ERB2_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/ERB2_UP.V1_UP
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Genes

388 genes differentially expressed following the ERB2_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACHE acetylcholinesterase (Yt blood group)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANKMY2 ankyrin repeat and MYND domain containing 2
ANXA6 annexin A6
APH1B APH1B gamma secretase subunit
APLP1 amyloid beta (A4) precursor-like protein 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPH aspartate beta-hydroxylase
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATXN1 ataxin 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BACE2 beta-site APP-cleaving enzyme 2
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BMPR1B bone morphogenetic protein receptor, type IB
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA8 carbonic anhydrase VIII
CADPS2 Ca++-dependent secretion activator 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CAPN5 calpain 5
CAST calpastatin
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLMN calmin (calponin-like, transmembrane)
CNOT8 CCR4-NOT transcription complex, subunit 8
CREB3L2 cAMP responsive element binding protein 3-like 2
CRLF1 cytokine receptor-like factor 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOCK10 dedicator of cytokinesis 10
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FAM174B family with sequence similarity 174, member B
FAM46C family with sequence similarity 46, member C
FER1L4 fer-1-like family member 4, pseudogene (functional)
FGF13 fibroblast growth factor 13
FGFR4 fibroblast growth factor receptor 4
FMO5 flavin containing monooxygenase 5
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAMT guanidinoacetate N-methyltransferase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GDF15 growth differentiation factor 15
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRAMD3 GRAM domain containing 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IL1R1 interleukin 1 receptor, type I
ITGB4 integrin, beta 4
ITGB6 integrin, beta 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0513 KIAA0513
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LAMB2 laminin, beta 2 (laminin S)
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL1 lysyl oxidase-like 1
LRP5 low density lipoprotein receptor-related protein 5
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
MAPRE3 microtubule-associated protein, RP/EB family, member 3
METRN meteorin, glial cell differentiation regulator
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIA3 melanoma inhibitory activity family, member 3
MPI mannose phosphate isomerase
MPZL2 myelin protein zero-like 2
MSX2 msh homeobox 2
MUC1 mucin 1, cell surface associated
MUC3B mucin 3B, cell surface associated
MVD mevalonate (diphospho) decarboxylase
MXRA7 matrix-remodelling associated 7
MYO1D myosin ID
NDRG1 N-myc downstream regulated 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNT nicotinamide nucleotide transhydrogenase
NOTCH3 notch 3
NPC2 Niemann-Pick disease, type C2
OPN3 opsin 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PACS1 phosphofurin acidic cluster sorting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH1 protocadherin 1
PCDH8 protocadherin 8
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PGPEP1 pyroglutamyl-peptidase I
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTMS parathymosin
PTOV1 prostate tumor overexpressed 1
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRU protein tyrosine phosphatase, receptor type, U
RAB5C RAB5C, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRAGD Ras-related GTP binding D
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP4 secretory carrier membrane protein 4
SCCPDH saccharopine dehydrogenase (putative)
SDCBP syndecan binding protein (syntenin)
SEPT10 septin 10
SERHL serine hydrolase-like (pseudogene)
SERHL2 serine hydrolase-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPTBN2 spectrin, beta, non-erythrocytic 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
THEM6 thioesterase superfamily member 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TPK1 thiamin pyrophosphokinase 1
TSPAN1 tetraspanin 1
TTC9 tetratricopeptide repeat domain 9
ULBP2 UL16 binding protein 2
UPK1A uroplakin 1A
UPK2 uroplakin 2
UPK3B uroplakin 3B
UROS uroporphyrinogen III synthase
VASP vasodilator-stimulated phosphoprotein
VEGFB vascular endothelial growth factor B
VIPR1 vasoactive intestinal peptide receptor 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA1 von Willebrand factor A domain containing 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF365 zinc finger protein 365
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABLIM1 actin binding LIM protein 1
ACTR6 ARP6 actin-related protein 6 homolog (yeast)
ADAM9 ADAM metallopeptidase domain 9
ADD3 adducin 3 (gamma)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD12 ankyrin repeat domain 12
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX5 armadillo repeat containing, X-linked 5
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATR ATR serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BRWD1 bromodomain and WD repeat domain containing 1
BST2 bone marrow stromal cell antigen 2
BTG3 BTG family, member 3
C16ORF45 chromosome 16 open reading frame 45
C18ORF8 chromosome 18 open reading frame 8
C1ORF109 chromosome 1 open reading frame 109
C2CD5 C2 calcium-dependent domain containing 5
C9ORF3 chromosome 9 open reading frame 3
CALB2 calbindin 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBR4 carbonyl reductase 4
CCDC59 coiled-coil domain containing 59
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPE centromere protein E, 312kDa
CETN3 centrin, EF-hand protein, 3
CHD1 chromodomain helicase DNA binding protein 1
CLIC3 chloride intracellular channel 3
COL9A3 collagen, type IX, alpha 3
CPOX coproporphyrinogen oxidase
CUL5 cullin 5
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEPDC1 DEP domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EGR3 early growth response 3
EHBP1 EH domain binding protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMC2 ER membrane protein complex subunit 2
ERI2 ERI1 exoribonuclease family member 2
FAM216A family with sequence similarity 216, member A
FASTKD1 FAST kinase domains 1
FBXO5 F-box protein 5
FHL2 four and a half LIM domains 2
FKTN fukutin
FLNB filamin B, beta
FOLR1 folate receptor 1 (adult)
GFRA1 GDNF family receptor alpha 1
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GOLGA4 golgin A4
GOLGA8A golgin A8 family, member A
GPER1 G protein-coupled estrogen receptor 1
GREB1 growth regulation by estrogen in breast cancer 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAUS3 HAUS augmin-like complex, subunit 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IAPP islet amyloid polypeptide
ICE1 interactor of little elongation complex ELL subunit 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFT57 intraflagellar transport 57
IGF1R insulin-like growth factor 1 receptor
INPP5F inositol polyphosphate-5-phosphatase F
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
JAK2 Janus kinase 2
KANK1 KN motif and ankyrin repeat domains 1
KCTD3 potassium channel tetramerization domain containing 3
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
LAMB1 laminin, beta 1
LIN7C lin-7 homolog C (C. elegans)
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTN1 listerin E3 ubiquitin protein ligase 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MED17 mediator complex subunit 17
MGP matrix Gla protein
MPDZ multiple PDZ domain protein
MRPL19 mitochondrial ribosomal protein L19
MSH2 mutS homolog 2
MSMB microseminoprotein, beta-
MTCL1 microtubule crosslinking factor 1
MTERF3 mitochondrial transcription termination factor 3
MTIF2 mitochondrial translational initiation factor 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPG non-SMC condensin I complex, subunit G
NMRK1 nicotinamide riboside kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL8 nucleolar protein 8
NPEPPS aminopeptidase puromycin sensitive
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PAK1IP1 PAK1 interacting protein 1
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PLA2G12A phospholipase A2, group XIIA
PLK4 polo-like kinase 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLI polymerase (DNA directed) iota
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRMT3 protein arginine methyltransferase 3
PSPH phosphoserine phosphatase
PTBP2 polypyrimidine tract binding protein 2
PUS1 pseudouridylate synthase 1
RAB31 RAB31, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RANBP6 RAN binding protein 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBBP8 retinoblastoma binding protein 8
RECQL RecQ helicase-like
RHOBTB3 Rho-related BTB domain containing 3
RIF1 replication timing regulatory factor 1
RMI1 RecQ mediated genome instability 1
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPAP3 RNA polymerase II associated protein 3
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RTCA RNA 3'-terminal phosphate cyclase
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLMO2 slowmo homolog 2 (Drosophila)
SMAD7 SMAD family member 7
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMC3 structural maintenance of chromosomes 3
SS18 synovial sarcoma translocation, chromosome 18
SSB Sjogren syndrome antigen B (autoantigen La)
SSFA2 sperm specific antigen 2
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMED5 transmembrane emp24 protein transport domain containing 5
TOPBP1 topoisomerase (DNA) II binding protein 1
TRMT61B tRNA methyltransferase 61B
TTC39A tetratricopeptide repeat domain 39A
TTK TTK protein kinase
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UBA6 ubiquitin-like modifier activating enzyme 6
USP16 ubiquitin specific peptidase 16
WDR43 WD repeat domain 43
WIPF1 WAS/WASL interacting protein family, member 1
WISP2 WNT1 inducible signaling pathway protein 2
XK X-linked Kx blood group
ZBTB10 zinc finger and BTB domain containing 10
ZBTB11 zinc finger and BTB domain containing 11
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF107 zinc finger protein 107
ZNF267 zinc finger protein 267
ZNF43 zinc finger protein 43
ZNF430 zinc finger protein 430
ZNF84 zinc finger protein 84