| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.360432 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.133926 |
| VIM | vimentin | 0.13124 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.123249 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.112194 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.101198 |
| EXT1 | exostosin glycosyltransferase 1 | 0.097303 |
| GPC6 | glypican 6 | 0.0946499 |
| FRMD4A | FERM domain containing 4A | 0.0864202 |
| ANXA2 | annexin A2 | 0.0849809 |
| NDRG1 | N-myc downstream regulated 1 | 0.0778244 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0775509 |
| RNF213 | ring finger protein 213 | 0.0759133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0730396 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0725101 |
| TMSB10 | thymosin beta 10 | 0.0724144 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0700783 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0671966 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0638063 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0637341 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0631553 |
| FLNA | filamin A, alpha | 0.0612467 |
| CALR | calreticulin | 0.0552744 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0539451 |
| CRY1 | cryptochrome circadian clock 1 | 0.0537428 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0527596 |
| CTBP2 | C-terminal binding protein 2 | 0.0523176 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0512434 |
| FAT1 | FAT atypical cadherin 1 | 0.0500507 |
| CTSD | cathepsin D | 0.0499806 |
| FAM107B | family with sequence similarity 107, member B | 0.0496839 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0496181 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0495349 |
| LDHA | lactate dehydrogenase A | 0.0488887 |
| HM13 | histocompatibility (minor) 13 | 0.048586 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0484481 |
| CA12 | carbonic anhydrase XII | 0.0477587 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0476827 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0470888 |
| PLEC | plectin | 0.0470292 |
| MLF1 | myeloid leukemia factor 1 | 0.0465875 |
| RND3 | Rho family GTPase 3 | 0.044607 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.044071 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0438133 |
| GOLGB1 | golgin B1 | 0.0434823 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0431423 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0417261 |
| APP | amyloid beta (A4) precursor protein | 0.0416137 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0409431 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0408731 |
| RPL23 | ribosomal protein L23 | 0.0402095 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.0401872 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0399556 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0395004 |
| FAM13A | family with sequence similarity 13, member A | 0.0394472 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0388487 |
| MYO1E | myosin IE | 0.0382743 |
| HDLBP | high density lipoprotein binding protein | 0.037685 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0368168 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0362625 |
| SP100 | SP100 nuclear antigen | 0.0361543 |
| ATF3 | activating transcription factor 3 | 0.0360729 |
| EGFR | epidermal growth factor receptor | 0.0357849 |
| RPS4X | ribosomal protein S4, X-linked | 0.0356935 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0354528 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0354253 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0346175 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0342435 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0341336 |
| CADM1 | cell adhesion molecule 1 | 0.0340349 |
| FLNC | filamin C, gamma | 0.0338839 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0331681 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0329043 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0321902 |
| CP | ceruloplasmin (ferroxidase) | 0.0315145 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0314867 |
| NAV2 | neuron navigator 2 | 0.0311995 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0307689 |
| SIK3 | SIK family kinase 3 | 0.0304034 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0302817 |
| PALLD | palladin, cytoskeletal associated protein | 0.0302648 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0302009 |
| HLA-B | major histocompatibility complex, class I, B | 0.0300843 |
| CAVIN1 | caveolae associated protein 1 | 0.0298821 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0298149 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0297702 |
| HLA-E | major histocompatibility complex, class I, E | 0.029439 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0294077 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0293372 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0293364 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0293008 |
| MYOF | myoferlin | 0.0292519 |
| GPR176 | G protein-coupled receptor 176 | 0.0288407 |
| ARF1 | ADP-ribosylation factor 1 | 0.0286017 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.02859 |
| OSMR | oncostatin M receptor | 0.0282797 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0282123 |
| CMIP | c-Maf inducing protein | 0.0280287 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0279779 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0278457 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.125322 |
| POTEF | POTE ankyrin domain family, member F | -0.100707 |
| RPS2 | ribosomal protein S2 | -0.0764887 |
| TXNRD1 | thioredoxin reductase 1 | -0.0661441 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0655137 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0636646 |
| NRP2 | neuropilin 2 | -0.0590722 |
| CENPF | centromere protein F, 350/400kDa | -0.0570979 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0464034 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0426309 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0421947 |
| MSN | moesin | -0.0412863 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.041227 |
| RPS6 | ribosomal protein S6 | -0.0405286 |
| SP3 | Sp3 transcription factor | -0.0394137 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0366597 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0365463 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0359349 |
| NLGN1 | neuroligin 1 | -0.0356782 |
| XPO1 | exportin 1 | -0.0354003 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.032519 |
| RAI14 | retinoic acid induced 14 | -0.0315318 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0308229 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0304387 |
| TUSC3 | tumor suppressor candidate 3 | -0.0301919 |
| ANLN | anillin, actin binding protein | -0.0295028 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0289825 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0285294 |
| B2M | beta-2-microglobulin | -0.0277277 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0275078 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0273185 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0271148 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0266945 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0266561 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0266262 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0263409 |
| TPX2 | TPX2, microtubule-associated | -0.0260937 |
| VCAN | versican | -0.0260591 |
| ASPH | aspartate beta-hydroxylase | -0.0258578 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0258312 |
| SET | SET nuclear proto-oncogene | -0.0255555 |
| SETD5 | SET domain containing 5 | -0.0253917 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0252671 |
| MKI67 | marker of proliferation Ki-67 | -0.024943 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | -0.0249336 |
| H3-3B | H3.3 histone B | -0.0249044 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0244075 |
| GOLT1B | golgi transport 1B | -0.0233879 |
| SAA2-SAA4 | SAA2-SAA4 readthrough | -0.0231 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0228025 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0226482 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0226024 |
| R3HDM1 | R3H domain containing 1 | -0.0225592 |
| SSH2 | slingshot protein phosphatase 2 | -0.0222359 |
| PTMA | prothymosin, alpha | -0.021881 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0218129 |
| HSPE1 | heat shock 10kDa protein 1 | -0.0215899 |
| LYPLA1 | lysophospholipase I | -0.0214209 |
| RNF145 | ring finger protein 145 | -0.0210988 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0207484 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0207114 |
| SRPK2 | SRSF protein kinase 2 | -0.020536 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0204853 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0201961 |
| G0S2 | G0/G1 switch 2 | -0.020105 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0200793 |
| SAA2 | serum amyloid A2 | -0.020044 |
| CDCP1 | CUB domain containing protein 1 | -0.0199326 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0198733 |
| TPR | translocated promoter region, nuclear basket protein | -0.0197594 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0196102 |
| PFN1 | profilin 1 | -0.0195475 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0195279 |
| NMD3 | NMD3 ribosome export adaptor | -0.0195 |
| ATXN10 | ataxin 10 | -0.0190937 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0189869 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0189794 |
| LOXL2 | lysyl oxidase-like 2 | -0.0189006 |
| ZNF706 | zinc finger protein 706 | -0.0187896 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0186124 |
| NFIB | nuclear factor I/B | -0.0184353 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.018421 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0183724 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0183416 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0182979 |
| CLTC | clathrin, heavy chain (Hc) | -0.0180492 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0178623 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.0178501 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.0178223 |
| CENPE | centromere protein E, 312kDa | -0.0176614 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.017568 |
| RBM39 | RNA binding motif protein 39 | -0.0175556 |
| ZBTB41 | zinc finger and BTB domain containing 41 | -0.017546 |
| IL6ST | interleukin 6 signal transducer | -0.0174006 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0173813 |
| UBQLN1 | ubiquilin 1 | -0.017324 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.0172958 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0171165 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0169543 |
| QKI | QKI, KH domain containing, RNA binding | -0.0168278 |
