ERBB signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0038127)
External Link http://amigo.geneontology.org/amigo/term/GO:0038127
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Genes

59 genes participating in the ERBB signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
AREG amphiregulin
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTC betacellulin
CPNE3 copine III
CRIPTO3 cripto, EGF-CFC family member 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL5 cullin 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPGN epithelial mitogen
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERBIN erbb2 interacting protein
EREG epiregulin
GAREM1 GRB2 associated regulator of MAPK1 subtype 1
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
HBEGF heparin-binding EGF-like growth factor
HDAC6 histone deacetylase 6
IQGAP1 IQ motif containing GTPase activating protein 1
KIF16B kinesin family member 16B
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MVP major vault protein
NCK2 NCK adaptor protein 2
NRG1 neuregulin 1
NRG2 neuregulin 2
NRG3 neuregulin 3
PDPK1 3-phosphoinositide dependent protein kinase 1
PIGR polymeric immunoglobulin receptor
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRR protein tyrosine phosphatase, receptor type, R
REPS2 RALBP1 associated Eps domain containing 2
SACK1A scaffolding CK1 anchoring protein A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC30A10 solute carrier family 30, member 10
SOS1 son of sevenless homolog 1 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TGFA transforming growth factor, alpha
VIL1 villin 1