ERK5-IN-2_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.396384
NAMPT nicotinamide phosphoribosyltransferase 0.0860873
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0842069
KMT2E lysine (K)-specific methyltransferase 2E 0.0654598
CDC73 cell division cycle 73 0.0647276
IGFBP3 insulin-like growth factor binding protein 3 0.0630943
LEF1 lymphoid enhancer-binding factor 1 0.0626104
CD109 CD109 molecule 0.0614698
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0598471
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0476253
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0470225
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0452247
EEF2 eukaryotic translation elongation factor 2 0.0422993
ANXA2 annexin A2 0.0404511
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0395195
TMEM178B transmembrane protein 178B 0.0392801
APP amyloid beta (A4) precursor protein 0.0391979
ZNF292 zinc finger protein 292 0.0386771
ESYT2 extended synaptotagmin-like protein 2 0.0378957
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0371711
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0367762
NDRG1 N-myc downstream regulated 1 0.0363074
TAC4 tachykinin 4 (hemokinin) 0.0349427
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.033341
BHLHE40 basic helix-loop-helix family, member e40 0.0333326
EPS8 epidermal growth factor receptor pathway substrate 8 0.0332721
DST dystonin 0.0328323
HELZ helicase with zinc finger 0.0323092
FNDC3B fibronectin type III domain containing 3B 0.0312557
NAV2 neuron navigator 2 0.0305109
SETBP1 SET binding protein 1 0.0304773
LOC112694756 uncharaterized LOC112694756 0.0302987
EIF4H eukaryotic translation initiation factor 4H 0.0300277
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0298327
PDIA4 protein disulfide isomerase family A, member 4 0.0296713
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0294861
KMT2C lysine (K)-specific methyltransferase 2C 0.0294614
MACF1 microtubule-actin crosslinking factor 1 0.0288156
ARRDC3 arrestin domain containing 3 0.0282559
TNNC1 troponin C type 1 (slow) 0.0277897
DDIT4 DNA-damage-inducible transcript 4 0.0277518
SPTBN1 spectrin, beta, non-erythrocytic 1 0.027378
AFDN afadin, adherens junction formation factor 0.0273559
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0273258
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0266029
UBE2H ubiquitin-conjugating enzyme E2H 0.0264972
ICAM1 intercellular adhesion molecule 1 0.0260694
RBM33 RNA binding motif protein 33 0.0256538
IL1RAP interleukin 1 receptor accessory protein 0.0252136
BSG basigin (Ok blood group) 0.0249993
RNF145 ring finger protein 145 0.0247824
LDHA lactate dehydrogenase A 0.0247659
NUP58 nucleoporin 58 0.024747
SRPK2 SRSF protein kinase 2 0.0246537
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0234793
VGF VGF nerve growth factor inducible 0.0234241
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.023221
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0229897
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0229449
IFRD1 interferon-related developmental regulator 1 0.0227385
UHMK1 U2AF homology motif (UHM) kinase 1 0.0225714
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0222056
LOC102724023 ES1 protein homolog, mitochondrial 0.0220915
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0220584
COG5 component of oligomeric golgi complex 5 0.0220434
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0220363
FOS FBJ murine osteosarcoma viral oncogene homolog 0.021921
CCNL1 cyclin L1 0.0214806
COPA coatomer protein complex, subunit alpha 0.0212226
SPRED1 sprouty-related, EVH1 domain containing 1 0.0210861
FLNA filamin A, alpha 0.0209094
CHSY1 chondroitin sulfate synthase 1 0.0208132
MRTFA myocardin related transcription factor A 0.0206078
SPAG9 sperm associated antigen 9 0.0203901
GAS7 growth arrest-specific 7 0.0198844
ACTN1 actinin, alpha 1 0.01975
TPR translocated promoter region, nuclear basket protein 0.0196188
AHR aryl hydrocarbon receptor 0.0194865
FTH1 ferritin, heavy polypeptide 1 0.0194848
NEK7 NIMA-related kinase 7 0.0193695
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0193492
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0190796
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0188699
RCAN1 regulator of calcineurin 1 0.018737
MKRN1 makorin ring finger protein 1 0.0184586
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0184079
ANO6 anoctamin 6 0.0183952
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0182249
RLF rearranged L-myc fusion 0.0180107
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0179156
TAGLN2 transgelin 2 0.0178921
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0176473
NHSL1 NHS-like 1 0.0174746
AFF4 AF4/FMR2 family, member 4 0.0173567
MYOF myoferlin 0.0173467
RYBP RING1 and YY1 binding protein 0.0172649
MATR3 matrin 3 0.0171607
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0170821
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0170249
GLS2 glutaminase 2 (liver, mitochondrial) 0.0168872

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172098
HLA-B major histocompatibility complex, class I, B -0.101168
VIM vimentin -0.0882426
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0819128
TMSB10 thymosin beta 10 -0.0810371
NLGN1 neuroligin 1 -0.0770829
PTMA prothymosin, alpha -0.0729744
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.07018
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0678399
IGFBP5 insulin-like growth factor binding protein 5 -0.0585084
GDF15 growth differentiation factor 15 -0.0566879
RPL35A ribosomal protein L35a -0.0502556
S100A6 S100 calcium binding protein A6 -0.0436535
TPT1 tumor protein, translationally-controlled 1 -0.0425782
RPS8 ribosomal protein S8 -0.0412967
FTL ferritin, light polypeptide -0.0377046
RPL37A ribosomal protein L37a -0.0358254
RPLP1 ribosomal protein, large, P1 -0.0355215
ACTG1 actin gamma 1 -0.0333112
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0326448
TRIM2 tripartite motif containing 2 -0.0317445
RPS6 ribosomal protein S6 -0.0315034
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0302665
RPL34 ribosomal protein L34 -0.0297776
RPL31 ribosomal protein L31 -0.0295662
SCFD2 sec1 family domain containing 2 -0.0291573
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0290906
RPS19 ribosomal protein S19 -0.0272697
IFI6 interferon, alpha-inducible protein 6 -0.0270421
GPC6 glypican 6 -0.026855
RPS24 ribosomal protein S24 -0.026605
MACROD2 MACRO domain containing 2 -0.0263696
PTCHD4 patched domain containing 4 -0.0260863
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.02581
IER3 immediate early response 3 -0.0249545
ENO2 enolase 2 (gamma, neuronal) -0.0247817
B2M beta-2-microglobulin -0.0247428
S100A9 S100 calcium binding protein A9 -0.0245058
CD63 CD63 molecule -0.0244441
RPS29 ribosomal protein S29 -0.0244113
RPL9 ribosomal protein L9 -0.0239351
VDAC1 voltage-dependent anion channel 1 -0.0233697
FRMD4A FERM domain containing 4A -0.0228555
RPL37 ribosomal protein L37 -0.0227819
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0226405
GNAS GNAS complex locus -0.022404
BACE2 beta-site APP-cleaving enzyme 2 -0.0223461
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0222174
ZNF704 zinc finger protein 704 -0.022215
RPLP2 ribosomal protein, large, P2 -0.0221853
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0215641
IGF2 insulin-like growth factor 2 -0.021393
RPS13 ribosomal protein S13 -0.0211872
OXR1 oxidation resistance 1 -0.0211307
MAML3 mastermind-like 3 (Drosophila) -0.0211002
PTPRD protein tyrosine phosphatase, receptor type, D -0.0208227
CUX1 cut-like homeobox 1 -0.0207747
RPL36 ribosomal protein L36 -0.0206805
RPS23 ribosomal protein S23 -0.0204141
FBXL7 F-box and leucine-rich repeat protein 7 -0.0202115
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0201005
HLA-A major histocompatibility complex, class I, A -0.019766
S100A10 S100 calcium binding protein A10 -0.0196428
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0193218
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0190726
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0189996
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0189959
RPL23 ribosomal protein L23 -0.0185023
HIP1 huntingtin interacting protein 1 -0.0184148
RPL38 ribosomal protein L38 -0.0183855
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0183305
HMGA2 high mobility group AT-hook 2 -0.0182832
RPL11 ribosomal protein L11 -0.0182067
RPS27A ribosomal protein S27a -0.0181973
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0181849
RPL28 ribosomal protein L28 -0.0181625
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0178762
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0178697
TBCA tubulin folding cofactor A -0.0174956
IFI16 interferon, gamma-inducible protein 16 -0.0170287
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.016366
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0161227
LMNA lamin A/C -0.0159478
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0156889
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0156615
RPL7A ribosomal protein L7a -0.0156279
TM4SF1 transmembrane 4 L six family member 1 -0.0153815
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0152388
PARVB parvin, beta -0.0152131
TBC1D22A TBC1 domain family, member 22A -0.0151459
DCT dopachrome tautomerase -0.0150818
ENO1 enolase 1, (alpha) -0.0148129
IFITM3 interferon induced transmembrane protein 3 -0.0147899
RPS21 ribosomal protein S21 -0.0146983
RPS15 ribosomal protein S15 -0.014659
CALD1 caldesmon 1 -0.0146505
RPL27A ribosomal protein L27a -0.0146112
MTDH metadherin -0.0145477
AKAP12 A kinase (PRKA) anchor protein 12 -0.0142495
RPL5 ribosomal protein L5 -0.0142408