ERBB4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description erb-b2 receptor tyrosine kinase 4|This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2066)
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Genes

326 genes differentially expressed following the ERBB4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FGD2 FYVE, RhoGEF and PH domain containing 2 3.2685
GDNF glial cell derived neurotrophic factor 3.2685
NFAM1 NFAT activating protein with ITAM motif 1 3.2685
FAM86B2 family with sequence similarity 86, member B2 3.2685
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.2685
ALPK2 alpha-kinase 2 3.2685
ARSF arylsulfatase F 3.2685
ANKRD34A ankyrin repeat domain 34A 3.2685
F7 coagulation factor VII (serum prothrombin conversion accelerator) 3.2685
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 3.2685
GSTM5 glutathione S-transferase mu 5 3.2685
PNMA5 paraneoplastic Ma antigen family member 5 3.2685
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.2685
WDR87 WD repeat domain 87 3.2685
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.2685
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.2685
IL22RA1 interleukin 22 receptor, alpha 1 3.2685
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.2685
FABP1 fatty acid binding protein 1, liver 3.2685
TM4SF1 transmembrane 4 L six family member 1 3.2685
PCDH8 protocadherin 8 3.2685
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 3.2685
MLNR motilin receptor 3.2685
BANF2 barrier to autointegration factor 2 3.2685
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.2685
IFITM10 interferon induced transmembrane protein 10 3.2685
TTC36 tetratricopeptide repeat domain 36 3.2685
A1CF APOBEC1 complementation factor 3.2685
TMEM156 transmembrane protein 156 3.2685
CLCNKA chloride channel, voltage-sensitive Ka 3.2685
CD8A CD8a molecule 3.2685
RAB7B RAB7B, member RAS oncogene family 3.2685
LPA lipoprotein, Lp(a) 3.2685
OR51A4 olfactory receptor, family 51, subfamily A, member 4 3.2685
SHH sonic hedgehog 3.2685
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.2685
MPL MPL proto-oncogene, thrombopoietin receptor 3.2685
MYO1G myosin IG 3.2685
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.2685
LOC105378220 macrophage receptor MARCO-like 3.2685
KIAA1755 KIAA1755 3.2685
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.2685
CD86 CD86 molecule 3.2685
IHO1 interactor of HORMAD1 1 3.2685
SPATA25 spermatogenesis associated 25 3.2685
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 3.2685
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.2685
PARVG parvin, gamma 3.2685
KL klotho 3.2685
PRDM7 PR domain containing 7 3.2685
LRRN4CL LRRN4 C-terminal like 3.2685
FGFBP2 fibroblast growth factor binding protein 2 3.2685
WNT16 wingless-type MMTV integration site family, member 16 3.2685
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.2685
PROX2 prospero homeobox 2 3.2685
H2BC3 H2B clustered histone 3 3.2685
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.2685
VSIR V-set immunoregulatory receptor 3.2685
SELE selectin E 3.2685
GBP3 guanylate binding protein 3 3.2685
MCHR1 melanin-concentrating hormone receptor 1 3.2685
VN1R1 vomeronasal 1 receptor 1 3.2685
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 3.2685
SAMD15 sterile alpha motif domain containing 15 3.2685
S100P S100 calcium binding protein P 3.2685
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.2685
LOC390937 Ets2 repressor factor-like 3.2685
FPR1 formyl peptide receptor 1 3.2685
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.2685
RHEX regulator of hemoglobinization and erythroid cell expansion 3.2685
HRH1 histamine receptor H1 3.2685
KLRC1 killer cell lectin-like receptor subfamily C, member 1 3.2685
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 3.2685
PARP3 poly (ADP-ribose) polymerase family, member 3 3.2685
PCDHA3 protocadherin alpha 3 3.2685
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.2685
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.2685
TFEC transcription factor EC 3.2685
ADGRG1 adhesion G protein-coupled receptor G1 3.2685
DMBX1 diencephalon/mesencephalon homeobox 1 3.2685
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.2685
CCR6 chemokine (C-C motif) receptor 6 3.2685
EDAR ectodysplasin A receptor 3.2685
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.2685
IRF5 interferon regulatory factor 5 3.2685
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.2685
ZCCHC12 zinc finger, CCHC domain containing 12 3.2685
RTBDN retbindin 3.2685
GLOD5 glyoxalase domain containing 5 3.2685
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.2685
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.2685
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.2685
SYNGR4 synaptogyrin 4 3.2685
GPR12 G protein-coupled receptor 12 3.2685
POF1B premature ovarian failure, 1B 3.2685
CERS3 ceramide synthase 3 3.2685
EDN3 endothelin 3 3.2685
IP6K3 inositol hexakisphosphate kinase 3 3.2685
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 3.2685
RSAD2 radical S-adenosyl methionine domain containing 2 3.2685
PRH2 proline-rich protein HaeIII subfamily 2 3.2685
INSM1 insulinoma-associated 1 3.2685
SOSTDC1 sclerostin domain containing 1 3.2685
VSTM1 V-set and transmembrane domain containing 1 3.2685
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.2685
HRCT1 histidine rich carboxyl terminus 1 3.2685
RAB40AL RAB40A, member RAS oncogene family-like 3.2685
KLK15 kallikrein-related peptidase 15 3.2685
TTC16 tetratricopeptide repeat domain 16 3.2685
COX7B2 cytochrome c oxidase subunit VIIb2 3.2685
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.2685
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.2685
OR10Z1 olfactory receptor, family 10, subfamily Z, member 1 3.2685
C20ORF144 chromosome 20 open reading frame 144 3.2685
IGF2 insulin-like growth factor 2 3.2685
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.2685
FAM135B family with sequence similarity 135, member B 3.2685
AQP7 aquaporin 7 3.2685
BPIFB3 BPI fold containing family B, member 3 3.2685
BPIFB4 BPI fold containing family B, member 4 3.2685
HK3 hexokinase 3 (white cell) 3.2685
GAL3ST2 galactose-3-O-sulfotransferase 2 3.2685
MYLK2 myosin light chain kinase 2 3.2685
ART1 ADP-ribosyltransferase 1 3.2685
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 3.2685
CARD9 caspase recruitment domain family, member 9 3.2685
CARD6 caspase recruitment domain family, member 6 3.2685
MST1 macrophage stimulating 1 3.2685
POTEI POTE ankyrin domain family, member I 3.2685
TTC24 tetratricopeptide repeat domain 24 3.2685
CHRM4 cholinergic receptor, muscarinic 4 3.2685
ZNF534 zinc finger protein 534 3.2685
RERGL RERG/RAS-like 3.2685
DRC1 dynein regulatory complex subunit 1 3.2685
OR11G2 olfactory receptor, family 11, subfamily G, member 2 3.2685
MB myoglobin 3.2685
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.2685
GJC2 gap junction protein, gamma 2, 47kDa 3.2685
UPK1B uroplakin 1B 3.2685
ADGRF5 adhesion G protein-coupled receptor F5 3.2685
CXORF58 chromosome X open reading frame 58 3.2685
CAPSL calcyphosine-like 3.2685
INSL6 insulin-like 6 3.2685
CSNK1A1L casein kinase 1, alpha 1-like 3.2685
PHOSPHO1 phosphatase, orphan 1 3.2685
KRT15 keratin 15, type I 3.2685
PCDHGB2 protocadherin gamma subfamily B, 2 3.2685
LAMB3 laminin, beta 3 3.2685
ZMYND10 zinc finger, MYND-type containing 10 3.2685
LMX1A LIM homeobox transcription factor 1, alpha 3.2685
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.2685
ESPNL espin-like 3.2685
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.2685
IER5L immediate early response 5-like 3.2685
HELZ2 helicase with zinc finger 2, transcriptional coactivator 3.24481
PTPRO protein tyrosine phosphatase, receptor type, O 3.12651
CROT carnitine O-octanoyltransferase 2.93686
DPY19L1 dpy-19-like 1 (C. elegans) 2.88298
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.88298
POFUT2 protein O-fucosyltransferase 2 2.8303
IQCJ IQ motif containing J 2.80516
KANK3 KN motif and ankyrin repeat domains 3 2.76415
ZAN zonadhesin (gene/pseudogene) 2.76193
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.70286
MAP3K7CL MAP3K7 C-terminal like 2.65195
ASCL3 achaete-scute family bHLH transcription factor 3 2.65195
RANBP9 RAN binding protein 9 2.61316
MISO1 mitochondrial inner membrane subdomain organizer 1 2.58287
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2.55616
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.53778
SARNP SAP domain containing ribonucleoprotein 2.51263
RIPPLY2 ripply transcriptional repressor 2 2.46143
RPUSD1 RNA pseudouridylate synthase domain containing 1 2.44327
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 2.42109
PARP15 poly (ADP-ribose) polymerase family, member 15 2.38974
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.38974
INO80D INO80 complex subunit D 2.37683
MFN2 mitofusin 2 2.33911
NPSR1 neuropeptide S receptor 1 2.32097
RFPL2 ret finger protein-like 2 2.32097
PGLYRP1 peptidoglycan recognition protein 1 2.32097
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.31528
GJA1 gap junction protein, alpha 1, 43kDa 2.30895
SAMD3 sterile alpha motif domain containing 3 2.30736
WDR90 WD repeat domain 90 2.29106
EFHD2 EF-hand domain family, member D2 2.28761
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.28342
NBPF3 neuroblastoma breakpoint family, member 3 2.28215
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 2.28069
PWWP2B PWWP domain containing 2B 2.27813
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.25124
MCPH1 microcephalin 1 2.25003
GALK1 galactokinase 1 2.21694
FMNL1 formin-like 1 2.20906
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.18423
RPL41 ribosomal protein L41 2.14526
H1-3 H1.3 linker histone, cluster member 2.12172
PNN pinin, desmosome associated protein 2.11135
H2AC12 H2A clustered histone 12 2.10033
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 2.08057
CCDC169 coiled-coil domain containing 169 2.07946
SIK2 salt-inducible kinase 2 2.07592
ZNF207 zinc finger protein 207 2.06871
TSPAN11 tetraspanin 11 2.06855
MXD1 MAX dimerization protein 1 2.06831
MCOLN1 mucolipin 1 2.06831
SP2 Sp2 transcription factor 2.06831
BBS1 Bardet-Biedl syndrome 1 2.03666
MYADM myeloid-associated differentiation marker 2.02843
MAK male germ cell-associated kinase 2.02274
ZNF786 zinc finger protein 786 2.01415
CNKSR3 CNKSR family member 3 2.00433
CD2AP CD2-associated protein 2.00433
PDS5B PDS5 cohesin associated factor B 2.0007

decreased expression

Symbol Name Standardized Value
TMEM35A transmembrane protein 35A -3.2685
C16ORF86 chromosome 16 open reading frame 86 -3.2685
LYPD1 LY6/PLAUR domain containing 1 -3.2685
ATG4A autophagy related 4A, cysteine peptidase -3.2685
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -3.2685
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -3.2685
TTK TTK protein kinase -3.2685
SHISA7 shisa family member 7 -3.2685
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 -3.23786
SHD Src homology 2 domain containing transforming protein D -3.22361
DISP3 dispatched RND transporter family member 3 -3.18544
EMCN endomucin -3.17583
SYCP2 synaptonemal complex protein 2 -3.17583
HIGD1C HIG1 hypoxia inducible domain family, member 1C -3.17583
PGAM4 phosphoglycerate mutase family member 4 -3.17583
TMEM235 transmembrane protein 235 -3.17583
ANGPT4 angiopoietin 4 -3.17583
MISP mitotic spindle positioning -3.17583
WNT3A wingless-type MMTV integration site family, member 3A -3.17583
HORMAD2 HORMA domain containing 2 -3.17583
NOD2 nucleotide-binding oligomerization domain containing 2 -3.17583
MEI1 meiosis inhibitor 1 -3.17583
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -3.17583
ADGRE3 adhesion G protein-coupled receptor E3 -3.17583
ARSI arylsulfatase family, member I -3.17583
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -3.17583
NSF N-ethylmaleimide-sensitive factor -3.17583
NPIPA6 nuclear pore complex interacting protein family, member A6 -3.17583
ZAR1L zygote arrest 1-like -3.17583
FAM163A family with sequence similarity 163, member A -3.17583
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -3.17583
FIBIN fin bud initiation factor homolog (zebrafish) -3.17583
FIMP1 fertilization-influencing membrane protein 1 -3.17583
PSPN persephin -3.17583
ITGAD integrin, alpha D -3.17583
ATP5MGL ATP synthase membrane subunit g like -3.17583
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -3.17583
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -3.17583
FAM131C family with sequence similarity 131, member C -3.17583
BRDT bromodomain, testis-specific -3.17583
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -3.17583
GJD3 gap junction protein, delta 3, 31.9kDa -3.17583
ANXA9 annexin A9 -3.17583
IGFBP3 insulin-like growth factor binding protein 3 -3.04463
EFCAB8 EF-hand calcium binding domain 8 -3.04463
LAT linker for activation of T cells -3.04463
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) -2.9711
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.93686
ISCA2 iron-sulfur cluster assembly 2 -2.89501
TMEM187 transmembrane protein 187 -2.87793
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.75586
MTMR9 myotubularin related protein 9 -2.74279
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.66854
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -2.65046
FBLN5 fibulin 5 -2.57251
GXYLT2 glucoside xylosyltransferase 2 -2.51576
FBXL16 F-box and leucine-rich repeat protein 16 -2.50568
LYPD3 LY6/PLAUR domain containing 3 -2.43341
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.43168
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.40963
ZNF365 zinc finger protein 365 -2.35978
NCR1 natural cytotoxicity triggering receptor 1 -2.35978
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.31677
FBXO4 F-box protein 4 -2.28342
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.28342
SCTR secretin receptor -2.28342
ANAPC2 anaphase promoting complex subunit 2 -2.28078
CACFD1 calcium channel flower domain containing 1 -2.28078
UBE2C ubiquitin-conjugating enzyme E2C -2.28078
SRGAP2B SLIT-ROBO Rho GTPase activating protein 2B -2.28078
CBLN1 cerebellin 1 precursor -2.27704
CARD10 caspase recruitment domain family, member 10 -2.25917
KLHDC8A kelch domain containing 8A -2.25124
MEP1B meprin A, beta -2.25124
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.25124
CATSPERD catsper channel auxiliary subunit delta -2.25124
NKAP NFKB activating protein -2.23373
NPM3 nucleophosmin/nucleoplasmin 3 -2.2328
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.22387
CSPG4 chondroitin sulfate proteoglycan 4 -2.21955
ADPRH ADP-ribosylarginine hydrolase -2.21955
VSIG1 V-set and immunoglobulin domain containing 1 -2.21955
SV2C synaptic vesicle glycoprotein 2C -2.21955
POMP proteasome maturation protein -2.21955
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.19985
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.19375
GSDMD gasdermin D -2.17401
ANKDD1A ankyrin repeat and death domain containing 1A -2.17401
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.17401
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) -2.16637
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 -2.16239
RARA retinoic acid receptor, alpha -2.15454
COQ8B coenzyme Q8B -2.12687
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 -2.10761
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.08951
ANKRD33B ankyrin repeat domain 33B -2.08806
EEF1G eukaryotic translation elongation factor 1 gamma -2.08701
CEP41 centrosomal protein 41kDa -2.07868
H2BC4 H2B clustered histone 4 -2.06855
TANK TRAF family member-associated NFKB activator -2.05446
RBM7 RNA binding motif protein 7 -2.02758
RPL18 ribosomal protein L18 -2.01858
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.01578
EMILIN3 elastin microfibril interfacer 3 -2.0125
CEP85L centrosomal protein 85kDa-like -2.00278
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00278
ICE1 interactor of little elongation complex ELL subunit 1 -2.00278
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -2.00278
TRIM41 tripartite motif containing 41 -2.00186
F10 coagulation factor X -2.00186
KLF12 Kruppel-like factor 12 -2.00186
ABHD18 abhydrolase domain containing 18 -2.0007