| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.128345 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0896658 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0667691 |
| EGFR | epidermal growth factor receptor | 0.0650412 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.06211 |
| FLNA | filamin A, alpha | 0.0562837 |
| HDAC9 | histone deacetylase 9 | 0.0547123 |
| PODXL | podocalyxin-like | 0.054652 |
| CDH13 | cadherin 13 | 0.0533737 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0506978 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.049575 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0472176 |
| DST | dystonin | 0.0434416 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0427244 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0415833 |
| CALR | calreticulin | 0.0415595 |
| COL5A1 | collagen, type V, alpha 1 | 0.0411387 |
| SEPTIN9 | septin 9 | 0.0397735 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0394254 |
| NAV2 | neuron navigator 2 | 0.0386985 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0381929 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0372554 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0369764 |
| FLNB | filamin B, beta | 0.0352511 |
| RUNX1 | runt-related transcription factor 1 | 0.0348097 |
| TPM3 | tropomyosin 3 | 0.0342499 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0339397 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0338046 |
| NAV1 | neuron navigator 1 | 0.0329489 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0326951 |
| ASPH | aspartate beta-hydroxylase | 0.0321806 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0304641 |
| APP | amyloid beta (A4) precursor protein | 0.0302044 |
| FNDC3B | fibronectin type III domain containing 3B | 0.028951 |
| THBS2 | thrombospondin 2 | 0.0286917 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0281571 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0273471 |
| LDHA | lactate dehydrogenase A | 0.0261664 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0257273 |
| CD44 | CD44 molecule (Indian blood group) | 0.0255984 |
| ANXA2 | annexin A2 | 0.0255796 |
| CANX | calnexin | 0.0255485 |
| ANKRD11 | ankyrin repeat domain 11 | 0.02529 |
| FNIP1 | folliculin interacting protein 1 | 0.0252147 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0249765 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0247301 |
| EFNA5 | ephrin-A5 | 0.0246577 |
| DSPP | dentin sialophosphoprotein | 0.0243008 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0235427 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.023535 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0234037 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.023061 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0223877 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0223065 |
| MSN | moesin | 0.0223044 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0218087 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0216656 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0214676 |
| PLEC | plectin | 0.0213173 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0211073 |
| MYOF | myoferlin | 0.020588 |
| FSTL1 | follistatin-like 1 | 0.0202864 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.02015 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0200422 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0200306 |
| CENPF | centromere protein F, 350/400kDa | 0.0200039 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0197155 |
| C1D | C1D nuclear receptor corepressor | 0.0195148 |
| EZR | ezrin | 0.0190081 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0187207 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0186169 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0185546 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0181468 |
| L1CAM | L1 cell adhesion molecule | 0.0178817 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0176299 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0176187 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0173659 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0173044 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0168693 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0167261 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0167143 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0166377 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.016495 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0164562 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0161789 |
| SMYD3 | SET and MYND domain containing 3 | 0.0161601 |
| DOCK5 | dedicator of cytokinesis 5 | 0.016133 |
| GOLGB1 | golgin B1 | 0.0161111 |
| PRELID2 | PRELI domain containing 2 | 0.015848 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0157978 |
| TENM3 | teneurin transmembrane protein 3 | 0.0157497 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0157481 |
| PRKCE | protein kinase C, epsilon | 0.0153759 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0152676 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0150218 |
| ANO6 | anoctamin 6 | 0.0149442 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0149076 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0146483 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0145892 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.014564 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.195467 |
| VIM | vimentin | -0.160255 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.142761 |
| MT2A | metallothionein 2A | -0.096781 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0782572 |
| B2M | beta-2-microglobulin | -0.0641937 |
| HLA-B | major histocompatibility complex, class I, B | -0.0584394 |
| PLAT | plasminogen activator, tissue | -0.0520239 |
| S100A6 | S100 calcium binding protein A6 | -0.0514067 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0500423 |
| S100A10 | S100 calcium binding protein A10 | -0.044822 |
| UBC | ubiquitin C | -0.0444048 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0384876 |
| MT1X | metallothionein 1X | -0.0374769 |
| FBN1 | fibrillin 1 | -0.0374017 |
| LMNA | lamin A/C | -0.0369879 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0359394 |
| COL1A2 | collagen, type I, alpha 2 | -0.0352519 |
| PTMA | prothymosin, alpha | -0.0351063 |
| SUCNR1 | succinate receptor 1 | -0.0342893 |
| CD99 | CD99 molecule | -0.0317436 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0312417 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0305544 |
| CSTB | cystatin B (stefin B) | -0.0301468 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0297905 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0293358 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0287798 |
| TAGLN2 | transgelin 2 | -0.0287476 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0277658 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0273032 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0270985 |
| S100A4 | S100 calcium binding protein A4 | -0.0265226 |
| PRSS23 | protease, serine, 23 | -0.0261596 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0257479 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0245412 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0234603 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0232321 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0222056 |
| FTL | ferritin, light polypeptide | -0.0220525 |
| LOX | lysyl oxidase | -0.0219658 |
| HLA-C | major histocompatibility complex, class I, C | -0.0218488 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0207513 |
| RPL35A | ribosomal protein L35a | -0.0204846 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0202955 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0198167 |
| PFN1 | profilin 1 | -0.0192734 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0189198 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0186613 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0182894 |
| FN1 | fibronectin 1 | -0.0182494 |
| S100A9 | S100 calcium binding protein A9 | -0.0182171 |
| GNAS | GNAS complex locus | -0.01765 |
| SEC61G | Sec61 gamma subunit | -0.0169672 |
| H3-3B | H3.3 histone B | -0.0168085 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0167448 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0166442 |
| IER3 | immediate early response 3 | -0.0164351 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0162435 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0159785 |
| STC1 | stanniocalcin 1 | -0.0156852 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0151495 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0150807 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0150436 |
| HLA-E | major histocompatibility complex, class I, E | -0.0150224 |
| KRT81 | keratin 81, type II | -0.0140183 |
| RPL34 | ribosomal protein L34 | -0.0138613 |
| MX2 | MX dynamin-like GTPase 2 | -0.01372 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0135205 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0134708 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0131564 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0130709 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0130289 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0129576 |
| RPL28 | ribosomal protein L28 | -0.0128336 |
| HLA-A | major histocompatibility complex, class I, A | -0.0126443 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0125118 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0124957 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0123142 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0122095 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0121525 |
| FAM162A | family with sequence similarity 162, member A | -0.0120717 |
| S100A11 | S100 calcium binding protein A11 | -0.0119358 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0118066 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0116764 |
| RRBP1 | ribosome binding protein 1 | -0.0116317 |
| WTAP | Wilms tumor 1 associated protein | -0.0114512 |
| VDAC1 | voltage-dependent anion channel 1 | -0.011428 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0113769 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0113048 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0112699 |
| RPS21 | ribosomal protein S21 | -0.0111974 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.011065 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0108208 |
| RPS24 | ribosomal protein S24 | -0.0108179 |
| POMP | proteasome maturation protein | -0.0107944 |
| SDC4 | syndecan 4 | -0.01058 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | -0.0105215 |
| CD63 | CD63 molecule | -0.0105185 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0104928 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0103655 |
