ERBB2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description erb-b2 receptor tyrosine kinase 2|This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2064)
External Link http://www.ncbi.nlm.nih.gov/gene/2064
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Genes

6 substrates of the kinase ERBB2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
BBC3 BCL2 binding component 3
CDK1 cyclin-dependent kinase 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DOCK7 dedicator of cytokinesis 7
ERBB2 erb-b2 receptor tyrosine kinase 2
PLXNB1 plexin B1