| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | erb-b2 receptor tyrosine kinase 3|This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2065) |
| External Link | https://ncbi.nlm.nih.gov/gene/2065 |
| Similar Terms | |
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498 genes differentially expressed following the ERBB3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SIRT3 | sirtuin 3 | 0.0100771 |
| MAGEA3 | melanoma antigen family A3 | 0.00888123 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00871918 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00861454 |
| SPRR3 | small proline-rich protein 3 | 0.00830472 |
| ADM | adrenomedullin | 0.00797824 |
| KRT5 | keratin 5, type II | 0.00785259 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00785063 |
| SNX11 | sorting nexin 11 | 0.00765125 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00755576 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00751372 |
| MMP10 | matrix metallopeptidase 10 | 0.00747345 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00744917 |
| CHEK1 | checkpoint kinase 1 | 0.00725675 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00725597 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00713567 |
| SPRR1B | small proline-rich protein 1B | 0.00710417 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00706095 |
| TNNC1 | troponin C type 1 (slow) | 0.00692693 |
| KRT13 | keratin 13, type I | 0.00691219 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.00664742 |
| MAGEA12 | melanoma antigen family A12 | 0.0066418 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00656542 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00656001 |
| ADGRE1 | adhesion G protein-coupled receptor E1 | 0.00649305 |
| S100A7 | S100 calcium binding protein A7 | 0.00640517 |
| MAGEA1 | melanoma antigen family A1 | 0.00639012 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.00630639 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0062495 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.00616064 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00614534 |
| NES | nestin | 0.00609584 |
| SPRR1A | small proline-rich protein 1A | 0.00608422 |
| BMP2 | bone morphogenetic protein 2 | 0.00596646 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00589783 |
| MEIS1 | Meis homeobox 1 | 0.00582264 |
| E2F2 | E2F transcription factor 2 | 0.00580754 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.00578515 |
| NLRP2 | NLR family, pyrin domain containing 2 | 0.00575407 |
| ANXA1 | annexin A1 | 0.00574792 |
| TRIM29 | tripartite motif containing 29 | 0.00568601 |
| CGA | glycoprotein hormones, alpha polypeptide | 0.00565205 |
| KRT6A | keratin 6A, type II | 0.00565003 |
| PDE8B | phosphodiesterase 8B | 0.00562992 |
| TUBB6 | tubulin, beta 6 class V | 0.00562943 |
| GLUL | glutamate-ammonia ligase | 0.00560596 |
| PITX3 | paired-like homeodomain 3 | 0.00558019 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | 0.00556768 |
| REEP1 | receptor accessory protein 1 | 0.00554616 |
| NDC1 | NDC1 transmembrane nucleoporin | 0.005509 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00545703 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.00543739 |
| NEBL | nebulette | 0.0053218 |
| TAGLN2 | transgelin 2 | 0.00532148 |
| POR | P450 (cytochrome) oxidoreductase | 0.00524126 |
| HOXB7 | homeobox B7 | 0.00518946 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00512272 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00506128 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00503071 |
| SMAD3 | SMAD family member 3 | 0.00501589 |
| GNAS | GNAS complex locus | 0.00499972 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.00499086 |
| IPO7 | importin 7 | 0.00498811 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0049881 |
| USP46 | ubiquitin specific peptidase 46 | 0.00498349 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.00493755 |
| MSX1 | msh homeobox 1 | 0.00493449 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.00493369 |
| GOLT1B | golgi transport 1B | 0.0048399 |
| ASS1 | argininosuccinate synthase 1 | 0.00483373 |
| FOXG1 | forkhead box G1 | 0.00479088 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.0047871 |
| TMPRSS4 | transmembrane protease, serine 4 | 0.00476437 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00475284 |
| OXTR | oxytocin receptor | 0.00473488 |
| GAL | galanin/GMAP prepropeptide | 0.0047164 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 0.00471617 |
| PTHLH | parathyroid hormone-like hormone | 0.00465749 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00464101 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00464078 |
| AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | 0.00459869 |
| MYOF | myoferlin | 0.0045984 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.00459599 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | 0.00458448 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00457679 |
| CTSB | cathepsin B | 0.00454436 |
| OLFML2A | olfactomedin-like 2A | 0.00454303 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00451883 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00450596 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00450387 |
| COG7 | component of oligomeric golgi complex 7 | 0.00450341 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.00450085 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00450042 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00448921 |
| FOLR1 | folate receptor 1 (adult) | 0.00448864 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.00447703 |
| BMP7 | bone morphogenetic protein 7 | 0.00447567 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.00447475 |
| TYRP1 | tyrosinase-related protein 1 | 0.00445836 |
| PEG10 | paternally expressed 10 | 0.00445719 |
| BAALC | brain and acute leukemia, cytoplasmic | 0.00444901 |
| STATH | statherin | 0.00444779 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00444379 |
| LRRC17 | leucine rich repeat containing 17 | 0.00444107 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 0.00443548 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0044287 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.00441496 |
| ECM1 | extracellular matrix protein 1 | 0.00441451 |
| S100A2 | S100 calcium binding protein A2 | 0.00440504 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00440456 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00438975 |
| S100A10 | S100 calcium binding protein A10 | 0.00438227 |
| AK1 | adenylate kinase 1 | 0.00437725 |
| FCGBP | Fc fragment of IgG binding protein | 0.00437227 |
| AUTS2 | autism susceptibility candidate 2 | 0.00434783 |
| DNM1L | dynamin 1-like | 0.00434765 |
| SFN | stratifin | 0.00432738 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.00432368 |
| LOXL2 | lysyl oxidase-like 2 | 0.0043204 |
| DUOX2 | dual oxidase 2 | 0.00428545 |
| MAT2B | methionine adenosyltransferase II, beta | 0.00425613 |
| SYNGR3 | synaptogyrin 3 | 0.00425554 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.00425245 |
| GAP43 | growth associated protein 43 | 0.00424442 |
| WASF2 | WAS protein family, member 2 | 0.00424299 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | 0.00424041 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00423771 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00423348 |
| MBD2 | methyl-CpG binding domain protein 2 | 0.004232 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.00421741 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.00421707 |
| ABI2 | abl-interactor 2 | 0.0042114 |
| ACOT9 | acyl-CoA thioesterase 9 | 0.0042072 |
| TPBG | trophoblast glycoprotein | 0.00420318 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 0.0041875 |
| PRDX1 | peroxiredoxin 1 | 0.00417836 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.00417773 |
| PLA2G10 | phospholipase A2, group X | 0.004176 |
| NMD3 | NMD3 ribosome export adaptor | 0.00416239 |
| KRT6B | keratin 6B, type II | 0.00415076 |
| EDN3 | endothelin 3 | 0.00414725 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.00414091 |
| PRDX6 | peroxiredoxin 6 | 0.00413775 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00413663 |
| LGALSL | lectin, galactoside-binding-like | 0.00413363 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00413234 |
| AURKB | aurora kinase B | 0.00410833 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.00410821 |
| DTNA | dystrobrevin, alpha | 0.00410067 |
| KRT17 | keratin 17, type I | 0.00408763 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.00406485 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.00405982 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 0.00404804 |
| MVP | major vault protein | 0.00404707 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.004033 |
| TEAD4 | TEA domain family member 4 | 0.00402925 |
| DAZAP2 | DAZ associated protein 2 | 0.00401545 |
| SCO2 | SCO2 cytochrome c oxidase assembly protein | 0.00401296 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.00400791 |
| NTS | neurotensin | 0.00400547 |
| LMNB1 | lamin B1 | 0.00399916 |
| VWF | von Willebrand factor | 0.00399734 |
| CNTN1 | contactin 1 | 0.00399135 |
| NXPE4 | neurexophilin and PC-esterase domain family, member 4 | 0.00398009 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00397424 |
| ZNF652 | zinc finger protein 652 | 0.00397214 |
| PER1 | period circadian clock 1 | 0.00397202 |
| SLN | sarcolipin | 0.00396914 |
| FAM107A | family with sequence similarity 107, member A | 0.00396826 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.00396674 |
| NRIP3 | nuclear receptor interacting protein 3 | 0.00396084 |
| MRC2 | mannose receptor, C type 2 | 0.00396019 |
| MSLN | mesothelin | 0.00395195 |
| PRKAA1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 0.00395098 |
| IFRD2 | interferon-related developmental regulator 2 | 0.00392601 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0039118 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.0039115 |
| ZNF750 | zinc finger protein 750 | 0.00390544 |
| MAP7 | microtubule-associated protein 7 | 0.00390202 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00390195 |
| DSC2 | desmocollin 2 | 0.00389573 |
| SGCE | sarcoglycan, epsilon | 0.00388962 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00386594 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.00385962 |
| RDX | radixin | 0.00385833 |
| GTF2I | general transcription factor IIi | 0.00385607 |
| ATF3 | activating transcription factor 3 | 0.00385554 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.00384829 |
| SMR3B | submaxillary gland androgen regulated protein 3B | 0.003843 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.00384078 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00383239 |
| SPRR2B | small proline-rich protein 2B | 0.00382884 |
| AREG | amphiregulin | 0.00382239 |
| PDZD2 | PDZ domain containing 2 | 0.00382221 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00381307 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.00380465 |
| CLTB | clathrin, light chain B | 0.00380146 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.00379165 |
| KLF6 | Kruppel-like factor 6 | 0.00379152 |
| COL4A6 | collagen, type IV, alpha 6 | 0.00377551 |
| FKBP5 | FK506 binding protein 5 | 0.00374987 |
| AKIP1 | A kinase (PRKA) interacting protein 1 | 0.0037383 |
| SYNC | syncoilin, intermediate filament protein | 0.00373813 |
| LGALS14 | lectin, galactoside-binding, soluble, 14 | 0.0037346 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.00373221 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00373217 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 0.00372128 |
| TP63 | tumor protein p63 | 0.00372109 |
| SRR | serine racemase | 0.00371891 |
| LINC00094 | long intergenic non-protein coding RNA 94 | 0.00371387 |
| TSPAN5 | tetraspanin 5 | 0.00370723 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 0.00370457 |
| FBN2 | fibrillin 2 | 0.00370282 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.00370179 |
| LRP2 | low density lipoprotein receptor-related protein 2 | 0.00369781 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00369263 |
| SP100 | SP100 nuclear antigen | 0.00366443 |
| NPTX2 | neuronal pentraxin II | 0.0036604 |
| EXOC5 | exocyst complex component 5 | 0.00364771 |
| DUOX1 | dual oxidase 1 | 0.00364741 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.00361724 |
| TMEM45A | transmembrane protein 45A | 0.00361504 |
| LINC00623 | long intergenic non-protein coding RNA 623 | 0.00361268 |
| PMP2 | peripheral myelin protein 2 | 0.00360528 |
| VIPR1 | vasoactive intestinal peptide receptor 1 | 0.00360215 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.00359534 |
| PFKP | phosphofructokinase, platelet | 0.00359179 |
| CBX1 | chromobox homolog 1 | 0.00358574 |
| OPHN1 | oligophrenin 1 | 0.0035841 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.00358288 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.00358001 |
| MCL1 | myeloid cell leukemia 1 | 0.00357566 |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.00357523 |
| PSCA | prostate stem cell antigen | 0.00357392 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0035736 |
| APH1A | APH1A gamma secretase subunit | 0.0035727 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | 0.00356926 |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 | 0.00356651 |
| DENND2B | DENN domain containing 2B | 0.00356519 |
| CLIC3 | chloride intracellular channel 3 | 0.00356305 |
| ODAM | odontogenic, ameloblast asssociated | 0.00356263 |
| DSG3 | desmoglein 3 | 0.00355769 |
| CTSZ | cathepsin Z | 0.0035557 |
| LAGE3 | L antigen family, member 3 | 0.0035517 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 0.00354588 |
| PDPN | podoplanin | 0.00354155 |
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 0.00353996 |
| CGGBP1 | CGG triplet repeat binding protein 1 | 0.00353444 |
| PRKCA | protein kinase C, alpha | 0.0035329 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.0102419 |
| TOX3 | TOX high mobility group box family member 3 | -0.0100398 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00934844 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00896258 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00835431 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00825418 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00813495 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.00800581 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00798376 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00796409 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -0.00789544 |
| MGP | matrix Gla protein | -0.00784173 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00771273 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00770578 |
| TRIB2 | tribbles pseudokinase 2 | -0.00761273 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00755424 |
| SMAD7 | SMAD family member 7 | -0.0074371 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00739283 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00714872 |
| ADIRF | adipogenesis regulatory factor | -0.00709272 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.00705052 |
| LCN2 | lipocalin 2 | -0.00690449 |
| APOD | apolipoprotein D | -0.00689434 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0067616 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.00669616 |
| CST7 | cystatin F (leukocystatin) | -0.00669336 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00666081 |
| CCDC92 | coiled-coil domain containing 92 | -0.00655868 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00653341 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00650115 |
| ZNF586 | zinc finger protein 586 | -0.0064388 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00637363 |
| NKG7 | natural killer cell granule protein 7 | -0.0063275 |
| TLR4 | toll-like receptor 4 | -0.0063257 |
| BCHE | butyrylcholinesterase | -0.00632134 |
| SLAMF7 | SLAM family member 7 | -0.00629382 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00620515 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -0.00617617 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00616142 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00615414 |
| IPO13 | importin 13 | -0.00613253 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.00605218 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00605093 |
| PLN | phospholamban | -0.00602996 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00602274 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00601053 |
| APMAP | adipocyte plasma membrane associated protein | -0.00600368 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00599975 |
| TGFA | transforming growth factor, alpha | -0.00598405 |
| CANT1 | calcium activated nucleotidase 1 | -0.00597208 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00594276 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00589461 |
| G0S2 | G0/G1 switch 2 | -0.0058876 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00588655 |
| RBM47 | RNA binding motif protein 47 | -0.00587256 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00585241 |
| CHRDL1 | chordin-like 1 | -0.00584338 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00582777 |
| REG1A | regenerating islet-derived 1 alpha | -0.00579541 |
| TARP | TCR gamma alternate reading frame protein | -0.00578759 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00578085 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00575425 |
| OLFM4 | olfactomedin 4 | -0.00573672 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.00573588 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00573344 |
| FRZB | frizzled-related protein | -0.00572681 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.00570366 |
| XCL1 | chemokine (C motif) ligand 1 | -0.00565546 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00565084 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00563324 |
| EDRF1 | erythroid differentiation regulatory factor 1 | -0.00560213 |
| DCN | decorin | -0.00558639 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00558532 |
| S100A12 | S100 calcium binding protein A12 | -0.00557098 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -0.00556913 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.00556055 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -0.00554878 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -0.00554093 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00553596 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00552417 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | -0.00549532 |
| SERINC5 | serine incorporator 5 | -0.00547697 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00546671 |
| PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | -0.00543858 |
| PLA1A | phospholipase A1 member A | -0.00543473 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00542024 |
| EVI2A | ecotropic viral integration site 2A | -0.00539494 |
| MMP9 | matrix metallopeptidase 9 | -0.00533035 |
| CYBB | cytochrome b-245, beta polypeptide | -0.00532515 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00532016 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.00531224 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | -0.00526711 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | -0.00525352 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00523774 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00521826 |
| MYO5C | myosin VC | -0.00520794 |
| RAPSN | receptor-associated protein of the synapse | -0.00520321 |
| GOLGA8H | golgin A8 family, member H | -0.00519995 |
| TSPAN8 | tetraspanin 8 | -0.00519449 |
| FRMD4B | FERM domain containing 4B | -0.00518489 |
| ASPN | asporin | -0.00517833 |
| MAMLD1 | mastermind-like domain containing 1 | -0.00517606 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -0.00516621 |
| PRPF4B | pre-mRNA processing factor 4B | -0.00515107 |
| TGM2 | transglutaminase 2 | -0.00512191 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | -0.00509258 |
| AOC3 | amine oxidase, copper containing 3 | -0.00508156 |
| ZNF91 | zinc finger protein 91 | -0.00507699 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00503015 |
| PLIN1 | perilipin 1 | -0.00500772 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | -0.00496955 |
| FAM8A1 | family with sequence similarity 8, member A1 | -0.00493275 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00492861 |
| MGAT2 | mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | -0.00492014 |
| AMOTL2 | angiomotin like 2 | -0.00489844 |
| C7 | complement component 7 | -0.00489022 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | -0.00484953 |
| C3ORF14 | chromosome 3 open reading frame 14 | -0.00483863 |
| EPCAM | epithelial cell adhesion molecule | -0.00479945 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00479442 |
| TCF15 | transcription factor 15 (basic helix-loop-helix) | -0.00478995 |
| TSPYL5 | TSPY-like 5 | -0.00478052 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.00477174 |
| MNDA | myeloid cell nuclear differentiation antigen | -0.00475176 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -0.00474299 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00473242 |
| RNF144A | ring finger protein 144A | -0.00471566 |
| PLEK | pleckstrin | -0.00469661 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00469258 |
| JMJD6 | jumonji domain containing 6 | -0.00468553 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00467962 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00467015 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.00465857 |
| PLXNC1 | plexin C1 | -0.00465504 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.00465155 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00464352 |
| ELAVL3 | ELAV like neuron-specific RNA binding protein 3 | -0.00462145 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.00459906 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.00459848 |
| LUM | lumican | -0.00459467 |
| GAS6 | growth arrest-specific 6 | -0.00458993 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.00458729 |
| FBLN1 | fibulin 1 | -0.00457589 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00457116 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | -0.00456739 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00454838 |
| LSR | lipolysis stimulated lipoprotein receptor | -0.00454722 |
| FAM46C | family with sequence similarity 46, member C | -0.00454515 |
| LAT2 | linker for activation of T cells family, member 2 | -0.00453319 |
| C2 | complement component 2 | -0.00452767 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | -0.004523 |
| GSAP | gamma-secretase activating protein | -0.00452254 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | -0.00451973 |
| DUSP5 | dual specificity phosphatase 5 | -0.00450453 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00449952 |
| CHMP6 | charged multivesicular body protein 6 | -0.00449597 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00448999 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | -0.00448575 |
| CCND2 | cyclin D2 | -0.00447784 |
| CYP11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2 | -0.00447105 |
| WASHC4 | WASH complex subunit 4 | -0.00446143 |
| LONP2 | lon peptidase 2, peroxisomal | -0.00445084 |
| CCR1 | chemokine (C-C motif) receptor 1 | -0.00443543 |
| ISCU | iron-sulfur cluster assembly enzyme | -0.0044245 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00441766 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.00441278 |
| FGL2 | fibrinogen-like 2 | -0.00440153 |
| CCL8 | chemokine (C-C motif) ligand 8 | -0.00439959 |
| LST1 | leukocyte specific transcript 1 | -0.00439761 |
| MARCH8 | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase | -0.00439687 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00439465 |
| FBLN2 | fibulin 2 | -0.00438779 |
| TMEM14B | transmembrane protein 14B | -0.00437647 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.00436999 |
| ADAMDEC1 | ADAM-like, decysin 1 | -0.00436948 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | -0.00435554 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.00435185 |
| DSE | dermatan sulfate epimerase | -0.00433492 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00431014 |
| MPDZ | multiple PDZ domain protein | -0.00430659 |
| TSPAN13 | tetraspanin 13 | -0.00429743 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.00429344 |
| TBC1D4 | TBC1 domain family, member 4 | -0.00426293 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.00424624 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00424083 |
| MZB1 | marginal zone B and B1 cell-specific protein | -0.00423963 |
| CD2 | CD2 molecule | -0.00422972 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.00422049 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00421195 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | -0.00420595 |
| GLS | glutaminase | -0.00420138 |
| CCL13 | chemokine (C-C motif) ligand 13 | -0.00419054 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.00418857 |
| HOXC6 | homeobox C6 | -0.00415624 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | -0.00415185 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00414546 |
| RAB38 | RAB38, member RAS oncogene family | -0.00414116 |
| NFIB | nuclear factor I/B | -0.00413693 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | -0.00413492 |
| CFH | complement factor H | -0.0041209 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00411511 |
| CFI | complement factor I | -0.0041073 |
| LYZ | lysozyme | -0.0040951 |
| CSAD | cysteine sulfinic acid decarboxylase | -0.00408823 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00408507 |
| MYRF | myelin regulatory factor | -0.00407956 |
| BLNK | B-cell linker | -0.00407648 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00407575 |
| ZNF443 | zinc finger protein 443 | -0.00406791 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00406747 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | -0.00404901 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | -0.00404845 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -0.00404659 |
| MYO1D | myosin ID | -0.00401478 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | -0.00401113 |
| PROM1 | prominin 1 | -0.00401085 |
| PDE9A | phosphodiesterase 9A | -0.00400693 |
| RHOB | ras homolog family member B | -0.00400387 |
| RNF167 | ring finger protein 167 | -0.00400307 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00399838 |
| CFB | complement factor B | -0.00399558 |
| WASL | Wiskott-Aldrich syndrome-like | -0.00398936 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | -0.00398773 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.00398695 |
| TPD52 | tumor protein D52 | -0.00398692 |
| EHD3 | EH-domain containing 3 | -0.00398604 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.00398317 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | -0.00397844 |
| KLK6 | kallikrein-related peptidase 6 | -0.00397822 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | -0.0039779 |
| KHK | ketohexokinase (fructokinase) | -0.00397662 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | -0.00396979 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 | -0.0039677 |
| TSC22D4 | TSC22 domain family, member 4 | -0.00396725 |
| CLDN4 | claudin 4 | -0.00396705 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -0.00395992 |
| RTN3 | reticulon 3 | -0.00395656 |
| BPI | bactericidal/permeability-increasing protein | -0.00395367 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00394973 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | -0.00393037 |
| CEL | carboxyl ester lipase | -0.00393019 |
| CTSH | cathepsin H | -0.00392379 |
| LARP4 | La ribonucleoprotein domain family, member 4 | -0.00391943 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.00391174 |
| LPPR1 | lipid phosphate phosphatase-related protein type 1 | -0.00390937 |
| TP53I11 | tumor protein p53 inducible protein 11 | -0.00389949 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | -0.00389305 |
| METTL7A | methyltransferase like 7A | -0.0038927 |
| CD8A | CD8a molecule | -0.00389209 |
