| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.148664 |
| FNDC3B | fibronectin type III domain containing 3B | 0.113915 |
| LAMC2 | laminin, gamma 2 | 0.0951457 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0929411 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0841721 |
| SMAD3 | SMAD family member 3 | 0.0748223 |
| LAMA4 | laminin, alpha 4 | 0.0713366 |
| APOL1 | apolipoprotein L, 1 | 0.0673587 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0655341 |
| RAD51B | RAD51 paralog B | 0.0654063 |
| GRB10 | growth factor receptor-bound protein 10 | 0.060888 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0607212 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0592398 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0582389 |
| EFNA5 | ephrin-A5 | 0.0578605 |
| NRG3 | neuregulin 3 | 0.0560306 |
| DTNA | dystrobrevin, alpha | 0.0551211 |
| CMIP | c-Maf inducing protein | 0.0546799 |
| TGM2 | transglutaminase 2 | 0.0544382 |
| VEGFA | vascular endothelial growth factor A | 0.0533315 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0482904 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0475445 |
| PLEC | plectin | 0.0466352 |
| MCL1 | myeloid cell leukemia 1 | 0.046085 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0457574 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0449519 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0441345 |
| FAM107B | family with sequence similarity 107, member B | 0.0431845 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0427066 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0425506 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0408447 |
| EXT1 | exostosin glycosyltransferase 1 | 0.039796 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0396649 |
| ANXA2 | annexin A2 | 0.0389083 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0387356 |
| ASPH | aspartate beta-hydroxylase | 0.0386172 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0377776 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0374568 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0373528 |
| LCN2 | lipocalin 2 | 0.0370751 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0369296 |
| EGR1 | early growth response 1 | 0.0367142 |
| SEPTIN9 | septin 9 | 0.0362228 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0354431 |
| KIAA1217 | KIAA1217 | 0.0348307 |
| ATXN1 | ataxin 1 | 0.0336106 |
| MYO1E | myosin IE | 0.0331416 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0330344 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0329497 |
| SGMS2 | sphingomyelin synthase 2 | 0.0327035 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0325726 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0310306 |
| CD44 | CD44 molecule (Indian blood group) | 0.0309572 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0302761 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0300131 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0298503 |
| ITGB4 | integrin, beta 4 | 0.0296674 |
| NDRG1 | N-myc downstream regulated 1 | 0.0296226 |
| NCOR2 | nuclear receptor corepressor 2 | 0.029527 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0293179 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0292657 |
| KRT19 | keratin 19, type I | 0.0291728 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0284411 |
| RNF213 | ring finger protein 213 | 0.0281314 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0276561 |
| INTS6 | integrator complex subunit 6 | 0.0272769 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0271774 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0270869 |
| ACTN1 | actinin, alpha 1 | 0.0264158 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0263593 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0260549 |
| APP | amyloid beta (A4) precursor protein | 0.025985 |
| MX1 | MX dynamin-like GTPase 1 | 0.0258015 |
| HDAC9 | histone deacetylase 9 | 0.025519 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0252045 |
| NAV2 | neuron navigator 2 | 0.0249516 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0244902 |
| OSMR | oncostatin M receptor | 0.0243434 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0243197 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0241712 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0241461 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0237184 |
| PLAT | plasminogen activator, tissue | 0.0236746 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0234436 |
| RCOR1 | REST corepressor 1 | 0.0232939 |
| NOTCH2 | notch 2 | 0.0232223 |
| HLA-C | major histocompatibility complex, class I, C | 0.0232021 |
| EGFR | epidermal growth factor receptor | 0.0231695 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0229802 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0229608 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0229449 |
| CFB | complement factor B | 0.0229352 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0228858 |
| SMYD3 | SET and MYND domain containing 3 | 0.0226748 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0226253 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0224208 |
| SVIL | supervillin | 0.0221668 |
| MUC16 | mucin 16, cell surface associated | 0.0221513 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.021905 |
| ECE1 | endothelin converting enzyme 1 | 0.0216843 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.173269 |
| TMSB10 | thymosin beta 10 | -0.143493 |
| PTMA | prothymosin, alpha | -0.119918 |
| MT1X | metallothionein 1X | -0.109096 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0966813 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0942495 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0914114 |
| FTL | ferritin, light polypeptide | -0.0904505 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0853598 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0830846 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0760974 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0745339 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0732439 |
| ACTG1 | actin gamma 1 | -0.0702842 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0612263 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0600614 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0591404 |
| RBM39 | RNA binding motif protein 39 | -0.0586644 |
| OGA | O-GlcNAcase | -0.0491375 |
| SPAG9 | sperm associated antigen 9 | -0.0472202 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0462425 |
| CD2AP | CD2-associated protein | -0.0438334 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0437273 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0416373 |
| RTN4 | reticulon 4 | -0.0416373 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0411489 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0409159 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0405595 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0400694 |
| RIOK3 | RIO kinase 3 | -0.0386057 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0383094 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0380764 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0378793 |
| HLA-B | major histocompatibility complex, class I, B | -0.0377331 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0375577 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | -0.0373084 |
| FAM162A | family with sequence similarity 162, member A | -0.0372198 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0370775 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0362614 |
| WDR45B | WD repeat domain 45B | -0.0359236 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.035766 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0351598 |
| UBC | ubiquitin C | -0.0346497 |
| CCNL1 | cyclin L1 | -0.0342363 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0339084 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0338434 |
| POTEF | POTE ankyrin domain family, member F | -0.0337531 |
| S100A6 | S100 calcium binding protein A6 | -0.0333847 |
| ZNF292 | zinc finger protein 292 | -0.0320984 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0317335 |
| RPLP0 | ribosomal protein, large, P0 | -0.0316772 |
| B2M | beta-2-microglobulin | -0.0316263 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0312983 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0302656 |
| SYNRG | synergin, gamma | -0.030236 |
| ABI1 | abl-interactor 1 | -0.0297779 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0296717 |
| CCNI | cyclin I | -0.0293532 |
| TMEM123 | transmembrane protein 123 | -0.0291821 |
| RPL35A | ribosomal protein L35a | -0.0291488 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0291454 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0287605 |
| TMSB4X | thymosin beta 4, X-linked | -0.028269 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0280793 |
| PLAU | plasminogen activator, urokinase | -0.0277233 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0273984 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0272736 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0271735 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0270723 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0268869 |
| VIM | vimentin | -0.0264992 |
| GNAS | GNAS complex locus | -0.0261928 |
| RPS21 | ribosomal protein S21 | -0.026169 |
| NOP58 | NOP58 ribonucleoprotein | -0.0260532 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0258911 |
| INSIG1 | insulin induced gene 1 | -0.0258194 |
| USP3 | ubiquitin specific peptidase 3 | -0.0258091 |
| FRMD5 | FERM domain containing 5 | -0.0257669 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0257541 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0256311 |
| RLF | rearranged L-myc fusion | -0.0255682 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0255245 |
| TOP1 | topoisomerase (DNA) I | -0.0255089 |
| PGK1 | phosphoglycerate kinase 1 | -0.025425 |
| JMJD1C | jumonji domain containing 1C | -0.0253549 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0245564 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0242311 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0241536 |
| RBM25 | RNA binding motif protein 25 | -0.0240375 |
| ENO1 | enolase 1, (alpha) | -0.0240084 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0238627 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0237713 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0235392 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0234259 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0233935 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0233476 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0233212 |
| MICU1 | mitochondrial calcium uptake 1 | -0.0229466 |
| IER3 | immediate early response 3 | -0.0227617 |
| FAM13A | family with sequence similarity 13, member A | -0.0225985 |
