| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.254519 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.10751 |
| FLNB | filamin B, beta | 0.106357 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.10328 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0917787 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.079059 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0762579 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0741936 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0716719 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0713435 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0692846 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0684391 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0623879 |
| MSN | moesin | 0.0595789 |
| SGMS2 | sphingomyelin synthase 2 | 0.0571737 |
| FAM107B | family with sequence similarity 107, member B | 0.0550556 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0549706 |
| PLEC | plectin | 0.0543994 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0538223 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.053206 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0522549 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.051497 |
| MXD1 | MAX dimerization protein 1 | 0.0514968 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0499643 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0497381 |
| MCL1 | myeloid cell leukemia 1 | 0.0491005 |
| TPM3 | tropomyosin 3 | 0.0487144 |
| PMM2 | phosphomannomutase 2 | 0.0482316 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0477672 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0475245 |
| FAM13A | family with sequence similarity 13, member A | 0.0474229 |
| FMNL2 | formin-like 2 | 0.0464251 |
| LAMC2 | laminin, gamma 2 | 0.0451996 |
| PCBP2 | poly(rC) binding protein 2 | 0.0437453 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.042009 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0415786 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0409429 |
| TGM2 | transglutaminase 2 | 0.0407558 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.040455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0376087 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0375369 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.037403 |
| DIAPH1 | diaphanous-related formin 1 | 0.0370037 |
| POTEF | POTE ankyrin domain family, member F | 0.0366643 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.035969 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0357841 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0352834 |
| OSMR | oncostatin M receptor | 0.0339956 |
| SMAD3 | SMAD family member 3 | 0.0339221 |
| CLMP | CXADR-like membrane protein | 0.0336171 |
| CAPRIN2 | caprin family member 2 | 0.0334328 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0327153 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.032546 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.032504 |
| BMP6 | bone morphogenetic protein 6 | 0.0324675 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0321755 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0318629 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0315856 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0315444 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0309973 |
| EGR1 | early growth response 1 | 0.0308079 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0299929 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0294984 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0293504 |
| CTBP2 | C-terminal binding protein 2 | 0.0291005 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0290261 |
| ARRDC3 | arrestin domain containing 3 | 0.0282382 |
| FLNA | filamin A, alpha | 0.028093 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0278891 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.027729 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0276804 |
| RUNX1 | runt-related transcription factor 1 | 0.0275839 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0270817 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0265002 |
| SIK3 | SIK family kinase 3 | 0.0262808 |
| SEC24A | SEC24 family member A | 0.0262356 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.025946 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0257016 |
| FA2H | fatty acid 2-hydroxylase | 0.0256779 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0249908 |
| OPTN | optineurin | 0.0247822 |
| DSPP | dentin sialophosphoprotein | 0.0245109 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.024488 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0243693 |
| LDHA | lactate dehydrogenase A | 0.0242161 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0241906 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0240911 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0237808 |
| VEGFA | vascular endothelial growth factor A | 0.0237189 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0236914 |
| NUP58 | nucleoporin 58 | 0.0231761 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.022967 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0229603 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0227477 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0226721 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0224652 |
| CD44 | CD44 molecule (Indian blood group) | 0.0223902 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0221085 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0218043 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0216697 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.19098 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.143721 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.121872 |
| PTMA | prothymosin, alpha | -0.115647 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.101263 |
| LMO7 | LIM domain 7 | -0.100921 |
| VIM | vimentin | -0.10004 |
| ACTG1 | actin gamma 1 | -0.0977482 |
| AHNAK | AHNAK nucleoprotein | -0.0843833 |
| SQSTM1 | sequestosome 1 | -0.0783405 |
| EMP1 | epithelial membrane protein 1 | -0.0776188 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0760993 |
| S100A10 | S100 calcium binding protein A10 | -0.0721944 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0686492 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0667884 |
| S100A4 | S100 calcium binding protein A4 | -0.0643189 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.061312 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0608131 |
| EPCAM | epithelial cell adhesion molecule | -0.0594501 |
| KLF6 | Kruppel-like factor 6 | -0.0568042 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0560628 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0557064 |
| LAMB3 | laminin, beta 3 | -0.0542418 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0509693 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0497881 |
| CD2AP | CD2-associated protein | -0.0482589 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0481439 |
| S100A6 | S100 calcium binding protein A6 | -0.0478001 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0472474 |
| ASPH | aspartate beta-hydroxylase | -0.0471968 |
| RPS24 | ribosomal protein S24 | -0.0452705 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0450892 |
| GNAS | GNAS complex locus | -0.044908 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0447983 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0438667 |
| RPLP0 | ribosomal protein, large, P0 | -0.0424679 |
| OGA | O-GlcNAcase | -0.0424624 |
| SEPTIN7 | septin 7 | -0.0422538 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0419603 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0418527 |
| IER3 | immediate early response 3 | -0.0413343 |
| RPL35A | ribosomal protein L35a | -0.0398135 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0395995 |
| KRT8 | keratin 8, type II | -0.0389524 |
| VCL | vinculin | -0.0387188 |
| RPL34 | ribosomal protein L34 | -0.0385264 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0377993 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0374492 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0363763 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0361386 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0357231 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0354405 |
| UBE2I | ubiquitin-conjugating enzyme E2I | -0.035259 |
| DSG2 | desmoglein 2 | -0.0349335 |
| FOXO3 | forkhead box O3 | -0.0344909 |
| RPL37A | ribosomal protein L37a | -0.0336751 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0335356 |
| H1-0 | H1.0 linker histone | -0.0330295 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0327326 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.03268 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0324452 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0321939 |
| KRT18 | keratin 18, type I | -0.0321696 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.031747 |
| MYO6 | myosin VI | -0.0316387 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0315739 |
| MYOF | myoferlin | -0.0310927 |
| RPL12 | ribosomal protein L12 | -0.0310082 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0309804 |
| VCAN | versican | -0.0306058 |
| RPS3 | ribosomal protein S3 | -0.0305111 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0302173 |
| RPL31 | ribosomal protein L31 | -0.0301743 |
| RPLP2 | ribosomal protein, large, P2 | -0.0301645 |
| RPL11 | ribosomal protein L11 | -0.0300258 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0300037 |
| RHEB | Ras homolog enriched in brain | -0.0299225 |
| RRBP1 | ribosome binding protein 1 | -0.0296932 |
| RBM39 | RNA binding motif protein 39 | -0.0293942 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0293461 |
| LMNA | lamin A/C | -0.0292804 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0292066 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0290919 |
| NEK7 | NIMA-related kinase 7 | -0.0285406 |
| RPS8 | ribosomal protein S8 | -0.0285365 |
| EHBP1 | EH domain binding protein 1 | -0.0284704 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0282259 |
| SP100 | SP100 nuclear antigen | -0.0281499 |
| RPS27A | ribosomal protein S27a | -0.0277483 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | -0.0275532 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0274016 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0273723 |
| RPS21 | ribosomal protein S21 | -0.0270534 |
| TNPO1 | transportin 1 | -0.0268243 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0267887 |
| TMEM41B | transmembrane protein 41B | -0.026616 |
| SEM1 | SEM1 26S proteasome subunit | -0.0263602 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0262651 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0261949 |
| TOP1 | topoisomerase (DNA) I | -0.0260026 |
