ERK5-IN-2_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.174152
EEF2 eukaryotic translation elongation factor 2 0.121264
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.096161
VIM vimentin 0.0921036
EIF1 eukaryotic translation initiation factor 1 0.0873129
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0851224
RPS6 ribosomal protein S6 0.0822024
ANXA2 annexin A2 0.0818475
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0763637
FTL ferritin, light polypeptide 0.0753406
PKM pyruvate kinase, muscle 0.0700617
ACTG1 actin gamma 1 0.0676882
RPS16 ribosomal protein S16 0.0659111
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0647692
FTH1 ferritin, heavy polypeptide 1 0.064242
AKAP12 A kinase (PRKA) anchor protein 12 0.0635847
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0611062
RPL23 ribosomal protein L23 0.0583434
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0579855
LDHA lactate dehydrogenase A 0.0547554
RPS19 ribosomal protein S19 0.0542354
RPL26 ribosomal protein L26 0.0533104
RPL13A ribosomal protein L13a 0.0531157
TPT1 tumor protein, translationally-controlled 1 0.0515659
RPLP1 ribosomal protein, large, P1 0.0489099
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0487661
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0487143
RPS17 ribosomal protein S17 0.0484437
TKT transketolase 0.0482742
TM4SF1 transmembrane 4 L six family member 1 0.0481521
RHCG Rh family, C glycoprotein 0.0456596
RPL4 ribosomal protein L4 0.0444482
EEF1G eukaryotic translation elongation factor 1 gamma 0.0443472
RPS3 ribosomal protein S3 0.0443323
GOLGA4 golgin A4 0.0438413
ENO1 enolase 1, (alpha) 0.0437696
STC1 stanniocalcin 1 0.0433413
RPS8 ribosomal protein S8 0.0432437
MCL1 myeloid cell leukemia 1 0.0429297
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0423465
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0416484
PGK1 phosphoglycerate kinase 1 0.041565
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0415235
RACK1 receptor for activated C kinase 1 0.0414681
PCBP2 poly(rC) binding protein 2 0.0414545
RPL12 ribosomal protein L12 0.0412989
CXCL8 chemokine (C-X-C motif) ligand 8 0.0409147
RPS13 ribosomal protein S13 0.0407285
RPL19 ribosomal protein L19 0.0402593
EIF4A1 eukaryotic translation initiation factor 4A1 0.0389712
RPL37A ribosomal protein L37a 0.0388848
SOD2 superoxide dismutase 2, mitochondrial 0.0386406
FAM107B family with sequence similarity 107, member B 0.0383286
PTMA prothymosin, alpha 0.0378211
TNIP1 TNFAIP3 interacting protein 1 0.0374463
UBC ubiquitin C 0.0373302
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0373196
RPL7 ribosomal protein L7 0.0371711
RPL7A ribosomal protein L7a 0.0364556
RPS2 ribosomal protein S2 0.035588
RPS27A ribosomal protein S27a 0.0355608
RPS12 ribosomal protein S12 0.0354729
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0354722
CEMIP cell migration inducing protein, hyaluronan binding 0.0353644
RPLP0 ribosomal protein, large, P0 0.0352975
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0351056
KYNU kynureninase 0.03481
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0344511
POTEF POTE ankyrin domain family, member F 0.0342058
FLNA filamin A, alpha 0.0332773
MYH9 myosin, heavy chain 9, non-muscle 0.0331025
ELL2 elongation factor, RNA polymerase II, 2 0.032391
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0322639
RPS23 ribosomal protein S23 0.0315611
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0313048
RPL8 ribosomal protein L8 0.0312924
RPL31 ribosomal protein L31 0.0308538
MT2A metallothionein 2A 0.0305216
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0302587
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0297777
ALCAM activated leukocyte cell adhesion molecule 0.0295243
RPS25 ribosomal protein S25 0.0293345
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.028843
ARHGAP26 Rho GTPase activating protein 26 0.0287901
PRRC2C proline-rich coiled-coil 2C 0.0287432
IRAK2 interleukin-1 receptor-associated kinase 2 0.0286936
RPS11 ribosomal protein S11 0.0284056
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0283518
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0283478
APP amyloid beta (A4) precursor protein 0.0282682
RPS5 ribosomal protein S5 0.0281954
SRRM2 serine/arginine repetitive matrix 2 0.0280198
RPS24 ribosomal protein S24 0.0279115
KTN1 kinectin 1 (kinesin receptor) 0.0278457
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0270152
MATR3 matrin 3 0.0268518
UBA2 ubiquitin-like modifier activating enzyme 2 0.0264686
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0264402
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0264131
KRT18 keratin 18, type I 0.0263034

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.216993
EFNA5 ephrin-A5 -0.15131
IGFBP3 insulin-like growth factor binding protein 3 -0.104267
AUTS2 autism susceptibility candidate 2 -0.0830319
GRB10 growth factor receptor-bound protein 10 -0.0734713
NDRG1 N-myc downstream regulated 1 -0.0642349
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0631272
PDE10A phosphodiesterase 10A -0.0603035
EHBP1 EH domain binding protein 1 -0.0602091
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0600622
MAML3 mastermind-like 3 (Drosophila) -0.0578179
THSD4 thrombospondin, type I, domain containing 4 -0.0543024
EGFR epidermal growth factor receptor -0.053313
RNF213 ring finger protein 213 -0.0525699
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.052393
HMGA2 high mobility group AT-hook 2 -0.0506652
PRKCA protein kinase C, alpha -0.0503307
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0498967
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0481672
TNS3 tensin 3 -0.047869
RIN2 Ras and Rab interactor 2 -0.047701
NPAS2 neuronal PAS domain protein 2 -0.0460232
MYO1E myosin IE -0.0459325
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0447845
GPC6 glypican 6 -0.0443616
TPM1 tropomyosin 1 (alpha) -0.0426239
PTPRM protein tyrosine phosphatase, receptor type, M -0.04142
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0404569
RAI14 retinoic acid induced 14 -0.0402587
SLC35F3 solute carrier family 35, member F3 -0.0377689
FLNB filamin B, beta -0.0365465
VCL vinculin -0.0356665
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0347908
DAPK1 death-associated protein kinase 1 -0.0331738
RRBP1 ribosome binding protein 1 -0.032345
IGSF11 immunoglobulin superfamily, member 11 -0.0320517
ZMYND8 zinc finger, MYND-type containing 8 -0.0317623
BASP1 brain abundant, membrane attached signal protein 1 -0.0317032
ZBTB20 zinc finger and BTB domain containing 20 -0.0308686
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0303296
DOCK5 dedicator of cytokinesis 5 -0.0301934
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0282803
PSD3 pleckstrin and Sec7 domain containing 3 -0.0277911
RIGI RNA sensor RIG-I -0.0274434
MT1X metallothionein 1X -0.0262605
NRP1 neuropilin 1 -0.0259392
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0256224
BICC1 BicC family RNA binding protein 1 -0.0250943
LOXL2 lysyl oxidase-like 2 -0.0247911
TJP1 tight junction protein 1 -0.0246646
MTCL1 microtubule crosslinking factor 1 -0.0245733
ANXA4 annexin A4 -0.0241506
PLSCR1 phospholipid scramblase 1 -0.0238993
ZFHX3 zinc finger homeobox 3 -0.0236653
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0229269
P3H2 prolyl 3-hydroxylase 2 -0.0213611
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0212589
LIMCH1 LIM and calponin homology domains 1 -0.0212445
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0209084
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0207107
ATXN1 ataxin 1 -0.0207106
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0206898
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0204937
COL5A2 collagen, type V, alpha 2 -0.0202904
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0201426
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0201188
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0191302
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0190221
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0189815
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0188903
RAD51B RAD51 paralog B -0.0188253
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0188098
COL4A5 collagen, type IV, alpha 5 -0.018471
TBC1D22A TBC1 domain family, member 22A -0.0184032
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0184021
PHF21A PHD finger protein 21A -0.0183573
TTC28 tetratricopeptide repeat domain 28 -0.0180541
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0179218
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0177801
H1-0 H1.0 linker histone -0.017535
CMIP c-Maf inducing protein -0.0175013
CCDC88A coiled-coil domain containing 88A -0.0173917
WSB1 WD repeat and SOCS box containing 1 -0.0171826
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0169635
NFIB nuclear factor I/B -0.016897
EXT1 exostosin glycosyltransferase 1 -0.0167068
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0167056
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0164845
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0163603
NHSL1 NHS-like 1 -0.0160886
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0160624
MAML2 mastermind-like 2 (Drosophila) -0.015838
TAS2R14 taste receptor, type 2, member 14 -0.0158327
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0158307
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0158125
CLMN calmin (calponin-like, transmembrane) -0.0155471
ATP10A ATPase, class V, type 10A -0.0154911
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0154903
MYOF myoferlin -0.0151971
MACF1 microtubule-actin crosslinking factor 1 -0.0150158