| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.150033 |
| HMGA2 | high mobility group AT-hook 2 | 0.0992637 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0894306 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0889713 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0888806 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0803654 |
| ASPH | aspartate beta-hydroxylase | 0.0744357 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0681737 |
| TMSB10 | thymosin beta 10 | 0.059004 |
| ACTG1 | actin gamma 1 | 0.0579517 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0576276 |
| PCDH7 | protocadherin 7 | 0.0571289 |
| RRM2 | ribonucleotide reductase M2 | 0.0547186 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.054601 |
| ADIPOR2 | adiponectin receptor 2 | 0.0543029 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0508428 |
| YAP1 | Yes-associated protein 1 | 0.05082 |
| RPS12 | ribosomal protein S12 | 0.0482723 |
| EGR1 | early growth response 1 | 0.0467836 |
| INTS6 | integrator complex subunit 6 | 0.044886 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0448217 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0446773 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.043576 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.042272 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0419956 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0419112 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0419057 |
| MMP12 | matrix metallopeptidase 12 | 0.0416795 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0411269 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0398966 |
| PTMA | prothymosin, alpha | 0.0393812 |
| RPS23 | ribosomal protein S23 | 0.0387202 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0386797 |
| PGK1 | phosphoglycerate kinase 1 | 0.038586 |
| RPS8 | ribosomal protein S8 | 0.0382801 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0381455 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0373538 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0367349 |
| RPL37A | ribosomal protein L37a | 0.0363412 |
| RPS3 | ribosomal protein S3 | 0.0361674 |
| RPL23 | ribosomal protein L23 | 0.0360202 |
| FTL | ferritin, light polypeptide | 0.0359068 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0357777 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0356782 |
| CMIP | c-Maf inducing protein | 0.034899 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0333975 |
| LDHA | lactate dehydrogenase A | 0.0333843 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0330275 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0329135 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0325753 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0321383 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0316362 |
| JMJD1C | jumonji domain containing 1C | 0.0316083 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0314823 |
| CALR | calreticulin | 0.0314296 |
| DST | dystonin | 0.0313421 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0311751 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0307669 |
| EHBP1 | EH domain binding protein 1 | 0.0297204 |
| VIM | vimentin | 0.0295125 |
| ZNF638 | zinc finger protein 638 | 0.0292221 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0291548 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0290998 |
| NHSL1 | NHS-like 1 | 0.0286111 |
| RPL31 | ribosomal protein L31 | 0.0285644 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0283282 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0280065 |
| RPS27A | ribosomal protein S27a | 0.0278071 |
| IPO7 | importin 7 | 0.02683 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0263328 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0261682 |
| HDLBP | high density lipoprotein binding protein | 0.0258014 |
| NAV3 | neuron navigator 3 | 0.0257681 |
| TPM3 | tropomyosin 3 | 0.0255798 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0247379 |
| RPL3 | ribosomal protein L3 | 0.0247014 |
| DENND5A | DENN/MADD domain containing 5A | 0.0246439 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.02446 |
| RPS29 | ribosomal protein S29 | 0.0243926 |
| MTAP | methylthioadenosine phosphorylase | 0.024346 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0241432 |
| RAN | RAN, member RAS oncogene family | 0.0240563 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0240113 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0238402 |
| ENO1 | enolase 1, (alpha) | 0.0234691 |
| CUX1 | cut-like homeobox 1 | 0.0234143 |
| LRRC23 | leucine rich repeat containing 23 | 0.0233288 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.023234 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0230794 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0229783 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0228542 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0228185 |
| MKI67 | marker of proliferation Ki-67 | 0.0227275 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0226413 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.022537 |
| RPS13 | ribosomal protein S13 | 0.0224699 |
| RPS6 | ribosomal protein S6 | 0.0223815 |
| FNIP1 | folliculin interacting protein 1 | 0.0223677 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.022239 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0221954 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0526306 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0435671 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0396884 |
| MGAT4C | MGAT4 family, member C | -0.036251 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0333974 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0322252 |
| CXADR | coxsackie virus and adenovirus receptor | -0.031987 |
| XPO1 | exportin 1 | -0.0306409 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0277441 |
| YBX3 | Y box binding protein 3 | -0.0267643 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0248859 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.023489 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0233197 |
| NEK7 | NIMA-related kinase 7 | -0.0231828 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0230977 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0217543 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0215155 |
| ZFR | zinc finger RNA binding protein | -0.020601 |
| AREG | amphiregulin | -0.0200741 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.019509 |
| ZNF292 | zinc finger protein 292 | -0.0190942 |
| CCNL1 | cyclin L1 | -0.0187212 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0181926 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0180952 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0177652 |
| EDN1 | endothelin 1 | -0.0176454 |
| NCOR1 | nuclear receptor corepressor 1 | -0.017485 |
| PFN1 | profilin 1 | -0.0171903 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0167115 |
| OXR1 | oxidation resistance 1 | -0.0165948 |
| H1-0 | H1.0 linker histone | -0.016507 |
| NKTR | natural killer cell triggering receptor | -0.0164808 |
| CPOX | coproporphyrinogen oxidase | -0.0164348 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0164152 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0156724 |
| TXNRD1 | thioredoxin reductase 1 | -0.0156178 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0153623 |
| TNPO1 | transportin 1 | -0.0151964 |
| RBM25 | RNA binding motif protein 25 | -0.0151596 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0151518 |
| ATP11B | ATPase, class VI, type 11B | -0.0151167 |
| PRKCI | protein kinase C, iota | -0.0146975 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0145953 |
| RPLP0 | ribosomal protein, large, P0 | -0.014495 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0144095 |
| MED13L | mediator complex subunit 13-like | -0.0141297 |
| CDC42SE2 | CDC42 small effector 2 | -0.013982 |
| KLHL24 | kelch-like family member 24 | -0.0139591 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0137979 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0135772 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.013545 |
| NEMF | nuclear export mediator factor | -0.0135276 |
| TMEM41B | transmembrane protein 41B | -0.0134524 |
| PNN | pinin, desmosome associated protein | -0.0134162 |
| THOC1 | THO complex 1 | -0.0133888 |
| REPS1 | RALBP1 associated Eps domain containing 1 | -0.0132784 |
| RBMX | RNA binding motif protein, X-linked | -0.0131074 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.0129884 |
| HLTF | helicase-like transcription factor | -0.0129201 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0128671 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0127001 |
| IL6ST | interleukin 6 signal transducer | -0.0126824 |
| FOXN2 | forkhead box N2 | -0.0125775 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0123694 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0121623 |
| IPMK | inositol polyphosphate multikinase | -0.0121309 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0119035 |
| TMEM47 | transmembrane protein 47 | -0.0117611 |
| CDK19 | cyclin-dependent kinase 19 | -0.0117356 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | -0.0116422 |
| MATR3 | matrin 3 | -0.011635 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.011448 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0113645 |
| USP3 | ubiquitin specific peptidase 3 | -0.0112863 |
| RNF13 | ring finger protein 13 | -0.0112728 |
| RNF145 | ring finger protein 145 | -0.0111993 |
| TBC1D32 | TBC1 domain family, member 32 | -0.0111901 |
| OGA | O-GlcNAcase | -0.0111512 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0111185 |
| CDK17 | cyclin-dependent kinase 17 | -0.0111065 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0110108 |
| AHNAK | AHNAK nucleoprotein | -0.0110032 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0109531 |
| RBM27 | RNA binding motif protein 27 | -0.0109222 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0109126 |
| CSMD1 | CUB and Sushi multiple domains 1 | -0.0108624 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0108151 |
| TCERG1 | transcription elongation regulator 1 | -0.0106603 |
| MPG | N-methylpurine-DNA glycosylase | -0.0106449 |
| SMAD5 | SMAD family member 5 | -0.0106447 |
| RHOT1 | ras homolog family member T1 | -0.0106363 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0106329 |
| SEPTIN7 | septin 7 | -0.0106021 |
| TRIM33 | tripartite motif containing 33 | -0.0105158 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0104844 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0104715 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0104592 |
| CPSF6 | cleavage and polyadenylation specific factor 6, 68kDa | -0.0103865 |
| CBX3 | chromobox homolog 3 | -0.0103732 |
| CDC73 | cell division cycle 73 | -0.0103551 |
