ERCC4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description excision repair cross-complementation group 4|The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 2072)
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Genes

357 genes differentially expressed following the ERCC4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NPFF neuropeptide FF-amide peptide precursor 3.18401
EOLA1 endothelium and lymphocyte associated ASCH domain 1 3.18401
PLEK2 pleckstrin 2 3.18401
PTH1R parathyroid hormone 1 receptor 3.18401
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.18401
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 3.18401
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.18401
TMEM213 transmembrane protein 213 3.18401
C11ORF86 chromosome 11 open reading frame 86 3.18401
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.18401
PARL presenilin associated, rhomboid-like 3.18401
C6ORF118 chromosome 6 open reading frame 118 3.18401
SYT15 synaptotagmin XV 3.18401
TREH trehalase (brush-border membrane glycoprotein) 3.18401
IRGM immunity-related GTPase family, M 3.18401
CD22 CD22 molecule 3.18401
CLRN1 clarin 1 3.18401
ELF4 E74-like factor 4 (ets domain transcription factor) 3.18401
SDS serine dehydratase 3.18401
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.18401
TMC2 transmembrane channel-like 2 3.18401
SPEGNB SPEG neighbor 3.18401
TMEM139 transmembrane protein 139 3.18401
INSL6 insulin-like 6 3.18401
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 3.18401
SV2C synaptic vesicle glycoprotein 2C 3.18401
PCDHB14 protocadherin beta 14 3.18401
PRICKLE4 prickle homolog 4 (Drosophila) 3.12739
NANOS3 nanos homolog 3 (Drosophila) 3.12739
PGBDF plakoglobin binding and degradation factor 3.12739
CTRC chymotrypsin C (caldecrin) 3.12739
GFRA3 GDNF family receptor alpha 3 3.12739
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.12739
TNNI1 troponin I type 1 (skeletal, slow) 3.12739
RASA4B RAS p21 protein activator 4B 3.12739
DNASE1L2 deoxyribonuclease I-like 2 3.12739
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.12739
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.12739
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.12739
GPR151 G protein-coupled receptor 151 3.12739
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.12739
TBX15 T-box 15 3.12739
MRPL53 mitochondrial ribosomal protein L53 3.12739
BAAT bile acid CoA:amino acid N-acyltransferase 3.12739
FAM216B family with sequence similarity 216, member B 3.12739
C9ORF152 chromosome 9 open reading frame 152 3.12739
CPB1 carboxypeptidase B1 (tissue) 3.12739
TTLL2 tubulin tyrosine ligase-like family member 2 3.12739
OCSTAMP osteoclast stimulatory transmembrane protein 3.12739
WNT8B wingless-type MMTV integration site family, member 8B 3.12739
MUC20 mucin 20, cell surface associated 3.12739
TREML2 triggering receptor expressed on myeloid cells-like 2 3.12739
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 3.12739
BMP8B bone morphogenetic protein 8b 3.12739
POSTN periostin, osteoblast specific factor 3.12739
PAX7 paired box 7 3.12739
XCL1 chemokine (C motif) ligand 1 3.12739
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.12739
LRRC61 leucine rich repeat containing 61 3.12739
SSTR5 somatostatin receptor 5 3.12739
GPR20 G protein-coupled receptor 20 3.12739
CA1 carbonic anhydrase I 3.12739
SP7 Sp7 transcription factor 3.12739
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 3.12739
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.12739
MMP20 matrix metallopeptidase 20 3.12739
LOC124900192 uncharacterized LOC124900192 3.12739
DIPK2B divergent protein kinase domain 2B 3.12739
DEPP1 DEPP autophagy regulator 1 3.12739
FYB1 FYN binding protein 1 3.12739
NECTIN4 nectin cell adhesion molecule 4 3.12739
ERVW-1 endogenous retrovirus group W, member 1 3.12739
RAG1 recombination activating gene 1 3.12739
YIPF7 Yip1 domain family, member 7 3.12739
C2ORF72 chromosome 2 open reading frame 72 3.12739
CLDN18 claudin 18 3.12739
FMO3 flavin containing monooxygenase 3 3.12739
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.12739
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.12739
CATSPERT catsper channel auxiliary subunit tau 3.12739
ACKR5 atypical chemokine receptor 5 3.12739
CIMAP2 ciliary microtubule associated protein 2 3.12739
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.12739
FAM240A family with sequence similarity 240 member A 3.12739
IHO1 interactor of HORMAD1 1 3.12739
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.12739
H2AC1 H2A clustered histone 1 3.12739
CHCT1 CHD1 helical C-terminal domain containing 1 3.12739
H2BC3 H2B clustered histone 3 3.12739
FOXN4 forkhead box N4 3.12739
TMPRSS4 transmembrane protease, serine 4 3.12739
TLR6 toll-like receptor 6 3.12739
PDZK1IP1 PDZK1 interacting protein 1 3.12739
MEOX1 mesenchyme homeobox 1 3.12739
THPO thrombopoietin 3.12739
PCDHB13 protocadherin beta 13 3.12739
CFAP141 cilia and flagella associated protein 141 3.12739
ACOT4 acyl-CoA thioesterase 4 3.12739
FPR2 formyl peptide receptor 2 3.12739
TBX22 T-box 22 3.12739
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.12739
TLR7 toll-like receptor 7 3.12739
GDF10 growth differentiation factor 10 3.12739
TRIM31 tripartite motif containing 31 3.12739
IGSF23 immunoglobulin superfamily, member 23 3.12739
FAM131C family with sequence similarity 131, member C 3.12739
SAA4 serum amyloid A4, constitutive 3.12739
PLB1 phospholipase B1 3.12739
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 3.12739
GSC goosecoid homeobox 3.12739
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.12739
C1QL2 complement component 1, q subcomponent-like 2 3.12739
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.12739
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 3.12739
RANBP3L RAN binding protein 3-like 3.12739
CT55 cancer/testis antigen 55 3.12739
SAMD9 sterile alpha motif domain containing 9 3.12739
TCEA3 transcription elongation factor A (SII), 3 3.12739
GAL3ST2 galactose-3-O-sulfotransferase 2 3.12739
A3GALT2 alpha 1,3-galactosyltransferase 2 3.12739
EPHA10 EPH receptor A10 3.12739
ZNF366 zinc finger protein 366 3.12739
APOC2 apolipoprotein C-II 3.12739
APOH apolipoprotein H (beta-2-glycoprotein I) 3.12739
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.12739
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.12739
EGR3 early growth response 3 3.12739
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.12739
CALR3 calreticulin 3 3.12739
TBC1D26 TBC1 domain family, member 26 3.12739
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.12739
CARD9 caspase recruitment domain family, member 9 3.12739
EDN1 endothelin 1 3.12739
AQP7 aquaporin 7 3.12739
CRYBB2 crystallin, beta B2 3.12739
PCDHGA3 protocadherin gamma subfamily A, 3 3.12739
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.12739
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.12739
CD244 CD244 molecule, natural killer cell receptor 2B4 3.12739
LMOD2 leiomodin 2 (cardiac) 3.12739
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 3.12739
ZCCHC12 zinc finger, CCHC domain containing 12 3.12739
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.12739
TDRD10 tudor domain containing 10 3.12739
TDRD15 tudor domain containing 15 3.12739
C20ORF144 chromosome 20 open reading frame 144 3.12739
HPD 4-hydroxyphenylpyruvate dioxygenase 3.12739
BPIFB1 BPI fold containing family B, member 1 3.12739
C2ORF66 chromosome 2 open reading frame 66 3.12739
SCML4 sex comb on midleg-like 4 (Drosophila) 3.12739
LRRC15 leucine rich repeat containing 15 3.12739
DUOX2 dual oxidase 2 3.12739
SP100 SP100 nuclear antigen 3.12739
CHD5 chromodomain helicase DNA binding protein 5 3.12739
KRTAP4-1 keratin associated protein 4-1 3.12739
EVI2A ecotropic viral integration site 2A 3.12739
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.12739
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.12739
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.12739
SOSTDC1 sclerostin domain containing 1 3.12739
PCDHAC2 protocadherin alpha subfamily C, 2 3.12739
PITX2 paired-like homeodomain 2 3.12739
HES2 hes family bHLH transcription factor 2 3.12739
BTG4 B-cell translocation gene 4 3.12739
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.12739
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.12739
PODNL1 podocan-like 1 3.12739
PHF5A PHD finger protein 5A 3.12739
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3.12739
NMUR1 neuromedin U receptor 1 3.12739
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.12739
ASCL1 achaete-scute family bHLH transcription factor 1 3.12739
ANKRD30A ankyrin repeat domain 30A 3.12739
IL17D interleukin 17D 3.12739
ADAM21 ADAM metallopeptidase domain 21 3.12739
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.12739
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.12739
CSDC2 cold shock domain containing C2, RNA binding 3.12739
TBX2 T-box 2 3.12739
GH1 growth hormone 1 3.12739
PXT1 peroxisomal, testis specific 1 3.12739
HLA-G major histocompatibility complex, class I, G 3.12739
PPY pancreatic polypeptide 3.12739
ADGRF5 adhesion G protein-coupled receptor F5 3.12739
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.12739
COL8A2 collagen, type VIII, alpha 2 3.04445
ZFP36L2 ZFP36 ring finger protein-like 2 3.03703
GSS glutathione synthetase 3.01482
SEPTIN4 septin 4 2.9771
CD99L2 CD99 molecule-like 2 2.94791
ZFP36 ZFP36 ring finger protein 2.94017
EFL1 elongation factor like GTPase 1 2.80031
SMIM18 small integral membrane protein 18 2.77503
SULF2 sulfatase 2 2.71174
KRT18 keratin 18, type I 2.67272
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.65071
ATF7IP2 activating transcription factor 7 interacting protein 2 2.64305
VWA1 von Willebrand factor A domain containing 1 2.63988
ATP5MJ ATP synthase membrane subunit j 2.63221
DTX2 deltex 2, E3 ubiquitin ligase 2.62505
ZSWIM7 zinc finger, SWIM-type containing 7 2.61786
CDHR3 cadherin-related family member 3 2.60338
THRB thyroid hormone receptor, beta 2.57707
RCCD1 RCC1 domain containing 1 2.54999
CCSAP centriole, cilia and spindle-associated protein 2.53971
RGL1 ral guanine nucleotide dissociation stimulator-like 1 2.53231
BCO2 beta-carotene oxygenase 2 2.52212
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.51662
CDH18 cadherin 18, type 2 2.48386
ZBTB41 zinc finger and BTB domain containing 41 2.47974
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2.47813
TMEM17 transmembrane protein 17 2.46202
ASIP agouti signaling protein 2.45907
CCDC47 coiled-coil domain containing 47 2.43774
ZFP64 ZFP64 zinc finger protein 2.42062
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.40952
SH3RF1 SH3 domain containing ring finger 1 2.3543
CD8B CD8b molecule 2.3167
SLC61A1 solute carrier family 61 member 1 2.31471
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 2.29637
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 2.27968
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) 2.27639
IFI30 interferon, gamma-inducible protein 30 2.27275
GARIN1B golgi associated RAB2 interactor 1B 2.25101
ZDHHC13 zinc finger, DHHC-type containing 13 2.21799
DGCR6L DiGeorge syndrome critical region gene 6-like 2.2046
P3H1 prolyl 3-hydroxylase 1 2.12745
RIC8B RIC8 guanine nucleotide exchange factor B 2.12225
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.1192
GAS2L1 growth arrest-specific 2 like 1 2.1192
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 2.1121
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.1121
OXCT1 3-oxoacid CoA transferase 1 2.11105
WHRN whirlin 2.11105
GRIK1 glutamate receptor, ionotropic, kainate 1 2.10754
CRPPA CDP-L-ribitol pyrophosphorylase A 2.10397
ZNF22 zinc finger protein 22 2.10397
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 2.10248
SPG11 spastic paraplegia 11 (autosomal recessive) 2.09564
ADCK5 aarF domain containing kinase 5 2.08702
THEMIS2 thymocyte selection associated family member 2 2.081
HPCAL1 hippocalcin-like 1 2.07914
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.07696
TTF2 transcription termination factor, RNA polymerase II 2.07696
NR2F6 nuclear receptor subfamily 2, group F, member 6 2.06417
VCL vinculin 2.04391
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 2.03512
KDM8 lysine (K)-specific demethylase 8 2.03512
SUOX sulfite oxidase 2.03512
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.01844

decreased expression

Symbol Name Standardized Value
ZNF599 zinc finger protein 599 -3.18401
C2 complement component 2 -3.18401
ZNF165 zinc finger protein 165 -3.18401
MANEAL mannosidase, endo-alpha-like -3.18401
MEIS2 Meis homeobox 2 -3.18401
SBSPON somatomedin B and thrombospondin, type 1 domain containing -3.18401
SFN stratifin -3.12739
TNS2 tensin 2 -3.12739
TMEM191C transmembrane protein 191C -3.12739
FER fer (fps/fes related) tyrosine kinase -3.12739
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -3.12739
IL11RA interleukin 11 receptor, alpha -3.12739
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -3.12739
LAMP5 lysosomal-associated membrane protein family, member 5 -3.12739
SCTR secretin receptor -3.12739
QRFPR pyroglutamylated RFamide peptide receptor -3.12739
NPR2 natriuretic peptide receptor 2 -3.12739
CBY3 chibby homolog 3 (Drosophila) -3.12739
RGPD4 RANBP2-like and GRIP domain containing 4 -3.12739
OVCH1 ovochymase 1 -3.12739
LHX6 LIM homeobox 6 -3.12739
CALY calcyon neuron-specific vesicular protein -3.12739
TDRD1 tudor domain containing 1 -3.12739
BMP8A bone morphogenetic protein 8a -3.12739
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -3.12739
CLIP4 CAP-GLY domain containing linker protein family, member 4 -3.12739
CATSPER4 cation channel, sperm associated 4 -3.12739
CFAP144 cilia and flagella associated protein 144 -3.12739
PSORS1C1 psoriasis susceptibility 1 candidate 1 -3.12739
CDCA4 cell division cycle associated 4 -3.12739
DND1 DND microRNA-mediated repression inhibitor 1 -3.12739
MYORG myogenesis regulating glycosidase (putative) -3.12739
CDH22 cadherin 22, type 2 -3.12739
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -3.12739
MEIS1 Meis homeobox 1 -3.12739
AANAT aralkylamine N-acetyltransferase -3.12739
C20ORF203 chromosome 20 open reading frame 203 -3.12739
CXCL17 chemokine (C-X-C motif) ligand 17 -3.12739
COL11A2 collagen, type XI, alpha 2 -3.12739
TTYH2 tweety family member 2 -3.12739
TPTE transmembrane phosphatase with tensin homology -3.12739
FBXO32 F-box protein 32 -3.12739
LAMA4 laminin, alpha 4 -3.12739
CMKLR1 chemerin chemokine-like receptor 1 -3.12739
PROC protein C (inactivator of coagulation factors Va and VIIIa) -3.12739
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -3.12739
AARD alanine and arginine rich domain containing protein -3.07712
THAP8 THAP domain containing 8 -3.05168
ZNF764 zinc finger protein 764 -3.01482
ARSD arylsulfatase D -3.01482
TRAF5 TNF receptor-associated factor 5 -2.90422
USP27X ubiquitin specific peptidase 27, X-linked -2.84782
ASIC1 acid sensing (proton gated) ion channel 1 -2.84782
NALCN sodium leak channel, non selective -2.84782
ONECUT2 one cut homeobox 2 -2.80031
TRMT5 tRNA methyltransferase 5 -2.74485
GPR18 G protein-coupled receptor 18 -2.61786
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.61786
ASPN asporin -2.61412
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.61412
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -2.53231
TEP1 telomerase-associated protein 1 -2.51662
ZC2HC1C zinc finger, C2HC-type containing 1C -2.51662
AURKC aurora kinase C -2.51035
PNCK pregnancy up-regulated nonubiquitous CaM kinase -2.51035
FOXO4 forkhead box O4 -2.51035
NCOA4 nuclear receptor coactivator 4 -2.51035
CHN1 chimerin 1 -2.49828
RNF4 ring finger protein 4 -2.46524
JPH3 junctophilin 3 -2.46202
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 -2.45361
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -2.4384
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 -2.42361
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.42286
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.42286
MMP24OS MMP24 opposite strand -2.37377
C13ORF42 chromosome 13 open reading frame 42 -2.34931
SBF2 SET binding factor 2 -2.34121
TSLIG1 tRNA splicing ligase complex subunit 1 -2.33657
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.3278
PNMA8A PNMA family member 8A -2.3278
ZNF736 zinc finger protein 736 -2.3167
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant -2.29637
CORO1A coronin, actin binding protein, 1A -2.26034
KATNAL1 katanin p60 subunit A-like 1 -2.25681
CDK19 cyclin-dependent kinase 19 -2.18949
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.18949
CHKA choline kinase alpha -2.18346
SOD1 superoxide dismutase 1, soluble -2.17259
RUSF1 RUS family member 1 -2.15624
GON7 GON7 subunit of KEOPS complex -2.12427
ZNF630 zinc finger protein 630 -2.1192
TMEM205 transmembrane protein 205 -2.11055
PHACTR1 phosphatase and actin regulator 1 -2.10346
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -2.10268
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -2.08645
SARS1 seryl-tRNA synthetase 1 -2.06417
TFDP1 transcription factor Dp-1 -2.06101
MBD1 methyl-CpG binding domain protein 1 -2.05297
RBL1 retinoblastoma-like 1 -2.05297
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.05297
MEIS3 Meis homeobox 3 -2.04524
NEXMIF neurite extension and migration factor -2.03653
CAPN7 calpain 7 -2.03242
CLMB calcimembrin -2.02714
GPX4 glutathione peroxidase 4 -2.02618
N4BP3 NEDD4 binding protein 3 -2.02618