| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.135425 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.121161 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.092043 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0853083 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0806483 |
| FMN1 | formin 1 | 0.079937 |
| LPIN1 | lipin 1 | 0.0778201 |
| HELZ | helicase with zinc finger | 0.0714258 |
| MSI2 | musashi RNA-binding protein 2 | 0.0713423 |
| FAM13A | family with sequence similarity 13, member A | 0.0663385 |
| SEPTIN9 | septin 9 | 0.066258 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0650538 |
| TLE4 | transducin-like enhancer of split 4 | 0.0557556 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0555247 |
| VEGFA | vascular endothelial growth factor A | 0.0542221 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0538764 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0530782 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.052442 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0501459 |
| DST | dystonin | 0.0483222 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0480879 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0476861 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0472429 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0469334 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0454759 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.045419 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0434624 |
| MED13 | mediator complex subunit 13 | 0.0434292 |
| PHIP | pleckstrin homology domain interacting protein | 0.0431546 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0430754 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0427457 |
| STK38L | serine/threonine kinase 38 like | 0.0405242 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0403365 |
| DTNA | dystrobrevin, alpha | 0.0403113 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0400806 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0398236 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0395254 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0385679 |
| FAM107B | family with sequence similarity 107, member B | 0.0381842 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0378624 |
| PCBP2 | poly(rC) binding protein 2 | 0.0366968 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0363758 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0351918 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0344611 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0339253 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0337692 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0335009 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0328538 |
| RPS12 | ribosomal protein S12 | 0.0327771 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0326999 |
| INTS6 | integrator complex subunit 6 | 0.0325937 |
| MYO1E | myosin IE | 0.0325472 |
| RPS2 | ribosomal protein S2 | 0.032429 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0318032 |
| MEIS2 | Meis homeobox 2 | 0.0317466 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0317113 |
| TRIB2 | tribbles pseudokinase 2 | 0.0314443 |
| RNF213 | ring finger protein 213 | 0.0313801 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0313581 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.030889 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0308059 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0306524 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0296687 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0294708 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.029246 |
| FERMT2 | fermitin family member 2 | 0.0292017 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0291473 |
| BRD2 | bromodomain containing 2 | 0.029138 |
| RBM6 | RNA binding motif protein 6 | 0.0290994 |
| PDS5B | PDS5 cohesin associated factor B | 0.028964 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0289316 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.028757 |
| TPM4 | tropomyosin 4 | 0.0287255 |
| RNF150 | ring finger protein 150 | 0.0285916 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0283063 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.028205 |
| ACTN1 | actinin, alpha 1 | 0.0278825 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0277045 |
| PCM1 | pericentriolar material 1 | 0.0276476 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0274592 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0273865 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0269596 |
| FAT1 | FAT atypical cadherin 1 | 0.0268468 |
| MMP2 | matrix metallopeptidase 2 | 0.0266721 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0265402 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0265237 |
| TPM3 | tropomyosin 3 | 0.026504 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0264283 |
| POTEF | POTE ankyrin domain family, member F | 0.0259112 |
| APP | amyloid beta (A4) precursor protein | 0.0257311 |
| RPL7 | ribosomal protein L7 | 0.0256245 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0254952 |
| VMP1 | vacuole membrane protein 1 | 0.0253985 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0244966 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.024377 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0243648 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0243606 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0243167 |
| ADAR | adenosine deaminase, RNA-specific | 0.0242537 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0242477 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.182718 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.179171 |
| NRG1 | neuregulin 1 | -0.0908841 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0770113 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0740729 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0723243 |
| SYT1 | synaptotagmin I | -0.060996 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0598358 |
| RPL35A | ribosomal protein L35a | -0.0566753 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0560089 |
| B2M | beta-2-microglobulin | -0.052894 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0504675 |
| MAP1B | microtubule-associated protein 1B | -0.049968 |
| PTMA | prothymosin, alpha | -0.0493246 |
| TMSB10 | thymosin beta 10 | -0.048593 |
| STC1 | stanniocalcin 1 | -0.0446597 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0445922 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0435 |
| CENPF | centromere protein F, 350/400kDa | -0.0428655 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0418272 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0411907 |
| GPC5 | glypican 5 | -0.041068 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0405026 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0404189 |
| RPL19 | ribosomal protein L19 | -0.0389452 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0389431 |
| ATRNL1 | attractin-like 1 | -0.0378749 |
| RPLP1 | ribosomal protein, large, P1 | -0.0372433 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0359684 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0353813 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0348753 |
| RPS23 | ribosomal protein S23 | -0.0347141 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0346623 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0336519 |
| ZNF804A | zinc finger protein 804A | -0.0330253 |
| PRR11 | proline rich 11 | -0.0330222 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0323878 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0323683 |
| CADM2 | cell adhesion molecule 2 | -0.0313924 |
| TNRC6B | trinucleotide repeat containing 6B | -0.030908 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0304635 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | -0.0300506 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0295654 |
| MAP4 | microtubule-associated protein 4 | -0.0293951 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0292739 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0292416 |
| RPL38 | ribosomal protein L38 | -0.0287957 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0283442 |
| DIAPH2 | diaphanous-related formin 2 | -0.0283086 |
| NME7 | NME/NM23 family member 7 | -0.0280419 |
| GATA3 | GATA binding protein 3 | -0.0278858 |
| CCND1 | cyclin D1 | -0.0277109 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0275836 |
| VIM | vimentin | -0.0272714 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0268069 |
| DEK | DEK proto-oncogene | -0.0264381 |
| SETD5 | SET domain containing 5 | -0.0262921 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0260035 |
| RPS6 | ribosomal protein S6 | -0.025803 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0257485 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0256532 |
| RPS21 | ribosomal protein S21 | -0.0256113 |
| RPL12 | ribosomal protein L12 | -0.0254683 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0254614 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0252631 |
| GDF15 | growth differentiation factor 15 | -0.0252172 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0250204 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0247138 |
| RANBP17 | RAN binding protein 17 | -0.0246443 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0246321 |
| SCG2 | secretogranin II | -0.0245667 |
| TXNRD1 | thioredoxin reductase 1 | -0.0244033 |
| SVIL | supervillin | -0.023838 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0233705 |
| PHOX2B | paired-like homeobox 2b | -0.0233606 |
| PHF14 | PHD finger protein 14 | -0.0231494 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | -0.0230378 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0230077 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.022959 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0229374 |
| CENPE | centromere protein E, 312kDa | -0.0227951 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.0227709 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | -0.0227455 |
| FNBP4 | formin binding protein 4 | -0.0223597 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.022277 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0222198 |
| FLNB | filamin B, beta | -0.0220747 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0220566 |
| MKI67 | marker of proliferation Ki-67 | -0.0220274 |
| RPS5 | ribosomal protein S5 | -0.0220243 |
| TBC1D19 | TBC1 domain family, member 19 | -0.0219034 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0218375 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.021782 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.0217614 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0217548 |
| CCDC47 | coiled-coil domain containing 47 | -0.0216729 |
| S100A6 | S100 calcium binding protein A6 | -0.0216311 |
| SPAG9 | sperm associated antigen 9 | -0.0214902 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0213122 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0212615 |
