ERBB4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description erb-b2 receptor tyrosine kinase 4|This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2066)
External Link http://www.ncbi.nlm.nih.gov/gene/2066
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313 interacting proteins for ERBB4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTBL2 actin, beta-like 2
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ARCN1 archain 1
AREG amphiregulin
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BAIAP2 BAI1-associated protein 2
BCR breakpoint cluster region
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTC betacellulin
BTK Bruton agammaglobulinemia tyrosine kinase
BYSL bystin-like
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CD247 CD247 molecule
CD28 CD28 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CD80 CD80 molecule
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH12 cadherin 12, type 2 (N-cadherin 2)
CDH13 cadherin 13
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDH16 cadherin 16, KSP-cadherin
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDH18 cadherin 18, type 2
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH20 cadherin 20, type 2
CDH22 cadherin 22, type 2
CDH23 cadherin-related 23
CDH24 cadherin 24, type 2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDH7 cadherin 7, type 2
CDH8 cadherin 8, type 2
CDH9 cadherin 9, type 2 (T1-cadherin)
CDHR1 cadherin-related family member 1
CDHR2 cadherin-related family member 2
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CNTRL centriolin
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
COPE coatomer protein complex, subunit epsilon
COPG1 coatomer protein complex, subunit gamma 1
COPG2 coatomer protein complex, subunit gamma 2
COPZ1 coatomer protein complex, subunit zeta 1
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSNK1A1L casein kinase 1, alpha 1-like
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUX1 cut-like homeobox 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCHS1 dachsous cadherin-related 1
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DLG1 discs, large homolog 1 (Drosophila)
DLG2 discs, large homolog 2 (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DNHD1 dynein heavy chain domain 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
FAT1 FAT atypical cadherin 1
FAT2 FAT atypical cadherin 2
FAT3 FAT atypical cadherin 3
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FGFR1OP2 FGFR1 oncogene partner 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FUOM fucose mutarotase
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GBA glucosidase, beta, acid
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
HBEGF heparin-binding EGF-like growth factor
HDAC6 histone deacetylase 6
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
ITCH itchy E3 ubiquitin protein ligase
ITK IL2-inducible T-cell kinase
KL klotho
KLB klotho beta
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MRAS muscle RAS oncogene homolog
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYO18A myosin XVIIIA
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NCOR1 nuclear receptor corepressor 1
NCSTN nicastrin
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NRG2 neuregulin 2
NRG3 neuregulin 3
NRG4 neuregulin 4
NUDCD1 NudC domain containing 1
PCDH1 protocadherin 1
PCDH10 protocadherin 10
PCDH11X protocadherin 11 X-linked
PCDH11Y protocadherin 11 Y-linked
PCDH12 protocadherin 12
PCDH15 protocadherin-related 15
PCDH18 protocadherin 18
PCDH19 protocadherin 19
PCDH20 protocadherin 20
PCDH7 protocadherin 7
PCDH8 protocadherin 8
PCDH9 protocadherin 9
PCDHA1 protocadherin alpha 1
PCDHA10 protocadherin alpha 10
PCDHA11 protocadherin alpha 11
PCDHA12 protocadherin alpha 12
PCDHA13 protocadherin alpha 13
PCDHA2 protocadherin alpha 2
PCDHA3 protocadherin alpha 3
PCDHA4 protocadherin alpha 4
PCDHA5 protocadherin alpha 5
PCDHA6 protocadherin alpha 6
PCDHA7 protocadherin alpha 7
PCDHA8 protocadherin alpha 8
PCDHA9 protocadherin alpha 9
PCDHAC1 protocadherin alpha subfamily C, 1
PCDHAC2 protocadherin alpha subfamily C, 2
PCDHB1 protocadherin beta 1
PCDHB10 protocadherin beta 10
PCDHB11 protocadherin beta 11
PCDHB12 protocadherin beta 12
PCDHB13 protocadherin beta 13
PCDHB14 protocadherin beta 14
PCDHB15 protocadherin beta 15
PCDHB16 protocadherin beta 16
PCDHB2 protocadherin beta 2
PCDHB3 protocadherin beta 3
PCDHB4 protocadherin beta 4
PCDHB5 protocadherin beta 5
PCDHB6 protocadherin beta 6
PCDHB7 protocadherin beta 7
PCDHB8 protocadherin beta 8
PCDHGA1 protocadherin gamma subfamily A, 1
PCDHGA10 protocadherin gamma subfamily A, 10
PCDHGA11 protocadherin gamma subfamily A, 11
PCDHGA12 protocadherin gamma subfamily A, 12
PCDHGA2 protocadherin gamma subfamily A, 2
PCDHGA3 protocadherin gamma subfamily A, 3
PCDHGA5 protocadherin gamma subfamily A, 5
PCDHGA6 protocadherin gamma subfamily A, 6
PCDHGA7 protocadherin gamma subfamily A, 7
PCDHGA8 protocadherin gamma subfamily A, 8
PCDHGB1 protocadherin gamma subfamily B, 1
PCDHGB2 protocadherin gamma subfamily B, 2
PCDHGB4 protocadherin gamma subfamily B, 4
PCDHGB6 protocadherin gamma subfamily B, 6
PCDHGB7 protocadherin gamma subfamily B, 7
PCDHGC3 protocadherin gamma subfamily C, 3
PCDHGC4 protocadherin gamma subfamily C, 4
PCDHGC5 protocadherin gamma subfamily C, 5
PDPK1 3-phosphoinositide dependent protein kinase 1
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RHOA ras homolog family member A
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPS27A ribosomal protein S27a
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOS1 son of sevenless homolog 1 (Drosophila)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY3 sprouty homolog 3 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TEC tec protein tyrosine kinase
TGFA transforming growth factor, alpha
TP53 tumor protein p53
TRIM24 tripartite motif containing 24
TRIM28 tripartite motif containing 28
TRO trophinin
TROAP trophinin associated protein
TXK TXK tyrosine kinase
UBC ubiquitin C
USP8 ubiquitin specific peptidase 8
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VWA8 von Willebrand factor A domain containing 8
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WWOX WW domain containing oxidoreductase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YAP1 Yes-associated protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZMYM2 zinc finger, MYM-type 2