ERK1 and ERK2 cascade Gene Set
Dataset
GO Biological Process Annotations 2025
Category
structural or functional annotations
Type
biological process
Description
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. (Gene Ontology , GO_0070371 )
External Link
http://amigo.geneontology.org/amigo/term/GO:0070371
Similar Terms
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Genes
23 genes participating in the ERK1 and ERK2 cascade biological process from the curated GO Biological Process Annotations 2025 dataset.
Symbol
Name
APOA1
apolipoprotein A-I
CDK1
cyclin-dependent kinase 1
CTSH
cathepsin H
DUSP5
dual specificity phosphatase 5
DUSP6
dual specificity phosphatase 6
DUSP7
dual specificity phosphatase 7
DUSP9
dual specificity phosphatase 9
EGF
epidermal growth factor
FGF10
fibroblast growth factor 10
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ITGAV
integrin, alpha V
KARS1
lysyl-tRNA synthetase 1
LGALS9
lectin, galactoside-binding, soluble, 9
MAP2K1
mitogen-activated protein kinase kinase 1
MAP2K2
mitogen-activated protein kinase kinase 2
MAPK1
mitogen-activated protein kinase 1
MAPK3
mitogen-activated protein kinase 3
MYC
v-myc avian myelocytomatosis viral oncogene homolog
PTGER4
prostaglandin E receptor 4 (subtype EP4)
RIPK2
receptor-interacting serine-threonine kinase 2
SOX9
SRY (sex determining region Y)-box 9
ZFP36L1
ZFP36 ring finger protein-like 1
ZFP36L2
ZFP36 ring finger protein-like 2
