| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0926423 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0683126 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0442458 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0404489 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.038087 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0365323 |
| NDRG1 | N-myc downstream regulated 1 | 0.0357653 |
| VEGFA | vascular endothelial growth factor A | 0.0339759 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0307314 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0297301 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0288651 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0283518 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0269605 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0255729 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0252839 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0248721 |
| SMAD3 | SMAD family member 3 | 0.0242233 |
| FNDC3A | fibronectin type III domain containing 3A | 0.023671 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0236567 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0234299 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0229302 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0220684 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0214792 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0212397 |
| PCBP2 | poly(rC) binding protein 2 | 0.0211387 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0205706 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0201905 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0201009 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0199198 |
| CLTC | clathrin, heavy chain (Hc) | 0.0197152 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0197122 |
| FAM13A | family with sequence similarity 13, member A | 0.0191124 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0189547 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0189277 |
| DUSP16 | dual specificity phosphatase 16 | 0.0189254 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.018632 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0180354 |
| EGFR | epidermal growth factor receptor | 0.0177278 |
| GRB10 | growth factor receptor-bound protein 10 | 0.017712 |
| FNDC3B | fibronectin type III domain containing 3B | 0.017704 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0176005 |
| FLNA | filamin A, alpha | 0.017589 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0175675 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0174915 |
| TXNRD1 | thioredoxin reductase 1 | 0.0174229 |
| TMEM165 | transmembrane protein 165 | 0.017382 |
| LDHA | lactate dehydrogenase A | 0.0173008 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0172375 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0169666 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0168727 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0168085 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0166768 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.0164487 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0160961 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0157939 |
| CCNL1 | cyclin L1 | 0.0157062 |
| STX16 | syntaxin 16 | 0.0156824 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 0.015601 |
| EZR | ezrin | 0.0155954 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0155758 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0151996 |
| DSPP | dentin sialophosphoprotein | 0.015115 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0149327 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0148603 |
| ATXN1 | ataxin 1 | 0.0147435 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.014499 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0142492 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0142485 |
| YAP1 | Yes-associated protein 1 | 0.0141895 |
| LRRC59 | leucine rich repeat containing 59 | 0.0141345 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0141055 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0140535 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0140448 |
| FAM219A | family with sequence similarity 219, member A | 0.0140105 |
| VIPR2 | vasoactive intestinal peptide receptor 2 | 0.0139985 |
| FAM168A | family with sequence similarity 168, member A | 0.013963 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0138822 |
| RPL3 | ribosomal protein L3 | 0.0138717 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0138319 |
| HELZ | helicase with zinc finger | 0.0138184 |
| FGB | fibrinogen beta chain | 0.0137487 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0136486 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0136258 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0134722 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0134471 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0133889 |
| CD24 | CD24 molecule | 0.0133868 |
| TPM3 | tropomyosin 3 | 0.0133484 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.013304 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0131686 |
| PLEC | plectin | 0.0130808 |
| BRD2 | bromodomain containing 2 | 0.0129517 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.012854 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.012844 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0127898 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0125817 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0125189 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.012479 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0124788 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0123853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.179778 |
| RPL19 | ribosomal protein L19 | -0.121055 |
| ACACA | acetyl-CoA carboxylase alpha | -0.112342 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0944814 |
| PTMA | prothymosin, alpha | -0.091441 |
| RPL23 | ribosomal protein L23 | -0.0868581 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0702475 |
| CDK12 | cyclin-dependent kinase 12 | -0.0554757 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0521263 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0492615 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0461342 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.044933 |
| RPL35A | ribosomal protein L35a | -0.0435124 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0401401 |
| ASPH | aspartate beta-hydroxylase | -0.0380323 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0378352 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0362489 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0355826 |
| ACTG1 | actin gamma 1 | -0.0350895 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0350616 |
| CCND1 | cyclin D1 | -0.0318521 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0296181 |
| CEP250 | centrosomal protein 250kDa | -0.0294052 |
| TMSB10 | thymosin beta 10 | -0.0294027 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.029065 |
| TMSB4X | thymosin beta 4, X-linked | -0.0287694 |
| FDPS | farnesyl diphosphate synthase | -0.027367 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0271362 |
| TTC6 | tetratricopeptide repeat domain 6 | -0.0271096 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0259527 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0255498 |
| RPS29 | ribosomal protein S29 | -0.0247691 |
| RESF1 | retroelement silencing factor 1 | -0.0247513 |
| RPS3 | ribosomal protein S3 | -0.0235856 |
| RPS24 | ribosomal protein S24 | -0.0233841 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0228869 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0225341 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0224795 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0217662 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0211394 |
| RPL12 | ribosomal protein L12 | -0.0208938 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.020549 |
| PARD3 | par-3 family cell polarity regulator | -0.0203446 |
| RPS8 | ribosomal protein S8 | -0.0203304 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.020128 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0199344 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0187295 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0184912 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0184409 |
| HLA-B | major histocompatibility complex, class I, B | -0.0184239 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0183396 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.0181194 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0180051 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0178896 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0178815 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0178156 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0177291 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0173152 |
| GNAS | GNAS complex locus | -0.017271 |
| TENM4 | teneurin transmembrane protein 4 | -0.0170488 |
| CD164 | CD164 molecule, sialomucin | -0.0169563 |
| PTK2 | protein tyrosine kinase 2 | -0.0165733 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0165203 |
| RPL34 | ribosomal protein L34 | -0.0164511 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0162809 |
| TPM4 | tropomyosin 4 | -0.0160214 |
| RPL31 | ribosomal protein L31 | -0.0159688 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0157096 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0156701 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0153293 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0153072 |
| TMC5 | transmembrane channel-like 5 | -0.015161 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0150806 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0150772 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0150558 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0150121 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0148738 |
| LMNA | lamin A/C | -0.0147982 |
| B2M | beta-2-microglobulin | -0.0147405 |
| RPS16 | ribosomal protein S16 | -0.0147202 |
| RPL37A | ribosomal protein L37a | -0.0146665 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0146216 |
| TMEM41B | transmembrane protein 41B | -0.014548 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0143546 |
| RPL9 | ribosomal protein L9 | -0.0143497 |
| AHNAK | AHNAK nucleoprotein | -0.0143084 |
| MAP4 | microtubule-associated protein 4 | -0.0140113 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0139797 |
| DST | dystonin | -0.0137062 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0136655 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0135252 |
| RPL7A | ribosomal protein L7a | -0.0135242 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | -0.0134648 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | -0.0134253 |
| LASP1 | LIM and SH3 protein 1 | -0.0134232 |
| RPS6 | ribosomal protein S6 | -0.0134231 |
| RPS27A | ribosomal protein S27a | -0.0134211 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0133913 |
| RPL38 | ribosomal protein L38 | -0.0133707 |
| HLA-C | major histocompatibility complex, class I, C | -0.013328 |
