2.14922
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.14922
PDE7B phosphodiesterase 7B 2.14922
GPR22 G protein-coupled receptor 22 2.14922
WNK1 WNK lysine deficient protein kinase 1 2.14922
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.14922
GFAP glial fibrillary acidic protein 2.14922
LRG1 leucine-rich alpha-2-glycoprotein 1 2.14922
KMT2C lysine (K)-specific methyltransferase 2C 2.14922
SLC30A7 solute carrier family 30 (zinc transporter), member 7 2.14922
OPRL1 opiate receptor-like 1 2.14922
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.14922
SCN2A sodium channel, voltage gated, type II alpha subunit 2.14922
PDCD2L programmed cell death 2-like 2.14922
ZNF467 zinc finger protein 467 2.14922
TNK1 tyrosine kinase, non-receptor, 1 2.14922
CNTNAP2 contactin associated protein-like 2 2.14922
OSGIN1 oxidative stress induced growth inhibitor 1 2.14922
SLC9C2 solute carrier family 9, member C2 (putative) 2.14922
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.14922
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.14922
TLX3 T-cell leukemia homeobox 3 2.14922
TSGA10IP testis specific, 10 interacting protein 2.14922
BORCS8 BLOC-1 related complex subunit 8 2.14922
STYXL2 serine/threonine/tyrosine interacting like 2 2.14922
NECTIN4 nectin cell adhesion molecule 4 2.14922
PHF24 PHD finger protein 24 2.14922
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.14922
ARX aristaless related homeobox 2.14922
YPEL4 yippee-like 4 (Drosophila) 2.14922
GPX5 glutathione peroxidase 5 2.14922
SPATA31C1 SPATA31 subfamily C, member 1 2.14922
PROX2 prospero homeobox 2 2.14922
TMEM40 transmembrane protein 40 2.14922
CBARP CACN subunit beta associated regulatory protein 2.14922
MYOCOS myocilin opposite strand 2.14922
CATSPERH catsper channel auxiliary subunit eta 2.14922
CIMIP2C ciliary microtubule inner protein 2C 2.14922
SPEGNB SPEG neighbor 2.14922
CIMAP1C ciliary microtubule associated protein 1C 2.14922
ZNF593OS ZNF593 opposite strand 2.14922
H2BC12L H2B clustered histone 12 like 2.14922
IHO1 interactor of HORMAD1 1 2.14922
CCDC197 coiled-coil domain containing 197 2.14922
CFAP141 cilia and flagella associated protein 141 2.14922
DNAAF8 dynein axonemal assembly factor 8 2.14922
GK3 glycerol kinase 3 2.14922
BDKRB1 bradykinin receptor B1 2.14922
GCSAM germinal center-associated, signaling and motility 2.14922
ULBP3 UL16 binding protein 3 2.14922
CATSPERD catsper channel auxiliary subunit delta 2.14922
MEOX2 mesenchyme homeobox 2 2.14922
GOLGA6L4 golgin A6 family-like 4 2.14922
SCN10A sodium channel, voltage gated, type X alpha subunit 2.14922
IL31RA interleukin 31 receptor A 2.14922
LRP10 low density lipoprotein receptor-related protein 10 2.14922
TMEM179 transmembrane protein 179 2.14922
C5ORF58 chromosome 5 open reading frame 58 2.14922
PCDHB11 protocadherin beta 11 2.14922
PCDHA5 protocadherin alpha 5 2.14922
HAP1 huntingtin-associated protein 1 2.14922
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.14922
GATA3 GATA binding protein 3 2.14922
RNF183 ring finger protein 183 2.14922
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.14922
COX8C cytochrome c oxidase subunit VIIIC 2.14922
LGSN lengsin, lens protein with glutamine synthetase domain 2.14922
PHTF1 putative homeodomain transcription factor 1 2.14922
LRRC71 leucine rich repeat containing 71 2.14922
STARD6 StAR-related lipid transfer (START) domain containing 6 2.14922
RBM46 RNA binding motif protein 46 2.14922
ORC2 origin recognition complex, subunit 2 2.14922
MYOT myotilin 2.14922
ISM2 isthmin 2 2.14922
TMEM187 transmembrane protein 187 2.14922
ERICH6B glutamate-rich 6B 2.14922
WFDC1 WAP four-disulfide core domain 1 2.14922
PINK1 PTEN induced putative kinase 1 2.14922
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 2.14922
EMP1 epithelial membrane protein 1 2.14922
SHISA8 shisa family member 8 2.14922
MUC17 mucin 17, cell surface associated 2.14922
VWA3A von Willebrand factor A domain containing 3A 2.14922
KISS1 KiSS-1 metastasis-suppressor 2.14922
HOPX HOP homeobox 2.14922
BPIFB1 BPI fold containing family B, member 1 2.14922
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.14922
GCOM1 GRINL1A complex locus 1 2.14922
ESAM endothelial cell adhesion molecule 2.14922
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.14922
RBMXL1 RNA binding motif protein, X-linked-like 1 2.14922
RGS11 regulator of G-protein signaling 11 2.14922
DNAH10 dynein, axonemal, heavy chain 10 2.14922
OPRK1 opioid receptor, kappa 1 2.14922
UBQLN3 ubiquilin 3 2.14922
C11ORF96 chromosome 11 open reading frame 96 2.14922
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.14922
CTAGE9 CTAGE family, member 9 2.14922
ALS2CL ALS2 C-terminal like 2.14922
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.14922
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.14922
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.14922
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.14922
MEIS2 Meis homeobox 2 2.14922
IL26 interleukin 26 2.14922
PLA2G5 phospholipase A2, group V 2.14922
TEX29 testis expressed 29 2.14922
ZPBP zona pellucida binding protein 2.14922
ZNF835 zinc finger protein 835 2.14922
TMEM163 transmembrane protein 163 2.14922
BHLHA15 basic helix-loop-helix family, member a15 2.14922
NMBR neuromedin B receptor 2.14922
TCAP titin-cap 2.14922
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.14922
RGS8 regulator of G-protein signaling 8 2.14922
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.14922
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.14922
EPHA3 EPH receptor A3 2.14922
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.14922
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.14922
SIGLEC11 sialic acid binding Ig-like lectin 11 2.14922
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.14922
USP6NL USP6 N-terminal like 2.14922
IP6K3 inositol hexakisphosphate kinase 3 2.14922
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.14922
NPAS4 neuronal PAS domain protein 4 2.14922
HMX1 H6 family homeobox 1 2.14922
CD8B CD8b molecule 2.14922
DUOXA1 dual oxidase maturation factor 1 2.14922
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.14922
TGM6 transglutaminase 6 2.14922
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.14922
ARGFX arginine-fifty homeobox 2.14922
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.14922
FRMPD2 FERM and PDZ domain containing 2 2.14922
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.14922
TPH1 tryptophan hydroxylase 1 2.14922
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.14922
ABRA actin binding Rho activating protein 2.14922
OTX1 orthodenticle homeobox 1 2.14922
CDCP2 CUB domain containing protein 2 2.14922
HORMAD1 HORMA domain containing 1 2.14922
LOXL4 lysyl oxidase-like 4 2.14922
ZBED1 zinc finger, BED-type containing 1 2.14922
EPN3 epsin 3 2.14922
AGR2 anterior gradient 2 2.14922
USP54 ubiquitin specific peptidase 54 2.14922
NTSR1 neurotensin receptor 1 (high affinity) 2.14922
CD164L2 CD164 sialomucin-like 2 2.14922
KIAA0930 KIAA0930 2.14922
OC90 otoconin 90 2.14922
PGM5 phosphoglucomutase 5 2.14922
ABHD3 abhydrolase domain containing 3 2.14922
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.14922
APOL3 apolipoprotein L, 3 2.14922
DPYSL3 dihydropyrimidinase-like 3 2.14922
MT1M metallothionein 1M 2.14922
CARNS1 carnosine synthase 1 2.14922
CARD9 caspase recruitment domain family, member 9 2.14922
MMP28 matrix metallopeptidase 28 2.14922
LPAR5 lysophosphatidic acid receptor 5 2.14922
STOML1 stomatin (EPB72)-like 1 2.14922
ZFAT zinc finger and AT hook domain containing 2.14716
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.13749
HMOX2 heme oxygenase 2 2.13612
CCNL2 cyclin L2 2.12722
FBXL19 F-box and leucine-rich repeat protein 19 2.12226
ORC1 origin recognition complex, subunit 1 2.12226
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.11135
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.10451
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.09833
SPG11 spastic paraplegia 11 (autosomal recessive) 2.09749
UTRN utrophin 2.09749
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.09552
MBD5 methyl-CpG binding domain protein 5 2.09263
STAG2 stromal antigen 2 2.08338
UNC13B unc-13 homolog B (C. elegans) 2.08226
ANKRD61 ankyrin repeat domain 61 2.06624
BASP1 brain abundant, membrane attached signal protein 1 2.06348
ZNF319 zinc finger protein 319 2.05756
HBEGF heparin-binding EGF-like growth factor 2.05756
CCDC9 coiled-coil domain containing 9 2.05433
PDE4DIP phosphodiesterase 4D interacting protein 2.04218
PUSL1 pseudouridylate synthase-like 1 2.04218
C21ORF58 chromosome 21 open reading frame 58 2.04218
SDHAF2 succinate dehydrogenase complex assembly factor 2 2.04218
SLC39A3 solute carrier family 39 (zinc transporter), member 3 2.04218
DTX3L deltex 3 like, E3 ubiquitin ligase 2.04218
FANCI Fanconi anemia, complementation group I 2.04218
GLE1 GLE1 RNA export mediator 2.04218
CENPN centromere protein N 2.04218
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) 2.04218
ANKRD10 ankyrin repeat domain 10 2.0417
NOCT nocturnin 2.01338

decreased expression

Symbol Name Standardized Value
ZNF287 zinc finger protein 287 -2.18819
AVPI1 arginine vasopressin-induced 1 -2.18819
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.18819
MRPS10 mitochondrial ribosomal protein S10 -2.18819
ZNF599 zinc finger protein 599 -2.18819
SNAI1 snail family zinc finger 1 -2.18819
KLHDC8B kelch domain containing 8B -2.18819
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.18819
PARP14 poly (ADP-ribose) polymerase family, member 14 -2.18819
SHCBP1 SHC SH2-domain binding protein 1 -2.18819
CCDC167 coiled-coil domain containing 167 -2.17596
CCDC172 coiled-coil domain containing 172 -2.17001
ADAMTSL3 ADAMTS-like 3 -2.14922
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -2.14922
HAS2 hyaluronan synthase 2 -2.14922
CLPSL2 colipase-like 2 -2.14922
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.14922
PCDHB3 protocadherin beta 3 -2.14922
ZNF311 zinc finger protein 311 -2.14922
KIF15 kinesin family member 15 -2.14922
ZNF791 zinc finger protein 791 -2.14922
WDR24 WD repeat domain 24 -2.14922
CCDC39 coiled-coil domain containing 39 -2.14922
ZNF799 zinc finger protein 799 -2.14922
MORN2 MORN repeat containing 2 -2.14922
GOLIM4 golgi integral membrane protein 4 -2.14922
SPAG1 sperm associated antigen 1 -2.14922
MDFI MyoD family inhibitor -2.14922
IL17RD interleukin 17 receptor D -2.14922
DCP1A decapping mRNA 1A -2.14922
TPST1 tyrosylprotein sulfotransferase 1 -2.14922
SGK2 serum/glucocorticoid regulated kinase 2 -2.14922
ZNF615 zinc finger protein 615 -2.14922
SRSF5 serine/arginine-rich splicing factor 5 -2.14922
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.14922
GLT8D2 glycosyltransferase 8 domain containing 2 -2.14922
C10ORF88 chromosome 10 open reading frame 88 -2.14922
S100A4 S100 calcium binding protein A4 -2.14922
KNL1 kinetochore scaffold 1 -2.14922
FIZ1 FLT3-interacting zinc finger 1 -2.14922
DNAL1 dynein, axonemal, light chain 1 -2.14922
ZMYM3 zinc finger, MYM-type 3 -2.14922
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.14922
TEX261 testis expressed 261 -2.14922
MFSD1 major facilitator superfamily domain containing 1 -2.14922
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.14922
IL15 interleukin 15 -2.14922
PCBP1 poly(rC) binding protein 1 -2.14922
GDF11 growth differentiation factor 11 -2.14922
WDR5 WD repeat domain 5 -2.14922
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.14922
EXTL3 exostosin-like glycosyltransferase 3 -2.14922
GBA2 glucosidase, beta (bile acid) 2 -2.14716
CAPZB capping protein (actin filament) muscle Z-line, beta -2.13718
ZNF473 zinc finger protein 473 -2.13612
HYLS1 hydrolethalus syndrome 1 -2.13612
COASY CoA synthase -2.13603
SAAL1 serum amyloid A-like 1 -2.13184
SZT2 seizure threshold 2 homolog (mouse) -2.12239
PEX13 peroxisomal biogenesis factor 13 -2.12226
DDB2 damage-specific DNA binding protein 2, 48kDa -2.12226
SMIM26 small integral membrane protein 26 -2.12226
KLHL7 kelch-like family member 7 -2.11645
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -2.11645
CSMD2 CUB and Sushi multiple domains 2 -2.11135
REV1 REV1, polymerase (DNA directed) -2.09749
GPR137 G protein-coupled receptor 137 -2.09263
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.08521
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.08338
ARC activity-regulated cytoskeleton-associated protein -2.08338
MYO6 myosin VI -2.08338
ZC3H11A zinc finger CCCH-type containing 11A -2.08338
FSD2 fibronectin type III and SPRY domain containing 2 -2.08338
PRLR prolactin receptor -2.08338
VMAC vimentin-type intermediate filament associated coiled-coil protein -2.08338
FES FES proto-oncogene, tyrosine kinase -2.08338
PLAC1 placenta-specific 1 -2.08338
PROM2 prominin 2 -2.08338
ARL9 ADP-ribosylation factor-like 9 -2.08338
ZNF112 zinc finger protein 112 -2.08338
TMEM97 transmembrane protein 97 -2.08015
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -2.07818
C1QL1 complement component 1, q subcomponent-like 1 -2.05433
GPSM1 G-protein signaling modulator 1 -2.05433
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.05433
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -2.04558
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.04218
GAS2 growth arrest-specific 2 -2.04218
ACTA1 actin, alpha 1, skeletal muscle -2.04218
C1QTNF12 C1q and TNF related 12 -2.04218
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.04218
PRRT1 proline-rich transmembrane protein 1 -2.04218
USP18 ubiquitin specific peptidase 18 -2.04218
SP140L SP140 nuclear body protein-like -2.04218
FKBPL FK506 binding protein like -2.04218
ADCY10 adenylate cyclase 10 (soluble) -2.04218
TMEM253 transmembrane protein 253 -2.04218
LEKR1 leucine, glutamate and lysine rich 1 -2.04218
GNMT glycine N-methyltransferase -2.04218
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.04218
CISH cytokine inducible SH2-containing protein -2.04218
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.04218
FAM43B family with sequence similarity 43, member B -2.04218
ZFP28 ZFP28 zinc finger protein -2.04218
TPPP tubulin polymerization promoting protein -2.04218
PAX5 paired box 5 -2.04218
TSHZ1 teashirt zinc finger homeobox 1 -2.04218
RPP38 ribonuclease P/MRP 38kDa subunit -2.04218
ZNF711 zinc finger protein 711 -2.04218
LGALS9 lectin, galactoside-binding, soluble, 9 -2.04218
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.04218
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.04218
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.04218
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.04218
NME5 NME/NM23 family member 5 -2.04218
STAG1 stromal antigen 1 -2.04218
CERCAM cerebral endothelial cell adhesion molecule -2.04218
FNDC8 fibronectin type III domain containing 8 -2.04218
C19ORF73 chromosome 19 open reading frame 73 -2.04218
ELF4 E74-like factor 4 (ets domain transcription factor) -2.04218
BAIAP3 BAI1-associated protein 3 -2.04218
SACK1A scaffolding CK1 anchoring protein A -2.04218
CRIP1 cysteine-rich protein 1 (intestinal) -2.04218
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.03618
BRD2 bromodomain containing 2 -2.0307
TOM1L2 target of myb1-like 2 (chicken) -2.02658
HPS1 Hermansky-Pudlak syndrome 1 -2.02562
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.02518
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.00624