ERF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Ets2 repressor factor|Members of the ETS family of transcription factors, such as ERF, regulate cell proliferation and differentiation. They share a highly conserved DNA-binding domain, the ETS domain, that recognizes the sequence GGAA/T (de Castro et al., 1997 [PubMed 9192842]). For further information on ETS transcription factors, see ETS1 (MIM 164720).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 2077)
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Genes

342 genes differentially expressed following the ERF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MEP1B meprin A, beta 3.42486
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.42486
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.42486
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.42486
NANOS2 nanos homolog 2 (Drosophila) 3.42486
GJB3 gap junction protein, beta 3, 31kDa 3.42486
FOXR1 forkhead box R1 3.42486
ARHGAP36 Rho GTPase activating protein 36 3.42486
SIGLEC7 sialic acid binding Ig-like lectin 7 3.42486
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.42486
OR11H4 olfactory receptor, family 11, subfamily H, member 4 3.42486
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 3.42486
ZACN zinc activated ligand-gated ion channel 3.42486
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.42486
FABP9 fatty acid binding protein 9, testis 3.42486
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.42486
GPR6 G protein-coupled receptor 6 3.42486
SIX2 SIX homeobox 2 3.42486
TMPRSS11A transmembrane protease, serine 11A 3.42486
IL4I1 interleukin 4 induced 1 3.42486
COL20A1 collagen, type XX, alpha 1 3.42486
CD274 CD274 molecule 3.42486
BIRC3 baculoviral IAP repeat containing 3 3.42486
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.42486
HAS1 hyaluronan synthase 1 3.42486
MYO1H myosin IH 3.42486
GYS2 glycogen synthase 2 (liver) 3.42486
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.42486
RTP3 receptor (chemosensory) transporter protein 3 3.42486
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.42486
CAMK1G calcium/calmodulin-dependent protein kinase IG 3.42486
HRG histidine-rich glycoprotein 3.42486
WFDC13 WAP four-disulfide core domain 13 3.42486
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 3.42486
JCHAIN joining chain of multimeric IgA and IgM 3.42486
ATOH8 atonal homolog 8 (Drosophila) 3.42486
OXT oxytocin/neurophysin I prepropeptide 3.42486
SFTPB surfactant protein B 3.42486
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.42486
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.42486
HCST hematopoietic cell signal transducer 3.42486
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.42486
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.42486
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.42486
PAEP progestagen-associated endometrial protein 3.42486
MUC22 mucin 22 3.42486
ACADL acyl-CoA dehydrogenase, long chain 3.42486
CALHM4 calcium homeostasis modulator family member 4 3.42486
LY6H lymphocyte antigen 6 complex, locus H 3.42486
GCSAM germinal center-associated, signaling and motility 3.42486
C15ORF62 chromosome 15 open reading frame 62 3.42486
RNF183 ring finger protein 183 3.42486
CCDC42 coiled-coil domain containing 42 3.42486
PRG4 proteoglycan 4 3.42486
LGSN lengsin, lens protein with glutamine synthetase domain 3.42486
DDTL D-dopachrome tautomerase-like 3.42486
STARD6 StAR-related lipid transfer (START) domain containing 6 3.42486
DNAAF1 dynein, axonemal, assembly factor 1 3.42486
CAPN9 calpain 9 3.42486
CLDN16 claudin 16 3.42486
TMEM272 transmembrane protein 272 3.42486
EZHIP EZH inhibitory protein 3.42486
GARIN1A golgi associated RAB2 interactor 1A 3.42486
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.42486
TMOD4 tropomodulin 4 (muscle) 3.42486
ALDOB aldolase B, fructose-bisphosphate 3.42486
OTOF otoferlin 3.42486
GPX5 glutathione peroxidase 5 3.42486
CLDN14 claudin 14 3.42486
UTS2 urotensin 2 3.42486
CCR4 chemokine (C-C motif) receptor 4 3.42486
NPFF neuropeptide FF-amide peptide precursor 3.42486
CHRD chordin 3.42486
CRLF2 cytokine receptor-like factor 2 3.42486
PCDHB13 protocadherin beta 13 3.42486
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 3.42486
ISM2 isthmin 2 3.42486
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.42486
FPR3 formyl peptide receptor 3 3.42486
FAM153A family with sequence similarity 153, member A 3.42486
SLC22A10 solute carrier family 22, member 10 3.42486
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.42486
MAG myelin associated glycoprotein 3.42486
GOLGA6L4 golgin A6 family-like 4 3.42486
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.42486
C1QL3 complement component 1, q subcomponent-like 3 3.42486
PGC progastricsin (pepsinogen C) 3.42486
TLR5 toll-like receptor 5 3.42486
TLR1 toll-like receptor 1 3.42486
IL6 interleukin 6 3.42486
SCRT1 scratch family zinc finger 1 3.42486
ZIC4 Zic family member 4 3.42486
TMCO2 transmembrane and coiled-coil domains 2 3.42486
SLC22A14 solute carrier family 22, member 14 3.42486
AOC1 amine oxidase, copper containing 1 3.42486
CD177 CD177 molecule 3.42486
EFCAB3 EF-hand calcium binding domain 3 3.42486
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.42486
OTC ornithine carbamoyltransferase 3.42486
KLHL1 kelch-like family member 1 3.42486
KLHL6 kelch-like family member 6 3.42486
C2ORF66 chromosome 2 open reading frame 66 3.42486
MKRN3 makorin ring finger protein 3 3.42486
ERICH6B glutamate-rich 6B 3.42486
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.42486
PCDHAC2 protocadherin alpha subfamily C, 2 3.42486
EDN1 endothelin 1 3.42486
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.42486
ANKRD62 ankyrin repeat domain 62 3.42486
TDRD10 tudor domain containing 10 3.42486
CIDEA cell death-inducing DFFA-like effector a 3.42486
COL11A2 collagen, type XI, alpha 2 3.42486
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.42486
SMIM22 small integral membrane protein 22 3.42486
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.42486
FNDC9 fibronectin type III domain containing 9 3.42486
CCL27 chemokine (C-C motif) ligand 27 3.42486
CD5L CD5 molecule-like 3.42486
CPA2 carboxypeptidase A2 (pancreatic) 3.42486
TCAP titin-cap 3.42486
NYX nyctalopin 3.42486
DEFB135 defensin, beta 135 3.42486
C1ORF105 chromosome 1 open reading frame 105 3.42486
DAOA D-amino acid oxidase activator 3.42486
C11ORF42 chromosome 11 open reading frame 42 3.42486
FAM151A family with sequence similarity 151, member A 3.42486
C10ORF105 chromosome 10 open reading frame 105 3.42486
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.42486
PLCD4 phospholipase C, delta 4 3.42486
TMEM31 transmembrane protein 31 3.42486
TPPP2 tubulin polymerization-promoting protein family member 2 3.42486
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.42486
FOXE3 forkhead box E3 3.42486
SHISA8 shisa family member 8 3.42486
ZDHHC24 zinc finger, DHHC-type containing 24 3.42486
TEKT1 tektin 1 3.42486
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.42486
SLC22A24 solute carrier family 22, member 24 3.42486
CHIT1 chitinase 1 (chitotriosidase) 3.42486
ANKRD53 ankyrin repeat domain 53 3.42486
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.42486
DEFB134 defensin, beta 134 3.42486
PXT1 peroxisomal, testis specific 1 3.42486
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.42486
CD80 CD80 molecule 3.42486
ANXA1 annexin A1 3.42486
PTCRA pre T-cell antigen receptor alpha 3.42486
GRAPL GRB2-related adaptor protein-like 3.42486
CIB3 calcium and integrin binding family member 3 3.42486
CIB4 calcium and integrin binding family member 4 3.42486
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.42486
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.42486
TGM1 transglutaminase 1 3.42486
ADAM29 ADAM metallopeptidase domain 29 3.42486
TAS2R46 taste receptor, type 2, member 46 3.42486
TRAF3IP3 TRAF3 interacting protein 3 3.42486
ANGPTL5 angiopoietin-like 5 3.42486
CLNK cytokine-dependent hematopoietic cell linker 3.42486
MST1 macrophage stimulating 1 3.42486
PTGDS prostaglandin D2 synthase 21kDa (brain) 3.42486
OR52I2 olfactory receptor, family 52, subfamily I, member 2 3.42486
ECM1 extracellular matrix protein 1 3.42486
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.42486
SLC7A4 solute carrier family 7, member 4 3.42486
NTSR1 neurotensin receptor 1 (high affinity) 3.42486
SHBG sex hormone-binding globulin 3.36445
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 3.36445
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 3.36445
FAM240C family with sequence similarity 240 member C 3.36445
FHIP1A FHF complex subunit HOOK interacting protein 1A 3.23278
MAGEL2 melanoma antigen family L2 3.23278
H2BC15 H2B clustered histone 15 3.02243
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 2.98374
DSN1 DSN1, MIS12 kinetochore complex component 2.91988
EIF1AX eukaryotic translation initiation factor 1A, X-linked 2.79924
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.69873
KPNA4 karyopherin alpha 4 (importin alpha 3) 2.62199
C17ORF67 chromosome 17 open reading frame 67 2.58326
ZFTRAF1 zinc finger TRAF-type containing 1 2.56022
CFAP298 cilia and flagella associated protein 298 2.52088
DNAAF3 dynein, axonemal, assembly factor 3 2.50952
CFAP91 cilia and flagella associated protein 91 2.5033
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.4797
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.4797
LYST lysosomal trafficking regulator 2.4797
GLIPR1 GLI pathogenesis-related 1 2.4797
JOSD2 Josephin domain containing 2 2.4797
GAB3 GRB2-associated binding protein 3 2.4797
LINC02560 long intergenic non-protein coding RNA 2560 2.4797
ATP5MGL ATP synthase membrane subunit g like 2.4797
NLRP1 NLR family, pyrin domain containing 1 2.4797
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 2.4797
RABL3 RAB, member of RAS oncogene family-like 3 2.46944
PROKR1 prokineticin receptor 1 2.46049
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.46049
RPL6 ribosomal protein L6 2.45973
ZFAND2A zinc finger, AN1-type domain 2A 2.45934
ENTREP1 endosomal transmembrane epsin interactor 1 2.43411
CDK9 cyclin-dependent kinase 9 2.37765
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.33765
MCM8 minichromosome maintenance complex component 8 2.27249
C5ORF63 chromosome 5 open reading frame 63 2.26698
KIFAP3 kinesin-associated protein 3 2.26399
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.22472
LEFTY2 left-right determination factor 2 2.22411
BZW2 basic leucine zipper and W2 domains 2 2.21586
CATSPERT catsper channel auxiliary subunit tau 2.20724
GCLC glutamate-cysteine ligase, catalytic subunit 2.20421
ZNF546 zinc finger protein 546 2.19494
ATXN7L3B ataxin 7-like 3B 2.18348
TXLNG taxilin gamma 2.1799
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.17584
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 2.17077
GIPR gastric inhibitory polypeptide receptor 2.16974
PER3 period circadian clock 3 2.16778
MSMO1 methylsterol monooxygenase 1 2.14937
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.13482
NBEAL2 neurobeachin-like 2 2.13031
ZNF189 zinc finger protein 189 2.11889
CAV2 caveolin 2 2.10165
ADGRL3 adhesion G protein-coupled receptor L3 2.09556
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.08175
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.05454
WNT5B wingless-type MMTV integration site family, member 5B 2.05454
RIN1 Ras and Rab interactor 1 2.05454
CBX4 chromobox homolog 4 2.05454
IARS1 isoleucyl-tRNA synthetase 1 2.04804
RALGDS ral guanine nucleotide dissociation stimulator 2.04025
EPB41L1 erythrocyte membrane protein band 4.1-like 1 2.03847
HAS2 hyaluronan synthase 2 2.03303
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2.03058
PARP11 poly (ADP-ribose) polymerase family, member 11 2.01547
TMEM150A transmembrane protein 150A 2.01547
PDHB pyruvate dehydrogenase (lipoamide) beta 2.00939
ZNF583 zinc finger protein 583 2.00869

decreased expression

Symbol Name Standardized Value
PRSS53 protease, serine, 53 -3.42486
LCAT lecithin-cholesterol acyltransferase -3.42486
SAR1A secretion associated, Ras related GTPase 1A -3.42486
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -3.42486
S100B S100 calcium binding protein B -3.42486
VSTM5 V-set and transmembrane domain containing 5 -3.42486
ALKBH5 AlkB family member 5, RNA demethylase -3.42486
PSPN persephin -3.42486
FGF16 fibroblast growth factor 16 -3.42486
LRRC41 leucine rich repeat containing 41 -3.42486
FGF23 fibroblast growth factor 23 -3.42486
ITLN2 intelectin 2 -3.42486
MEI1 meiosis inhibitor 1 -3.42486
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -3.42486
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -3.29732
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -3.28704
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -3.25161
TMEM107 transmembrane protein 107 -3.23317
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -3.23278
GYPE glycophorin E (MNS blood group) -3.23278
SLC46A3 solute carrier family 46, member 3 -3.23278
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.23278
TDRD1 tudor domain containing 1 -3.23278
OPRL1 opiate receptor-like 1 -3.23278
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -3.23278
OVOL3 ovo-like zinc finger 3 -3.23278
FIMP1 fertilization-influencing membrane protein 1 -3.23278
HRH1 histamine receptor H1 -3.23278
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -3.23278
FXYD3 FXYD domain containing ion transport regulator 3 -3.23278
ARMC12 armadillo repeat containing 12 -3.23278
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -3.23278
WFDC1 WAP four-disulfide core domain 1 -3.23278
NRIP2 nuclear receptor interacting protein 2 -3.23278
SV2C synaptic vesicle glycoprotein 2C -3.23278
PDCD1LG2 programmed cell death 1 ligand 2 -3.23278
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -3.23278
PIERCE2 piercer of microtubule wall 2 -3.23278
RIBC1 RIB43A domain with coiled-coils 1 -3.23278
DNAH10 dynein, axonemal, heavy chain 10 -3.23278
WNT16 wingless-type MMTV integration site family, member 16 -3.23278
MYADML2 myeloid-associated differentiation marker-like 2 -3.23278
APOH apolipoprotein H (beta-2-glycoprotein I) -3.23278
PLA2G2C phospholipase A2, group IIC -3.23278
EFNB1 ephrin-B1 -3.17508
CLDN23 claudin 23 -3.17508
MAP9 microtubule-associated protein 9 -3.17432
MYO1C myosin IC -3.15205
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B -3.1353
ACKR4 atypical chemokine receptor 4 -3.08656
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -3.04416
SLC38A12 solute carrier family 38 member 12 -3.03001
PELP1 proline, glutamate and leucine rich protein 1 -2.77721
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.77181
SRM spermidine synthase -2.70927
ZNF527 zinc finger protein 527 -2.69671
CIAO1 cytosolic iron-sulfur assembly component 1 -2.6442
DLG4 discs, large homolog 4 (Drosophila) -2.63628
HDAC7 histone deacetylase 7 -2.62231
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.62199
COL6A1 collagen, type VI, alpha 1 -2.60652
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.56022
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -2.55362
STX1A syntaxin 1A (brain) -2.54975
PRSS35 protease, serine, 35 -2.49856
CFAP95 cilia and flagella associated protein 95 -2.4797
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -2.4797
ADAM23 ADAM metallopeptidase domain 23 -2.4797
UNC80 unc-80 homolog (C. elegans) -2.47857
BOLA2B bolA family member 2B -2.46049
HAP1 huntingtin-associated protein 1 -2.45934
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.45934
TAPBPL TAP binding protein-like -2.45934
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.4323
BLMH bleomycin hydrolase -2.39202
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.37633
COL28A1 collagen, type XXVIII, alpha 1 -2.36601
FDXR ferredoxin reductase -2.35327
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.29456
UBTF upstream binding transcription factor, RNA polymerase I -2.28076
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.25559
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.22638
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 -2.22638
YBX3 Y box binding protein 3 -2.22411
C19ORF85 chromosome 19 open reading frame 85 -2.19617
SPIDR scaffolding protein involved in DNA repair -2.19494
RPUSD1 RNA pseudouridylate synthase domain containing 1 -2.18449
ZNF214 zinc finger protein 214 -2.1799
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -2.17989
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) -2.16974
PARL presenilin associated, rhomboid-like -2.13482
CISD3 CDGSH iron sulfur domain 3 -2.13482
NLRX1 NLR family member X1 -2.12947
GHDC GH3 domain containing -2.12934
CERCAM cerebral endothelial cell adhesion molecule -2.12934
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -2.1104
MNS1 meiosis-specific nuclear structural 1 -2.10772
ZNF37A zinc finger protein 37A -2.0668
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -2.06535
PRR12 proline rich 12 -2.05454
EGFL8 EGF-like-domain, multiple 8 -2.04025
RIPPLY2 ripply transcriptional repressor 2 -2.04025
OAF OAF homolog (Drosophila) -2.04025
ARSB arylsulfatase B -2.03629
HAPLN4 hyaluronan and proteoglycan link protein 4 -2.02696
BVES blood vessel epicardial substance -2.00208
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.00208