ERK5-IN-2_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.125508
PDE4D phosphodiesterase 4D, cAMP-specific 0.119803
EEF2 eukaryotic translation elongation factor 2 0.0878742
VEGFA vascular endothelial growth factor A 0.0760568
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0737599
FGFR1 fibroblast growth factor receptor 1 0.0663439
TMSB4X thymosin beta 4, X-linked 0.0660381
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0609102
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0520768
TOP2B topoisomerase (DNA) II beta 180kDa 0.0382906
FBXL7 F-box and leucine-rich repeat protein 7 0.0382393
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0382225
USP9X ubiquitin specific peptidase 9, X-linked 0.037094
TNS3 tensin 3 0.0359371
GSE1 Gse1 coiled-coil protein 0.0358905
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0356459
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0353957
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0342634
TRIO trio Rho guanine nucleotide exchange factor 0.0331555
MSRB3 methionine sulfoxide reductase B3 0.0330072
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0326128
ZNF608 zinc finger protein 608 0.0321593
HSPA8 heat shock 70kDa protein 8 0.0316706
MACF1 microtubule-actin crosslinking factor 1 0.0307625
BCOR BCL6 corepressor 0.030648
EIF4H eukaryotic translation initiation factor 4H 0.0305392
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0301504
TSHZ2 teashirt zinc finger homeobox 2 0.0295261
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0294445
DST dystonin 0.0292682
PDE4B phosphodiesterase 4B, cAMP-specific 0.0283146
BTBD3 BTB (POZ) domain containing 3 0.027746
CALR calreticulin 0.0264077
SAMD4A sterile alpha motif domain containing 4A 0.0258353
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0257172
BOC BOC cell adhesion associated, oncogene regulated 0.0254833
PRELID2 PRELI domain containing 2 0.0254488
RAD51B RAD51 paralog B 0.0254004
RPS18 ribosomal protein S18 0.0253403
EGFR epidermal growth factor receptor 0.025258
OGA O-GlcNAcase 0.0250765
BBS9 Bardet-Biedl syndrome 9 0.0250046
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.024809
NAP1L1 nucleosome assembly protein 1-like 1 0.0247513
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0245838
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.024276
PRRC2A proline-rich coiled-coil 2A 0.0241993
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.024176
ATRNL1 attractin-like 1 0.0239105
KIF5B kinesin family member 5B 0.0238084
AKAP13 A kinase (PRKA) anchor protein 13 0.0237323
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0235739
SRRM2 serine/arginine repetitive matrix 2 0.023453
FAM13A family with sequence similarity 13, member A 0.0233815
DLG1 discs, large homolog 1 (Drosophila) 0.0229567
MATR3 matrin 3 0.0223735
MYOF myoferlin 0.0222758
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.022232
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0221729
CTBP2 C-terminal binding protein 2 0.0221468
FTH1 ferritin, heavy polypeptide 1 0.0218932
SOD2 superoxide dismutase 2, mitochondrial 0.0218703
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0217141
PHF3 PHD finger protein 3 0.0217108
EZR ezrin 0.0216888
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0216685
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0216084
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0214414
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0213315
ARHGAP21 Rho GTPase activating protein 21 0.0212102
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0208417
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0207419
EHBP1 EH domain binding protein 1 0.0205729
GPATCH2L G patch domain containing 2-like 0.0205449
DSCAM Down syndrome cell adhesion molecule 0.0204778
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0203476
PBX3 pre-B-cell leukemia homeobox 3 0.0203395
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0202076
SAFB scaffold attachment factor B 0.0201791
FGFR2 fibroblast growth factor receptor 2 0.0201382
GIGYF2 GRB10 interacting GYF protein 2 0.0199919
MYH10 myosin, heavy chain 10, non-muscle 0.0198937
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0198471
CEP290 centrosomal protein 290kDa 0.0196955
MKI67 marker of proliferation Ki-67 0.0195016
PCBP2 poly(rC) binding protein 2 0.0194369
EWSR1 EWS RNA-binding protein 1 0.0193785
XRN1 5'-3' exoribonuclease 1 0.0193542
NSD3 nuclear receptor binding SET domain protein 3 0.0191487
RTN4 reticulon 4 0.0190001
SHROOM3 shroom family member 3 0.019
ARB2A ARB2 cotranscriptional regulator A 0.0189674
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0189289
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0188819
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0188733
ZNF516 zinc finger protein 516 0.0188217
PCM1 pericentriolar material 1 0.0187335
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0187171
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0186708
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0186058

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.203336
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132683
PRKG1 protein kinase, cGMP-dependent, type I -0.122066
MGP matrix Gla protein -0.113228
CADM2 cell adhesion molecule 2 -0.109345
MEST mesoderm specific transcript -0.104091
TMSB10 thymosin beta 10 -0.0926842
RPS6 ribosomal protein S6 -0.0813544
RPL34 ribosomal protein L34 -0.0747495
RPL35A ribosomal protein L35a -0.0728227
RPS23 ribosomal protein S23 -0.0718674
RPS24 ribosomal protein S24 -0.0694936
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0667257
MT2A metallothionein 2A -0.0652957
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0651303
PTMA prothymosin, alpha -0.0638268
RPLP0 ribosomal protein, large, P0 -0.0563242
RPS8 ribosomal protein S8 -0.056104
RPLP1 ribosomal protein, large, P1 -0.0554315
S100A9 S100 calcium binding protein A9 -0.053784
RPS21 ribosomal protein S21 -0.0534861
RPLP2 ribosomal protein, large, P2 -0.0529883
RPS19 ribosomal protein S19 -0.0524557
RPL11 ribosomal protein L11 -0.0484816
RACK1 receptor for activated C kinase 1 -0.0465102
HMGA1 high mobility group AT-hook 1 -0.0455497
RPL12 ribosomal protein L12 -0.0455483
RPS13 ribosomal protein S13 -0.0440925
ACTG1 actin gamma 1 -0.0437049
RPS11 ribosomal protein S11 -0.0424423
RPS14 ribosomal protein S14 -0.0420427
WSB1 WD repeat and SOCS box containing 1 -0.0413798
FTL ferritin, light polypeptide -0.0411902
QKI QKI, KH domain containing, RNA binding -0.0403927
RPS5 ribosomal protein S5 -0.0400686
SOX4 SRY (sex determining region Y)-box 4 -0.0390793
JMJD1C jumonji domain containing 1C -0.0366812
DEK DEK proto-oncogene -0.0356272
FOXC1 forkhead box C1 -0.0342769
RPL27A ribosomal protein L27a -0.0326222
RPL28 ribosomal protein L28 -0.0314108
RPS15 ribosomal protein S15 -0.0305701
RBM25 RNA binding motif protein 25 -0.0304695
RPL36 ribosomal protein L36 -0.0302401
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0296899
RPL30 ribosomal protein L30 -0.0296883
POTEF POTE ankyrin domain family, member F -0.0295164
RPL31 ribosomal protein L31 -0.0293644
RPS16 ribosomal protein S16 -0.0289927
NFIA nuclear factor I/A -0.0289228
RPL19 ribosomal protein L19 -0.0286434
CBX3 chromobox homolog 3 -0.0285646
ATP5F1B ATP synthase F1 subunit beta -0.0281714
TPT1 tumor protein, translationally-controlled 1 -0.0278371
RAB7A RAB7A, member RAS oncogene family -0.0277171
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0276826
HSPB1 heat shock 27kDa protein 1 -0.027042
RPL37 ribosomal protein L37 -0.0269979
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0267328
RPL32 ribosomal protein L32 -0.0257546
RPL8 ribosomal protein L8 -0.0255902
NFIB nuclear factor I/B -0.025433
NCOA1 nuclear receptor coactivator 1 -0.025113
RPL7A ribosomal protein L7a -0.0247914
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0247298
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0244214
RPL15 ribosomal protein L15 -0.0241477
RPL23 ribosomal protein L23 -0.0240945
PFN1 profilin 1 -0.0240808
CCNI cyclin I -0.0240107
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0239571
SMC3 structural maintenance of chromosomes 3 -0.0238935
KMT2E lysine (K)-specific methyltransferase 2E -0.0237776
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0233757
DCAF7 DDB1 and CUL4 associated factor 7 -0.0231856
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0229979
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0229685
RPL7 ribosomal protein L7 -0.0229345
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0227897
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0227683
RPL37A ribosomal protein L37a -0.0227052
VEZT vezatin, adherens junctions transmembrane protein -0.0225744
HMGB1 high mobility group box 1 -0.0224525
RPS25 ribosomal protein S25 -0.0224287
CALD1 caldesmon 1 -0.0223296
SRPK2 SRSF protein kinase 2 -0.02182
BRD4 bromodomain containing 4 -0.0216336
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0216079
RPS29 ribosomal protein S29 -0.0214705
NDUFA4 NDUFA4, mitochondrial complex associated -0.0212686
PDGFC platelet derived growth factor C -0.0208582
S100A6 S100 calcium binding protein A6 -0.0208102
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.0207776
SLC38A2 solute carrier family 38, member 2 -0.0207507
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0203816
TBCA tubulin folding cofactor A -0.0203143
RPL35 ribosomal protein L35 -0.0202025
COL1A2 collagen, type I, alpha 2 -0.0201822
RPS27A ribosomal protein S27a -0.0198871
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0198762