ERG Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description v-ets avian erythroblastosis virus E26 oncogene homolog|This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] (NCBI Entrez Gene Database, 2078)
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Genes

324 genes differentially expressed following the ERG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ACR acrosin 3.23452
DNASE1L2 deoxyribonuclease I-like 2 3.23452
CELA3B chymotrypsin-like elastase family, member 3B 3.23452
PNMA5 paraneoplastic Ma antigen family member 5 3.23452
GRXCR2 glutaredoxin, cysteine rich 2 3.23452
LEPR leptin receptor 3.23452
LRRC14B leucine rich repeat containing 14B 3.23452
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 3.23452
SLC25A47 solute carrier family 25, member 47 3.23452
GJB5 gap junction protein, beta 5, 31.1kDa 3.23452
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.23452
HEATR9 HEAT repeat containing 9 3.23452
SLC46A3 solute carrier family 46, member 3 3.23452
TAS2R3 taste receptor, type 2, member 3 3.23452
TMPRSS11A transmembrane protease, serine 11A 3.23452
ZACN zinc activated ligand-gated ion channel 3.23452
MYO7B myosin VIIB 3.23452
VTN vitronectin 3.23452
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.23452
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.23452
SIGLECL1 SIGLEC family like 1 3.23452
KNG1 kininogen 1 3.23452
FOXR1 forkhead box R1 3.23452
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.23452
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.23452
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.23452
S100A1 S100 calcium binding protein A1 3.23452
NPIPA8 nuclear pore complex interacting protein family, member A8 3.23452
GNRH2 gonadotropin-releasing hormone 2 3.23452
TREML1 triggering receptor expressed on myeloid cells-like 1 3.23452
OR2G6 olfactory receptor, family 2, subfamily G, member 6 3.23452
IL2RG interleukin 2 receptor, gamma 3.23452
AVP arginine vasopressin 3.23452
CRYAA crystallin, alpha A 3.23452
TMEM89 transmembrane protein 89 3.23452
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.23452
ACVRL1 activin A receptor type II-like 1 3.23452
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.23452
FBLN7 fibulin 7 3.23452
UNC45B unc-45 homolog B (C. elegans) 3.23452
NCKAP1L NCK-associated protein 1-like 3.23452
BSX brain-specific homeobox 3.23452
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.23452
PCDH8 protocadherin 8 3.23452
RAB2A RAB2A, member RAS oncogene family 3.23452
PAEP progestagen-associated endometrial protein 3.23452
RNF39 ring finger protein 39 3.23452
LOC124901449 uncharacterized LOC124901449 3.23452
SMIM41 small integral membrane protein 41 3.23452
GMCL2 germ cell-less 2, spermatogenesis associated 3.23452
ERVW-1 endogenous retrovirus group W, member 1 3.23452
MCHR1 melanin-concentrating hormone receptor 1 3.23452
STMN4 stathmin-like 4 3.23452
TBC1D3L TBC1 domain family, member 3L 3.23452
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.23452
DOK7 docking protein 7 3.23452
OR52E6 olfactory receptor, family 52, subfamily E, member 6 3.23452
LORICRIN loricrin cornified envelope precursor protein 3.23452
ANKRD40CL ANKRD40 C-terminal like 3.23452
CALHM5 calcium homeostasis modulator family member 5 3.23452
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.23452
TEKTL1 tektin like 1 3.23452
DAAM2-AS1 DAAM2 antisense RNA 1 3.23452
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.23452
LOC124904411 uncharacterized LOC124904411 3.23452
SERTM2 serine rich and transmembrane domain containing 2 3.23452
GSTT4 glutathione S-transferase theta 4 3.23452
H1-8 H1.8 linker histone 3.23452
JAML junction adhesion molecule like 3.23452
DYNLRB2 dynein, light chain, roadblock-type 2 3.23452
GATA3 GATA binding protein 3 3.23452
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.23452
SLAMF6 SLAM family member 6 3.23452
NHLRC4 NHL repeat containing 4 3.23452
DMBX1 diencephalon/mesencephalon homeobox 1 3.23452
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.23452
TMCO2 transmembrane and coiled-coil domains 2 3.23452
CCIN calicin 3.23452
NKX2-2 NK2 homeobox 2 3.23452
FOXD1 forkhead box D1 3.23452
LIPF lipase, gastric 3.23452
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.23452
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 3.23452
SPDYC speedy/RINGO cell cycle regulator family member C 3.23452
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.23452
SYT15 synaptotagmin XV 3.23452
ZG16B zymogen granule protein 16B 3.23452
LTB lymphotoxin beta (TNF superfamily, member 3) 3.23452
LGSN lengsin, lens protein with glutamine synthetase domain 3.23452
LRRC71 leucine rich repeat containing 71 3.23452
FAM131C family with sequence similarity 131, member C 3.23452
BLNK B-cell linker 3.23452
VCX3A variable charge, X-linked 3A 3.23452
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.23452
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 3.23452
CLDN34 claudin 34 3.23452
CST7 cystatin F (leukocystatin) 3.23452
OTC ornithine carbamoyltransferase 3.23452
RNASE10 ribonuclease, RNase A family, 10 (non-active) 3.23452
CPA3 carboxypeptidase A3 (mast cell) 3.23452
CPA2 carboxypeptidase A2 (pancreatic) 3.23452
NPBWR1 neuropeptides B/W receptor 1 3.23452
APOC2 apolipoprotein C-II 3.23452
APOC4 apolipoprotein C-IV 3.23452
RGSL1 regulator of G-protein signaling like 1 3.23452
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.23452
PHOSPHO1 phosphatase, orphan 1 3.23452
CLEC7A C-type lectin domain family 7, member A 3.23452
APOD apolipoprotein D 3.23452
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.23452
ZSCAN4 zinc finger and SCAN domain containing 4 3.23452
CLIC3 chloride intracellular channel 3 3.23452
CNTF ciliary neurotrophic factor 3.23452
RGS11 regulator of G-protein signaling 11 3.23452
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.23452
CLEC4D C-type lectin domain family 4, member D 3.23452
PCDHGA2 protocadherin gamma subfamily A, 2 3.23452
MUCL1 mucin-like 1 3.23452
CSF1R colony stimulating factor 1 receptor 3.23452
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.23452
CFAP126 cilia and flagella associated protein 126 3.23452
LGALS16 lectin, galactoside-binding, soluble, 16 3.23452
MEIS1 Meis homeobox 1 3.23452
GAS2L2 growth arrest-specific 2 like 2 3.23452
MGP matrix Gla protein 3.23452
MB myoglobin 3.23452
GOLGA8R golgin A8 family, member R 3.23452
PSG9 pregnancy specific beta-1-glycoprotein 9 3.23452
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.23452
NUPR1 nuclear protein, transcriptional regulator, 1 3.23452
TEKT2 tektin 2 (testicular) 3.23452
ANKRD20A1 ankyrin repeat domain 20 family, member A1 3.23452
KLK12 kallikrein-related peptidase 12 3.23452
FBXO47 F-box protein 47 3.23452
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.23452
OCM oncomodulin 3.23452
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.23452
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.23452
BCL2A1 BCL2-related protein A1 3.23452
CIDEA cell death-inducing DFFA-like effector a 3.23452
BTBD16 BTB (POZ) domain containing 16 3.23452
DMRTC1 DMRT-like family C1 3.23452
IL10RA interleukin 10 receptor, alpha 3.23452
TMEM156 transmembrane protein 156 3.23452
CEP170 centrosomal protein 170kDa 3.23452
ADRA1B adrenoceptor alpha 1B 3.23452
KRTAP8-1 keratin associated protein 8-1 3.23452
ANGPTL7 angiopoietin-like 7 3.23452
SLC35G5 solute carrier family 35, member G5 3.23452
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.23452
NLRP5 NLR family, pyrin domain containing 5 3.23452
NLRP4 NLR family, pyrin domain containing 4 3.23452
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.23452
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.23452
NPC1L1 NPC1-like 1 3.23452
GALP galanin-like peptide 3.23452
CD22 CD22 molecule 3.23452
NPR3 natriuretic peptide receptor 3 3.23452
CHAD chondroadherin 3.23452
TMEM86A transmembrane protein 86A 3.23452
PRR15L proline rich 15-like 3.23452
LRRC74A leucine rich repeat containing 74A 3.23452
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.23452
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.23452
GH2 growth hormone 2 3.23452
PRSS55 protease, serine, 55 3.23452
HSF4 heat shock transcription factor 4 3.23452
ZMYND10 zinc finger, MYND-type containing 10 3.23452
SPMIP3 sperm microtubule inner protein 3 3.18436
AANAT aralkylamine N-acetyltransferase 3.18436
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 2.79327
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 2.77225
PIKFYVE phosphoinositide kinase, FYVE finger containing 2.6631
C16ORF54 chromosome 16 open reading frame 54 2.66202
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.64245
GTPBP2 GTP binding protein 2 2.6376
ZNF32 zinc finger protein 32 2.58531
STYX serine/threonine/tyrosine interacting protein 2.54343
CYB561A3 cytochrome b561 family, member A3 2.5151
ZFHX3 zinc finger homeobox 3 2.47985
ICE1 interactor of little elongation complex ELL subunit 1 2.46765
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) 2.45715
UPK3B uroplakin 3B 2.44244
KIF27 kinesin family member 27 2.40069
ZFP62 ZFP62 zinc finger protein 2.36846
SPMIP8 sperm microtubule inner protein 8 2.33546
IL17REL interleukin 17 receptor E-like 2.31972
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.30574
RBM4B RNA binding motif protein 4B 2.27309
PCP4 Purkinje cell protein 4 2.23618
SYN1 synapsin I 2.22692
STK35 serine/threonine kinase 35 2.22627
RBKS ribokinase 2.20449
PAQR8 progestin and adipoQ receptor family member VIII 2.2033
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.19142
SDHAF4 succinate dehydrogenase complex assembly factor 4 2.18773
NRBP1 nuclear receptor binding protein 1 2.18443
GLOD4 glyoxalase domain containing 4 2.16911
MAPK3 mitogen-activated protein kinase 3 2.16347
ZC3H11C zinc finger CCCH-type containing 11C 2.16019
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.16019
NHLH1 nescient helix loop helix 1 2.16019
NUP35 nucleoporin 35kDa 2.16019
ZCCHC3 zinc finger, CCHC domain containing 3 2.15903
SEC14L1 SEC14-like 1 (S. cerevisiae) 2.15903
ARMC7 armadillo repeat containing 7 2.14702
ARLN allregulin 2.13481
PLXNC1 plexin C1 2.13476
FAM133A family with sequence similarity 133, member A 2.12314
RAB1B RAB1B, member RAS oncogene family 2.12088
MAIP1 matrix AAA peptidase interacting protein 1 2.10542
HIPK2 homeodomain interacting protein kinase 2 2.10094
DENR density-regulated protein 2.08384
SAXO6 stabilizer of axonemal microtubules 6 2.0743
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.074
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.0588
YDJC YdjC homolog (bacterial) 2.04199
ZNF260 zinc finger protein 260 2.01969
MYOF myoferlin 2.00915

decreased expression

Symbol Name Standardized Value
GARIN1A golgi associated RAB2 interactor 1A -3.23452
SP7 Sp7 transcription factor -3.23452
C2ORF80 chromosome 2 open reading frame 80 -3.23452
LRRC73 leucine rich repeat containing 73 -3.23452
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -3.23452
TPRX1 tetra-peptide repeat homeobox 1 -3.23452
IL17B interleukin 17B -3.23452
GGN gametogenetin -3.23452
LTB4R leukotriene B4 receptor -3.23452
IFITM10 interferon induced transmembrane protein 10 -3.23452
LY6G5C lymphocyte antigen 6 complex, locus G5C -3.23452
MYO16 myosin XVI -3.23452
NAT16 N-acetyltransferase 16 (GCN5-related, putative) -3.23452
SFN stratifin -3.23452
SHCBP1L SHC SH2-domain binding protein 1-like -3.23452
TBX15 T-box 15 -3.23452
SPINK1 serine peptidase inhibitor, Kazal type 1 -3.23452
MLN motilin -3.23452
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -3.23452
XKR3 XK, Kell blood group complex subunit-related family, member 3 -3.23452
MYH13 myosin, heavy chain 13, skeletal muscle -3.23452
C10ORF67 chromosome 10 open reading frame 67 -3.23452
CCR6 chemokine (C-C motif) receptor 6 -3.23452
PTPRQ protein tyrosine phosphatase, receptor type, Q -3.23452
OASL 2'-5'-oligoadenylate synthetase-like -3.23452
IZUMO4 IZUMO family member 4 -3.23452
GJA9 gap junction protein, alpha 9, 59kDa -3.23452
NPAP1 nuclear pore associated protein 1 -3.23452
WDR87 WD repeat domain 87 -3.23452
TRO trophinin -3.23452
VTCN1 V-set domain containing T cell activation inhibitor 1 -3.23452
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -3.23452
ARHGAP20 Rho GTPase activating protein 20 -3.23452
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.23452
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -3.23452
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -3.23452
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -3.23452
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -3.23452
CYS1 cystin 1 -3.23452
TMEM132D transmembrane protein 132D -3.23452
DUSP15 dual specificity phosphatase 15 -3.21337
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -3.18436
LIPA lipase A, lysosomal acid, cholesterol esterase -3.13002
SYNPO2 synaptopodin 2 -2.90082
MPND MPN domain containing -2.82746
SPATA2 spermatogenesis associated 2 -2.79136
DDAH2 dimethylarginine dimethylaminohydrolase 2 -2.71236
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -2.65381
THRAP3 thyroid hormone receptor associated protein 3 -2.61163
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -2.58801
THAP1 THAP domain containing, apoptosis associated protein 1 -2.58215
MYCBPAP MYCBP associated protein -2.58072
CEP19 centrosomal protein 19kDa -2.54343
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) -2.52098
CHD4 chromodomain helicase DNA binding protein 4 -2.50538
SMTNL1 smoothelin-like 1 -2.4932
PCDHA13 protocadherin alpha 13 -2.4932
MXI1 MAX interactor 1, dimerization protein -2.46795
EMILIN1 elastin microfibril interfacer 1 -2.43874
OARD1 O-acyl-ADP-ribose deacylase 1 -2.43874
CRYBG1 crystallin beta-gamma domain containing 1 -2.42933
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.41738
USP6 ubiquitin specific peptidase 6 -2.37758
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -2.36347
KLHDC2 kelch domain containing 2 -2.36246
MAP7D2 MAP7 domain containing 2 -2.30574
TSPAN14 tetraspanin 14 -2.28362
KHK ketohexokinase (fructokinase) -2.27187
EFTUD2 elongation factor Tu GTP binding domain containing 2 -2.27016
FYN FYN proto-oncogene, Src family tyrosine kinase -2.25324
PPME1 protein phosphatase methylesterase 1 -2.2525
TGOLN2 trans-golgi network protein 2 -2.25161
LRRC32 leucine rich repeat containing 32 -2.23252
SP140 SP140 nuclear body protein -2.23001
PCP4L1 Purkinje cell protein 4 like 1 -2.23001
GAB3 GRB2-associated binding protein 3 -2.23001
ALPK2 alpha-kinase 2 -2.23001
LEFTY2 left-right determination factor 2 -2.22951
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.20971
CTXN1 cortexin 1 -2.20437
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.20007
MST1 macrophage stimulating 1 -2.18443
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.18443
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -2.16944
IKZF4 IKAROS family zinc finger 4 (Eos) -2.16911
ZC3H18 zinc finger CCCH-type containing 18 -2.16911
YTHDC1 YTH domain containing 1 -2.16911
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -2.16911
KY kyphoscoliosis peptidase -2.15903
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.13481
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.13481
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.11611
PRR5L proline rich 5 like -2.1133
CIMAP2 ciliary microtubule associated protein 2 -2.10094
ATG9B autophagy related 9B -2.10094
DPYD dihydropyrimidine dehydrogenase -2.08831
MBD1 methyl-CpG binding domain protein 1 -2.06639
TYSND1 trypsin domain containing 1 -2.05848
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.04448
PCNX2 pecanex 2 -2.03759
TMEM139 transmembrane protein 139 -2.02707
ARL14EP ADP-ribosylation factor-like 14 effector protein -2.02254
AP5B1 adaptor-related protein complex 5, beta 1 subunit -2.01329
NOP2 NOP2 nucleolar protein -2.01156
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.00352