ERG Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description v-ets avian erythroblastosis virus E26 oncogene homolog|This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] (NCBI Entrez Gene Database, 2078)
External Link http://www.ncbi.nlm.nih.gov/gene/2078
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100 interacting proteins for ERG from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTB actin, beta
ADAR adenosine deaminase, RNA-specific
APP amyloid beta (A4) precursor protein
AR androgen receptor
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ASXL1 additional sex combs like transcriptional regulator 1
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CDC5L cell division cycle 5-like
CLTC clathrin, heavy chain (Hc)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELAVL1 ELAV like RNA binding protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBL fibrillarin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA1 forkhead box A1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
JUN jun proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KMT2A lysine (K)-specific methyltransferase 2A
KMT2D lysine (K)-specific methyltransferase 2D
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRK2 leucine-rich repeat kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MATR3 matrin 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NONO non-POU domain containing, octamer-binding
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUCLEOLIN nucleolin multifunctional protein
NUMA1 nuclear mitotic apparatus protein 1
PARP1 poly (ADP-ribose) polymerase 1
PCBP1 poly(rC) binding protein 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPF8 pre-mRNA processing factor 8
PUF60 poly-U binding splicing factor 60KDa
RCC2 regulator of chromosome condensation 2
RPL7A ribosomal protein L7a
RPLP0 ribosomal protein, large, P0
RPS18 ribosomal protein S18
SETDB1 SET domain, bifurcated 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFPQ splicing factor proline/glutamine-rich
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPI1 Spi-1 proto-oncogene
SPTAN1 spectrin, alpha, non-erythrocytic 1
SYN1 synapsin I
TOP1 topoisomerase (DNA) I
TOP2B topoisomerase (DNA) II beta 180kDa
TPM1 tropomyosin 1 (alpha)
TRIM21 tripartite motif containing 21
TUBB tubulin, beta class I
UBC ubiquitin C
USP9X ubiquitin specific peptidase 9, X-linked
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XRN2 5'-3' exoribonuclease 2