ERK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase 1|This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5594)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase ERK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
PERM1 PPARGC1 and ESRR induced regulator, muscle 1
FAM65A family with sequence similarity 65, member A
EPC1 enhancer of polycomb homolog 1 (Drosophila)
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
N4BP3 NEDD4 binding protein 3
CHAMP1 chromosome alignment maintaining phosphoprotein 1
INPPL1 inositol polyphosphate phosphatase-like 1
KMT2D lysine (K)-specific methyltransferase 2D
FMNL2 formin-like 2
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
REPS1 RALBP1 associated Eps domain containing 1
C19ORF26 chromosome 19 open reading frame 26
RCSD1 RCSD domain containing 1
LARP1 La ribonucleoprotein domain family, member 1
LARP4 La ribonucleoprotein domain family, member 4
SEC24B SEC24 family member B
CIC capicua transcriptional repressor
MKI67 marker of proliferation Ki-67
IRS2 insulin receptor substrate 2
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
MED13 mediator complex subunit 13
KMT2A lysine (K)-specific methyltransferase 2A
MACF1 microtubule-actin crosslinking factor 1
PCLO piccolo presynaptic cytomatrix protein
DOT1L DOT1-like histone H3K79 methyltransferase
TEP1 telomerase-associated protein 1
CEP89 centrosomal protein 89kDa
CFAP97 cilia and flagella associated protein 97
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RSBN1L round spermatid basic protein 1-like
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEND5 BEN domain containing 5
TGIF1 TGFB-induced factor homeobox 1
FAM63A family with sequence similarity 63, member A
BEST3 bestrophin 3
ATF7IP activating transcription factor 7 interacting protein
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
AHNAK AHNAK nucleoprotein
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
BCL9L B-cell CLL/lymphoma 9-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
ZNF638 zinc finger protein 638
LSP1 lymphocyte-specific protein 1
ZMYND8 zinc finger, MYND-type containing 8
CASKIN1 CASK interacting protein 1
SAMD14 sterile alpha motif domain containing 14
PTH1R parathyroid hormone 1 receptor
RAD9A RAD9 homolog A (S. pombe)
KIAA0753 KIAA0753
TMEM131 transmembrane protein 131
NREP neuronal regeneration related protein
PROSER3 proline and serine rich 3
ATAD2 ATPase family, AAA domain containing 2
BUD13 BUD13 homolog (S. cerevisiae)
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
FHDC1 FH2 domain containing 1
RB1 retinoblastoma 1
SRCAP Snf2-related CREBBP activator protein
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
ZNF598 zinc finger protein 598
MAPT microtubule-associated protein tau
BCLAF1 BCL2-associated transcription factor 1
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
ACACA acetyl-CoA carboxylase alpha
KLHDC4 kelch domain containing 4
MTX1 metaxin 1
USP10 ubiquitin specific peptidase 10
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
DOCK5 dedicator of cytokinesis 5
TH tyrosine hydroxylase
USP36 ubiquitin specific peptidase 36
GTSE1 G-2 and S-phase expressed 1
RSBN1 round spermatid basic protein 1
DMWD dystrophia myotonica, WD repeat containing
MSL1 male-specific lethal 1 homolog (Drosophila)
TSC2 tuberous sclerosis 2
MAST1 microtubule associated serine/threonine kinase 1
MAST2 microtubule associated serine/threonine kinase 2
MAST4 microtubule associated serine/threonine kinase family member 4
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RAVER1 ribonucleoprotein, PTB-binding 1
KANSL1 KAT8 regulatory NSL complex subunit 1
WIZ widely interspaced zinc finger motifs
FLNC filamin C, gamma
GRIP2 glutamate receptor interacting protein 2
ZNF318 zinc finger protein 318
IL4R interleukin 4 receptor
RABGAP1 RAB GTPase activating protein 1
GPATCH2L G patch domain containing 2-like
LSR lipolysis stimulated lipoprotein receptor
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ITPKB inositol-trisphosphate 3-kinase B
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
SYTL2 synaptotagmin-like 2
SVIL supervillin
FOXO3 forkhead box O3
NOP9 NOP9 nucleolar protein