ERCC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description excision repair cross-complementation group 1|The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 2067)
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Genes

357 genes differentially expressed following the ERCC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPATA20 spermatogenesis associated 20 2.75709
ILDR2 immunoglobulin-like domain containing receptor 2 2.75709
NTF4 neurotrophin 4 2.75709
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.75709
PCDHA11 protocadherin alpha 11 2.75709
GLUD2 glutamate dehydrogenase 2 2.75709
SOX30 SRY (sex determining region Y)-box 30 2.75709
ALOX15 arachidonate 15-lipoxygenase 2.75709
IL19 interleukin 19 2.75709
PRDM1 PR domain containing 1, with ZNF domain 2.75709
VWC2L von Willebrand factor C domain containing protein 2-like 2.75709
DRD3 dopamine receptor D3 2.75709
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.75709
SGK2 serum/glucocorticoid regulated kinase 2 2.75709
TMED6 transmembrane emp24 protein transport domain containing 6 2.75709
RIPK4 receptor-interacting serine-threonine kinase 4 2.75709
EHF ets homologous factor 2.75709
FRMPD2 FERM and PDZ domain containing 2 2.75709
PKD1L1 polycystic kidney disease 1 like 1 2.75709
NPFF neuropeptide FF-amide peptide precursor 2.75709
CCER2 coiled-coil glutamate-rich protein 2 2.75709
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.75709
MIA melanoma inhibitory activity 2.75709
ZMYND15 zinc finger, MYND-type containing 15 2.75709
DRC1 dynein regulatory complex subunit 1 2.75709
CCDC92 coiled-coil domain containing 92 2.75709
GBX2 gastrulation brain homeobox 2 2.75709
MYLK4 myosin light chain kinase family, member 4 2.75709
RLBP1 retinaldehyde binding protein 1 2.75709
ITGA8 integrin, alpha 8 2.75709
CD79A CD79a molecule, immunoglobulin-associated alpha 2.67397
GDA guanine deaminase 2.67397
FNBP1 formin binding protein 1 2.67397
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.67397
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.67397
MYBPHL myosin binding protein H-like 2.67397
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.67397
CD96 CD96 molecule 2.67397
CLDN9 claudin 9 2.67397
MYOM2 myomesin 2 2.67397
AGTR1 angiotensin II receptor, type 1 2.67397
PCDHA3 protocadherin alpha 3 2.67397
CD274 CD274 molecule 2.67397
ASB15 ankyrin repeat and SOCS box containing 15 2.67397
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.67397
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.67397
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.67397
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.67397
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.67397
TNC tenascin C 2.67397
TCAF2 TRPM8 channel-associated factor 2 2.67397
RFPL3 ret finger protein-like 3 2.67397
THRSP thyroid hormone responsive 2.67397
CXCL2 chemokine (C-X-C motif) ligand 2 2.67397
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.67397
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.67397
IL5RA interleukin 5 receptor, alpha 2.67397
HORMAD1 HORMA domain containing 1 2.67397
ZNF492 zinc finger protein 492 2.67397
COLEC10 collectin sub-family member 10 (C-type lectin) 2.67397
SACK1H scaffolding CK1 anchoring protein H 2.67397
PI16 peptidase inhibitor 16 2.67397
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.67397
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.67397
CD19 CD19 molecule 2.67397
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.67397
PGAM4 phosphoglycerate mutase family member 4 2.67397
CELA3A chymotrypsin-like elastase family, member 3A 2.67397
PCDHB6 protocadherin beta 6 2.67397
ARSI arylsulfatase family, member I 2.67397
ULBP1 UL16 binding protein 1 2.67397
LOC107986837 uncharacterized LOC107986837 2.67397
CATSPERZ catsper channel auxiliary subunit zeta 2.67397
TERB1 telomere repeat binding bouquet formation protein 1 2.67397
ERFE erythroferrone 2.67397
CFAP141 cilia and flagella associated protein 141 2.67397
RNF227 ring finger protein 227 2.67397
CRACDL CRACD like 2.67397
PLAAT2 phospholipase A and acyltransferase 2 2.67397
MYOCOS myocilin opposite strand 2.67397
SMIM41 small integral membrane protein 41 2.67397
EPOP elongin BC and polycomb repressive complex 2 associated protein 2.67397
TAFA1 TAFA chemokine like family member 1 2.67397
H2AC1 H2A clustered histone 1 2.67397
H3C14 H3 clustered histone 14 2.67397
LRTM3 leucine rich repeat transmembrane protein 3 2.67397
FAM90A24 family with sequence similarity 90 member A24 2.67397
CPNE8-AS1 CPNE8 antisense RNA 1 2.67397
SAXO4 stabilizer of axonemal microtubules 4 2.67397
SPMIP3 sperm microtubule inner protein 3 2.67397
CIMAP1B ciliary microtubule associated protein 1B 2.67397
LOC124906010 uncharacterized LOC124906010 2.67397
LOC124902436 talanin 2.67397
H3C13 H3 clustered histone 13 2.67397
GREP1 glycine rich extracellular protein 1 2.67397
SPATS1 spermatogenesis associated, serine-rich 1 2.67397
YIPF7 Yip1 domain family, member 7 2.67397
CLDN22 claudin 22 2.67397
CCR4 chemokine (C-C motif) receptor 4 2.67397
EXOC3L1 exocyst complex component 3-like 1 2.67397
SPDYE16 speedy/RINGO cell cycle regulator family member E16 2.67397
FAM186A family with sequence similarity 186, member A 2.67397
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.67397
C1QTNF7 C1q and tumor necrosis factor related protein 7 2.67397
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.67397
GDF10 growth differentiation factor 10 2.67397
TFEC transcription factor EC 2.67397
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.67397
FGFBP2 fibroblast growth factor binding protein 2 2.67397
ROPN1 rhophilin associated tail protein 1 2.67397
BEND2 BEN domain containing 2 2.67397
CXCL13 chemokine (C-X-C motif) ligand 13 2.67397
HTRA1 HtrA serine peptidase 1 2.67397
SAG S-antigen; retina and pineal gland (arrestin) 2.67397
MYPN myopalladin 2.67397
CMKLR1 chemerin chemokine-like receptor 1 2.67397
F5 coagulation factor V (proaccelerin, labile factor) 2.67397
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.67397
IL16 interleukin 16 2.67397
PCDHGC3 protocadherin gamma subfamily C, 3 2.67397
TMEM236 transmembrane protein 236 2.67397
SLC51B solute carrier family 51, beta subunit 2.67397
ZNF366 zinc finger protein 366 2.67397
MAGEA2B melanoma antigen family A2B 2.67397
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.67397
TCEA3 transcription elongation factor A (SII), 3 2.67397
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like 2.67397
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.67397
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.67397
AQP3 aquaporin 3 (Gill blood group) 2.67397
CTAGE9 CTAGE family, member 9 2.67397
FBXO32 F-box protein 32 2.67397
DYTN dystrotelin 2.67397
ERMN ermin, ERM-like protein 2.67397
TMEM86A transmembrane protein 86A 2.67397
POTEF POTE ankyrin domain family, member F 2.67397
ROM1 retinal outer segment membrane protein 1 2.67397
DAND5 DAN domain family member 5, BMP antagonist 2.67397
PRSS55 protease, serine, 55 2.67397
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.67397
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.67397
KRT17 keratin 17, type I 2.67397
DOC2B double C2-like domains, beta 2.67397
HSPA1L heat shock 70kDa protein 1-like 2.67397
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.67397
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.67397
VAV1 vav 1 guanine nucleotide exchange factor 2.67397
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.67397
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.67397
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.67397
TMEM255A transmembrane protein 255A 2.67397
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.67397
GOLGA8R golgin A8 family, member R 2.67397
MZB1 marginal zone B and B1 cell-specific protein 2.67397
MAGT1 magnesium transporter 1 2.67397
CFAP61 cilia and flagella associated protein 61 2.67397
CHIT1 chitinase 1 (chitotriosidase) 2.67397
UTS2R urotensin 2 receptor 2.67397
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.67397
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.67397
CPA3 carboxypeptidase A3 (mast cell) 2.67397
PCDHGA5 protocadherin gamma subfamily A, 5 2.67397
AGXT2 alanine--glyoxylate aminotransferase 2 2.67397
ZCCHC12 zinc finger, CCHC domain containing 12 2.67397
C8ORF89 chromosome 8 open reading frame 89 2.67397
ZFP92 ZFP92 zinc finger protein 2.67397
HK3 hexokinase 3 (white cell) 2.67397
NLRP14 NLR family, pyrin domain containing 14 2.67397
GUCY2F guanylate cyclase 2F, retinal 2.67397
RLN3 relaxin 3 2.67397
SOST sclerostin 2.67397
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.67397
SFTPB surfactant protein B 2.67397
C8ORF74 chromosome 8 open reading frame 74 2.67397
CCDC38 coiled-coil domain containing 38 2.67397
S100A1 S100 calcium binding protein A1 2.67397
GNRHR gonadotropin-releasing hormone receptor 2.67397
LEP leptin 2.67397
ASGR2 asialoglycoprotein receptor 2 2.67397
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.67397
EXOC3 exocyst complex component 3 2.67397
ETV2 ets variant 2 2.67397
NWD2 NACHT and WD repeat domain containing 2 2.67397
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.67397
SMIM5 small integral membrane protein 5 2.67397
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.67397
PCDH9 protocadherin 9 2.67397
CLDN34 claudin 34 2.67397
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.67397
C1ORF146 chromosome 1 open reading frame 146 2.67397
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 2.67397
SLC38A11 solute carrier family 38, member 11 2.67397
NLRP3 NLR family, pyrin domain containing 3 2.67397
LRRC10B leucine rich repeat containing 10B 2.67397
ATOH7 atonal homolog 7 (Drosophila) 2.67397
TSSK1B testis-specific serine kinase 1B 2.67397
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.67397
CD226 CD226 molecule 2.67397
KCNIP3 Kv channel interacting protein 3, calsenilin 2.67397
RABL2B RAB, member of RAS oncogene family-like 2B 2.62936
BRD3 bromodomain containing 3 2.62355
RTBDN retbindin 2.59839
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.58185
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.55277
ZSCAN20 zinc finger and SCAN domain containing 20 2.52878
DPPA2 developmental pluripotency associated 2 2.49744
DLG1 discs, large homolog 1 (Drosophila) 2.49011
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.47478
PYM1 PYM homolog 1, exon junction complex associated factor 2.46233
CFP complement factor properdin 2.40712
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.40712
MANSC1 MANSC domain containing 1 2.39917
PRRC1 proline-rich coiled-coil 1 2.31676
SRPK1 SRSF protein kinase 1 2.30191
ZNF852 zinc finger protein 852 2.30134
ZNF423 zinc finger protein 423 2.29961
PTDSS1 phosphatidylserine synthase 1 2.29379
PRSS23 protease, serine, 23 2.29041
NRXN3 neurexin 3 2.26983
MON1A MON1 secretory trafficking family member A 2.26336
PHLDA1 pleckstrin homology-like domain, family A, member 1 2.23627
SMOC2 SPARC related modular calcium binding 2 2.23555
SMG7 SMG7 nonsense mediated mRNA decay factor 2.20972
TMEM67 transmembrane protein 67 2.19721
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.18207
H2AC21 H2A clustered histone 21 2.14602
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.14266
ITM2A integral membrane protein 2A 2.12507
TSPAN3 tetraspanin 3 2.12294
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.11996
SRXN1 sulfiredoxin 1 2.11448
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 2.1063
FAM219B family with sequence similarity 219, member B 2.10377
EFR3B EFR3 homolog B (S. cerevisiae) 2.08889
TCEA1 transcription elongation factor A (SII), 1 2.08813
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.04069
MAT2A methionine adenosyltransferase II, alpha 2.04069
TMEM41B transmembrane protein 41B 2.04069
CIRSR corepressor of RBPJ and splicing regulator 2.03602
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.01907
NALF1 NALCN channel auxiliary factor 1 2.00714
ZNF774 zinc finger protein 774 2.00714
CYBRD1 cytochrome b reductase 1 2.00714

decreased expression

Symbol Name Standardized Value
PCDHGA10 protocadherin gamma subfamily A, 10 -2.75709
INSYN2B inhibitory synaptic factor family member 2B -2.67397
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.67397
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.67397
CSNK1G2 casein kinase 1, gamma 2 -2.67397
LMOD1 leiomodin 1 (smooth muscle) -2.67397
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase -2.67397
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.67397
XAB2 XPA binding protein 2 -2.67397
KRT10 keratin 10, type I -2.67397
SAR1B secretion associated, Ras related GTPase 1B -2.67397
AOPEP aminopeptidase O (putative) -2.67397
STRIT1 small transmembrane regulator of ion transport 1 -2.67397
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 -2.67397
HJV hemojuvelin BMP co-receptor -2.67397
LRIF1 ligand dependent nuclear receptor interacting factor 1 -2.67397
PACC1 proton activated chloride channel 1 -2.67397
WNT3 wingless-type MMTV integration site family, member 3 -2.64139
EGFL6 EGF-like-domain, multiple 6 -2.59839
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -2.59839
RPH3A rabphilin 3A -2.59839
ZNF471 zinc finger protein 471 -2.59839
FBXO47 F-box protein 47 -2.59839
VSTM2L V-set and transmembrane domain containing 2 like -2.59839
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 -2.59839
BMP2 bone morphogenetic protein 2 -2.59839
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.59839
SHOX short stature homeobox -2.59839
SLC25A45 solute carrier family 25, member 45 -2.59839
C10ORF90 chromosome 10 open reading frame 90 -2.59839
DUSP10 dual specificity phosphatase 10 -2.59839
LMO2 LIM domain only 2 (rhombotin-like 1) -2.59839
ADAM33 ADAM metallopeptidase domain 33 -2.59839
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.59839
SMKR1 small lysine-rich protein 1 -2.59839
DPF3 D4, zinc and double PHD fingers, family 3 -2.59839
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -2.59839
KCTD13 potassium channel tetramerization domain containing 13 -2.59839
PNLIPRP2 pancreatic lipase-related protein 2 -2.59839
SPI1 Spi-1 proto-oncogene -2.59839
RBM24 RNA binding motif protein 24 -2.59839
ZGLP1 zinc finger, GATA-like protein 1 -2.59839
CIMAP2 ciliary microtubule associated protein 2 -2.59839
GPR87 G protein-coupled receptor 87 -2.59839
SPEF2 sperm flagellar 2 -2.59839
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.59839
PCDHB14 protocadherin beta 14 -2.59839
ADAM8 ADAM metallopeptidase domain 8 -2.59839
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.59839
STAR steroidogenic acute regulatory protein -2.59839
PAGE4 P antigen family, member 4 (prostate associated) -2.59839
EPHA10 EPH receptor A10 -2.59839
LHFPL7 LHFPL tetraspan subfamily member 7 -2.59839
ACSL1 acyl-CoA synthetase long-chain family member 1 -2.58741
PTCHD1 patched domain containing 1 -2.57151
DPH2 DPH2 homolog (S. cerevisiae) -2.56081
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -2.52688
MXD3 MAX dimerization protein 3 -2.51166
SLC22A31 solute carrier family 22, member 31 -2.49744
ADRA2B adrenoceptor alpha 2B -2.49744
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 -2.48347
GANC glucosidase, alpha; neutral C -2.4724
ERCC1 excision repair cross-complementation group 1 -2.46233
ELAVL1 ELAV like RNA binding protein 1 -2.44631
CRYL1 crystallin, lambda 1 -2.43133
PPAN peter pan homolog (Drosophila) -2.43092
IFT88 intraflagellar transport 88 -2.43092
ARF6 ADP-ribosylation factor 6 -2.40712
STIM1 stromal interaction molecule 1 -2.40234
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.40175
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.39386
TM9SF1 transmembrane 9 superfamily member 1 -2.39386
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.36223
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.33471
NHEJ1 nonhomologous end-joining factor 1 -2.30747
ZNF385A zinc finger protein 385A -2.30218
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 -2.27659
RPL18 ribosomal protein L18 -2.23786
ADCY3 adenylate cyclase 3 -2.21567
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.20711
CFAP70 cilia and flagella associated protein 70 -2.20711
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -2.17919
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.17428
FUZ fuzzy planar cell polarity protein -2.16541
MARVELD2 MARVEL domain containing 2 -2.12755
CPVL carboxypeptidase, vitellogenic-like -2.10729
UBE3B ubiquitin protein ligase E3B -2.08478
PRMT1 protein arginine methyltransferase 1 -2.08072
TMEM125 transmembrane protein 125 -2.07973
SDF2L1 stromal cell-derived factor 2-like 1 -2.07546
TSEN15 TSEN15 tRNA splicing endonuclease subunit -2.07271
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.06309
CDV3 CDV3 homolog (mouse) -2.06309
TSPAN12 tetraspanin 12 -2.06309
ODAD4 outer dynein arm docking complex subunit 4 -2.04069
IFT70A intraflagellar transport 70A -2.04069
UBE3A ubiquitin protein ligase E3A -2.04069
RPS14 ribosomal protein S14 -2.04069
SP3 Sp3 transcription factor -2.04069
CACYBP calcyclin binding protein -2.04069
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.04069
SGSM3 small G protein signaling modulator 3 -2.04069
UBE2N ubiquitin-conjugating enzyme E2N -2.03602
COX5B cytochrome c oxidase subunit Vb -2.02351
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 -2.01858
GPR39 G protein-coupled receptor 39 -2.00714
TMEM169 transmembrane protein 169 -2.00714
EXT1 exostosin glycosyltransferase 1 -2.00714
SEC61B Sec61 beta subunit -2.00714
TCP11L1 t-complex 11, testis-specific-like 1 -2.00714
PDE10A phosphodiesterase 10A -2.0065
CDC25C cell division cycle 25C -2.00459
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -2.0039
ZSCAN31 zinc finger and SCAN domain containing 31 -2.00175