| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.322624 |
| COL6A3 | collagen, type VI, alpha 3 | 0.241748 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0770027 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0711917 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0701303 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.065588 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0650835 |
| COL5A1 | collagen, type V, alpha 1 | 0.0640272 |
| EGR1 | early growth response 1 | 0.0607999 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0593604 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0582846 |
| LDHA | lactate dehydrogenase A | 0.0573667 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0573096 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0520872 |
| KYNU | kynureninase | 0.0504048 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0499854 |
| VEGFA | vascular endothelial growth factor A | 0.0494749 |
| NAV2 | neuron navigator 2 | 0.0447017 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0444653 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0435907 |
| ASPH | aspartate beta-hydroxylase | 0.0428728 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0428035 |
| CD44 | CD44 molecule (Indian blood group) | 0.0413098 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0402783 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0400668 |
| FLNA | filamin A, alpha | 0.0393369 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0382937 |
| MSN | moesin | 0.0378163 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0371448 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0366321 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0364115 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0363064 |
| B2M | beta-2-microglobulin | 0.0362656 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0356798 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0354806 |
| FN1 | fibronectin 1 | 0.0341256 |
| HDAC9 | histone deacetylase 9 | 0.0340844 |
| NLGN1 | neuroligin 1 | 0.0340133 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0336958 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0325859 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0324139 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0323636 |
| RUNX1 | runt-related transcription factor 1 | 0.0322619 |
| TPM3 | tropomyosin 3 | 0.0320367 |
| FNIP1 | folliculin interacting protein 1 | 0.0319166 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0318928 |
| SQSTM1 | sequestosome 1 | 0.0315967 |
| LOX | lysyl oxidase | 0.0314892 |
| PKM | pyruvate kinase, muscle | 0.0307309 |
| DTNA | dystrobrevin, alpha | 0.0293842 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0292206 |
| ADM | adrenomedullin | 0.0289745 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0289127 |
| SMAD3 | SMAD family member 3 | 0.0286953 |
| HLA-A | major histocompatibility complex, class I, A | 0.028656 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.027958 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0279299 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0272942 |
| MORF4L2 | mortality factor 4 like 2 | 0.0272566 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0271919 |
| MYO10 | myosin X | 0.0269812 |
| FAM13A | family with sequence similarity 13, member A | 0.0261315 |
| MYOF | myoferlin | 0.0258783 |
| YEATS2 | YEATS domain containing 2 | 0.0256607 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0256236 |
| PCBP2 | poly(rC) binding protein 2 | 0.0252603 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0252028 |
| MCL1 | myeloid cell leukemia 1 | 0.0251588 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0251432 |
| LOXL2 | lysyl oxidase-like 2 | 0.0250794 |
| PLEC | plectin | 0.0250773 |
| EXT1 | exostosin glycosyltransferase 1 | 0.024979 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0247359 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0240982 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0240479 |
| FAM219A | family with sequence similarity 219, member A | 0.0239849 |
| APP | amyloid beta (A4) precursor protein | 0.0236724 |
| HLA-B | major histocompatibility complex, class I, B | 0.0234334 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0233794 |
| HDLBP | high density lipoprotein binding protein | 0.0231757 |
| VMP1 | vacuole membrane protein 1 | 0.0231302 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0230655 |
| NDRG1 | N-myc downstream regulated 1 | 0.0230558 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0227877 |
| GPATCH2L | G patch domain containing 2-like | 0.0225255 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0224595 |
| VCL | vinculin | 0.0219451 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0217268 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0214525 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0212976 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0211161 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0203962 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0203085 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.020044 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0200084 |
| JUN | jun proto-oncogene | 0.0196483 |
| NAV1 | neuron navigator 1 | 0.019603 |
| ENO1 | enolase 1, (alpha) | 0.0195629 |
| GLG1 | golgi glycoprotein 1 | 0.019507 |
| SEC24A | SEC24 family member A | 0.0193947 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.275503 |
| TMSB10 | thymosin beta 10 | -0.0728998 |
| AHNAK | AHNAK nucleoprotein | -0.0534622 |
| FTL | ferritin, light polypeptide | -0.0501519 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.044425 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0416643 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.040567 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0375787 |
| RPL35A | ribosomal protein L35a | -0.0365376 |
| PTMA | prothymosin, alpha | -0.0350396 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0308946 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0304497 |
| RPS24 | ribosomal protein S24 | -0.0279575 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0237748 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0231261 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0216745 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0214144 |
| S100A6 | S100 calcium binding protein A6 | -0.0211383 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0208202 |
| STK17A | serine/threonine kinase 17a | -0.0208179 |
| OGA | O-GlcNAcase | -0.0207455 |
| URI1 | URI1, prefoldin-like chaperone | -0.0205955 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0201006 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0200093 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0198917 |
| CADM1 | cell adhesion molecule 1 | -0.0189398 |
| NF1 | neurofibromin 1 | -0.018749 |
| TMEM41B | transmembrane protein 41B | -0.0185647 |
| TXNRD1 | thioredoxin reductase 1 | -0.0183611 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0180409 |
| RPLP0 | ribosomal protein, large, P0 | -0.017896 |
| ATM | ATM serine/threonine kinase | -0.0178375 |
| IER3 | immediate early response 3 | -0.0177769 |
| RPL9 | ribosomal protein L9 | -0.0176982 |
| SMAP2 | small ArfGAP2 | -0.0176605 |
| CDK13 | cyclin-dependent kinase 13 | -0.017651 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0176173 |
| RHEB | Ras homolog enriched in brain | -0.0172402 |
| RPS21 | ribosomal protein S21 | -0.017044 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.01652 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0161267 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0160211 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0159491 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0158966 |
| CEP95 | centrosomal protein 95kDa | -0.0157388 |
| RPLP1 | ribosomal protein, large, P1 | -0.015714 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0150089 |
| MMP3 | matrix metallopeptidase 3 | -0.0149908 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0149889 |
| JAK1 | Janus kinase 1 | -0.0148906 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0148397 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0148014 |
| GNAS | GNAS complex locus | -0.0147622 |
| RAB18 | RAB18, member RAS oncogene family | -0.0146639 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0146076 |
| PTX3 | pentraxin 3, long | -0.0144204 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0142735 |
| ZFR | zinc finger RNA binding protein | -0.0140015 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0136207 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0135573 |
| RPL11 | ribosomal protein L11 | -0.0134168 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | -0.0133759 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.013343 |
| RPL38 | ribosomal protein L38 | -0.0133324 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0133057 |
| LMNA | lamin A/C | -0.0132901 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0130948 |
| RPS23 | ribosomal protein S23 | -0.0130897 |
| SPAG9 | sperm associated antigen 9 | -0.0129207 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0129141 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0127222 |
| XPO7 | exportin 7 | -0.0127206 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0126423 |
| HMGB2 | high mobility group box 2 | -0.0125511 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0124945 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0124285 |
| RPS8 | ribosomal protein S8 | -0.0123947 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0123909 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0123735 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0123452 |
| RLF | rearranged L-myc fusion | -0.0122058 |
| SBF2 | SET binding factor 2 | -0.0122054 |
| UBQLN1 | ubiquilin 1 | -0.0122047 |
| NEK7 | NIMA-related kinase 7 | -0.0121958 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0121467 |
| CCM2 | cerebral cavernous malformation 2 | -0.0119976 |
| TNNC1 | troponin C type 1 (slow) | -0.0119647 |
| RPS25 | ribosomal protein S25 | -0.0118651 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | -0.0118438 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0117563 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0117467 |
| USP3 | ubiquitin specific peptidase 3 | -0.011732 |
| RPL19 | ribosomal protein L19 | -0.0117103 |
| TMEM263 | transmembrane protein 263 | -0.0116644 |
| PREPL | prolyl endopeptidase-like | -0.0116484 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0116483 |
| XPO1 | exportin 1 | -0.0116441 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0115845 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.0115542 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0114945 |
