ERK5-IN-2_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.178362
COL5A2 collagen, type V, alpha 2 0.147836
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.138959
ZNF608 zinc finger protein 608 0.115402
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.112672
JMJD1C jumonji domain containing 1C 0.0940064
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0876825
USP9X ubiquitin specific peptidase 9, X-linked 0.0818765
KMT2C lysine (K)-specific methyltransferase 2C 0.079748
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0747552
RAD51B RAD51 paralog B 0.0703841
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0679896
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0655958
DST dystonin 0.0643878
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0626581
SOX5 SRY (sex determining region Y)-box 5 0.0622392
TOX thymocyte selection-associated high mobility group box 0.0622307
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0619143
PCBP2 poly(rC) binding protein 2 0.0608522
USP34 ubiquitin specific peptidase 34 0.060761
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0587084
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0585832
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0579609
NBEAL1 neurobeachin-like 1 0.0568694
JARID2 jumonji, AT rich interactive domain 2 0.0562665
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0554911
NFIA nuclear factor I/A 0.0554109
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0549415
ZSWIM6 zinc finger, SWIM-type containing 6 0.0547954
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0547145
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0546805
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0545672
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0544985
ADGRG6 adhesion G protein-coupled receptor G6 0.0531319
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.051797
ERBB4 erb-b2 receptor tyrosine kinase 4 0.051116
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0508334
ATP11A ATPase, class VI, type 11A 0.0494683
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0480995
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0479823
NALF1 NALCN channel auxiliary factor 1 0.0474697
ZNF638 zinc finger protein 638 0.0474064
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0472826
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0465625
CABIN1 calcineurin binding protein 1 0.0453764
PTK2 protein tyrosine kinase 2 0.0450198
EXT1 exostosin glycosyltransferase 1 0.0445969
ZNF292 zinc finger protein 292 0.0444735
CHD7 chromodomain helicase DNA binding protein 7 0.0437176
AUTS2 autism susceptibility candidate 2 0.043474
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0433653
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0432142
KDM2A lysine (K)-specific demethylase 2A 0.0430412
QKI QKI, KH domain containing, RNA binding 0.0430305
SMYD3 SET and MYND domain containing 3 0.0427815
ESYT2 extended synaptotagmin-like protein 2 0.0424746
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0422987
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0421453
RPL3 ribosomal protein L3 0.0413864
KDM6A lysine (K)-specific demethylase 6A 0.0413497
NGLY1 N-glycanase 1 0.0411618
SIK3 SIK family kinase 3 0.0403167
EIF4B eukaryotic translation initiation factor 4B 0.0401438
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0398802
KIF1B kinesin family member 1B 0.0398118
ATRN attractin 0.0396057
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0392263
NCKAP1 NCK-associated protein 1 0.0390449
MED13L mediator complex subunit 13-like 0.0389644
KMT2E lysine (K)-specific methyltransferase 2E 0.0378952
RLF rearranged L-myc fusion 0.0373358
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0372081
MCL1 myeloid cell leukemia 1 0.0372013
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0370626
HELZ helicase with zinc finger 0.0370061
MATR3 matrin 3 0.0369398
HSPA8 heat shock 70kDa protein 8 0.0367535
KDM3A lysine (K)-specific demethylase 3A 0.0367179
CELF2 CUGBP, Elav-like family member 2 0.0366074
CDC73 cell division cycle 73 0.0362003
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.035803
RTN4 reticulon 4 0.0357841
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0356071
ATAD2 ATPase family, AAA domain containing 2 0.0354387
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.035427
ARFGEF3 ARFGEF family member 3 0.0351582
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0350771
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.034679
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0345923
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0345233
GYS1 glycogen synthase 1 (muscle) 0.0344967
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0343908
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0343491
WNK1 WNK lysine deficient protein kinase 1 0.0340036
RPL13A ribosomal protein L13a 0.0337855
PEAK1 pseudopodium-enriched atypical kinase 1 0.0337828
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0336454
ZFAND3 zinc finger, AN1-type domain 3 0.0335871
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0334871
PHF21A PHD finger protein 21A 0.033344

decreased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) -0.137151
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0998703
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0995705
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0976678
NPAS3 neuronal PAS domain protein 3 -0.087459
TMSB10 thymosin beta 10 -0.0551312
RPS21 ribosomal protein S21 -0.0545729
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0451626
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0451317
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0409309
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0393647
SOX4 SRY (sex determining region Y)-box 4 -0.0382956
RPS24 ribosomal protein S24 -0.0370004
PTMA prothymosin, alpha -0.0360128
ACTG1 actin gamma 1 -0.0355184
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0341633
HMGB1 high mobility group box 1 -0.0330954
RPS8 ribosomal protein S8 -0.0311567
RPL27A ribosomal protein L27a -0.0309118
NRG1 neuregulin 1 -0.0300929
OSBPL10 oxysterol binding protein-like 10 -0.0296859
RPL34 ribosomal protein L34 -0.0295524
RPL28 ribosomal protein L28 -0.0289449
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0274233
RSL1D1 ribosomal L1 domain containing 1 -0.0259564
RPLP2 ribosomal protein, large, P2 -0.0259355
HMGA1 high mobility group AT-hook 1 -0.0257625
MSH4 mutS homolog 4 -0.0256346
PFN1 profilin 1 -0.0253821
MYL12B myosin, light chain 12B, regulatory -0.0240417
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0234472
TBC1D22A TBC1 domain family, member 22A -0.0225202
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0224406
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0224192
TENM2 teneurin transmembrane protein 2 -0.0220173
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.021768
GARS1 glycyl-tRNA synthetase 1 -0.0216133
NAP1L1 nucleosome assembly protein 1-like 1 -0.0214975
PABPN1 poly(A) binding protein, nuclear 1 -0.0214885
RPS15 ribosomal protein S15 -0.0210263
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0209221
RPL35A ribosomal protein L35a -0.0199559
RPLP1 ribosomal protein, large, P1 -0.0198464
TAS2R14 taste receptor, type 2, member 14 -0.0197419
RPL38 ribosomal protein L38 -0.0196589
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.019545
IARS1 isoleucyl-tRNA synthetase 1 -0.0195041
SALL4 spalt-like transcription factor 4 -0.019261
IGF2 insulin-like growth factor 2 -0.0190506
GTPBP4 GTP binding protein 4 -0.0189439
SOX2 SRY (sex determining region Y)-box 2 -0.0188845
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0188839
ATM ATM serine/threonine kinase -0.0188508
RPS29 ribosomal protein S29 -0.0187797
KPNB1 karyopherin (importin) beta 1 -0.018678
S100A9 S100 calcium binding protein A9 -0.0183633
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -0.0180311
SCG2 secretogranin II -0.0177654
RPL18 ribosomal protein L18 -0.0174407
MTAP methylthioadenosine phosphorylase -0.0173229
NARS1 asparaginyl-tRNA synthetase 1 -0.016885
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0168642
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0168192
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0166775
VDAC1 voltage-dependent anion channel 1 -0.0165467
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0165212
RPL27 ribosomal protein L27 -0.016255
RPS19 ribosomal protein S19 -0.0160946
RPS10 ribosomal protein S10 -0.0160434
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.016033
NOP56 NOP56 ribonucleoprotein -0.015951
RPL9 ribosomal protein L9 -0.0157179
KIAA0753 KIAA0753 -0.0156777
RBM28 RNA binding motif protein 28 -0.0155251
RPL5 ribosomal protein L5 -0.0154576
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0154001
THBS1 thrombospondin 1 -0.0152818
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.015253
S100A10 S100 calcium binding protein A10 -0.0149703
NT5C2 5'-nucleotidase, cytosolic II -0.0149054
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.014669
NUDCD1 NudC domain containing 1 -0.0146351
RPS5 ribosomal protein S5 -0.0145735
HMGA2 high mobility group AT-hook 2 -0.0145612
ATP9A ATPase, class II, type 9A -0.0145298
ATXN10 ataxin 10 -0.0144884
ZNF33A zinc finger protein 33A -0.0144395
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0142576
CCDC138 coiled-coil domain containing 138 -0.0141686
RPS27A ribosomal protein S27a -0.0141473
RPL31 ribosomal protein L31 -0.0139495
THOC2 THO complex 2 -0.0139472
CADM2 cell adhesion molecule 2 -0.0137042
LARS1 leucyl-tRNA synthetase 1 -0.0136636
PDCD11 programmed cell death 11 -0.0136393
ENOSF1 enolase superfamily member 1 -0.0135877
HAUS6 HAUS augmin-like complex, subunit 6 -0.0134606
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -0.0134421
SRP72 signal recognition particle 72kDa -0.0133314
MAP4 microtubule-associated protein 4 -0.0131516