| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.257082 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.128848 |
| RNF213 | ring finger protein 213 | 0.117234 |
| EXT1 | exostosin glycosyltransferase 1 | 0.114749 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.11446 |
| SMAD3 | SMAD family member 3 | 0.113518 |
| ANXA2 | annexin A2 | 0.102786 |
| INTS6 | integrator complex subunit 6 | 0.101805 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0999755 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0919531 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0896472 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0748593 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0733668 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.073108 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0717472 |
| SP100 | SP100 nuclear antigen | 0.0671832 |
| MYO1E | myosin IE | 0.0646837 |
| MX1 | MX dynamin-like GTPase 1 | 0.0616224 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0613736 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0605446 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0592355 |
| ERBIN | erbb2 interacting protein | 0.0588351 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0580653 |
| EFNB2 | ephrin-B2 | 0.0562028 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0553084 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.053738 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0529181 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0524407 |
| MAP7 | microtubule-associated protein 7 | 0.0515644 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0498454 |
| PLSCR1 | phospholipid scramblase 1 | 0.0491801 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0489168 |
| RIGI | RNA sensor RIG-I | 0.0475743 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0475185 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0474717 |
| TMC5 | transmembrane channel-like 5 | 0.0474286 |
| TJP1 | tight junction protein 1 | 0.0465447 |
| ASPH | aspartate beta-hydroxylase | 0.0464458 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0463816 |
| DIAPH1 | diaphanous-related formin 1 | 0.0455872 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0455216 |
| PHF3 | PHD finger protein 3 | 0.0453056 |
| MSI2 | musashi RNA-binding protein 2 | 0.0452869 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0445953 |
| MCU | mitochondrial calcium uniporter | 0.0436669 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.04359 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0429003 |
| PLSCR2 | phospholipid scramblase 2 | 0.0424972 |
| RAD51B | RAD51 paralog B | 0.0422724 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0409572 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0407076 |
| ATP11A | ATPase, class VI, type 11A | 0.0406509 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0405121 |
| MX2 | MX dynamin-like GTPase 2 | 0.0398658 |
| PRKCA | protein kinase C, alpha | 0.0396251 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.039622 |
| MYO5B | myosin VB | 0.0396187 |
| ETV6 | ets variant 6 | 0.0395539 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0389203 |
| SERINC5 | serine incorporator 5 | 0.038761 |
| VCL | vinculin | 0.0380156 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0361157 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0355185 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.035452 |
| RBM47 | RNA binding motif protein 47 | 0.0353744 |
| DST | dystonin | 0.0352852 |
| VMP1 | vacuole membrane protein 1 | 0.0349592 |
| SPATA13 | spermatogenesis associated 13 | 0.0344767 |
| FNIP2 | folliculin interacting protein 2 | 0.0340359 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0339047 |
| SEPTIN9 | septin 9 | 0.0338822 |
| DUSP10 | dual specificity phosphatase 10 | 0.0335972 |
| ITGA6 | integrin, alpha 6 | 0.0333467 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0333162 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0328964 |
| STK24 | serine/threonine kinase 24 | 0.0323787 |
| KYNU | kynureninase | 0.032359 |
| FAT1 | FAT atypical cadherin 1 | 0.0323042 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0320877 |
| SQSTM1 | sequestosome 1 | 0.0319105 |
| AREG | amphiregulin | 0.0318711 |
| EPHB2 | EPH receptor B2 | 0.0318617 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0316957 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0314091 |
| HKDC1 | hexokinase domain containing 1 | 0.0313949 |
| POU2F2 | POU class 2 homeobox 2 | 0.0313648 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0310616 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0310519 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0302433 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0301712 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0300952 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0300558 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0300292 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0298665 |
| APP | amyloid beta (A4) precursor protein | 0.029622 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.02961 |
| MCL1 | myeloid cell leukemia 1 | 0.0295819 |
| PDZD8 | PDZ domain containing 8 | 0.0291074 |
| UBAP2 | ubiquitin associated protein 2 | 0.0290269 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0288831 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.122475 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0871334 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0705382 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0680539 |
| TXNIP | thioredoxin interacting protein | -0.046097 |
| RNF149 | ring finger protein 149 | -0.0449667 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0449289 |
| B2M | beta-2-microglobulin | -0.0446018 |
| H1-0 | H1.0 linker histone | -0.0430721 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0412215 |
| PTMA | prothymosin, alpha | -0.0398692 |
| NDRG1 | N-myc downstream regulated 1 | -0.0368229 |
| HLA-B | major histocompatibility complex, class I, B | -0.0341604 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0326938 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0318463 |
| RPL35A | ribosomal protein L35a | -0.0301349 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0293988 |
| PTEN | phosphatase and tensin homolog | -0.0286499 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0280246 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0270124 |
| GOLGA4 | golgin A4 | -0.0269771 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0268116 |
| MT2A | metallothionein 2A | -0.0267664 |
| GNAS | GNAS complex locus | -0.0255486 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.025475 |
| RPS6 | ribosomal protein S6 | -0.0250905 |
| FTL | ferritin, light polypeptide | -0.0244309 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0237689 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0234231 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0233161 |
| RPL12 | ribosomal protein L12 | -0.0228969 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0227645 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0223905 |
| TMSB10 | thymosin beta 10 | -0.0223168 |
| USP3 | ubiquitin specific peptidase 3 | -0.0219842 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.021967 |
| AGR2 | anterior gradient 2 | -0.0219549 |
| TMEM263 | transmembrane protein 263 | -0.0218977 |
| MKI67 | marker of proliferation Ki-67 | -0.0217053 |
| RNF43 | ring finger protein 43 | -0.0215341 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.020987 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0208306 |
| DIAPH3 | diaphanous-related formin 3 | -0.0208293 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0206685 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0206606 |
| MT1X | metallothionein 1X | -0.0204469 |
| RPLP1 | ribosomal protein, large, P1 | -0.0203617 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0193752 |
| WDR45B | WD repeat domain 45B | -0.0191591 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.019027 |
| SFXN1 | sideroflexin 1 | -0.0189963 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.018987 |
| H3-3B | H3.3 histone B | -0.0189719 |
| CANX | calnexin | -0.018868 |
| DSTN | destrin (actin depolymerizing factor) | -0.0185119 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0184759 |
| RPS24 | ribosomal protein S24 | -0.0184667 |
| MORF4L2 | mortality factor 4 like 2 | -0.0182447 |
| FDPS | farnesyl diphosphate synthase | -0.0178136 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.017351 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0170728 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0170341 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0169031 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0168518 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.016783 |
| RPS19 | ribosomal protein S19 | -0.0166603 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.016455 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0164359 |
| RBM39 | RNA binding motif protein 39 | -0.0163245 |
| RPL34 | ribosomal protein L34 | -0.0162393 |
| RPS8 | ribosomal protein S8 | -0.0161888 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.016153 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0160988 |
| S100A9 | S100 calcium binding protein A9 | -0.015956 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0159452 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0158475 |
| RPL19 | ribosomal protein L19 | -0.0157709 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0157221 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.015612 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -0.015604 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0155565 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0154974 |
| GRAMD2B | GRAM domain containing 2B | -0.0154354 |
| OGA | O-GlcNAcase | -0.0153895 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.015334 |
| BRCA2 | breast cancer 2, early onset | -0.0152452 |
| FANCI | Fanconi anemia, complementation group I | -0.0152239 |
| COG6 | component of oligomeric golgi complex 6 | -0.0151662 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0151387 |
| TMEM87A | transmembrane protein 87A | -0.0151334 |
| CALR | calreticulin | -0.0150842 |
| CALU | calumenin | -0.0150829 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0150801 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0150049 |
| ANLN | anillin, actin binding protein | -0.014962 |
| XPO1 | exportin 1 | -0.014917 |
| RSF1 | remodeling and spacing factor 1 | -0.0148292 |
| GOLGA2 | golgin A2 | -0.0146795 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0146695 |
| WASF2 | WAS protein family, member 2 | -0.0146314 |
