| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | erb-b2 receptor tyrosine kinase 4|This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2066) |
| External Link | https://ncbi.nlm.nih.gov/gene/2066 |
| Similar Terms | |
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499 genes differentially expressed following the ERBB4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| XIC | X chromosome inactivation center | 0.0191732 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0177218 |
| ADD3 | adducin 3 (gamma) | 0.0140526 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0140491 |
| PITX3 | paired-like homeodomain 3 | 0.0135015 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.0134712 |
| KLK10 | kallikrein-related peptidase 10 | 0.0134324 |
| DOK5 | docking protein 5 | 0.0129967 |
| RGCC | regulator of cell cycle | 0.0123759 |
| TUBB2B | tubulin, beta 2B class IIb | 0.0120724 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0119801 |
| ECM1 | extracellular matrix protein 1 | 0.0117149 |
| FCGBP | Fc fragment of IgG binding protein | 0.0115366 |
| CLDN10 | claudin 10 | 0.0114157 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0112689 |
| ANXA1 | annexin A1 | 0.0112412 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.0109994 |
| MT1X | metallothionein 1X | 0.0108485 |
| TXLNA | taxilin alpha | 0.0107085 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0106625 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0103956 |
| THBS2 | thrombospondin 2 | 0.0103498 |
| AREG | amphiregulin | 0.0103323 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0102976 |
| OXTR | oxytocin receptor | 0.0100979 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.0100103 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00990558 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00988887 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00981847 |
| KLK6 | kallikrein-related peptidase 6 | 0.00958191 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00954687 |
| EMX2 | empty spiracles homeobox 2 | 0.00935325 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00925925 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00925857 |
| TYRP1 | tyrosinase-related protein 1 | 0.00921477 |
| EMP1 | epithelial membrane protein 1 | 0.00916015 |
| DEFB1 | defensin, beta 1 | 0.00900134 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00893804 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00879235 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00877823 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.00876 |
| TWIST1 | twist family bHLH transcription factor 1 | 0.00873796 |
| KLK5 | kallikrein-related peptidase 5 | 0.00871296 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00870508 |
| GRAMD2B | GRAM domain containing 2B | 0.00869505 |
| ATF3 | activating transcription factor 3 | 0.00863926 |
| LOXL1 | lysyl oxidase-like 1 | 0.00863575 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.00861987 |
| MT1F | metallothionein 1F | 0.00860139 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00858358 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00856499 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00847754 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 0.00844108 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00843137 |
| CLTB | clathrin, light chain B | 0.0084176 |
| MFAP5 | microfibrillar associated protein 5 | 0.0084033 |
| KLK7 | kallikrein-related peptidase 7 | 0.0083887 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00838127 |
| CD200 | CD200 molecule | 0.00836637 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00835357 |
| RPS27L | ribosomal protein S27-like | 0.00834422 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00827491 |
| KLK8 | kallikrein-related peptidase 8 | 0.00826616 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00825037 |
| RCAN1 | regulator of calcineurin 1 | 0.00817939 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.00815397 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00811263 |
| TOX | thymocyte selection-associated high mobility group box | 0.00809039 |
| MEN1 | multiple endocrine neoplasia I | 0.0080645 |
| LPPR4 | lipid phosphate phosphatase-related protein type 4 | 0.00802861 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.00792094 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00791515 |
| CLIC5 | chloride intracellular channel 5 | 0.00787852 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.00784631 |
| ADIRF | adipogenesis regulatory factor | 0.00777357 |
| TSPAN3 | tetraspanin 3 | 0.00776426 |
| MX1 | MX dynamin-like GTPase 1 | 0.00774178 |
| CFI | complement factor I | 0.00765604 |
| MME | membrane metallo-endopeptidase | 0.00764151 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.00760436 |
| RGS4 | regulator of G-protein signaling 4 | 0.00759436 |
| BTG3 | BTG family, member 3 | 0.00758993 |
| FGB | fibrinogen beta chain | 0.00758338 |
| SST | somatostatin | 0.00753622 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.0074309 |
| MUC16 | mucin 16, cell surface associated | 0.00742527 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.00740872 |
| MMD | monocyte to macrophage differentiation-associated | 0.00729802 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00728723 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00727721 |
| DIPK1A | divergent protein kinase domain 1A | 0.00726757 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00725923 |
| TCTA | T-cell leukemia translocation altered | 0.00724486 |
| PMP2 | peripheral myelin protein 2 | 0.00722441 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0071966 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.00714559 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00714015 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00713293 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.00709785 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.00708483 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00708223 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00700898 |
| IQCG | IQ motif containing G | 0.00696859 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00696586 |
| MAL | mal, T-cell differentiation protein | 0.00695841 |
| OLFML3 | olfactomedin-like 3 | 0.00695822 |
| RBBP4 | retinoblastoma binding protein 4 | 0.00694306 |
| RELN | reelin | 0.00693616 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00690278 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.00688555 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00687362 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.00684745 |
| CP | ceruloplasmin (ferroxidase) | 0.00683544 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00683542 |
| PPP2R2B | protein phosphatase 2, regulatory subunit B, beta | 0.00683212 |
| NRN1 | neuritin 1 | 0.00681739 |
| CD99 | CD99 molecule | 0.00680773 |
| MT1H | metallothionein 1H | 0.00677764 |
| CFAP20 | cilia and flagella associated protein 20 | 0.0067716 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00675634 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00674739 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 0.00674633 |
| TAGLN2 | transgelin 2 | 0.00668181 |
| SGCE | sarcoglycan, epsilon | 0.00667941 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00665629 |
| BEX4 | brain expressed, X-linked 4 | 0.00664303 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00663555 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00660023 |
| HOMER1 | homer scaffolding protein 1 | 0.00657531 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00656055 |
| CD248 | CD248 molecule, endosialin | 0.00653218 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00650868 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00648034 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.00648001 |
| GOLGA8H | golgin A8 family, member H | 0.00647887 |
| SLIRP | SRA stem-loop interacting RNA binding protein | 0.00647218 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 0.00644322 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0064317 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00642675 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 0.00639171 |
| GPR137B | G protein-coupled receptor 137B | 0.00638111 |
| ADRA2A | adrenoceptor alpha 2A | 0.00637437 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00637076 |
| KLK11 | kallikrein-related peptidase 11 | 0.0063654 |
| THBS1 | thrombospondin 1 | 0.00635103 |
| BCL2A1 | BCL2-related protein A1 | 0.0063421 |
| ATP5PD | ATP synthase peripheral stalk subunit d | 0.00633327 |
| PLSCR4 | phospholipid scramblase 4 | 0.0063295 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00632892 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.00632179 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00631411 |
| MXRA5 | matrix-remodelling associated 5 | 0.00631327 |
| GNAS | GNAS complex locus | 0.00630119 |
| AK4 | adenylate kinase 4 | 0.00628006 |
| RHOC | ras homolog family member C | 0.00627772 |
| H1-2 | H1.2 linker histone, cluster member | 0.0062435 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00621343 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 0.0062114 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.00620491 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00619813 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.00619458 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00617839 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0061478 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00614727 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.00613694 |
| ETHE1 | ethylmalonic encephalopathy 1 | 0.00612801 |
| FOXG1 | forkhead box G1 | 0.00612542 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 0.00611748 |
| COL3A1 | collagen, type III, alpha 1 | 0.00611505 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00611356 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00610965 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0061037 |
| COPZ2 | coatomer protein complex, subunit zeta 2 | 0.00609601 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.00608748 |
| MT1G | metallothionein 1G | 0.0060727 |
| IL1R1 | interleukin 1 receptor, type I | 0.0060425 |
| TXN | thioredoxin | 0.00603981 |
| PEG3 | paternally expressed 3 | 0.00602656 |
| MEOX2 | mesenchyme homeobox 2 | 0.00601751 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.00600206 |
| DAAM2 | dishevelled associated activator of morphogenesis 2 | 0.00599962 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.00597896 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00596302 |
| BEX1 | brain expressed, X-linked 1 | 0.00595942 |
| SSPN | sarcospan | 0.00595342 |
| PODXL | podocalyxin-like | 0.00594844 |
| PLTP | phospholipid transfer protein | 0.00594344 |
| HSP90B2P | heat shock protein 90kDa beta (Grp94), member 2, pseudogene | 0.00593432 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | 0.00593405 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00588965 |
| HMOX1 | heme oxygenase 1 | 0.0058858 |
| SELE | selectin E | 0.0058722 |
| MMP19 | matrix metallopeptidase 19 | 0.00585654 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.00585459 |
| ELOVL2 | ELOVL fatty acid elongase 2 | 0.00585407 |
| GSTP1 | glutathione S-transferase pi 1 | 0.00584856 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.00579881 |
| STC2 | stanniocalcin 2 | 0.00579042 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.005774 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.00576159 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | 0.0057587 |
| ITPKB | inositol-trisphosphate 3-kinase B | 0.00575452 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00575112 |
| CCNG1 | cyclin G1 | 0.00574392 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00574256 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00574229 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | 0.00571093 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.00570663 |
| PON2 | paraoxonase 2 | 0.00570387 |
| IFI44 | interferon-induced protein 44 | 0.00569507 |
| MX2 | MX dynamin-like GTPase 2 | 0.00568685 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | 0.00567523 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00566568 |
| TCF4 | transcription factor 4 | 0.00564069 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.00563437 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.00563423 |
| MARCH2 | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase | 0.00563111 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00562515 |
| S100A7 | S100 calcium binding protein A7 | 0.00562357 |
| MT1E | metallothionein 1E | 0.00562065 |
| ZFHX4 | zinc finger homeobox 4 | 0.0056204 |
| IFI44L | interferon-induced protein 44-like | 0.00561692 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.00561333 |
| CHMP2A | charged multivesicular body protein 2A | 0.00561054 |
| TP53TG1 | TP53 target 1 (non-protein coding) | 0.00560683 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00559142 |
| GMFB | glia maturation factor, beta | 0.00558047 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | 0.00557687 |
| C5AR1 | complement component 5a receptor 1 | 0.00557474 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | 0.00556276 |
| SPRR3 | small proline-rich protein 3 | 0.00554972 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00553043 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 0.0055296 |
| KRT14 | keratin 14, type I | 0.00552804 |
| FMO1 | flavin containing monooxygenase 1 | 0.00552713 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0055239 |
| EBNA1BP2 | EBNA1 binding protein 2 | 0.00551576 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.00551317 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.00550433 |
| IRF7 | interferon regulatory factor 7 | 0.00548837 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00548262 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00548253 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00546756 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00546439 |
| CD69 | CD69 molecule | 0.00545544 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.00544747 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00544494 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.00543728 |
| FN1 | fibronectin 1 | 0.00543076 |
| YIPF5 | Yip1 domain family, member 5 | 0.00542943 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0153617 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.0135529 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.0111623 |
| PRDX2 | peroxiredoxin 2 | -0.0110319 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0108045 |
| DES | desmin | -0.0106615 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.0105472 |
| TGM2 | transglutaminase 2 | -0.0105143 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | -0.010471 |
| RXRA | retinoid X receptor, alpha | -0.0103666 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.0103501 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0101811 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0093372 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00917378 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.00917072 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.00896869 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -0.00890805 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.00889792 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00868639 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00864809 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00857725 |
| SVIL | supervillin | -0.00848991 |
| FGL2 | fibrinogen-like 2 | -0.00848965 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00846238 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00841732 |
| NVL | nuclear VCP-like | -0.00837444 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0083342 |
| NEFH | neurofilament, heavy polypeptide | -0.00809142 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00805887 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00800519 |
| EFHD2 | EF-hand domain family, member D2 | -0.00792273 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00790322 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -0.00775373 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | -0.00772099 |
| IL7R | interleukin 7 receptor | -0.00770592 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00769968 |
| SFN | stratifin | -0.00760941 |
| USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | -0.00750204 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00742831 |
| SDC1 | syndecan 1 | -0.00740622 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -0.00738928 |
| FHOD3 | formin homology 2 domain containing 3 | -0.00734713 |
| ACP3 | acid phosphatase 3 | -0.00730115 |
| MICU2 | mitochondrial calcium uptake 2 | -0.00728575 |
| MEIS2 | Meis homeobox 2 | -0.00721603 |
| KLHDC3 | kelch domain containing 3 | -0.00719963 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00718885 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00718838 |
| CD2 | CD2 molecule | -0.00718003 |
| LMNB2 | lamin B2 | -0.00717571 |
| PCP4 | Purkinje cell protein 4 | -0.00714345 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00702252 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00701828 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | -0.00698852 |
| KLK2 | kallikrein-related peptidase 2 | -0.00698569 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00693461 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00690752 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | -0.00688759 |
| CLEC10A | C-type lectin domain family 10, member A | -0.00684007 |
| PRF1 | perforin 1 (pore forming protein) | -0.00683997 |
| TLK2 | tousled-like kinase 2 | -0.00683772 |
| PLK1 | polo-like kinase 1 | -0.00683176 |
| CD8A | CD8a molecule | -0.00683014 |
| RTN2 | reticulon 2 | -0.00682719 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -0.00681909 |
| SMTN | smoothelin | -0.00681527 |
| KLHDC2 | kelch domain containing 2 | -0.0068002 |
| CERK | ceramide kinase | -0.0067745 |
| PLN | phospholamban | -0.0067629 |
| PRKCZ | protein kinase C, zeta | -0.00673795 |
| S100A4 | S100 calcium binding protein A4 | -0.00672768 |
| NELL2 | NEL-like 2 (chicken) | -0.00669644 |
| ELP1 | elongator acetyltransferase complex subunit 1 | -0.00666076 |
| FBLN1 | fibulin 1 | -0.0066565 |
| NELFB | negative elongation factor complex member B | -0.00665423 |
| UBP1 | upstream binding protein 1 (LBP-1a) | -0.00663957 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.0065844 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00653089 |
| S100A2 | S100 calcium binding protein A2 | -0.00652101 |
| FOXM1 | forkhead box M1 | -0.00651531 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00647553 |
| PDGFC | platelet derived growth factor C | -0.00643671 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00642984 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00640955 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00634713 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | -0.00633957 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.00632314 |
| PFKM | phosphofructokinase, muscle | -0.00631436 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00629604 |
| COL4A6 | collagen, type IV, alpha 6 | -0.00629394 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00628725 |
| FASN | fatty acid synthase | -0.00626818 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.00624311 |
| IL2RB | interleukin 2 receptor, beta | -0.00621023 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.0062076 |
| CKAP2 | cytoskeleton associated protein 2 | -0.00619374 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00616862 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00613514 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | -0.00611251 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00610941 |
| NADK | NAD kinase | -0.00609781 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00609405 |
| DVL1 | dishevelled segment polarity protein 1 | -0.00609291 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00607413 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.00604858 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00604529 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00599408 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00598644 |
| CDK8 | cyclin-dependent kinase 8 | -0.00595987 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | -0.00595657 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00595573 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.00595388 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.00594588 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | -0.0058904 |
| RACGAP1 | Rac GTPase activating protein 1 | -0.00587259 |
| KLK3 | kallikrein-related peptidase 3 | -0.0058569 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.00583889 |
| PRPF19 | pre-mRNA processing factor 19 | -0.00583724 |
| HOMER2 | homer scaffolding protein 2 | -0.00579992 |
| CLSTN1 | calsyntenin 1 | -0.00579579 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.00577745 |
| GSTT1 | glutathione S-transferase theta 1 | -0.00576377 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00573172 |
| CDC20 | cell division cycle 20 | -0.00571549 |
| NDNF | neuron-derived neurotrophic factor | -0.00569882 |
| AHSP | alpha hemoglobin stabilizing protein | -0.00569483 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00568648 |
| VLDLR | very low density lipoprotein receptor | -0.00567993 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | -0.00565059 |
| SFTPD | surfactant protein D | -0.00564479 |
| MEX3D | mex-3 RNA binding family member D | -0.00563079 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.00561956 |
| TARDBP | TAR DNA binding protein | -0.00561695 |
| PMM2 | phosphomannomutase 2 | -0.00559215 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0055905 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | -0.00558385 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.00558267 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00557954 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.00557942 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.00557808 |
| FAM120A | family with sequence similarity 120A | -0.00557485 |
| DGKZ | diacylglycerol kinase, zeta | -0.0055612 |
| KCNH2 | potassium channel, voltage gated eag related subfamily H, member 2 | -0.00556058 |
| PDLIM3 | PDZ and LIM domain 3 | -0.00554917 |
| XCL1 | chemokine (C motif) ligand 1 | -0.00553408 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00552041 |
| NKG7 | natural killer cell granule protein 7 | -0.00550478 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.00549652 |
| G6PD | glucose-6-phosphate dehydrogenase | -0.00549647 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | -0.00546822 |
| PLXNA2 | plexin A2 | -0.00545276 |
| EREG | epiregulin | -0.00544337 |
| CENPU | centromere protein U | -0.0054402 |
| FAM13A | family with sequence similarity 13, member A | -0.00540623 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.00537973 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | -0.00537925 |
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | -0.00535566 |
| CCDC47 | coiled-coil domain containing 47 | -0.00535323 |
| TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | -0.00534828 |
| MYBPC2 | myosin binding protein C, fast type | -0.00534667 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00532421 |
| MRPS2 | mitochondrial ribosomal protein S2 | -0.00532094 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | -0.00531131 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.00530956 |
| C7ORF26 | chromosome 7 open reading frame 26 | -0.00530152 |
| CCNB2 | cyclin B2 | -0.00529688 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00529118 |
| PYCARD | PYD and CARD domain containing | -0.00528721 |
| MLPH | melanophilin | -0.00528172 |
| CWH43 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | -0.00525634 |
| CNN1 | calponin 1, basic, smooth muscle | -0.00525317 |
| MSMB | microseminoprotein, beta- | -0.00523797 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00523682 |
| PLCL2 | phospholipase C-like 2 | -0.00522829 |
| REEP1 | receptor accessory protein 1 | -0.00522685 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | -0.00522401 |
| CD46 | CD46 molecule, complement regulatory protein | -0.00521791 |
| BTBD2 | BTB (POZ) domain containing 2 | -0.00521553 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00520951 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00518552 |
| CLASRP | CLK4-associating serine/arginine rich protein | -0.0051679 |
| RAD21 | RAD21 homolog (S. pombe) | -0.00516424 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00516269 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.00513825 |
| RNPEP | arginyl aminopeptidase (aminopeptidase B) | -0.00512915 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.00512885 |
| TIMELESS | timeless circadian clock | -0.00511154 |
| OLFM4 | olfactomedin 4 | -0.00510892 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.005103 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00510275 |
| PAGE4 | P antigen family, member 4 (prostate associated) | -0.0050992 |
| BST2 | bone marrow stromal cell antigen 2 | -0.0050964 |
| TGFB1 | transforming growth factor, beta 1 | -0.00509292 |
| GNLY | granulysin | -0.00508891 |
| ABHD17A | abhydrolase domain containing 17A | -0.00508798 |
| GANAB | glucosidase, alpha; neutral AB | -0.00508136 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00507651 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00505302 |
| CRTC3 | CREB regulated transcription coactivator 3 | -0.00505138 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.0050458 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.00504504 |
| SHROOM2 | shroom family member 2 | -0.00504314 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.00503549 |
| CDCP1 | CUB domain containing protein 1 | -0.00503193 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.00502322 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.00500934 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00500742 |
| IL10RA | interleukin 10 receptor, alpha | -0.00500703 |
| MB | myoglobin | -0.00500356 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00499924 |
| TSPYL5 | TSPY-like 5 | -0.00499918 |
| PRSS8 | protease, serine, 8 | -0.00499194 |
| TST | thiosulfate sulfurtransferase (rhodanese) | -0.00498382 |
| FOXA1 | forkhead box A1 | -0.00496961 |
| KAZN | kazrin, periplakin interacting protein | -0.00496838 |
| CTSH | cathepsin H | -0.00495192 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | -0.00495033 |
| ANAPC2 | anaphase promoting complex subunit 2 | -0.00494991 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.0049321 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.00492982 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.00492866 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00491911 |
| SYPL1 | synaptophysin-like 1 | -0.00491304 |
| ADCY9 | adenylate cyclase 9 | -0.00491233 |
| FZD2 | frizzled class receptor 2 | -0.00490915 |
| GATA2 | GATA binding protein 2 | -0.00489997 |
| RPA1 | replication protein A1, 70kDa | -0.00489676 |
| TNC | tenascin C | -0.00489146 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.00488723 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.0048866 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | -0.00488283 |
| CROCCP2 | ciliary rootlet coiled-coil, rootletin pseudogene 2 | -0.00487576 |
| SUN1 | Sad1 and UNC84 domain containing 1 | -0.00486726 |
| GPC1 | glypican 1 | -0.0048471 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | -0.00484099 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00482638 |
| ENO3 | enolase 3 (beta, muscle) | -0.0048248 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | -0.00481166 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00480889 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | -0.00480774 |
| FRY | furry homolog (Drosophila) | -0.00479566 |
| THUMPD1 | THUMP domain containing 1 | -0.0047943 |
| CCND1 | cyclin D1 | -0.00478601 |
| WWC3 | WWC family member 3 | -0.0047853 |
| LYZ | lysozyme | -0.00478382 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00478079 |
| LRRC47 | leucine rich repeat containing 47 | -0.00477251 |
| CDK11A | cyclin-dependent kinase 11A | -0.00476439 |
| USP48 | ubiquitin specific peptidase 48 | -0.00475616 |
