ERBB3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description erb-b2 receptor tyrosine kinase 3|This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2065)
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Genes

340 genes differentially expressed following the ERBB3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
EXTL1 exostosin-like glycosyltransferase 1 2.53003
SCGN secretagogin, EF-hand calcium binding protein 2.53003
ZNF575 zinc finger protein 575 2.53003
ADAMTSL2 ADAMTS-like 2 2.53003
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 2.53003
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.53003
ANKRD33 ankyrin repeat domain 33 2.53003
CER1 cerberus 1, DAN family BMP antagonist 2.53003
AQP4 aquaporin 4 2.53003
SBNO1 strawberry notch homolog 1 (Drosophila) 2.53003
CD36 CD36 molecule (thrombospondin receptor) 2.53003
RPS21-DT RPS21 divergent transcript 2.53003
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.53003
IGFBP7 insulin-like growth factor binding protein 7 2.53003
PCDHGA11 protocadherin gamma subfamily A, 11 2.53003
CATSPERT catsper channel auxiliary subunit tau 2.53003
LOXL4 lysyl oxidase-like 4 2.53003
NRSN1 neurensin 1 2.53003
GAGE10 G antigen 10 2.53003
FPR1 formyl peptide receptor 1 2.53003
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.53003
C11ORF86 chromosome 11 open reading frame 86 2.53003
HYOU1 hypoxia up-regulated 1 2.53003
NELL1 NEL-like 1 (chicken) 2.52924
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.5018
BDKRB1 bradykinin receptor B1 2.5018
MFAP4 microfibrillar-associated protein 4 2.5018
GRAP GRB2-related adaptor protein 2.5018
LY6K lymphocyte antigen 6 complex, locus K 2.5018
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.5018
DOK7 docking protein 7 2.5018
LMBR1 limb development membrane protein 1 2.5018
BSG basigin (Ok blood group) 2.5018
OTUD6A OTU deubiquitinase 6A 2.5018
BIRC7 baculoviral IAP repeat containing 7 2.5018
SDCBP2 syndecan binding protein (syntenin) 2 2.5018
NEUROG3 neurogenin 3 2.5018
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.5018
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.5018
SCIN scinderin 2.5018
METTL21C methyltransferase like 21C 2.5018
TWIST1 twist family bHLH transcription factor 1 2.5018
G6PC2 glucose-6-phosphatase, catalytic, 2 2.5018
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.5018
PSD2 pleckstrin and Sec7 domain containing 2 2.5018
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.5018
DNAAF1 dynein, axonemal, assembly factor 1 2.5018
ANKK1 ankyrin repeat and kinase domain containing 1 2.5018
GNRH2 gonadotropin-releasing hormone 2 2.5018
PAPOLB poly(A) polymerase beta (testis specific) 2.5018
DBNL drebrin-like 2.5018
TRPC5OS TRPC5 opposite strand 2.5018
GRP gastrin-releasing peptide 2.5018
STMN4 stathmin-like 4 2.5018
STEAP4 STEAP family member 4 2.5018
PDZK1 PDZ domain containing 1 2.5018
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.5018
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.5018
DUXB double homeobox B 2.5018
SCN2B sodium channel, voltage gated, type II beta subunit 2.5018
PLIN1 perilipin 1 2.5018
IL31RA interleukin 31 receptor A 2.5018
DNASE1L2 deoxyribonuclease I-like 2 2.5018
CD160 CD160 molecule 2.5018
PDIA2 protein disulfide isomerase family A, member 2 2.5018
USP26 ubiquitin specific peptidase 26 2.5018
ARID3C AT rich interactive domain 3C (BRIGHT-like) 2.5018
MAGEB3 melanoma antigen family B3 2.5018
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.5018
ISM2 isthmin 2 2.5018
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.5018
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.5018
TMEM95 transmembrane protein 95 2.5018
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.5018
SIX6 SIX homeobox 6 2.5018
HLF hepatic leukemia factor 2.5018
PDYN prodynorphin 2.5018
KIAA1671 KIAA1671 2.5018
SLC22A25 solute carrier family 22, member 25 2.5018
PDE7B phosphodiesterase 7B 2.5018
GDF6 growth differentiation factor 6 2.5018
PLCH2 phospholipase C, eta 2 2.5018
CEP295NL CEP295 N-terminal like 2.5018
TLR8 toll-like receptor 8 2.5018
SSMEM1 serine-rich single-pass membrane protein 1 2.5018
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.5018
LTK leukocyte receptor tyrosine kinase 2.5018
OR2J2 olfactory receptor, family 2, subfamily J, member 2 2.5018
CDKN2A cyclin-dependent kinase inhibitor 2A 2.5018
SH2D7 SH2 domain containing 7 2.5018
LYST lysosomal trafficking regulator 2.5018
ULBP1 UL16 binding protein 1 2.5018
SCRT2 scratch family zinc finger 2 2.5018
HES7 hes family bHLH transcription factor 7 2.5018
SOX13 SRY (sex determining region Y)-box 13 2.5018
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.5018
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.5018
DRICH1 aspartate-rich 1 2.5018
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.5018
GLYATL1B glycine-N-acyltransferase like 1B 2.5018
NHERF4 NHERF family PDZ scaffold protein 4 2.5018
C2CD4B C2 calcium-dependent domain containing 4B 2.5018
MUCL1 mucin-like 1 2.5018
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.5018
CCL15 chemokine (C-C motif) ligand 15 2.5018
BCO1 beta-carotene oxygenase 1 2.5018
TEKT2 tektin 2 (testicular) 2.5018
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.5018
TDRD10 tudor domain containing 10 2.5018
SPMIP3 sperm microtubule inner protein 3 2.5018
ADAM7 ADAM metallopeptidase domain 7 2.5018
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.5018
EHF ets homologous factor 2.5018
FATE1 fetal and adult testis expressed 1 2.5018
S100A14 S100 calcium binding protein A14 2.5018
SMIM35 small integral membrane protein 35 2.5018
VNN1 vanin 1 2.5018
H4C14 H4 clustered histone 14 2.5018
CIMAP1B ciliary microtubule associated protein 1B 2.5018
HOPX HOP homeobox 2.5018
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.5018
LINC02268 long intergenic non-protein coding RNA 2268 2.5018
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.5018
ABLIM3 actin binding LIM protein family, member 3 2.5018
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.5018
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.5018
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.5018
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.5018
NPY2R neuropeptide Y receptor Y2 2.5018
TTC24 tetratricopeptide repeat domain 24 2.5018
SPATA31G1 SPATA31 subfamily G member 1 2.5018
OR56B2 olfactory receptor family 56 subfamily B member 2 2.5018
RGS8 regulator of G-protein signaling 8 2.5018
FSHR follicle stimulating hormone receptor 2.5018
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.5018
RBM20 RNA binding motif protein 20 2.5018
AMN amnion associated transmembrane protein 2.5018
GFRAL GDNF family receptor alpha like 2.5018
PLA2G12B phospholipase A2, group XIIB 2.5018
STRIT1 small transmembrane regulator of ion transport 1 2.5018
THSD8 thrombospondin type 1 domain containing 8 2.5018
DRC1 dynein regulatory complex subunit 1 2.5018
NRGN neurogranin (protein kinase C substrate, RC3) 2.5018
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.5018
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.5018
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.5018
APOL6 apolipoprotein L, 6 2.5018
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.5018
RAG2 recombination activating gene 2 2.5018
LST1 leukocyte specific transcript 1 2.5018
NECTIN4 nectin cell adhesion molecule 4 2.5018
TEX36 testis expressed 36 2.5018
TEX35 testis expressed 35 2.5018
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.5018
NEUROD2 neuronal differentiation 2 2.5018
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.5018
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.5018
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.5018
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.5018
LTB4R2 leukotriene B4 receptor 2 2.5018
SHISA3 shisa family member 3 2.5018
ANXA1 annexin A1 2.5018
UFM1 ubiquitin-fold modifier 1 2.5018
PLGLB2 plasminogen-like B2 2.5018
TMEM259 transmembrane protein 259 2.5018
ERMN ermin, ERM-like protein 2.5018
ESAM endothelial cell adhesion molecule 2.5018
CABP2 calcium binding protein 2 2.5018
TMEM109 transmembrane protein 109 2.5018
FNDC8 fibronectin type III domain containing 8 2.5018
MUCL3 mucin like 3 2.5018
RSAD2 radical S-adenosyl methionine domain containing 2 2.5018
SOWAHA sosondowah ankyrin repeat domain family member A 2.5018
GARIN1A golgi associated RAB2 interactor 1A 2.5018
NOG noggin 2.5018
VSIR V-set immunoregulatory receptor 2.5018
EXOSC2 exosome component 2 2.5018
C9ORF50 chromosome 9 open reading frame 50 2.5018
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.5018
BCLAF3 BCLAF1 and THRAP3 family member 3 2.5018
CALML6 calmodulin-like 6 2.5018
GASK1B golgi associated kinase 1B 2.5018
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.5018
ONECUT3 one cut homeobox 3 2.5018
DGKD diacylglycerol kinase, delta 130kDa 2.50023
NUP62CL nucleoporin 62kDa C-terminal like 2.49194
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 2.441
MVD mevalonate (diphospho) decarboxylase 2.40284
CD27 CD27 molecule 2.40284
COG5 component of oligomeric golgi complex 5 2.3888
BMP8A bone morphogenetic protein 8a 2.38674
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.38674
ZNF804B zinc finger protein 804B 2.38674
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.38674
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.38674
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.38674
SENP6 SUMO1/sentrin specific peptidase 6 2.38498
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.38228
KLF6 Kruppel-like factor 6 2.36469
SLC26A11 solute carrier family 26 (anion exchanger), member 11 2.35662
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 2.35662
BTLA B and T lymphocyte associated 2.35662
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 2.35656
BBIP1 BBSome interacting protein 1 2.32013
ZBTB33 zinc finger and BTB domain containing 33 2.3066
PHTF2 putative homeodomain transcription factor 2 2.29164
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.27549
GLRX2 glutaredoxin 2 2.27326
GASK1A golgi associated kinase 1A 2.25933
MCTP1 multiple C2 domains, transmembrane 1 2.24901
PGRMC2 progesterone receptor membrane component 2 2.2226
BVES blood vessel epicardial substance 2.20631
RBM4 RNA binding motif protein 4 2.20631
TOLLIP toll interacting protein 2.20631
ZNF675 zinc finger protein 675 2.19629
MRPL57 mitochondrial ribosomal protein L57 2.16435
BBS9 Bardet-Biedl syndrome 9 2.1548
PSEN2 presenilin 2 2.15132
TMEM248 transmembrane protein 248 2.13588
GLRA2 glycine receptor, alpha 2 2.12808
CDC123 cell division cycle 123 2.12808
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.12358
TMEM135 transmembrane protein 135 2.12219
PADI2 peptidyl arginine deiminase, type II 2.12219
TYK2 tyrosine kinase 2 2.12116
ZNF587 zinc finger protein 587 2.11795
CRIP3 cysteine-rich protein 3 2.11089
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.11089
ARHGAP10 Rho GTPase activating protein 10 2.1063
ZNF660-ZNF197 ZNF660-ZNF197 readthrough 2.10517
MZT2A mitotic spindle organizing protein 2A 2.09549
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2.08891
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.07728
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.06399
ZNF714 zinc finger protein 714 2.06399
ZFP1 ZFP1 zinc finger protein 2.05496
CCDC180 coiled-coil domain containing 180 2.05354
TENT4B terminal nucleotidyltransferase 4B 2.05354
ZFR2 zinc finger RNA binding protein 2 2.02805
ATP5F1B ATP synthase F1 subunit beta 2.02594
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast) 2.02104
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 2.01508
TCAIM T cell activation inhibitor, mitochondrial 2.01468
TOB2 transducer of ERBB2, 2 2.00872
SAMD4A sterile alpha motif domain containing 4A 2.00031

decreased expression

Symbol Name Standardized Value
BMP6 bone morphogenetic protein 6 -2.53003
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 -2.53003
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.53003
TRIM54 tripartite motif containing 54 -2.53003
ZNF70 zinc finger protein 70 -2.53003
OLIG1 oligodendrocyte transcription factor 1 -2.5018
FDX1 ferredoxin 1 -2.5018
FNDC10 fibronectin type III domain containing 10 -2.5018
PARP9 poly (ADP-ribose) polymerase family, member 9 -2.5018
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.5018
UBE2M ubiquitin-conjugating enzyme E2M -2.5018
MKI67 marker of proliferation Ki-67 -2.5018
ARRDC3 arrestin domain containing 3 -2.5018
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 -2.5018
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.5018
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -2.5018
LGALS2 lectin, galactoside-binding, soluble, 2 -2.5018
FAM181B family with sequence similarity 181, member B -2.5018
IL18R1 interleukin 18 receptor 1 -2.5018
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E -2.5018
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.5018
UBE2L5 ubiquitin conjugating enzyme E2 L5 -2.5018
VXN vexin -2.5018
DNAI7 dynein axonemal intermediate chain 7 -2.5018
DEPP1 DEPP autophagy regulator 1 -2.5018
FDX2 ferredoxin 2 -2.5018
PRDM7 PR domain containing 7 -2.5018
PXDC1 PX domain containing 1 -2.5018
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -2.5018
ARHGAP9 Rho GTPase activating protein 9 -2.5018
CALCA calcitonin-related polypeptide alpha -2.5018
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) -2.5018
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -2.5018
FAM43B family with sequence similarity 43, member B -2.5018
IL15RA interleukin 15 receptor, alpha -2.5018
ATP13A4 ATPase type 13A4 -2.5018
ZC2HC1B zinc finger, C2HC-type containing 1B -2.5018
CLNK cytokine-dependent hematopoietic cell linker -2.5018
NAP1L5 nucleosome assembly protein 1-like 5 -2.5018
MAMLD1 mastermind-like domain containing 1 -2.5018
FBXO47 F-box protein 47 -2.5018
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.5018
CFAP47 cilia and flagella associated protein 47 -2.5018
CDO1 cysteine dioxygenase type 1 -2.5018
C11ORF98 chromosome 11 open reading frame 98 -2.5018
OLFML1 olfactomedin-like 1 -2.5018
SSUH2 ssu-2 homolog (C. elegans) -2.5018
NMBR neuromedin B receptor -2.5018
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.5018
MUC16 mucin 16, cell surface associated -2.5018
FAM227B family with sequence similarity 227, member B -2.5018
CCDC174 coiled-coil domain containing 174 -2.5018
EPN3 epsin 3 -2.5018
SHISA8 shisa family member 8 -2.5018
WNT9A wingless-type MMTV integration site family, member 9A -2.5018
HEPACAM hepatic and glial cell adhesion molecule -2.5018
BHLHA15 basic helix-loop-helix family, member a15 -2.5018
GRIK2 glutamate receptor, ionotropic, kainate 2 -2.5018
BCAS1 breast carcinoma amplified sequence 1 -2.50023
KLF15 Kruppel-like factor 15 -2.48994
CD40 CD40 molecule, TNF receptor superfamily member 5 -2.44103
KLHL5 kelch-like family member 5 -2.43791
DHCR7 7-dehydrocholesterol reductase -2.41259
SQSTM1 sequestosome 1 -2.41124
SEPTIN5 septin 5 -2.36841
TMEM52 transmembrane protein 52 -2.35656
SPRYD3 SPRY domain containing 3 -2.34502
TMEM33 transmembrane protein 33 -2.34035
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.33148
TRIM65 tripartite motif containing 65 -2.33148
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.31109
KLHDC8B kelch domain containing 8B -2.30916
ADPRH ADP-ribosylarginine hydrolase -2.278
HLA-DMA major histocompatibility complex, class II, DM alpha -2.25671
PRIM2 primase, DNA, polypeptide 2 (58kDa) -2.24502
ASPHD2 aspartate beta-hydroxylase domain containing 2 -2.23535
FXYD5 FXYD domain containing ion transport regulator 5 -2.21089
SCAND1 SCAN domain containing 1 -2.17951
NUP88 nucleoporin 88kDa -2.15132
CFAP161 cilia and flagella associated protein 161 -2.14511
MED18 mediator complex subunit 18 -2.12219
ABI3 ABI family, member 3 -2.12116
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.12116
RAB27B RAB27B, member RAS oncogene family -2.12116
MID1 midline 1 -2.1168
HLA-F major histocompatibility complex, class I, F -2.1164
ABHD1 abhydrolase domain containing 1 -2.1063
SHLD3 shieldin complex subunit 3 -2.1063
NT5DC3 5'-nucleotidase domain containing 3 -2.09549
QARS1 glutaminyl-tRNA synthetase 1 -2.08891
CRYL1 crystallin, lambda 1 -2.07728
SPDYE1 speedy/RINGO cell cycle regulator family member E1 -2.03564
MED26 mediator complex subunit 26 -2.02995
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.01539
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.00031