| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | erb-b2 receptor tyrosine kinase 2|This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2064) |
| External Link | https://ncbi.nlm.nih.gov/gene/2064 |
| Similar Terms | |
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500 genes differentially expressed following the ERBB2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TENT5A | terminal nucleotidyltransferase 5A | 0.00741528 |
| RTN2 | reticulon 2 | 0.0071134 |
| NRCAM | neuronal cell adhesion molecule | 0.00698791 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00641713 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.00634648 |
| MAP7 | microtubule-associated protein 7 | 0.00603892 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00602648 |
| XIC | X chromosome inactivation center | 0.00602349 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00600318 |
| NIBAN1 | niban apoptosis regulator 1 | 0.00590585 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00584842 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00578967 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00577577 |
| FHL1 | four and a half LIM domains 1 | 0.00577453 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 0.00576069 |
| TMSB15A | thymosin beta 15a | 0.00573942 |
| DNM1L | dynamin 1-like | 0.00571067 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00565422 |
| CRYAB | crystallin, alpha B | 0.00555124 |
| PTN | pleiotrophin | 0.00544506 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 0.0053883 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00537975 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00532153 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00531451 |
| CHKB | choline kinase beta | 0.00531131 |
| S100A10 | S100 calcium binding protein A10 | 0.00529352 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00520555 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00518084 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.00515484 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.00494093 |
| CPE | carboxypeptidase E | 0.00492911 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00489639 |
| IFI44L | interferon-induced protein 44-like | 0.00470058 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | 0.00469095 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00468451 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00468383 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00464301 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.00458953 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.00458574 |
| ASS1 | argininosuccinate synthase 1 | 0.00456095 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00452436 |
| CKM | creatine kinase, muscle | 0.00449263 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.00448285 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00447684 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.00444068 |
| HIST1H2BK | histone cluster 1, H2bk | 0.0044345 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00440862 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.00438252 |
| TLE4 | transducin-like enhancer of split 4 | 0.00435762 |
| SCG5 | secretogranin V | 0.00434554 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00434219 |
| NCALD | neurocalcin delta | 0.00433074 |
| RNF167 | ring finger protein 167 | 0.00431844 |
| REEP1 | receptor accessory protein 1 | 0.00431077 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00429096 |
| ITM2A | integral membrane protein 2A | 0.00426677 |
| PEG10 | paternally expressed 10 | 0.00425795 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | 0.00425778 |
| IER5 | immediate early response 5 | 0.00424762 |
| FOLR1 | folate receptor 1 (adult) | 0.0042385 |
| GOLT1B | golgi transport 1B | 0.00423832 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00421637 |
| JAK1 | Janus kinase 1 | 0.00420469 |
| ATF3 | activating transcription factor 3 | 0.00417699 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.00417286 |
| AHR | aryl hydrocarbon receptor | 0.00410092 |
| DIAPH1 | diaphanous-related formin 1 | 0.00408072 |
| HMOX1 | heme oxygenase 1 | 0.0040621 |
| REEP5 | receptor accessory protein 5 | 0.00406034 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00404082 |
| CADM1 | cell adhesion molecule 1 | 0.00401114 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0040068 |
| TCTA | T-cell leukemia translocation altered | 0.00400404 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.00400038 |
| ARF3 | ADP-ribosylation factor 3 | 0.00399447 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.00398902 |
| EGR2 | early growth response 2 | 0.00397177 |
| EPHA4 | EPH receptor A4 | 0.00394932 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00394812 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.00394809 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.003906 |
| ABHD6 | abhydrolase domain containing 6 | 0.00388077 |
| CAVIN1 | caveolae associated protein 1 | 0.0038382 |
| DACH1 | dachshund family transcription factor 1 | 0.00382769 |
| MX1 | MX dynamin-like GTPase 1 | 0.00382498 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00382341 |
| WASL | Wiskott-Aldrich syndrome-like | 0.00381106 |
| HTRA1 | HtrA serine peptidase 1 | 0.00380149 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.00380122 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.00380103 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.00379792 |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.00379458 |
| YAP1 | Yes-associated protein 1 | 0.0037635 |
| SIRPA | signal-regulatory protein alpha | 0.00375781 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.00375107 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.00373288 |
| SLN | sarcolipin | 0.00373118 |
| ABHD4 | abhydrolase domain containing 4 | 0.00372306 |
| CAV2 | caveolin 2 | 0.0037194 |
| MB | myoglobin | 0.00370364 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.00370171 |
| TTN | titin | 0.00370122 |
| TUBA4A | tubulin, alpha 4a | 0.00370028 |
| PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 | 0.00368334 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.00367714 |
| PTHLH | parathyroid hormone-like hormone | 0.00367436 |
| CST3 | cystatin C | 0.00366854 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00366577 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.00361932 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.00361641 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | 0.00360475 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.00360344 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00359809 |
| RAB32 | RAB32, member RAS oncogene family | 0.00358824 |
| MGAM | maltase-glucoamylase | 0.00358124 |
| FRMD4B | FERM domain containing 4B | 0.00357887 |
| RIN2 | Ras and Rab interactor 2 | 0.00357852 |
| CA2 | carbonic anhydrase II | 0.00357332 |
| NKX2-2 | NK2 homeobox 2 | 0.00354861 |
| PDLIM3 | PDZ and LIM domain 3 | 0.00354811 |
| NSG1 | neuron specific gene family member 1 | 0.00353932 |
| AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | 0.00353355 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.00353316 |
| LCN2 | lipocalin 2 | 0.00352967 |
| SOCS6 | suppressor of cytokine signaling 6 | 0.00352935 |
| LRP2 | low density lipoprotein receptor-related protein 2 | 0.00352752 |
| NLRP2 | NLR family, pyrin domain containing 2 | 0.00352439 |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.00349434 |
| LDB3 | LIM domain binding 3 | 0.00349271 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.00347095 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00346909 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00345977 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.00345275 |
| PMM2 | phosphomannomutase 2 | 0.00343394 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.00342779 |
| CD99 | CD99 molecule | 0.00342266 |
| BAX | BCL2-associated X protein | 0.00342167 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.00341473 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00341407 |
| PON2 | paraoxonase 2 | 0.0033906 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.0033866 |
| TNNC2 | troponin C type 2 (fast) | 0.00338178 |
| FN1 | fibronectin 1 | 0.00337827 |
| PGBD5 | piggyBac transposable element derived 5 | 0.00337666 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00336725 |
| SNAI2 | snail family zinc finger 2 | 0.00335921 |
| CALML5 | calmodulin-like 5 | 0.00334982 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00334573 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 0.00333545 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.00333202 |
| G6PD | glucose-6-phosphate dehydrogenase | 0.00332995 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 0.00332575 |
| ACTN2 | actinin, alpha 2 | 0.00330645 |
| RTL8C | retrotransposon Gag like 8C | 0.00330608 |
| CLC | Charcot-Leyden crystal galectin | 0.00330488 |
| EFNB2 | ephrin-B2 | 0.00328889 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.00328739 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00328388 |
| EFNA1 | ephrin-A1 | 0.00328329 |
| APOA1 | apolipoprotein A-I | 0.00328248 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.00326565 |
| CARD10 | caspase recruitment domain family, member 10 | 0.00326288 |
| SMPX | small muscle protein, X-linked | 0.00325928 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.00325768 |
| CYBRD1 | cytochrome b reductase 1 | 0.00324285 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00323596 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 0.00323574 |
| SORT1 | sortilin 1 | 0.00323186 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00323103 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 0.00322645 |
| INSM1 | insulinoma-associated 1 | 0.00322184 |
| REPS2 | RALBP1 associated Eps domain containing 2 | 0.00322074 |
| TBX3 | T-box 3 | 0.00321383 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.00321016 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | 0.00320331 |
| AK4 | adenylate kinase 4 | 0.00320319 |
| AMACR | alpha-methylacyl-CoA racemase | 0.00319678 |
| THBS4 | thrombospondin 4 | 0.00319463 |
| COL4A6 | collagen, type IV, alpha 6 | 0.00319437 |
| KRT14 | keratin 14, type I | 0.0031928 |
| BMP2 | bone morphogenetic protein 2 | 0.00318325 |
| LYPLA1 | lysophospholipase I | 0.00318013 |
| FAM110B | family with sequence similarity 110, member B | 0.00317512 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.00316556 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00315418 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00315126 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 0.00314462 |
| CGA | glycoprotein hormones, alpha polypeptide | 0.00314435 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.00314187 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00313996 |
| TYROBP | TYRO protein tyrosine kinase binding protein | 0.00313617 |
| FST | follistatin | 0.0031257 |
| CD69 | CD69 molecule | 0.00312386 |
| SELE | selectin E | 0.00311852 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.00311661 |
| CD52 | CD52 molecule | 0.00311379 |
| KLHL41 | kelch-like family member 41 | 0.00310567 |
| BIN1 | bridging integrator 1 | 0.00310515 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.00309866 |
| IDS | iduronate 2-sulfatase | 0.00309739 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00309723 |
| PLAU | plasminogen activator, urokinase | 0.00309351 |
| IL6R | interleukin 6 receptor | 0.00309347 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00308098 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 0.00307848 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00307558 |
| ARG1 | arginase 1 | 0.00307186 |
| KLK11 | kallikrein-related peptidase 11 | 0.00306981 |
| ITGAV | integrin, alpha V | 0.00306546 |
| CCND2 | cyclin D2 | 0.00306391 |
| TRAM1 | translocation associated membrane protein 1 | 0.00306132 |
| PON3 | paraoxonase 3 | 0.00304509 |
| DPP4 | dipeptidyl-peptidase 4 | 0.00303672 |
| ARSL | arylsulfatase L | 0.00302824 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | 0.00302417 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.00302032 |
| CHMP4A | charged multivesicular body protein 4A | 0.00302015 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00301978 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0030177 |
| MSRB1 | methionine sulfoxide reductase B1 | 0.00301484 |
| MYOZ2 | myozenin 2 | 0.0030058 |
| MYOF | myoferlin | 0.00300377 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00300349 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 0.00299891 |
| SDCBP | syndecan binding protein (syntenin) | 0.00299675 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | 0.00298891 |
| TOX | thymocyte selection-associated high mobility group box | 0.00298828 |
| DDA1 | DET1 and DDB1 associated 1 | 0.00298237 |
| CD34 | CD34 molecule | 0.00296454 |
| RYR1 | ryanodine receptor 1 (skeletal) | 0.00296203 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 0.00296152 |
| SNX7 | sorting nexin 7 | 0.00295809 |
| HOXD1 | homeobox D1 | 0.00295735 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | 0.00295651 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.00294659 |
| MYOM2 | myomesin 2 | 0.00294518 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 0.00294252 |
| DYSF | dysferlin | 0.00293005 |
| DLX2 | distal-less homeobox 2 | 0.0029268 |
| ACE2 | angiotensin I converting enzyme 2 | 0.00292453 |
| NDP | Norrie disease (pseudoglioma) | 0.00291928 |
| ORMDL2 | ORMDL sphingolipid biosynthesis regulator 2 | 0.00291382 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | 0.00291362 |
| LYST | lysosomal trafficking regulator | 0.00290877 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00290819 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.00290736 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 0.00290689 |
| INHBA | inhibin, beta A | 0.0028989 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00289859 |
| GSN | gelsolin | 0.00289636 |
| Symbol | Name | Standardized Value |
|---|---|---|
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.0064455 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00619452 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.00583311 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00576701 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.00549372 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00512239 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.00509475 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00507033 |
| NUP85 | nucleoporin 85kDa | -0.00487829 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00483283 |
| HOXB6 | homeobox B6 | -0.0047353 |
| TLK2 | tousled-like kinase 2 | -0.00471468 |
| BPIFA1 | BPI fold containing family A, member 1 | -0.00463911 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | -0.00454099 |
| CD38 | CD38 molecule | -0.00451822 |
| CA12 | carbonic anhydrase XII | -0.00446267 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00444702 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00440977 |
| CCN2 | cellular communication network factor 2 | -0.00433625 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.00432102 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00430515 |
| TBC1D16 | TBC1 domain family, member 16 | -0.00430042 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00424228 |
| MELK | maternal embryonic leucine zipper kinase | -0.0042225 |
| INSR | insulin receptor | -0.00415336 |
| LXN | latexin | -0.00411998 |
| CHPT1 | choline phosphotransferase 1 | -0.00410705 |
| RHOH | ras homolog family member H | -0.0040893 |
| TAGLN | transgelin | -0.0040788 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.0040184 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00400746 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.00399102 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.00398268 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.00392596 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.00390627 |
| LTF | lactotransferrin | -0.00389247 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.00387026 |
| KRT19 | keratin 19, type I | -0.00382946 |
| PLS1 | plastin 1 | -0.00382813 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00381937 |
| MAGEA3 | melanoma antigen family A3 | -0.00380508 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00377127 |
| FAM46C | family with sequence similarity 46, member C | -0.00376134 |
| SEH1L | SEH1-like (S. cerevisiae) | -0.00374369 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00372683 |
| PFKL | phosphofructokinase, liver | -0.00369293 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0036755 |
| MRPL58 | mitochondrial ribosomal protein L58 | -0.00362052 |
| CCDC47 | coiled-coil domain containing 47 | -0.00361756 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00360937 |
| DDHD2 | DDHD domain containing 2 | -0.00360259 |
| SYNGR2 | synaptogyrin 2 | -0.00359863 |
| PTCH1 | patched 1 | -0.00359504 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00358061 |
| NARF | nuclear prelamin A recognition factor | -0.00353541 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0035353 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.00352249 |
| PCGF2 | polycomb group ring finger 2 | -0.00352169 |
| ADORA2B | adenosine A2b receptor | -0.00351629 |
| HELLS | helicase, lymphoid-specific | -0.00346202 |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 | -0.00345562 |
| ERLIN2 | ER lipid raft associated 2 | -0.00344059 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00341796 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.00339812 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | -0.00339069 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00338479 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.00336892 |
| COPS7A | COP9 signalosome subunit 7A | -0.00336248 |
| TXNIP | thioredoxin interacting protein | -0.00335456 |
| MED22 | mediator complex subunit 22 | -0.00335254 |
| HMGB2 | high mobility group box 2 | -0.00335034 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.00333295 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | -0.00332905 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00332684 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00331592 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | -0.0033151 |
| HOXC6 | homeobox C6 | -0.00331437 |
| C3 | complement component 3 | -0.00331145 |
| PTPN2 | protein tyrosine phosphatase, non-receptor type 2 | -0.00330905 |
| CCL21 | chemokine (C-C motif) ligand 21 | -0.00330884 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00329066 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.00328437 |
| ATP6V0A4 | ATPase, H+ transporting, lysosomal V0 subunit a4 | -0.00327752 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00327443 |
| KIAA0125 | KIAA0125 | -0.00327035 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | -0.0032547 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -0.00324783 |
| CPOX | coproporphyrinogen oxidase | -0.00324402 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -0.00324324 |
| ZNF587 | zinc finger protein 587 | -0.00324169 |
| BLNK | B-cell linker | -0.00323451 |
| MZB1 | marginal zone B and B1 cell-specific protein | -0.00322872 |
| MRPS27 | mitochondrial ribosomal protein S27 | -0.00322623 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00322096 |
| WEE1 | WEE1 G2 checkpoint kinase | -0.003218 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00321188 |
| MARCO | macrophage receptor with collagenous structure | -0.00320458 |
| ZNF586 | zinc finger protein 586 | -0.00320185 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00319815 |
| CAPN1 | calpain 1, (mu/I) large subunit | -0.00319513 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.00319337 |
| FLOT2 | flotillin 2 | -0.00319225 |
| RREB1 | ras responsive element binding protein 1 | -0.00318378 |
| FASN | fatty acid synthase | -0.00317701 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00317453 |
| MED13 | mediator complex subunit 13 | -0.00317027 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -0.0031582 |
| ZNF331 | zinc finger protein 331 | -0.00315618 |
| MCOLN1 | mucolipin 1 | -0.00315535 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.00314921 |
| TMEM63A | transmembrane protein 63A | -0.00314451 |
| RPL36 | ribosomal protein L36 | -0.00313111 |
| PODXL | podocalyxin-like | -0.00312426 |
| GPRASP1 | G protein-coupled receptor associated sorting protein 1 | -0.0031184 |
| MTMR4 | myotubularin related protein 4 | -0.00311377 |
| C7 | complement component 7 | -0.00311069 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00310619 |
| TCTN2 | tectonic family member 2 | -0.00310511 |
| UPK1B | uroplakin 1B | -0.00310305 |
| FECH | ferrochelatase | -0.00309878 |
| CDC20 | cell division cycle 20 | -0.00308935 |
| POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | -0.00308022 |
| SFXN1 | sideroflexin 1 | -0.00307703 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00306066 |
| FAM3C | family with sequence similarity 3, member C | -0.00305883 |
| WDR43 | WD repeat domain 43 | -0.00305047 |
| EAF2 | ELL associated factor 2 | -0.0030502 |
| PASK | PAS domain containing serine/threonine kinase | -0.00304941 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | -0.0030484 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00304571 |
| GSE1 | Gse1 coiled-coil protein | -0.00304185 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.00303393 |
| KIF5C | kinesin family member 5C | -0.00302255 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00302048 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | -0.00300188 |
| GLTP | glycolipid transfer protein | -0.00299875 |
| RGS4 | regulator of G-protein signaling 4 | -0.00298077 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.00297044 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.00296586 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.00296285 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | -0.00295523 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0029548 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.00294564 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | -0.00294235 |
| BLVRB | biliverdin reductase B | -0.00294069 |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 | -0.00291495 |
| TFDP1 | transcription factor Dp-1 | -0.00291409 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0029083 |
| FOXK2 | forkhead box K2 | -0.00290624 |
| GGA3 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3 | -0.00290461 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.00290294 |
| MT2A | metallothionein 2A | -0.00290192 |
| AMZ2 | archaelysin family metallopeptidase 2 | -0.00289443 |
| CANT1 | calcium activated nucleotidase 1 | -0.00289429 |
| GTPBP3 | GTP binding protein 3 (mitochondrial) | -0.00289411 |
| ESR1 | estrogen receptor 1 | -0.00289196 |
| RPL36AL | ribosomal protein L36a-like | -0.00288621 |
| SFTPB | surfactant protein B | -0.00288512 |
| TBCD | tubulin folding cofactor D | -0.00287786 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | -0.00287774 |
| BUB3 | BUB3 mitotic checkpoint protein | -0.00287106 |
| PRPSAP1 | phosphoribosyl pyrophosphate synthetase-associated protein 1 | -0.00286934 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.00286644 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00285993 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.00285984 |
| PLS3 | plastin 3 | -0.00285982 |
| TRIP13 | thyroid hormone receptor interactor 13 | -0.00285887 |
| RPIA | ribose 5-phosphate isomerase A | -0.00285752 |
| UMOD | uromodulin | -0.00285273 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.00285239 |
| SLC35E3 | solute carrier family 35, member E3 | -0.00284822 |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | -0.00284813 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.00284747 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.00284624 |
| HOXB7 | homeobox B7 | -0.00284612 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.00284283 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.00283558 |
| ADAMDEC1 | ADAM-like, decysin 1 | -0.00283483 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00282975 |
| METTL7A | methyltransferase like 7A | -0.00282459 |
| TPD52 | tumor protein D52 | -0.00282439 |
| EXOC7 | exocyst complex component 7 | -0.00282392 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00281918 |
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | -0.00281185 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00280528 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.00279247 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.00279205 |
| SFTPC | surfactant protein C | -0.00278884 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.00278102 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | -0.00278021 |
| PRKCSH | protein kinase C substrate 80K-H | -0.00277095 |
| LYRM4 | LYR motif containing 4 | -0.00276814 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.00276181 |
| MIS18A | MIS18 kinetochore protein A | -0.00275607 |
| SIRT3 | sirtuin 3 | -0.00275461 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | -0.00275348 |
| HMGA1 | high mobility group AT-hook 1 | -0.00274166 |
| IL7R | interleukin 7 receptor | -0.00274033 |
| MZT2A | mitotic spindle organizing protein 2A | -0.0027341 |
| NOAZFP | nucleolar atypical zinc finger | -0.00273313 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.00273222 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.00273181 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.00273121 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.00271741 |
| PFN2 | profilin 2 | -0.00271533 |
| RPL14 | ribosomal protein L14 | -0.00271518 |
| RBM26 | RNA binding motif protein 26 | -0.00270721 |
| PRKCA | protein kinase C, alpha | -0.00270524 |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase | -0.00270266 |
| MDN1 | MDN1, midasin homolog (yeast) | -0.00269647 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.00268735 |
| FANCG | Fanconi anemia, complementation group G | -0.00267998 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.00266697 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00266579 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.00266475 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | -0.0026521 |
| TK1 | thymidine kinase 1, soluble | -0.00265131 |
| CYBC1 | cytochrome b-245 chaperone 1 | -0.00263797 |
| PITX1 | paired-like homeodomain 1 | -0.0026358 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.00263373 |
| TMC6 | transmembrane channel-like 6 | -0.00263328 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | -0.00262537 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00262337 |
| KLF1 | Kruppel-like factor 1 (erythroid) | -0.0026232 |
| EIF2D | eukaryotic translation initiation factor 2D | -0.0026221 |
| DPH5 | diphthamide biosynthesis 5 | -0.00261512 |
| ATP5PD | ATP synthase peripheral stalk subunit d | -0.0026143 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.00261124 |
| FOXO3 | forkhead box O3 | -0.00260922 |
| PCDH9 | protocadherin 9 | -0.00260903 |
| WBP2 | WW domain binding protein 2 | -0.00260493 |
| JADE1 | jade family PHD finger 1 | -0.0025994 |
| FAIM | Fas apoptotic inhibitory molecule | -0.0025977 |
| FAM162A | family with sequence similarity 162, member A | -0.00259585 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | -0.0025913 |
| NAP1L3 | nucleosome assembly protein 1-like 3 | -0.00258705 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.00258502 |
| HSPA13 | heat shock protein 70kDa family, member 13 | -0.00258075 |
| ZNF217 | zinc finger protein 217 | -0.00257994 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.00257815 |
| MRPS7 | mitochondrial ribosomal protein S7 | -0.00257631 |
| CPNE3 | copine III | -0.00256973 |
| ICAM2 | intercellular adhesion molecule 2 | -0.00256836 |
| POLR1E | polymerase (RNA) I polypeptide E, 53kDa | -0.00256489 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00256352 |
| GIMAP5 | GTPase, IMAP family member 5 | -0.00255565 |
| LRRC23 | leucine rich repeat containing 23 | -0.00255373 |
| VEZF1 | vascular endothelial zinc finger 1 | -0.00254587 |
| CALCA | calcitonin-related polypeptide alpha | -0.00254319 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00254301 |
