ERK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase 3|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5595)
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100 substrates of the kinase ERK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
DAB2IP DAB2 interacting protein
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
MYRF myelin regulatory factor
EPS8L3 EPS8-like 3
ATXN2L ataxin 2-like
N4BP3 NEDD4 binding protein 3
CHAMP1 chromosome alignment maintaining phosphoprotein 1
INPPL1 inositol polyphosphate phosphatase-like 1
USP20 ubiquitin specific peptidase 20
NECAB2 N-terminal EF-hand calcium binding protein 2
SYNPO2L synaptopodin 2-like
MICALL1 MICAL-like 1
PDZD3 PDZ domain containing 3
IRS2 insulin receptor substrate 2
RGL3 ral guanine nucleotide dissociation stimulator-like 3
ANKRD34A ankyrin repeat domain 34A
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
MED13 mediator complex subunit 13
MACF1 microtubule-actin crosslinking factor 1
C19ORF26 chromosome 19 open reading frame 26
PERM1 PPARGC1 and ESRR induced regulator, muscle 1
FAM65A family with sequence similarity 65, member A
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
BBC3 BCL2 binding component 3
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
HSPA12B heat shock 70kD protein 12B
GATA4 GATA binding protein 4
SRP72 signal recognition particle 72kDa
CEP89 centrosomal protein 89kDa
ADRB1 adrenoceptor beta 1
DUSP8 dual specificity phosphatase 8
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
HTRA2 HtrA serine peptidase 2
SAMD14 sterile alpha motif domain containing 14
C2CD3 C2 calcium-dependent domain containing 3
FLJ22184
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
ERBB2 erb-b2 receptor tyrosine kinase 2
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
NKX2-4 NK2 homeobox 4
BCL9L B-cell CLL/lymphoma 9-like
INO80B INO80 complex subunit B
ARHGAP4 Rho GTPase activating protein 4
RERE arginine-glutamic acid dipeptide (RE) repeats
DTX1 deltex 1, E3 ubiquitin ligase
BRSK1 BR serine/threonine kinase 1
CAPN3 calpain 3, (p94)
RAD9A RAD9 homolog A (S. pombe)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
ISL2 ISL LIM homeobox 2
TMEM131 transmembrane protein 131
BAHCC1 BAH domain and coiled-coil containing 1
PROSER3 proline and serine rich 3
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
KLRG2 killer cell lectin-like receptor subfamily G, member 2
POM121 POM121 transmembrane nucleoporin
SRCAP Snf2-related CREBBP activator protein
AHDC1 AT hook, DNA binding motif, containing 1
ZNF598 zinc finger protein 598
MAPT microtubule-associated protein tau
TH tyrosine hydroxylase
COL14A1 collagen, type XIV, alpha 1
KLHDC4 kelch domain containing 4
NOTCH3 notch 3
KCTD14 potassium channel tetramerization domain containing 14
BCL2L11 BCL2-like 11 (apoptosis facilitator)
ERF Ets2 repressor factor
MTX1 metaxin 1
AFF2 AF4/FMR2 family, member 2
KIAA0195 KIAA0195
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
ARHGAP22 Rho GTPase activating protein 22
ENDOV endonuclease V
MSL1 male-specific lethal 1 homolog (Drosophila)
MAST1 microtubule associated serine/threonine kinase 1
MAST2 microtubule associated serine/threonine kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
ARID5A AT rich interactive domain 5A (MRF1-like)
FAM110D family with sequence similarity 110, member D
SPEG SPEG complex locus
LARP1 La ribonucleoprotein domain family, member 1
LARP4 La ribonucleoprotein domain family, member 4
DMWD dystrophia myotonica, WD repeat containing
GRIP2 glutamate receptor interacting protein 2
TTC31 tetratricopeptide repeat domain 31
ACVR2A activin A receptor, type IIA
LIG3 ligase III, DNA, ATP-dependent
LSR lipolysis stimulated lipoprotein receptor
BAG3 BCL2-associated athanogene 3
KANK2 KN motif and ankyrin repeat domains 2
WDFY4 WDFY family member 4
UBAP2L ubiquitin associated protein 2-like
TNRC18 trinucleotide repeat containing 18
ITPKB inositol-trisphosphate 3-kinase B
SYTL5 synaptotagmin-like 5
TUSC1 tumor suppressor candidate 1